Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2562527109', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-2320', 'title': 'Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas', 'display_name': 'Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W2562527109', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-2320', 'mag': '2562527109'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-2320', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060378524', 'display_name': 'Zoltán Wiener', 'orcid': 'https://orcid.org/0000-0001-7056-4926'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Zoltan Wiener', 'raw_affiliation_strings': ['1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;'], 'affiliations': [{'raw_affiliation_string': '1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007234456', 'display_name': 'Jenny Högström', 'orcid': 'https://orcid.org/0000-0001-5932-0146'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Jenny Högström', 'raw_affiliation_strings': ['1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;'], 'affiliations': [{'raw_affiliation_string': '1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023694703', 'display_name': 'Ville Hyvönen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Ville Hyvönen', 'raw_affiliation_strings': ['1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;'], 'affiliations': [{'raw_affiliation_string': '1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034693641', 'display_name': 'Pauliina Kallio', 'orcid': 'https://orcid.org/0000-0001-6374-6203'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Pauliina Kallio', 'raw_affiliation_strings': ['1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;'], 'affiliations': [{'raw_affiliation_string': '1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087078093', 'display_name': 'Sarika Heino', 'orcid': 'https://orcid.org/0000-0003-4658-3232'}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Sarika Heino', 'raw_affiliation_strings': ['1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;'], 'affiliations': [{'raw_affiliation_string': '1Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland;', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023660858', 'display_name': 'Kari Alitalo', 'orcid': 'https://orcid.org/0000-0002-7331-0902'}, 'institutions': [{'id': 'https://openalex.org/I4210102054', 'display_name': 'Wihuri Research Institute', 'ror': 'https://ror.org/01jbjy689', 'country_code': 'FI', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210102054']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'education', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI'], 'is_corresponding': False, 'raw_author_name': 'Kari Alitalo', 'raw_affiliation_strings': ['2Translational Cancer Biology Program and Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.'], 'affiliations': [{'raw_affiliation_string': '2Translational Cancer Biology Program and Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.', 'institution_ids': ['https://openalex.org/I4210102054', 'https://openalex.org/I133731052']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '75', 'issue': '15_Supplement', 'first_page': '2320', 'last_page': '2320'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9548, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9548, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/organoid', 'display_name': 'Organoid', 'score': 0.41465208}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6852497}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.66174525}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.6003652}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.5031788}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.4380721}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4152392}, {'id': 'https://openalex.org/C31695470', 'wikidata': 'https://www.wikidata.org/wiki/Q11293125', 'display_name': 'Organoid', 'level': 2, 'score': 0.41465208}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37541595}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31113183}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19256264}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10792744}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-2320', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.8, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4386439204', 'https://openalex.org/W4307092668', 'https://openalex.org/W4282828373', 'https://openalex.org/W4281715121', 'https://openalex.org/W4280609759', 'https://openalex.org/W3215034816', 'https://openalex.org/W3094248195', 'https://openalex.org/W3033121461', 'https://openalex.org/W2811397904', 'https://openalex.org/W2150479858'], 'abstract_inverted_index': {'Abstract': [0], 'Colorectal': [1], 'cancer': [2], '(CRC)': [3], 'initiation': [4], 'and': [5, 54, 63, 77, 80, 96, 121], 'growth': [6, 84], 'is': [7, 15, 108], 'often': [8], 'attributed': [9], 'to': [10, 142, 194, 199], 'stem': [11, 38, 75, 115, 138, 205, 244], 'cells,': [12, 202], 'yet': [13], 'little': [14], 'known': [16], 'about': [17, 219], 'the': [18, 33, 47, 72, 97, 111, 114, 127, 131, 136, 143, 163, 170, 173, 180, 200, 209, 220, 223, 258, 263], 'regulation': [19], 'of': [20, 30, 60, 74, 91, 99, 113, 130, 165, 172, 222, 257, 262], 'this': [21, 159], 'cell': [22, 39, 78, 116, 145, 187, 211, 245], 'population.': [23, 212], 'We': [24], 'have': [25, 37], 'shown': [26], 'that': [27, 68, 247], 'a': [28, 190, 243], 'subpopulation': [29], 'cells': [31, 76, 102, 139, 206], 'expressing': [32], 'Prox1': [34, 69, 92, 107, 224, 241], 'transcription': [35], 'factor': [36], 'activity': [40, 167], 'in': [41, 46, 51, 85, 103, 118, 140, 169, 179, 208, 251], 'intestinal': [42, 82, 119, 150, 252], 'adenomas,': [43], 'but': [44], 'not': [45], 'normal': [48, 128], 'intestine.': [49], 'Using': [50], 'vivo': [52, 57], 'models': [53], '3D': [55], 'ex': [56], 'organoid': [58], 'cultures': [59], 'mouse': [61], 'adenomas': [62, 120], 'human': [64], 'CRC,': [65], 'we': [66, 147], 'found': [67], 'deletion': [70], 'reduced': [71], 'number': [73], 'proliferation': [79], 'decreased': [81, 94], 'tumor': [83, 101, 104, 249], 'multiple': [86], 'CRC': [87, 122], 'model': [88], 'systems.': [89], 'Loss': [90], 'also': [93], 'autophagy': [95], 'survival': [98], 'hypoxic': [100], 'transplants.': [105], 'Thus,': [106], 'essential': [109], 'for': [110, 126, 266], 'expansion': [112], 'pool': [117], 'without': [123], 'being': [124], 'critical': [125], 'functions': [129], 'gut.': [132], 'To': [133], 'further': [134], 'study': [135], 'adenoma': [137, 182], 'relation': [141], 'Prox1-positive': [144, 181, 210], 'population,': [146], 'analyzed': [148], 'Apc-mutant': [149], 'organoids': [151, 197], 'derived': [152], 'from': [153], 'Prox1-CreER;': [154], 'tdTomatoflox/Stop/flox;': [155], 'Apcmin/+': [156], 'mice.': [157], 'In': [158], 'lineage': [160], 'tracing': [161], 'model,': [162], 'induction': [164], 'Cre': [166], 'results': [168], 'expression': [171, 214], 'red': [174], 'fluorescent': [175], 'protein': [176], 'tdTomato': [177], 'only': [178], 'cells.': [183, 226], 'FACS': [184], 'sorted': [185], 'tdTomato-positive': [186], 'population': [188, 246], 'displayed': [189], 'highly': [191], 'elevated': [192], 'capability': [193], 'form': [195], 'new': [196, 217], 'compared': [198], 'tdTomato-negative': [201], 'consistent': [203], 'with': [204], 'enrichment': [207], 'Gene': [213], 'analysis': [215], 'provided': [216], 'clues': [218], 'identity': [221], 'positive': [225], 'Citation': [227], 'Format:': [228], 'Zoltan': [229], 'Wiener,': [230], 'Jenny': [231], 'Högström,': [232], 'Ville': [233], 'Hyvönen,': [234], 'Pauliina': [235], 'Kallio,': [236], 'Sarika': [237], 'Heino,': [238], 'Kari': [239], 'Alitalo.': [240], 'marks': [242], 'promotes': [248], 'progression': [250], 'adenomas.': [253], '[abstract].': [254], 'In:': [255], 'Proceedings': [256], '106th': [259], 'Annual': [260], 'Meeting': [261], 'American': [264], 'Association': [265], 'Cancer': [267, 277], 'Research;': [268], '2015': [269], 'Apr': [270], '18-22;': [271], 'Philadelphia,': [272], 'PA.': [273], 'Philadelphia': [274], '(PA):': [275], 'AACR;': [276], 'Res': [278], '2015;75(15': [279], 'Suppl):Abstract': [280], 'nr': [281], '2320.': [282], 'doi:10.1158/1538-7445.AM2015-2320': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2562527109', 'counts_by_year': [], 'updated_date': '2024-12-12T01:15:05.520379', 'created_date': '2017-01-06'}