Publication Information

{'id': 'https://openalex.org/W2564119591', 'doi': 'https://doi.org/10.18632/oncotarget.13947', 'title': 'Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway', 'display_name': 'Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway', 'publication_year': 2016, 'publication_date': '2016-12-15', 'ids': {'openalex': 'https://openalex.org/W2564119591', 'doi': 'https://doi.org/10.18632/oncotarget.13947', 'mag': '2564119591', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27992365', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5351600'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13947', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13947&path%5B%5D=44459', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13947&path%5B%5D=44459', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110934589', 'display_name': 'Wuping Wang', 'orcid': 'https://orcid.org/0000-0002-6791-2050'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wu-ping Wang', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029389146', 'display_name': 'Ying Sun', 'orcid': 'https://orcid.org/0000-0002-4076-051X'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Sun', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101898964', 'display_name': 'Qiang Lü', 'orcid': 'https://orcid.org/0000-0001-6004-9242'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiang Lu', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101835709', 'display_name': 'Jinbo Zhao', 'orcid': 'https://orcid.org/0000-0002-7806-6072'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin-bo Zhao', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100617088', 'display_name': 'Xuejiao Wang', 'orcid': 'https://orcid.org/0009-0003-4163-4237'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue-jiao Wang', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083517238', 'display_name': 'Chen Zhao', 'orcid': 'https://orcid.org/0000-0003-3888-297X'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhao Chen', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111678069', 'display_name': 'Yunfeng Ni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun-feng Ni', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083847873', 'display_name': 'Ju-zheng Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ju-zheng Wang', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100383653', 'display_name': 'Yong Han', 'orcid': 'https://orcid.org/0000-0002-5325-1722'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong Han', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084231663', 'display_name': 'Zhipei Zhang', 'orcid': 'https://orcid.org/0000-0002-8133-0778'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-pei Zhang', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479', 'https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070916237', 'display_name': 'Xiaolong Yan', 'orcid': 'https://orcid.org/0000-0003-2419-9707'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xiao-long Yan', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100358305', 'display_name': 'Xiaofei Li', 'orcid': 'https://orcid.org/0000-0002-6061-0164'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-fei Li', 'raw_affiliation_strings': ["Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China"], 'affiliations': [{'raw_affiliation_string': "Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China", 'institution_ids': ['https://openalex.org/I9916479']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5070916237'], 'corresponding_institution_ids': ['https://openalex.org/I9916479'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.775, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.884188, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '8', 'issue': '4', 'first_page': '5909', 'last_page': '5923'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ectopic-expression', 'display_name': 'Ectopic expression', 'score': 0.49330893}, {'id': 'https://openalex.org/keywords/mmp2', 'display_name': 'MMP2', 'score': 0.43385288}], 'concepts': [{'id': 'https://openalex.org/C147447768', 'wikidata': 'https://www.wikidata.org/wiki/Q411624', 'display_name': 'Vimentin', 'level': 3, 'score': 0.76697254}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.7483927}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.59832895}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.5588918}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.54176044}, {'id': 'https://openalex.org/C97037327', 'wikidata': 'https://www.wikidata.org/wiki/Q5334291', 'display_name': 'Ectopic expression', 'level': 3, 'score': 0.49330893}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.44165868}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43712062}, {'id': 'https://openalex.org/C2780699576', 'wikidata': 'https://www.wikidata.org/wiki/Q15327913', 'display_name': 'MMP2', 'level': 4, 'score': 0.43385288}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42067304}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.41988325}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4071382}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3073416}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30184236}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.22982746}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19190264}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.18366656}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.11412552}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000072283', 'descriptor_name': 'A549 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13947', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13947&path%5B%5D=44459', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5351600', 'pdf_url': 'https://europepmc.org/articles/pmc5351600?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351600', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27992365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13947', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13947&path%5B%5D=44459', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'score': 0.73, 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1491983812', 'https://openalex.org/W1578810612', 'https://openalex.org/W1591877903', 'https://openalex.org/W1770585052', 'https://openalex.org/W183282993', 'https://openalex.org/W1911017240', 'https://openalex.org/W1964081206', 'https://openalex.org/W1972317605', 'https://openalex.org/W1995778320', 'https://openalex.org/W2002621222', 'https://openalex.org/W2007638982', 'https://openalex.org/W2011398252', 'https://openalex.org/W2016360721', 'https://openalex.org/W2020830322', 'https://openalex.org/W2025806971', 'https://openalex.org/W2044724701', 'https://openalex.org/W2046317081', 'https://openalex.org/W2046847797', 'https://openalex.org/W2050753692', 'https://openalex.org/W2054364834', 'https://openalex.org/W2063011414', 'https://openalex.org/W2070214548', 'https://openalex.org/W2080217598', 'https://openalex.org/W2084645564', 'https://openalex.org/W2088720324', 'https://openalex.org/W2095003166', 'https://openalex.org/W2099645146', 'https://openalex.org/W2100592123', 'https://openalex.org/W2113095561', 'https://openalex.org/W2125571326', 'https://openalex.org/W2126170617', 'https://openalex.org/W2140551998', 'https://openalex.org/W2142394111', 'https://openalex.org/W2147209050', 'https://openalex.org/W2153386524', 'https://openalex.org/W2157245210', 'https://openalex.org/W2167962791', 'https://openalex.org/W2168104515', 'https://openalex.org/W2219079964', 'https://openalex.org/W2295732866', 'https://openalex.org/W2319571985', 'https://openalex.org/W2337758609', 'https://openalex.org/W234727535', 'https://openalex.org/W2566863750'], 'related_works': ['https://openalex.org/W4220905054', 'https://openalex.org/W3175565016', 'https://openalex.org/W3041026090', 'https://openalex.org/W2945477824', 'https://openalex.org/W2911874947', 'https://openalex.org/W2564119591', 'https://openalex.org/W2303355011', 'https://openalex.org/W2295552376', 'https://openalex.org/W2176631918', 'https://openalex.org/W1499339123'], 'abstract_inverted_index': {'//': [0], 'Wu-ping': [1], 'Wang': [2, 21, 33], '1,': [3, 8, 13], '*': [4, 9, 14, 66], ',': [5, 10, 15, 19, 23, 27, 31, 35, 39, 43, 47], 'Ying': [6], 'Sun': [7], 'Qiang': [11], 'Lu': [12], 'Jin-bo': [16], 'Zhao': [17, 24], '1': [18, 22, 26, 30, 34, 38, 42, 46, 50, 51], 'Xue-jiao': [20], 'Chen': [25], 'Yun-feng': [28], 'Ni': [29], 'Ju-zheng': [32], 'Yong': [36], 'Han': [37], 'Zhi-pei': [40, 76], 'Zhang': [41], 'Xiao-long': [44, 80], 'Yan': [45], 'Xiao-fei': [48, 84], 'Li': [49], 'Department': [52], 'of': [53, 135, 147, 174, 183, 202, 254], 'Thoracic': [54], 'Surgery,': [55], 'Tangdu': [56], 'Hospital,': [57], 'The': [58, 143, 228], 'Fourth': [59], 'Military': [60], 'Medical': [61], 'University,': [62], 'Xi’an,': [63], '710038,': [64], 'China': [65], 'These': [67, 192], 'authors': [68], 'contributed': [69], 'equally': [70], 'to': [71, 240], 'this': [72, 128, 163], 'work': [73], 'Correspondence': [74], 'to:': [75], 'Zhang,': [77], 'email:': [78, 82, 86], '[email protected]': [79], 'Yan,': [81], '[email protected]': [83], 'Li,': [85], '[email protected]': [87], 'Keywords:': [88], 'NSCLC,': [89], 'gankyrin,': [90], 'EMT,': [91], 'metastasis,': [92], 'closed': [93, 265], 'circle': [94, 266], 'Received:': [95], 'September': [96], '02,': [97], '2016     ': [98, 102], 'Accepted:': [99], 'December': [100, 104], '08,': [101], 'Published:': [103], '15,': [105], '2016': [106], 'ABSTRACT': [107], 'Our': [108], 'previous': [109], 'research': [110], 'showed': [111, 207], 'that': [112, 172, 195, 208, 233], 'Gankyrin': [113, 136, 148, 161, 175, 196, 209, 255], 'was': [114, 211, 237], 'overexpressed': [115], 'in': [116, 141, 155, 166, 225, 260], 'NSCLC': [117, 156, 167, 226, 261], 'and': [118, 124, 139, 153, 180, 185, 189, 200, 222, 242, 258, 269], 'significantly': [119], 'associated': [120], 'with': [121, 214, 220, 267], 'clinicopathologic': [122], 'features': [123], 'poor': [125], 'prognosis.': [126], 'In': [127, 158], 'study,': [129], 'we': [130], 'will': [131], 'explore': [132], 'potential': [133], 'effect': [134], 'on': [137], 'EMT': [138, 236, 257], 'metastasis': [140, 259], 'NSCLC.': [142], 'ectopic': [144], 'higher': [145], 'expression': [146, 179, 182, 210, 224], 'markedly': [149], 'increased': [150], 'the': [151, 234], 'migration': [152], 'invasion': [154], 'cells.': [157, 168], 'contrast,': [159], 'silencing': [160], 'inhibit': [162], 'aggressive': [164], 'behavior': [165], 'Further': [169], 'study': [170, 230], 'demonstrated': [171], 'overexpression': [173], 'could': [176, 197], 'decrease': [177], 'E-cadherin': [178, 215], 'increase': [181], 'Vimentin': [184, 221], 'Twist1': [186, 223], 'at': [187], 'mRNA': [188], 'protein': [190], 'levels.': [191], 'data': [193, 249], 'indicated': [194], 'facilitate': [198], 'occurrence': [199], 'development': [201], 'EMT.': [203], 'Also': [204], 'IHC': [205], 'analysis': [206], 'negatively': [212], 'correlated': [213, 219], 'expression,': [216], 'while': [217], 'positively': [218], 'tissues.': [227], 'mechanism': [229, 253], 'finally': [231], 'suggested': [232], 'Gankyrin-driven': [235], 'partially': [238], 'due': [239], 'IL-6/p-STAT3': [241, 268], 'TGF-β/p-SMAD3': [243, 270], 'pathways': [244], 'activation.': [245], 'Taken': [246], 'together,': [247], 'our': [248], 'provided': [250], 'a': [251, 264], 'novel': [252], 'promoting': [256], 'through': [262], 'forming': [263], 'signaling': [271], 'pathway.': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2564119591', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-12T17:21:09.543083', 'created_date': '2017-01-06'}