Publication Information

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1850, 2214, 2323, 2376, 2719, 3059, 3592, 3602, 3831, 3992, 4068, 4122, 4281, 4305, 4331], 'give': [575], 'rise': [576], 'an': [578, 692, 1033, 1257, 2404, 2959, 3370, 3784, 4188], 'impaired': [579], 'immune': [580, 942, 1479, 1496, 1656, 1693, 1819, 1836, 1964, 1994, 2900, 2976, 3998, 4168, 4341], 'response.': [581, 1480, 2987], 'The': [582, 925, 979, 1285, 1886, 2281, 2822, 2881, 3299, 3345, 3443, 3840, 4048], 'regulatory': [583, 774, 1286, 1321, 4190], 'mechanisms': [584, 775, 1097, 4067], 'govern': [586], 'appearance': [588, 926], 'function': [590, 3999], 'cell': [593, 637, 1416, 1500, 1663, 1672, 1726, 1789, 1884, 1970, 1999, 2062, 2552, 2568, 2670, 2792, 2978, 2983, 3085, 3718, 4109, 4173], 'subset': [594, 929, 955, 3483, 4052], 'during': [595, 790, 930, 4179], 'aging': [596, 931, 4026, 4235], 'several': [599, 4028], 'inflammatory': [601, 891, 1439, 2986, 4033], 'disorders': [602], 'remain': [603, 1106, 4075], 'controversial.': [604], 'Here,': [605, 1388, 4302], 'we': [606, 1389, 1624, 2303, 2951, 3278, 3590, 4303], 'present': [607], 'gene': [613, 762, 1275, 1351, 1485, 1506, 1597, 1906, 1932, 2363, 2632, 3265, 3493, 3512, 3622, 3808, 3885, 3933], 'expression': [614, 729, 805, 1161, 1276, 1352, 1396, 1425, 1486, 1507, 1598, 1705, 1908, 1933, 2075, 2146, 2306, 2325, 2364, 2461, 2480, 2512, 2633, 3494, 3560, 3599, 3623, 3658, 3696, 3749, 3777, 3809, 3818, 3855, 3925, 3931, 3934, 3968, 4145, 4253, 4291], 'profiles': [615, 1397, 4146], 'cells': [619, 690, 718, 749, 789, 803, 823, 830, 853, 867, 991, 1105, 1192, 1203, 1459, 1490, 1511, 1605, 1682, 1760, 1840, 1856, 1937, 2044, 2056, 2086, 2128, 2204, 2225, 2383, 2471, 2476, 2527, 2575, 2618, 2637, 2753, 2846, 2867, 3066, 3103, 3185, 3217, 3353, 3362, 3406, 3498, 3529, 3595, 3753, 3822, 3835, 3991, 4013, 4090, 4203, 4214, 4316], 'its': [621, 1118, 2278, 3776, 3791, 4071, 4150], 'CD28+': [622, 700, 1401, 1514, 1587, 1985, 2139, 2391, 2474, 2497, 2523, 2573, 2606, 2685, 2767, 3292, 3351, 3386, 3402, 3525, 3668, 3826, 3872, 3913, 3977, 4151], 'counterpart.': [623, 4152], 'A': [624, 639, 2772, 2988, 4007], 'comparative': [625], 'analysis': [626, 685, 1627, 1736, 2485, 2658, 2860, 2954, 2990, 3057, 3395, 3467, 3911], 'revealed': [627, 2661, 2958, 3058, 3303], '296': [629, 1406], 'genes': [630, 643, 670, 732, 1291, 1300, 1409, 1427, 1558, 1846, 1887, 1957, 2037, 2093, 2103, 2187, 2206, 2216, 2288, 2309, 2463, 2488, 2869, 2873, 2890, 2932, 2938, 3006, 3062, 3079, 3099, 3109, 3143, 3204, 3232, 3523, 3568, 3618, 3636, 3870, 4164, 4338], 'differentially': [632, 1407, 1556, 1973, 2747, 2763, 2910, 3097, 3519, 3616, 3866], 'methylated': [633, 1408, 2748, 2764, 2834, 2911, 3005, 3098, 3520, 3617, 3802, 3867], 'between': [634, 1508, 1984, 2682, 2766, 2780, 3290, 3385, 3518, 3691], 'two': [636, 1539, 1778, 2666, 2788, 3409], 'subsets.': [638, 1403, 2783], 'total': [640, 4018], '160': [642], 'cytotoxicity': [646, 1420, 2625, 3044, 3086, 3175, 3792, 4345], '(e.g.': [647, 655, 678, 1307, 1323], 'GRZB,': [648], 'TYROBP,': [649], 'RUNX3)': [651], 'cytokine/chemokine': [653, 3088, 4347], 'signaling': [654, 676, 2623, 2924, 3075, 3089, 3113, 3146, 3210], 'CX3CR1,': [656, 3025, 3153, 3166, 3545, 3704], 'CD27,': [657, 3014], 'IL-1R)': [659], 'demethylated': [661, 2700, 2870, 2937, 3078, 3272, 3553, 3712, 4332], 'cells,': [665, 702, 1062, 1701, 1831, 2169, 2434, 2705, 3310, 3564, 3780, 3852, 4286], 'while': [666, 1010, 1193, 1312, 1702, 2100, 2728, 3359, 4256], '136': [667, 2872], 'novo-methylated': [669, 2713, 2931, 3061, 3108, 3214, 3578, 3848], 'matched': [671], 'defects': [672, 1412, 1940], 'TCR': [675, 1414, 2622, 3207, 3261, 3286, 3397, 4170], 'pathway': [677, 1432, 2211, 2452, 2925, 3095, 3114, 3147], 'ITK,': [679, 3116, 3234, 3571], 'TXK,': [680, 3845], 'CD3G,': [681, 3117], 'LCK).': [683], 'TCR-landscape': [684], 'confirmed': [686, 2322], 'oligo/monoclonal': [693, 3371], 'expansion': [694, 986, 3372], 'over': [695, 1131], 'polyclonal': [697], 'background': [698], 'but': [703, 882, 2416, 4035, 4064], 'feature': [704], 'Vβ': [706, 3300, 3431, 3472], 'family': [707, 2082, 2252], 'repertoire': [708, 3384, 3398], 'specific': [709, 1007, 1139, 1290, 1449, 3313, 3365, 4163, 4327], 'each': [711, 1544, 1796, 2046, 2892, 3316, 3485, 3767, 3884], 'individual.': [712, 1258], 'We': [713, 1404, 1502, 1553, 1649, 1772, 2068, 2212, 2321, 2373, 2627, 2676, 3201, 3514, 3534, 3633, 4329], 'reported': [714, 872, 4280], 'show': [719, 1012, 2033, 3363, 3596, 3965, 4304], 'preactivation': [721], 'state': [722, 2439], 'characterized': [723], 'higher': [726, 2335, 2385, 3304, 3557, 3746], 'level': [727, 2513, 3558, 3694, 3747, 3906, 4240], 'inflammasome-related': [731], 'leads': [734, 3603], 'release': [737, 2403, 2428], 'IL-1β': [739, 2410, 2430, 2561], 'when': [740], 'activated.': [741], 'Overall,': [742], 'results': [744, 1446, 1809, 3725], 'demonstrate': [745], 'unique': [752, 4209], 'landscape,': [755], 'differences': [760, 1532, 2809], 'expression,': [763], 'contributing': [764], 'functionality': [767, 1755, 2967, 4128], 'these': [769, 772, 788, 988, 1155, 1248, 1335, 1622, 1757, 1839, 1845, 2168, 2301, 2308, 2441, 2949, 2992], 'cells.': [770, 1444, 1948, 1978, 1989, 2201, 2298, 2372, 2442, 2456, 2608, 2771, 2915, 2929, 3276, 3390, 3723, 3805, 3979, 4006, 4184], 'Understanding': [771], 'epigenetic': [773, 4177], 'could': [776, 1938, 3774], 'suggest': [777, 998, 1112, 1433], 'novel': [778], 'therapeutic': [779, 1047, 1114], 'strategies': [780], 'prevent': [782, 1117], 'accumulation': [784, 1119, 4002, 4072], 'activation': [786, 1065, 1673, 1945, 3039, 3208], 'aging.': [791], 'Introduction': [792], 'During': [793], 'differentiation': [794, 1267, 4180, 4200], 'homeostatic': [796], 'proliferation': [797, 817], 'lymphocytes,': [801, 1364, 2971, 4197], 'some': [802, 1289, 4038], 'lose': [804], 'molecule,': [810], 'fundamental': [813], 'activation,': [816, 2984], 'survival': [819], '(Vallejo': [824], 'et': [825, 879, 910, 914, 918, 922, 1038, 1043, 1079, 1083, 1087, 1091, 1148, 1176, 1205, 1235, 1278, 1282, 1331, 1354, 1358, 1385, 2065, 4045, 4216, 4220, 4224, 4272, 4277], 'al.,': [826, 880, 911, 915, 919, 923, 1039, 1044, 1080, 1084, 1088, 1092, 1149, 1177, 1206, 1236, 1279, 1283, 1332, 1355, 1359, 1386, 2066, 4046, 4217, 4221, 4225, 4273], '2002).': [827], '(now': [831], 'known': [832, 2155, 3734], 'as': [833, 850, 1020, 1064, 1198, 1715, 1895, 1920, 2152, 2156, 2192, 2654, 2973, 3338, 3415, 3450, 3570, 3735, 3783, 4199, 4344], 'cells)': [836], 'acquire': [837], 'phenotypic': [839], 'compared': [843, 2472, 3823], 'those': [845], 'conventional': [847, 1456], 'CD4+CD28+': [848], '(named': [849], 'CD28+)': [851], '(Maly': [854], '&': [855, 3198], 'Schirmer,': [856], '2015).': [857, 1284, 2067, 4226], 'An': [858, 1593], 'increase': [859], 'percentage': [862, 962, 1058, 3335, 3892], 'age': [869, 1231, 1255, 4267], 'has': [870, 1123, 1212, 4022, 4053], 'been': [871, 1050, 1124, 1214, 1762, 4023, 4054, 4084], 'not': [873, 993, 2417, 3187, 3812], 'only': [874, 957, 2350, 2541, 4261], 'healthy': [876, 1518, 2319, 2506, 2531, 2803, 3410, 3676, 3881, 3922, 3951, 4039, 4116], 'donors': [877, 1519, 1543, 2804, 3677, 4117], '(Weng': [878, 4044], '2009),': [881], 'also': [883, 1901, 1925, 2197, 2290, 2374, 4036], 'patients': [885, 4093], 'infections': [887, 1748], '(CMV,': [888], 'HCV,': [889], 'HIV),': [890], 'disorders,': [892], 'autoimmune': [893, 1746], 'diseases': [894], '(rheumatoid': [895], 'arthritis,': [896], 'ankylosing': [897], 'spondylitis,': [898], 'multiple': [899], 'sclerosis),': [900], 'cardiovascular': [902], 'diseases,': [903, 1747], 'or': [904, 1071, 1076, 1172, 1200, 1345, 1568, 1640, 1749, 1805, 2158, 2589, 2680, 2854, 3548, 3574, 3665, 3939, 4204, 4349], 'solid': [906], 'organ': [907], 'transplantation': [908], '(Scarsi': [909], '2011;': [912, 1085, 1089], 'Broux': [913], '2012;': [916, 1280, 4222], 'Téo': [917], '2013;': [920], 'Shabir': [921], '2016).': [924, 1178, 4274], 'can': [932, 1185, 1250, 1338], 'compromise': [933], 'T-cell': [936, 977, 1402, 2313, 2339, 2500, 2686, 2782, 2921, 3038, 3072, 3111, 3280, 3295, 3482, 3631, 3671, 3875, 3916, 3945], 'compartment,': [937], 'leading': [938, 1098], 'reduced': [941], 'response': [943, 1004, 1342, 1497, 1657, 1668, 1716, 1784, 1965, 1995, 2901, 2980, 3194], 'pathogens': [945], 'vaccines': [947], 'elderly.': [950], 'By': [951], 'contrast,': [952], 'detectable': [958], 'low': [961, 1365, 2118], 'young': [964, 4040], 'middle-aged': [966, 4042], 'individuals,': [967, 1534], 'although': [968, 3757], 'it': [969, 1211], 'sometimes': [971], 'highly': [972, 3714, 3801], 'enriched': [973, 1678, 1741], 'compartment.': [978], 'nature': [980], 'stimuli': [983], 'trigger': [985], 'fully': [994, 2833], 'understood.': [995], 'Some': [996, 1046, 1151, 1843], 'studies': [997, 1152, 4082, 4228], 'they': [1000, 1014, 2263, 2399], 'generated': [1002, 2786], 'repeated': [1006, 4061], 'auto-antigen': [1008], 'stimulation,': [1009, 2398, 4063], 'others': [1011, 1313], 'respond': [1015], 'ubiquitous': [1017], 'antigens': [1018, 1027], 'such': [1019, 1063, 1197, 1714, 1894, 1919, 2151, 2191, 2972, 4198, 4343], 'heat-shock': [1021], 'proteins': [1022, 3245], '(Hsp': [1023], '60)': [1024], 'viral': [1026], '(proteins': [1028], 'from': [1029, 1517, 2317, 2504, 2529, 2650, 2787, 2798, 2826, 3408, 3454, 3537, 3674, 3879, 3898, 3920, 3949, 4092], 'CMV),': [1030], 'thereby': [1031, 3781], 'acquiring': [1032], 'innate': [1034], 'T-cell-like': [1035], 'phenotype': [1036, 1440, 1469, 4210], '(Zal': [1037], '2004;': [1040], 'van': [1041], 'Bergen': [1042], '2009).': [1045, 1387, 4047], 'approaches': [1048], 'proposed': [1051], 'purpose': [1054], 'reducing': [1056], 'presence': [1068, 1435], 'IL-12': [1070], 'treatments': [1072], 'statins,': [1074], 'abatacept,': [1075], 'ATG': [1077], '(Warrington': [1078], '2003;': [1081], 'Link': [1082], 'Scarsi': [1086], 'Duftner': [1090], '2012).': [1093, 1150, 1360], 'However,': [1094, 1334], 'basic': [1096], 'generation': [1101, 4049], 'unknown.': [1107], 'Knowledge': [1108], 'them': [1110], 'might': [1111], 'options': [1115], 'function.': [1121], 'gradual': [1127], 'lifespan,': [1133], 'marked': [1134], 'global': [1136, 4231, 4309], 'hypomethylation': [1137], 'hypermethylation': [1140], 'promoter-associated': [1142], 'CpG': [1143, 1224, 2726, 2735, 2852, 3487], 'islands': [1144, 2736], '(Martin,': [1145], '2005;': [1146, 1207], 'Heyn': [1147], 'linked': [1154], 'alterations': [1158, 2641, 3447], 'levels': [1162, 1221, 1366, 2076, 2089, 2119, 2326, 2365, 2388, 2562, 2824, 3659, 3926, 3969, 4157, 4258], 'DNMT1': [1164, 4242, 4260, 4288], 'DNMT3B': [1166, 4252], 'regardless': [1167, 1606], 'nutritional': [1169], 'habits,': [1170], 'lifestyle,': [1171], 'clinical': [1173], 'parameters': [1174], '(Ciccarone': [1175, 4271], 'In': [1179, 1361], 'way,': [1181], 'age-associated': [1182, 1475, 3986], "'epigenetic": [1183, 1239], "drift'": [1184], 'potentially': [1186], 'restrict': [1187], 'plasticity': [1189], 'supporting': [1194], 'phenotypes,': [1196], 'exhausted': [1199], 'senescent': [1201], '(Fraga': [1204], 'Issa,': [1208], '2014).': [1209, 1237], 'Moreover,': [1210, 2145, 4275], 'recently': [1213], 'shown': [1215, 2940, 2995, 3339, 3887], 'certain': [1223, 1304], 'sites': [1225, 1249], 'closely': [1227], 'individuals': [1233, 1473, 4043], '(Florath': [1234], 'This': [1238, 1905, 4135], "clock'": [1240], 'demonstrates': [1241, 4121], 'using': [1243, 1628, 2647, 2815], 'small': [1245], 'number': [1246, 2035, 2888], 'accurately': [1251], 'predict': [1252], 'chronological': [1254], 'key': [1263, 4193], 'process': [1264], 'hematopoietic': [1266], 'maintenance': [1270, 1465, 4074], 'subset-specific': [1272], 'lymphocyte': [1274, 1914], '(Calvanese': [1277], 'Rodriguez': [1281], 'regions': [1287, 1322, 2701, 2714, 2718, 2749, 2762, 4161, 4333], 'transcription': [1293, 1897, 3301], 'factors': [1294], 'demethylated,': [1296], 'therefore,': [1298], 'overexpressed': [1302, 1827, 2222], 'subsets': [1306, 2501, 2687, 3296, 3672, 3876, 3917, 3946], 'IFNG': [1308, 1324], 'Th1': [1310], 'repressed': [1315], 'novo': [1318], 'at': [1320, 1520, 2520, 4118], 'FOXP3': [1326], 'Th2': [1328], 'cells;': [1329], 'Suárez-Álvarez': [1330], '2013).': [1333, 3200], 'patterns': [1337], 'be': [1339, 3212, 3625, 3857, 4077], 'altered': [1340, 1781, 2621, 2920], 'intrinsic': [1344], 'external': [1346], 'stimuli,': [1347], 'causing': [1348, 3853], '(Agrawal': [1353], '2010;': [1356], 'Suarez-Alvarez': [1357, 4219], 'Dnmt1': [1368], 'Dnmt3a': [1370], 'lead': [1371], 'overexpression': [1378, 4295], 'CD70,': [1380, 4297], 'perforin,': [1381], 'KIR2DL4': [1383, 4300], '(Liu': [1384], 'examined': [1390, 2628, 3279], 'identified': [1405, 1554], 'related': [1410, 1428, 1654, 1691, 1744, 1816, 2188, 2464, 2964, 3505, 4165, 4339], 'signaling,': [1415, 4171, 4348], 'death': [1417, 1501, 1664, 1727, 2000, 2063, 4174], 'pathways,': [1418], 'ability.': [1421, 3793], 'Alterations': [1422, 3380], 'inflammasome': [1431, 2210, 2451, 2467, 2487], 'preactivated': [1438], 'Our': [1445, 1808, 4111], 'indicate': [1447, 1981], 'dynamics': [1454], 'contribute': [1460, 2619, 3993, 4069, 4125], 'may': [1471, 3624], 'predispose': [1472], 'decline': [1476, 3996], 'their': [1478, 1513, 1586, 2058, 2138, 2390, 2755, 3641, 3825, 3854], 'Results': [1481, 3412], 'Overall': [1482], 'gain': [1483, 1595, 1834, 2729, 4321], 'programmed': [1499, 1662, 1788, 1969, 1998, 2061], 'analyzed': [1503, 1774, 2304, 3515, 3653, 3935], 'differential': [1505], 'counterparts': [1515, 1588, 2140, 2392], 'isolated': [1516, 2315, 2502, 2528, 2649, 3407, 3673, 3877, 3918, 3947, 4091], 'different': [1521, 4119], 'ages': [1522], 'avoid': [1524], 'due': [1526, 2639, 3754], 'pathologies.': [1528], 'To': [1529, 1616, 2299, 2943, 4079], 'minimize': [1530, 2807], 'among': [1533, 2810, 3550], 'samples': [1535, 2314, 2340], 'were': [1536, 1575, 1580, 1676, 1697, 1826, 1900, 1924, 2027, 2108, 2196, 2221, 2289, 2334, 2366, 2400, 2638, 2711, 2723, 2785, 2813, 3007, 3067, 3080, 3552, 3576, 3660, 3726, 3846], 'grouped': [1537], 'into': [1538, 2277], 'pools': [1540, 2653, 2667], '12': [1542, 2802], '(range:': [1545, 3678], '45–75': [1546], 'years;': [1547, 3680], 'average:': [1548], '62.1': [1549], '±': [1550, 3683], '9.9': [1551], 'years).': [1552, 3685], '1978': [1555], 'expressed': [1557, 1853, 1974, 2087, 2294, 2353, 3522, 3715, 3869], '(DEGs;': [1559], 'adjusted': [1560, 2017, 2877], 'P': [1561, 1633, 2018, 2603, 2878, 3105, 3973], '<': [1562, 1634, 1799, 2019, 2879, 3974], '0.01': [1563, 1635, 1800, 2020], 'FC': [1565, 1637, 1802], '≥': [1566, 1638, 1803, 2022], '1.5': [1567, 1804], '≤': [1569, 1641, 1806], '−1.5),': [1570], '1205': [1573], '(60.9%)': [1574], 'upregulated': [1576, 1644, 1698, 2038], '773': [1578], '(39.1%)': [1579], 'downregulated': [1581, 1647, 2040, 2110, 2368, 3580], 'relative': [1584], '(Table': [1589, 2688, 3090], 'S1,': [1590], 'Supporting': [1591, 1614, 1688, 1733, 1770, 2143, 2674, 2690, 3587, 3612], 'information).': [1592, 1615, 1689, 1734, 1771, 2144, 2675, 2691, 3003, 3588, 3613], 'overall': [1594], 'was': [1599, 1706, 2165, 2349, 2419, 2548, 2732, 3271, 3399, 3652, 3687, 3711, 3764, 3800], 'observed': [1600, 1650, 2069, 2124, 2375, 4230, 4330], 'fold-change': [1609], 'criteria': [1610, 1631, 2015], 'used': [1611], '(Fig.': [1612, 1683, 1728, 1765, 1841, 2111, 2141, 2226, 2341, 2393, 2412, 2672, 2715, 2737, 2955, 3218, 3297, 3373, 3585, 3610, 3698], 'S1A,': [1613], 'study': [1617], 'functions': [1620, 1837, 2963], 'involving': [1621], 'genes,': [1623, 1824, 3539, 3842], 'performed': [1625, 2952, 3400], 'GO': [1626, 1652, 2953], 'severe': [1630], '(adjusted': [1632], '3': [1639, 2237], '−3;': [1642], '545': [1643], '125': [1646], 'genes).': [1648], 'terms': [1653], '(GO:': [1658, 1665, 1669, 1674, 2001], '0006955),': [1659], 'regulation': [1660, 1786, 1967], '0043067),': [1666], 'defense': [1667, 1695, 2974], '0006952),': [1670], '0001775)': [1675], 'markedly': [1677], 'S1B': [1684], 'Table': [1686, 1731, 1768, 3000, 3092], 'S2,': [1687, 1732, 1769], 'Genes': [1690, 1990, 2896, 3106], 'responses': [1696], 'wider': [1710], 'range': [1711], 'functions,': [1713], 'stress,': [1718], 'macromolecule': [1720], 'catabolic': [1721], 'process,': [1722], 'chromatin': [1723, 3509], 'modifications,': [1724], 'S2': [1729], 'KEGG': [1735, 3056, 3094], 'showed': [1737, 1810, 2384], 'DEGs': [1739, 1794, 1815, 1983], 'pathways': [1743, 4175], 'allograft': [1750], 'rejection,': [1751], 'had': [1761, 3555, 3744], 'previously': [1763], 'demonstrated': [1764], 'S1C': [1766], 'then': [1773], 'detail': [1776], 'most': [1779, 1812, 1961, 2883, 3984, 4081], 'significantly': [1780, 2109, 2291], 'categories—immune': [1783], 'death—by': [1790], 'considering': [1791], 'all': [1792, 1982, 2215, 2337, 2862, 3832], 'within': [1795], 'category': [1797], '(P': [1798], '−1.5).': [1807], 'system': [1820], '(94': [1821], '112': [1823], '84%)': [1825], 'suggesting': [1832, 2435], '1).': [1842, 2112, 3091], 'correspond': [1847], 'receptors': [1849], 'strongly': [1852, 1903, 2293, 2352], 'NK': [1855], '(LILRB3,': [1857], 'LILRB2),': [1858], 'chemokines': [1859, 3023], '(CCR6,': [1860], 'CCL20),': [1861], 'cytokines': [1862, 3016], '(IL-10,': [1863], 'IL-18,': [1864], 'IL-6R,': [1865], 'IL-1R2),': [1866], 'adhesion': [1868, 3029], 'molecules': [1869, 3011, 3030, 3035, 3743], '(CD14,': [1870], 'CD1C,': [1871], 'CD86,': [1872], 'TNFSF8,': [1873], 'TNFSF13B,': [1874], 'TNFSF14),': [1875], 'regulate': [1877, 3260], 'migration': [1879], 'recruitment': [1881, 2250], 'other': [1883, 3615], 'types.': [1885], 'involved': [1888, 2182, 2207, 3082, 3707], 'interferon': [1891], '(IFN)': [1892], 'pathway,': [1893, 3076], 'IRF8': [1896], 'factor': [1898], '(TF),': [1899], 'expressed.': [1904], 'regulates': [1907], 'LST1': [1910], 'protein,': [1911, 3269], 'inhibits': [1913], 'proliferation.': [1915], 'Other': [1916, 2186], 'autoimmunity-related': [1917], 'TFs,': [1918], 'ETS-1': [1921], 'AIRE,': [1923], 'upregulated.': [1926], 'Conversely,': [1927, 3794], 'CD40LG': [1931], 'involve': [1939], 'interaction': [1943, 3126, 3160], 'B': [1947], 'Figure': [1949, 2443, 2739, 3375, 3859], '1Open': [1950], 'figure': [1952, 2446, 2742, 3378, 3862], 'viewerPowerPoint': [1953, 2447, 2743, 3379, 3863], 'Volcano': [1954], 'plots': [1955, 3954, 3964], 'representative': [1962, 2593, 3956], 'categories,': [1963], 'death,': [1971], 'Gray': [1979], 'dots': [1980], '(GO:0006955)': [1996], '0043067)': [2002], 'categories': [2003, 2885, 2993], 'highlighted': [2005, 2934], 'blue': [2007, 3456], 'red,': [2009], 'respectively.': [2010, 3442], 'For': [2011, 2533, 3883], 'analysis,': [2013], '1.5-fold': [2023], 'change': [2024], 'size': [2026], 'used.': [2028], 'Numbers': [2029], 'corners': [2032], 'category.': [2048], 'One': [2049, 3981], 'main': [2052], 'resistance': [2059], '(Kovalcsik': [2064], 'clear': [2071], 'deregulation': [2072], 'Bcl-2': [2079], '(B-cell': [2080], 'lymphoma-2)': [2081], 'members.': [2083], 'high': [2088, 3334, 4008], 'antiapoptotic': [2092], 'BCL2,': [2094, 3547], 'BCL2L1': [2095], '(encoding': [2096], 'Bcl-x),': [2097], 'MCL-1,': [2099], 'pro-apoptotic': [2102], 'BAX': [2104], 'BCL2L11': [2106], '(BIM)': [2107], 'These': [2113, 2228], 'data': [2114, 3536, 3897], 'correlates': [2115], 'Annexin': [2121], 'V': [2122], 'staining': [2123], 'before': [2129, 2576], 'after': [2131, 2578], 'staurosporine-induced': [2132], 'apoptosis': [2133, 2149], 'comparison': [2136], 'S3,': [2142, 2689], 'negative': [2148], 'regulators': [2150], 'CFLAR': [2153], '(also': [2154, 3733], 'FLIP': [2157], 'CASPER),': [2159], 'BIRC2': [2160], '(cIAP-1)': [2161], 'BIRC3': [2163], '(cIAP-2)': [2164], 'stronger': [2166], 'contrast': [2171], 'downregulation': [2174], 'positive': [2177], 'regulator': [2178], 'DIABLO,': [2179], 'caspase': [2184, 2249, 2423], 'activation.': [2185, 3632], 'necroptosis,': [2190], 'RIPK1': [2193], 'MLKL,': [2195], 'underexpressed': [2198], 'overexpress': [2205], 'found': [2213, 3202], 'comprising': [2217], 'NLRP3-inflammasome': [2219], 'complex': [2220, 3224], '2A).': [2227], 'included': [2229], 'NOD-like': [2231], 'receptor': [2232, 2922, 3073, 3112, 3125, 3159], '(NLR)': [2233], 'pyrin': [2234], 'domain': [2235, 2251], 'containing': [2236], '(NLRP3),': [2238], 'ASC': [2240], 'adaptor': [2241, 3238, 3251, 3256], 'protein': [2242, 2267, 3228, 3239], 'encoded': [2243], 'PYCARD': [2246, 2329], 'gene,': [2247], 'member': [2253], '8': [2254], '(CARD8),': [2255], 'inactive': [2258, 2345], 'pro-form': [2259], 'caspase-1': [2260, 2276, 2348, 2387, 2519], '(CASP1).': [2261], 'Together,': [2262], 'form': [2264, 2346, 2406, 2517, 2545], 'multimolecular': [2266], 'complex,': [2268], 'essential': [2271, 4189], 'cleavage': [2274], 'active': [2279, 2386, 2405, 2516, 2544], 'form.': [2280], 'pro-forms': [2282], 'IL-1B': [2285], 'IL-18': [2287, 2333], 'corroborate': [2300, 3591], 'findings,': [2302], 'paired': [2311], 'CD28null/CD28+': [2312], 'individually': [2316, 2503, 3878, 3919, 3948], '10': [2318, 2505, 3675], 'donors.': [2320, 2507, 2532, 3411, 3882, 3952], 'NLRP3,': [2328, 2493], '(ASC),': [2330], 'IL-1B,': [2331], '2B).': [2342], 'Nonetheless,': [2343], 'four': [2355], 'ten': [2357, 2882, 3880, 3921, 3950, 3961, 3971], '(40%)': [2358], 'samples,': [2359], 'CARD8': [2362], 'often': [2367], 'baseline': [2379, 2521], 'state,': [2380], 'than': [2389], '2C),': [2394], 'under': [2396], 'nigericin': [2397, 2586], 'able': [2401, 3188], 'pro-inflammatory': [2409, 4058], 'cytokine': [2411], '2D).': [2413], 'Nigericin': [2414], 'alone,': [2415], 'TNF-α,': [2418], 'sufficient': [2420], 'activate': [2422], '1': [2424], 'induce': [2426], 'basal': [2437], 'preactivating': [2438], '2Open': [2444], 'Overexpression': [2448], '(A)': [2457, 2758, 3391], 'Difference': [2458], 'based': [2477, 3530, 3895, 3927], 'on': [2478, 3531, 3637, 3716, 3766, 3896, 3928], 'array': [2481, 3532, 3810], 'data.': [2482, 3533], '(B)': [2483, 2839, 3462], 'RT–PCR': [2484], '(pro-IL-1B,': [2489], 'pro-IL-18,': [2490], 'CARD8,': [2491], 'CASP-1,': [2492], 'PYCARD)': [2495], '(C)': [2508, 2856], 'Histograms': [2509, 2591, 3463], 'showing': [2510, 2761, 3464], 'three': [2530, 2595], 'purpose,': [2535], 'FLICA': [2537], 'probe,': [2538], 'binds': [2540], 'caspase,': [2547], 'added': [2549], 'culture': [2553], 'further': [2555, 3628], 'detected': [2556, 2677], 'flow': [2558, 3663, 3828, 3937], 'cytometry.': [2559], '(D)': [2560, 2895], 'quantified': [2563], 'ELISA': [2565], 'supernatants': [2569], 'overnight': [2579], 'stimulation': [2580, 3196], 'TNF-α': [2582], '(5': [2583], 'ng': [2584], 'mL−1),': [2585], '(10': [2587], 'μm),': [2588], 'both.': [2590], 'independent': [2596], 'experiments': [2597], 'assayed': [2599], 'duplicates.': [2601], '*': [2602], '<0.05': [2604], 'versus': [2605, 3976], 'Changes': [2609, 3499, 4153], 'profile': [2614, 3302, 3357, 4312], 'ability': [2626, 3045], 'whether': [2629], 'profile,': [2646], 'same': [2652, 2817], 'before.': [2655], 'Unsupervised': [2656], 'clustering': [2657], 'scatterplots': [2660], 'reproducibility': [2663], 'both': [2669], 'types': [2671], 'S4,': [2673], '317': [2678, 2775], 'probes': [2679, 2695, 2708, 2776], 'DMRs': [2681, 2842, 2863], 'Of': [2692], 'these,': [2693], '170': [2694, 3538], '(160': [2696, 2868], 'genes)': [2697, 2710, 2778], 'corresponded': [2698], '147': [2707], '(136': [2709], '3A).': [2716], 'Most': [2717], 'lost': [2720], 'located': [2724], 'outside': [2725], 'islands,': [2727], '3B).': [2738], '3Open': [2740], 'Overview': [2744], 'implication.': [2757], 'Heat': [2759], 'map': [2760], '(DMRs)': [2765], 'set': [2773], '(296': [2777], 'differed': [2779, 4101], 'Datasets': [2784], 'replicates': [2790], 'per': [2791, 2820], 'type': [2793], '(#1': [2794], '#2),': [2796], 'obtained': [2797, 3727], 'pool': [2800], 'each,': [2805], 'individuals.': [2811], 'Samples': [2812], 'pooled': [2814], 'quantity': [2819], 'donor.': [2821, 3486, 3768], 'vary': [2825], 'unmethylated': [2827], '(β': [2828, 2835], '=': [2829, 2836], '0,': [2830], 'red)': [2831], '1,': [2837], 'green).': [2838], 'Distribution': [2840], 'according': [2847], 'localization': [2849], 'island': [2853], 'not.': [2855], 'Gene': [2857], 'ontology': [2858], '(GO)': [2859], 'novo-methylated)': [2875], '0.01.': [2880], 'significant': [2884], 'shown.': [2894], '(cytotoxic': [2902], 'molecules,': [2903, 2905], 'cytokines,': [2906], 'chemokines)': [2908], '(E)': [2916], 'Illustration': [2917], '(TCR)': [2923, 3074], 'De': [2930, 3107], 'red;': [2936], 'green.': [2942], 'determine': [2944], 'relevance': [2947, 3643], 'changes,': [2950], '3C),': [2956], 'enrichment': [2960], 'cellular': [2962, 3709], 'response,': [2975, 2977, 4169, 4346], 'adhesion,': [2979], 'wounding,': [2982], 'detailed': [2989], 'Fig.': [2997, 3054], 'S5': [2998], 'S4': [3001], '(Supporting': [3002], 'Differentially': [3004], '(ICOS,': [3012], 'PDCD1,': [3013], 'CD226),': [3015], '(IL-19,': [3017], 'IL-27,': [3018], 'IL-24,': [3019, 3131], 'IL-32,': [3020], 'IL-21R,': [3021, 3165], 'LTA),': [3022], '(CCL21,': [3024], 'CXCL1,': [3026, 3128], 'CCL4,': [3027], 'CXCR6),': [3028], '(ITGAL,': [3031], 'KLRG1,': [3032], 'LY9),': [3033], 'apoptosis-related': [3034], '(BCL2,': [3036], 'FASLG),': [3037], '(WAS,': [3040], 'LCK,': [3041, 3120], 'SLA-2),': [3042], '(TYROBP,': [3046], 'GZMB,': [3047, 3178, 3546], 'GZMH,': [3048], 'LYZ,': [3049], 'CD244,': [3050, 3177], 'CD59,': [3051], 'NKG7,': [3052], 'RUNX3;': [3053], '3D).': [3055], 'mainly': [3068, 3081, 4335], 'whereas': [3077], 'NK-mediated': [3084], '1.': [3093], 'Pathway': [3104], 'hsa04660': [3110], '2.25E-04': [3115], 'CD3D,': [3118, 3139], 'ICOS,': [3119, 3140], 'GRAP2,': [3121], 'PDCD1': [3122], 'hsa04060': [3123, 3157], 'Cytokine–cytokine': [3124, 3158], '0.0194': [3127], 'CXCR6,': [3129], 'FASLG,': [3130], 'BMPR1B,': [3132], 'LTA,': [3133], 'EPO': [3134], 'hsa05340': [3135], 'Primary': [3136], 'immunodeficiency': [3137], '0.0333': [3138], 'LCK': [3141], 'Demethylated': [3142], 'hsa04062': [3144], 'Chemokine': [3145], '0.0016': [3148], 'FGR,': [3149], 'CCL21,': [3150, 3163], 'NCF1,': [3151], 'PREX1,': [3152], 'CCL8,': [3154, 3167], 'WAS,': [3155], 'CCL4': [3156, 3170], '0.0027': [3161], 'LTBR,': [3162], 'IL-19,': [3164], 'CSF3R,': [3168], 'IFNGR2,': [3169, 3180], 'hsa04650': [3171], 'Natural': [3172], 'killer': [3173], 'cell-mediated': [3174], '0.0358': [3176], 'FCGR3B,': [3179], 'TYROBP': [3181, 3549, 3732], 'Senescent': [3182], 'mount': [3190], 'robust': [3192], 'proliferative': [3193], '(Chou': [3197], 'Effros,': [3199], 'many': [3203], '3E),': [3219], 'example,': [3221, 3701], 'CD3': [3223], '(CD3G': [3225], 'CD3D),': [3227], 'tyrosine': [3229], 'kinase': [3230], '(PTK)': [3231], '(LCK,': [3233], 'TXK),': [3235], 'Grb-2-related': [3237], '(GRAP2),': [3241], 'adapter': [3244, 3730], 'SIT1': [3246], '(signaling': [3247], 'threshold': [3248], 'regulating': [3249], 'transmembrane': [3250], '1)': [3252], 'SLA2': [3254], '(Scr-like': [3255], '2),': [3257], 'negatively': [3259], 'signaling.': [3262], 'Only': [3263], 'encoding': [3266], 'FYN-binding': [3268], 'FYB,': [3270], 'Additionally,': [3277, 3589], 'diversity': [3281], 'selection': [3283], 'analyzing': [3285], '(β-chain)': [3287], 'usage': [3288], 'biases': [3289], '4A).': [3298], 'Vβ/HPRT': [3305, 3434, 3477], 'ratios': [3306], 'corresponding': [3311], 'families': [3314, 3473], 'sample': [3317], '(Vβ6': [3318], 'Vβ21': [3320], 'first': [3323, 4138], 'individual;': [3324], 'Vβ8': [3325], 'Vβ13': [3327], 'second),': [3330], 'accumulate': [3332], 'alterations,': [3337], 'dark': [3342, 3459], 'red': [3343, 3460], 'color.': [3344], 'length': [3346, 3367], 'distribution': [3347], 'CDR3': [3349, 3366, 3440, 3469], 'shows': [3354], 'Gaussian': [3356], '(polyclonal),': [3358], 'distribution,': [3368], 'resembling': [3369], '4B).': [3374], '4Open': [3376], 'TCRVB': [3383], 'Quantitative': [3392], 'qualitative': [3394], 'displayed': [3414], 'three-dimensional': [3417], 'TcLandscape®': [3418], 'X,': [3422], 'Y,': [3423], 'Z': [3425], 'axes': [3426], 'represent': [3427], '26': [3429], 'human': [3430, 3989], 'families,': [3432], '(nonregulated': [3435], 'gene)': [3436], 'ratios,': [3437], 'lengths,': [3441], 'percentages': [3444], 'CDR3-LD': [3446], 'represented': [3449], 'color': [3452], 'code': [3453], 'deep': [3455], '(−30%)': [3457], '(+30%).': [3461], 'spectratype': [3466], 'lengths': [3470], 'highest': [3476], 'ratio': [3478], 'inversely': [3490], 'correlated': [3491], 'directly': [3504], 'modifications': [3507], 'structure': [3510], 'expression.': [3513, 4245], 'association': [3517], 'took': [3535], '31': [3542], '(18.23%;': [3543], 'LILRB3,': [3544], 'others)': [3551], '13': [3566], '(7.64%)': [3567], '(such': [3569], 'LY9,': [3572], 'SLA2,': [3573], 'LTA)': [3575], 'S6,': [3586], 'lesser': [3598], 'Lck': [3601], 'diminished': [3606], 'phosphorylation': [3607], 'ZAP70': [3609], 'S7,': [3611], 'All': [3614], 'without': [3619], 'primed': [3626], 'alteration': [3629], 'upon': [3630], 'selected': [3634], 'six': [3635], 'basis': [3639], 'immunological': [3642], 'validate': [3645], 'replicate': [3647], 'array-based': [3649], 'results.': [3650], 'Methylation': [3651], 'bisulfite': [3655, 3909], 'pyrosequencing,': [3656], 'evaluated': [3661], 'cytometry': [3664, 3829, 3938], 'qRT–PCR': [3666, 3940], '48–92': [3679], 'average': [3681, 3967], '70.2': [3682], '11.6': [3684], 'There': [3686, 4246], 'strong': [3689], 'correlation': [3690], 'status': [3697], '5),': [3699], 'chemokine': [3703], 'migration,': [3710], 'surface': [3719], 'Similar': [3724], 'DAP12)': [3736], 'cytotoxic': [3739], 'GZMB.': [3741], 'Both': [3742], 'demethylation,': [3756], 'degree': [3759], 'demethylation': [3761, 4233, 4293], 'GZMB': [3763], 'dependent': [3765], 'Demethylation': [3769], 'DAP12': [3772], 'locus': [3773], 'facilitate': [3775], 'acting': [3782], 'activating': [3785], 'signal': [3786], 'transduction': [3787], 'element': [3788], 'enhancing': [3790], 'TNFRSF7': [3798], '(CD27)': [3799], 'Although': [3806], 'did': [3811], 'confirm': [3813], 'CD27': [3817], 'counterparts,': [3827], 'corroborated': [3830], 'lacked': [3836], 'molecule.': [3839], 'PTK': [3841], 'ITK': [3843], 'downregulated.': [3858], '5Open': [3860], 'Validation': [3864], '(from': [3888], 'left': [3889], 'right):': [3891], 'Illumina': [3900, 3930], 'Infinium': [3901], 'HumanMethylation27': [3902], 'BeadChip': [3903], 'array;': [3904, 3932], 'pyrosequencing': [3910], 'donors;': [3923], 'mRNA': [3924], 'CD28+;': [3942], 'Dot': [3953], 'one': [3958], 'experiments.': [3962], 'Box': [3963], 'donors.*': [3972], '0.05': [3975], 'Discussion': [3980], 'consistent': [3985], 'frequency': [4009], '(up': [4014], '50%': [4016], 'lymphocytes)': [4021], 'described': [4024], 'pathologies': [4029], 'chronic': [4032], 'processes,': [4034], 'mostly': [4055], 'attributed': [4056], 'environments': [4059], 'antigen': [4062], 'molecular': [4066], 'elucidated.': [4078], 'date,': [4080], 'carried': [4085, 4113], 'out': [4086, 4114], 'whose': [4094], 'disease': [4095], 'etiology,': [4096], 'treatments,': [4097], 'concomitant': [4099], 'effects': [4100], 'substantially,': [4102], 'increasing': [4103], 'variability': [4105], 'subset.': [4110], 'study,': [4112], 'ages,': [4120], 'lymphocytes.': [4134], 'report': [4139], 'promoter': [4160], 'reveal': [4176], 'control': [4178], 'mechanism': [4191], 'processes': [4194], 'effector': [4202], 'establishment': [4206], 'memory': [4213], '(Li': [4215], '2009;': [4218], 'Komori': [4223], 'Previous': [4227], 'lower': [4239], 'DNMT3A/B': [4244], 'linear': [4249], 'decrease': [4250], 'age,': [4255], 'gradually': [4262], 'decreased': [4263, 4287], 'up': [4264], '64': [4269], 'years': [4270], 'Li': [4276], 'al.': [4278], '(2009)': [4279], "'senescent'": [4283], 'DNMT3A': [4290], 'causes': [4292], 'PRF,': [4298], 'genes.': [4301, 4328], 'equally': [4318], 'function,': [4342], 'costimulation.': [4350], 'Resu': [4351]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2561830264', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-12-13T19:44:57.306523', 'created_date': '2017-01-06'}