Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2564817172', 'doi': 'https://doi.org/10.1016/s1525-0016(16)33477-3', 'title': '669. rAAV-Based and Intraprostatically Delivered miR-34a Therapeutics for Efficient Inhibition of Prostate Cancer Progression', 'display_name': '669. rAAV-Based and Intraprostatically Delivered miR-34a Therapeutics for Efficient Inhibition of Prostate Cancer Progression', 'publication_year': 2016, 'publication_date': '2016-05-01', 'ids': {'openalex': 'https://openalex.org/W2564817172', 'doi': 'https://doi.org/10.1016/s1525-0016(16)33477-3', 'mag': '2564817172'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1525-0016(16)33477-3', 'pdf_url': 'http://www.cell.com/article/S1525001616334773/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.cell.com/article/S1525001616334773/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082429124', 'display_name': 'Jianzhong Ai', 'orcid': 'https://orcid.org/0000-0003-0617-9286'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianzhong Ai', 'raw_affiliation_strings': ['Department of Urology, West China Hospital, Sichuan University, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, West China Hospital, Sichuan University, Chengdu, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101756934', 'display_name': 'Yi Lu', 'orcid': 'https://orcid.org/0000-0002-0912-7724'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yi Lu', 'raw_affiliation_strings': ['Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA'], 'affiliations': [{'raw_affiliation_string': 'Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100652147', 'display_name': 'Jia Li', 'orcid': 'https://orcid.org/0000-0003-4017-1157'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jia Li', 'raw_affiliation_strings': ['Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA'], 'affiliations': [{'raw_affiliation_string': 'Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036576811', 'display_name': 'Qin Su', 'orcid': 'https://orcid.org/0000-0001-9437-6292'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qin Su', 'raw_affiliation_strings': ['Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA'], 'affiliations': [{'raw_affiliation_string': 'Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA', 'institution_ids': ['https://openalex.org/I166722992']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100367073', 'display_name': 'Qiang Wei', 'orcid': 'https://orcid.org/0000-0003-3750-3042'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiang Wei', 'raw_affiliation_strings': ['Department of Urology, West China Hospital, Sichuan University, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, West China Hospital, Sichuan University, Chengdu, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100339427', 'display_name': 'Hong Li', 'orcid': 'https://orcid.org/0000-0003-0280-4697'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Li', 'raw_affiliation_strings': ['Department of Urology, West China Hospital, Sichuan University, Chengdu, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, West China Hospital, Sichuan University, Chengdu, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009470292', 'display_name': 'Guangping Gao', 'orcid': 'https://orcid.org/0000-0003-0097-9012'}, 'institutions': [{'id': 'https://openalex.org/I166722992', 'display_name': 'University of Massachusetts Chan Medical School', 'ror': 'https://ror.org/0464eyp60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I166722992']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guangping Gao', 'raw_affiliation_strings': ['Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA'], 'affiliations': [{'raw_affiliation_string': 'Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA', 'institution_ids': ['https://openalex.org/I166722992']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'apc_paid': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'fwci': 0.119, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.392579, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '24', 'issue': None, 'first_page': 'S264', 'last_page': 'S265'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9848, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11970', 'display_name': 'Molecular Biology Techniques and Applications', 'score': 0.9698, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tramp', 'display_name': 'Tramp', 'score': 0.95571685}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.49716333}], 'concepts': [{'id': 'https://openalex.org/C2780940892', 'wikidata': 'https://www.wikidata.org/wiki/Q1965933', 'display_name': 'Tramp', 'level': 4, 'score': 0.95571685}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8154179}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.65215206}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6290232}, {'id': 'https://openalex.org/C199835354', 'wikidata': 'https://www.wikidata.org/wiki/Q15311861', 'display_name': 'Cyclin D1', 'level': 4, 'score': 0.61828244}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.60674083}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.51039547}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.50302213}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.49716333}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.45786172}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4569744}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.42105263}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.30804205}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27250737}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.25867808}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12338674}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1525-0016(16)33477-3', 'pdf_url': 'http://www.cell.com/article/S1525001616334773/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s1525-0016(16)33477-3', 'pdf_url': 'http://www.cell.com/article/S1525001616334773/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362625413', 'https://openalex.org/W4362615349', 'https://openalex.org/W4239461568', 'https://openalex.org/W2970890933', 'https://openalex.org/W2889144148', 'https://openalex.org/W2412141626', 'https://openalex.org/W2125989214', 'https://openalex.org/W2109008667', 'https://openalex.org/W2104969420', 'https://openalex.org/W2072990083'], 'abstract_inverted_index': {'Prostate': [0], 'cancer': [1, 9], '(PCa)': [2], 'is': [3, 23], 'the': [4, 11, 41, 80, 103, 136, 192, 216, 228, 240, 245, 254, 266, 271, 282, 286, 290, 294, 311, 314, 324], 'second': [5], 'most': [6], 'common': [7], 'diagnosed': [8], 'and': [10, 34, 117, 155, 172, 186, 268, 330], 'fifth': [12], 'cause': [13], 'of': [14, 43, 62, 82, 98, 106, 133, 138, 151, 194, 197, 210, 256, 297, 316, 320], 'cancer-related': [15], 'mortality': [16], 'for': [17, 27, 37, 71, 167, 208, 310, 326], 'males': [18], 'worldwide.': [19], 'At': [20], 'present,': [21], 'there': [22], 'no': [24], 'effective': [25], 'treatment': [26, 217, 250], 'PCa.': [28], 'Towards': [29], 'further': [30], 'understanding': [31], 'molecular': [32, 295, 332], 'mechanism': [33, 296], 'developing': [35], 'therapeutics': [36], 'PCa,': [38], 'we': [39, 77, 145, 189, 263], 'investigated': [40], 'role': [42], 'miR34a': [44, 63, 83, 299], 'in': [45, 57, 84, 129, 157, 170, 175, 244, 270, 281, 323, 334], 'PCa': [46, 58, 72, 111, 143, 173, 211, 303, 328, 335], 'progression.': [47, 212, 304], 'Previous': [48], 'studies': [49], 'have': [50], 'reported': [51], 'that': [52, 96, 215, 265], 'miR-34a': [53, 99], 'was': [54], 'significantly': [55, 101, 221, 252, 275], 'downregulated': [56], 'cells;': [59], 'therefore,': [60], 'modulation': [61, 319], 'expression': [64, 322], 'might': [65], 'be': [66], 'a': [67], 'promising': [68], 'therapeutic': [69], 'approach': [70], 'treatment.': [73], 'To': [74, 126], 'this': [75], 'end,': [76], 'first': [78, 190, 312], 'verified': [79], 'downregulation': [81], 'prostate': [85, 91, 169, 325], 'tumor': [86, 242], 'from': [87, 232, 239], 'transgenic': [88], 'adenocarcinoma': [89], 'mouse': [90], '(TRAMP)': [92], 'model.': [93], 'We': [94, 213], 'found': [95], 'overexpression': [97], 'could': [100], 'inhibit': [102, 142], 'cell': [104, 112, 174], 'cycle': [105], 'PC3': [107], 'cells': [108], '(a': [109], 'human': [110], 'line)': [113], 'by': [114], 'prolonging': [115], 'G1': [116], 'shortening': [118], 'S': [119], 'phases': [120], 'through': [121], 'targeting': [122], 'cyclin': [123], 'D1': [124], '(CCND1).': [125], 'investigate': [127], 'if': [128], 'vivo': [130, 158, 171], 'gene': [131, 159], 'delivery': [132, 160], 'pri-miR34a': [134], 'to': [135, 147, 203, 227, 279, 292, 300], 'prostates': [137, 273], 'TRAMP': [139, 206, 257], 'mice': [140, 207, 258], 'can': [141], 'progression,': [144], 'opted': [146], 'screen': [148], '12': [149], 'serotypes': [150], 'rAAVs,': [152], 'an': [153], 'efficient': [154, 168, 318], 'safe': [156], 'platform': [161], 'with': [162], 'serotype': [163], 'dependent': [164], 'tissue': [165], 'tropisms': [166], 'vitro': [176], 'transduction.': [177], 'Among': [178], 'several': [179], 'leading': [180], 'candidate': [181], 'vectors': [182], '(i.e.': [183], 'AAV6.2,': [184], 'AAV7': [185], 'AAV9)': [187], 'identified,': [188], 'tested': [191], 'concept': [193], 'intraprostatic': [195], 'injection': [196], 'rAAV9': [198], 'pri': [199], '-miR34a': [200, 249], '(4×1011': [201], 'GCs/prostate)': [202], '8-week': [204], 'old': [205], 'inhibition': [209], 'observed': [214], 'lowered': [218], 'body': [219], 'weights': [220], '(p': [222, 259], '<': [223, 260], '0.05)': [224], 'as': [225], 'compared': [226, 278], 'control': [229, 246, 283], 'group': [230], 'starting': [231], '24': [233], 'weeks': [234], 'after': [235], 'injection,': [236], 'likely': [237], 'resulted': [238], 'higher': [241], 'burden': [243], 'group.': [247, 284], 'rAAV9.pri': [248], 'also': [251], 'extended': [253], 'lifespan': [255], '0.05).': [261], 'Moreover,': [262], 'confirmed': [264], 'proliferation': [267], 'neoplasia': [269], 'treated': [272], 'were': [274], 'diminished': [276], 'when': [277], 'those': [280], 'Currently,': [285], 'experiments': [287], 'are': [288], 'under': [289], 'way': [291], 'elucidate': [293], 'overexpressed': [298], 'slow': [301], 'down': [302], 'Taken': [305], 'together,': [306], 'our': [307], 'results': [308], 'demonstrated,': [309], 'time,': [313], 'potentials': [315], 'rAAV-mediated': [317], 'miRNA': [321], 'inhibiting': [327], 'progression': [329], 'studying': [331], 'mechanisms': [333], 'development.': [336]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2564817172', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-13T05:20:38.024737', 'created_date': '2017-01-06'}