Publication Information

{'id': 'https://openalex.org/W2562461810', 'doi': 'https://doi.org/10.3389/fnins.2016.00581', 'title': 'A Role for Insulin in Diabetic Neuropathy', 'display_name': 'A Role for Insulin in Diabetic Neuropathy', 'publication_year': 2016, 'publication_date': '2016-12-23', 'ids': {'openalex': 'https://openalex.org/W2562461810', 'doi': 'https://doi.org/10.3389/fnins.2016.00581', 'mag': '2562461810', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28066166', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5179551'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2016.00581', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2016.00581/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2016.00581/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087768156', 'display_name': 'Caleb W. Grote', 'orcid': 'https://orcid.org/0000-0002-9071-7202'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Caleb W. Grote', 'raw_affiliation_strings': ['Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA', 'institution_ids': ['https://openalex.org/I4210128618']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029593570', 'display_name': 'Douglas E. Wright', 'orcid': 'https://orcid.org/0000-0002-3748-7874'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Douglas E. Wright', 'raw_affiliation_strings': ['Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA', 'institution_ids': ['https://openalex.org/I4210128618']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5029593570'], 'corresponding_institution_ids': ['https://openalex.org/I4210128618'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.577, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.57508, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '10', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prediabetes', 'display_name': 'Prediabetes', 'score': 0.6546675}, {'id': 'https://openalex.org/keywords/peripheral-nervous-system', 'display_name': 'Peripheral Nervous System', 'score': 0.6402768}, {'id': 'https://openalex.org/keywords/diabetic-neuropathy', 'display_name': 'Diabetic Neuropathy', 'score': 0.49058118}], 'concepts': [{'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.7880206}, {'id': 'https://openalex.org/C2779668308', 'wikidata': 'https://www.wikidata.org/wiki/Q2087205', 'display_name': 'Prediabetes', 'level': 4, 'score': 0.6546675}, {'id': 'https://openalex.org/C545314008', 'wikidata': 'https://www.wikidata.org/wiki/Q169953', 'display_name': 'Peripheral nervous system', 'level': 3, 'score': 0.6402768}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.59060395}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.5662577}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.54319793}, {'id': 'https://openalex.org/C2779901536', 'wikidata': 'https://www.wikidata.org/wiki/Q945238', 'display_name': 'Peripheral neuropathy', 'level': 3, 'score': 0.5039641}, {'id': 'https://openalex.org/C112446052', 'wikidata': 'https://www.wikidata.org/wiki/Q422579', 'display_name': 'Insulin receptor', 'level': 4, 'score': 0.500602}, {'id': 'https://openalex.org/C2779178840', 'wikidata': 'https://www.wikidata.org/wiki/Q2046550', 'display_name': 'Diabetic neuropathy', 'level': 3, 'score': 0.49058118}, {'id': 'https://openalex.org/C94487597', 'wikidata': 'https://www.wikidata.org/wiki/Q11101', 'display_name': 'Sensory system', 'level': 2, 'score': 0.45588005}, {'id': 'https://openalex.org/C545706735', 'wikidata': 'https://www.wikidata.org/wiki/Q9404', 'display_name': 'Nervous system', 'level': 2, 'score': 0.44960856}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.4342804}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.42444718}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.39170426}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.380935}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3717033}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24668664}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.22950453}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.13878384}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2016.00581', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2016.00581/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5179551', 'pdf_url': 'https://europepmc.org/articles/pmc5179551?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179551', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28066166', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2016.00581', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2016.00581/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.77, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P20GM1033418'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'RO1NS43314'}], 'datasets': [], 'versions': [], 'referenced_works_count': 107, 'referenced_works': ['https://openalex.org/W1495740709', 'https://openalex.org/W1503951893', 'https://openalex.org/W1515929023', 'https://openalex.org/W1531652687', 'https://openalex.org/W1558785828', 'https://openalex.org/W1569155484', 'https://openalex.org/W1609815362', 'https://openalex.org/W1866620858', 'https://openalex.org/W1948134539', 'https://openalex.org/W1963570934', 'https://openalex.org/W1963807245', 'https://openalex.org/W1964216200', 'https://openalex.org/W1964532167', 'https://openalex.org/W1969533761', 'https://openalex.org/W1972974949', 'https://openalex.org/W1976619844', 'https://openalex.org/W1977787290', 'https://openalex.org/W1977915597', 'https://openalex.org/W1978468194', 'https://openalex.org/W1982794401', 'https://openalex.org/W1982795519', 'https://openalex.org/W1987522063', 'https://openalex.org/W1989571923', 'https://openalex.org/W1990578421', 'https://openalex.org/W1991157941', 'https://openalex.org/W1991561562', 'https://openalex.org/W1996552127', 'https://openalex.org/W1997565232', 'https://openalex.org/W1998048321', 'https://openalex.org/W1998493448', 'https://openalex.org/W1998933601', 'https://openalex.org/W1999209305', 'https://openalex.org/W2001919780', 'https://openalex.org/W2003321154', 'https://openalex.org/W2004222535', 'https://openalex.org/W2008404457', 'https://openalex.org/W2011430246', 'https://openalex.org/W2014920745', 'https://openalex.org/W2017807856', 'https://openalex.org/W2020267609', 'https://openalex.org/W2025703082', 'https://openalex.org/W2028380492', 'https://openalex.org/W2030345626', 'https://openalex.org/W2033411034', 'https://openalex.org/W2035825704', 'https://openalex.org/W2037851900', 'https://openalex.org/W2042211739', 'https://openalex.org/W2043529034', 'https://openalex.org/W2047528124', 'https://openalex.org/W2049850281', 'https://openalex.org/W2056933324', 'https://openalex.org/W2058890442', 'https://openalex.org/W2060874207', 'https://openalex.org/W2067198165', 'https://openalex.org/W2067902437', 'https://openalex.org/W2069911669', 'https://openalex.org/W2070302167', 'https://openalex.org/W2071189759', 'https://openalex.org/W2075082524', 'https://openalex.org/W2080252996', 'https://openalex.org/W2082733905', 'https://openalex.org/W2083264147', 'https://openalex.org/W2083810261', 'https://openalex.org/W2084590535', 'https://openalex.org/W2087042369', 'https://openalex.org/W2088642279', 'https://openalex.org/W2089673013', 'https://openalex.org/W2091438070', 'https://openalex.org/W2094974632', 'https://openalex.org/W2097767970', 'https://openalex.org/W2104623692', 'https://openalex.org/W2105036397', 'https://openalex.org/W2105042598', 'https://openalex.org/W2108385748', 'https://openalex.org/W2110174113', 'https://openalex.org/W2113716304', 'https://openalex.org/W2118156146', 'https://openalex.org/W2119608943', 'https://openalex.org/W2120646453', 'https://openalex.org/W2121532472', 'https://openalex.org/W2124370415', 'https://openalex.org/W2134183006', 'https://openalex.org/W2135456335', 'https://openalex.org/W2141277427', 'https://openalex.org/W2149284026', 'https://openalex.org/W2153284686', 'https://openalex.org/W2156177387', 'https://openalex.org/W2159406238', 'https://openalex.org/W2161291167', 'https://openalex.org/W2163772343', 'https://openalex.org/W2166008733', 'https://openalex.org/W2166483018', 'https://openalex.org/W2170232341', 'https://openalex.org/W2170873073', 'https://openalex.org/W2205233891', 'https://openalex.org/W2313656256', 'https://openalex.org/W2342490021', 'https://openalex.org/W2473276824', 'https://openalex.org/W2530226416', 'https://openalex.org/W2887886667', 'https://openalex.org/W30707096', 'https://openalex.org/W4211055971', 'https://openalex.org/W4211240576', 'https://openalex.org/W4214669416', 'https://openalex.org/W4241277272', 'https://openalex.org/W4245107010', 'https://openalex.org/W832234686'], 'related_works': ['https://openalex.org/W4321115625', 'https://openalex.org/W4244988148', 'https://openalex.org/W3084006752', 'https://openalex.org/W2945745351', 'https://openalex.org/W2414156024', 'https://openalex.org/W2285022769', 'https://openalex.org/W2116128857', 'https://openalex.org/W2025134267', 'https://openalex.org/W1967026120', 'https://openalex.org/W1530908620'], 'abstract_inverted_index': {'The': [0, 16], 'peripheral': [1, 36, 105, 131, 190], 'nervous': [2, 37, 132, 193], 'system': [3, 133, 194], 'is': [4, 19, 39, 53, 69, 85], 'one': [5], 'of': [6, 46], 'several': [7], 'organ': [8], 'systems': [9, 38], 'that': [10, 20, 57, 113, 146, 162], 'are': [11, 160, 166], 'profoundly': [12], 'affected': [13], 'in': [14, 28, 32, 65, 104, 119, 129, 188], 'diabetes.': [15], 'longstanding': [17], 'view': [18], 'insulin': [21, 47, 58, 114, 136, 152, 163], 'does': [22], 'not': [23], 'have': [24], 'a': [25, 100, 117], 'major': [26], 'role': [27, 98, 118, 187], 'modulating': [29], 'neuronal': [30], 'function': [31], 'both': [33, 189], 'central': [34, 192], 'and': [35, 81, 173, 180, 191], 'now': [40, 144], 'being': [41], 'challenged.': [42], 'In': [43, 122], 'the': [44, 91, 111, 130], 'setting': [45], 'deficiency': [48, 115], 'or': [49], 'excess': [50], 'insulin,': [51], 'it': [52], 'logical': [54], 'to': [55, 62, 96, 135, 138, 169], 'propose': [56], 'dysregulation': [59], 'can': [60, 149], 'contribute': [61], 'neuropathic': [63], 'changes': [64], 'sensory': [66, 73, 127, 147, 170], 'neurons.': [67], 'This': [68], 'particularly': [70], 'important': [71], 'as': [72, 99, 108, 110], 'nerve': [74, 106, 171], 'damage': [75], 'associated': [76], 'with': [77], 'prediabetes,': [78], 'type': [79, 82], '1': [80], '2': [83], 'diabetes': [84], 'so': [86], 'prevalent.': [87], 'Here,': [88], 'we': [89, 124], 'discuss': [90, 125], 'current': [92], 'experimental': [93], 'literature': [94], 'related': [95], "insulin's": [97, 186], 'potential': [101], 'neurotrophic': [102], 'factor': [103], 'function,': [107], 'well': [109], 'possibility': [112], 'plays': [116], 'diabetic': [120], 'neuropathy.': [121], 'addition,': [123], 'how': [126], 'neurons': [128, 148], 'respond': [134], 'similar': [137], 'other': [139, 155], 'insulin-sensitive': [140], 'tissues.': [141, 156], 'Moreover,': [142], 'studies': [143, 159], 'suggest': [145], 'also': [150], 'become': [151], 'resistant': [153], 'like': [154], 'Collectively,': [157], 'emerging': [158], 'revealing': [161], 'signaling': [164], 'pathways': [165], 'active': [167], 'contributors': [168], 'modulation,': [172], 'this': [174, 177], 'review': [175], 'highlights': [176], 'novel': [178], 'activity': [179], 'should': [181], 'provide': [182], 'new': [183], 'insight': [184], 'into': [185], 'diseases.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2562461810', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-02T16:42:42.355778', 'created_date': '2017-01-06'}