Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2561277036', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-lb-214', 'title': 'Abstract LB-214: DNAJB1-PRKACA chimera increases Aurora kinase A expression in fibrolamellar hepatocellular carcinoma', 'display_name': 'Abstract LB-214: DNAJB1-PRKACA chimera increases Aurora kinase A expression in fibrolamellar hepatocellular carcinoma', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W2561277036', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-lb-214', 'mag': '2561277036'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-lb-214', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022267121', 'display_name': 'Irene Isabel P. Lim', 'orcid': 'https://orcid.org/0000-0002-1711-443X'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Irene Isabel P. Lim', 'raw_affiliation_strings': ['1Memorial Sloan Kettering Cancer Center, New York, NY;'], 'affiliations': [{'raw_affiliation_string': '1Memorial Sloan Kettering Cancer Center, New York, NY;', 'institution_ids': ['https://openalex.org/I39965400', 'https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055759165', 'display_name': 'Emily Greene‐Colozzi', 'orcid': 'https://orcid.org/0000-0002-0021-8582'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emily A. Greene-Colozzi', 'raw_affiliation_strings': ['2Rockefeller University, New York, NY.'], 'affiliations': [{'raw_affiliation_string': '2Rockefeller University, New York, NY.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076214965', 'display_name': 'Jennifer M. Murphy', 'orcid': 'https://orcid.org/0000-0002-8492-4918'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer M. Murphy', 'raw_affiliation_strings': ['1Memorial Sloan Kettering Cancer Center, New York, NY;'], 'affiliations': [{'raw_affiliation_string': '1Memorial Sloan Kettering Cancer Center, New York, NY;', 'institution_ids': ['https://openalex.org/I39965400', 'https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010909964', 'display_name': 'Todd E. Heaton', 'orcid': 'https://orcid.org/0000-0003-3515-0028'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd E. Heaton', 'raw_affiliation_strings': ['1Memorial Sloan Kettering Cancer Center, New York, NY;'], 'affiliations': [{'raw_affiliation_string': '1Memorial Sloan Kettering Cancer Center, New York, NY;', 'institution_ids': ['https://openalex.org/I39965400', 'https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036195107', 'display_name': 'Sanford M. Simon', 'orcid': 'https://orcid.org/0000-0002-8615-4224'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sanford M. Simon', 'raw_affiliation_strings': ['2Rockefeller University, New York, NY.'], 'affiliations': [{'raw_affiliation_string': '2Rockefeller University, New York, NY.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002140630', 'display_name': 'Michael P. LaQuaglia', 'orcid': 'https://orcid.org/0000-0002-7059-9851'}, 'institutions': [{'id': 'https://openalex.org/I39965400', 'display_name': 'Kettering University', 'ror': 'https://ror.org/03rcspa57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39965400']}, {'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael P. LaQuaglia', 'raw_affiliation_strings': ['1Memorial Sloan Kettering Cancer Center, New York, NY;'], 'affiliations': [{'raw_affiliation_string': '1Memorial Sloan Kettering Cancer Center, New York, NY;', 'institution_ids': ['https://openalex.org/I39965400', 'https://openalex.org/I1334819555']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.528022, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 79}, 'biblio': {'volume': '75', 'issue': '15_Supplement', 'first_page': 'LB', 'last_page': '214'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9626, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9536, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chimera', 'display_name': 'Chimera (genetics)', 'score': 0.7031113}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.70712256}, {'id': 'https://openalex.org/C30278631', 'wikidata': 'https://www.wikidata.org/wiki/Q281721', 'display_name': 'Chimera (genetics)', 'level': 3, 'score': 0.7031113}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50354666}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.48605636}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11703631}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09704229}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-lb-214', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W644041026', 'https://openalex.org/W2412952866', 'https://openalex.org/W2397542473', 'https://openalex.org/W2151382064', 'https://openalex.org/W2139504042', 'https://openalex.org/W2120053927', 'https://openalex.org/W2065464189', 'https://openalex.org/W2032850224', 'https://openalex.org/W2005849031', 'https://openalex.org/W1919167960'], 'abstract_inverted_index': {'Abstract': [0], 'Purpose:': [1], 'Treatment': [2], 'of': [3, 62, 84, 105, 109, 186, 195, 215, 262, 272, 279, 290, 314, 367, 372], 'fibrolamellar': [4, 361], 'hepatocellular': [5, 362], 'carcinoma': [6], '(FL-HCC),': [7], 'a': [8, 46, 58, 72, 107, 146, 150, 159, 167, 187, 263, 318, 323], 'rare': [9], 'liver': [10], 'cancer': [11], 'affecting': [12], 'the': [13, 75, 81, 127, 177, 184, 196, 213, 234, 242, 251, 280, 307, 312, 368, 373], 'pediatric': [14], 'and': [15, 80, 111, 158, 191, 246, 316], 'adolescent': [16], 'population,': [17], 'is': [18, 113, 130], 'limited': [19], 'to': [20, 238], 'surgical': [21], 'resection': [22], 'with': [23, 45, 120, 149, 166, 241, 250], 'no': [24, 327], 'agents': [25], 'or': [26, 176], 'therapeutic': [27, 320], 'modalities': [28], 'available': [29], 'for': [30, 132, 203, 212, 297, 322, 376], 'unresectable': [31], 'disease.': [32], 'There': [33], 'has': [34, 101, 326], 'been': [35], 'recent': [36], 'interest': [37], 'in': [38, 52, 66, 71, 89, 115, 134, 137, 205, 217, 227, 230, 257, 284, 287, 292, 301, 311, 360], 'using': [39], 'Aurora': [40, 356], 'kinase': [41, 86, 357], 'A': [42, 358], '(AURKA)': [43], 'inhibitors,': [44], 'clinical': [47], 'trial': [48], 'evaluating': [49], 'its': [50], 'efficacy': [51], 'FL-HCC': [53, 91, 116, 315], 'pending.': [54], 'Previously,': [55], 'we': [56], 'described': [57], 'consistent': [59], 'single': [60], 'deletion': [61], 'approximately': [63], '400': [64], 'kB': [65], 'chromosome': [67], '19': [68], 'that': [69, 103, 126, 325], 'results': [70, 283], 'chimera': [73, 129, 142, 253, 282, 354], 'between': [74, 275], 'heat': [76], 'shock': [77], 'protein': [78, 85, 273], 'DNAJB1': [79], 'catalytic': [82], 'subunit': [83], 'A,': [87], 'PRKACA,': [88], 'all': [90, 218], 'tumor': [92, 117, 299], 'tissue': [93, 118], 'studied.': [94], 'Furthermore,': [95], 'comparative': [96], 'ribonucleic': [97], 'acid': [98], 'sequence': [99], 'analysis': [100, 223], 'demonstrated': [102, 254], 'expression': [104, 136, 194, 207, 359], 'AURKA,': [106, 291], 'regulator': [108], 'cytokinesis': [110], 'mitosis,': [112], 'increased': [114], 'compared': [119], 'adjacent': [121], 'normal': [122], 'tissue.': [123], 'We': [124], 'hypothesize': [125], 'DNAJB1-PRKACA': [128, 141, 178, 235, 252, 281, 308, 353], 'responsible': [131, 296], 'changes': [133, 204], 'AURKA': [135, 206, 216, 228, 258], 'FL-HCC.': [138, 302], 'Methods:': [139], 'The': [140], 'was': [143, 181], 'cloned': [144], 'into': [145], 'lentiviral': [147], 'vector': [148], 'fluorescent': [151], 'reporter.': [152], 'Two': [153], 'stable': [154], 'cell': [155, 161], 'lines': [156], '(HeLa': [157], 'hepatocyte': [160], 'line,': [162], 'Huh-7)': [163], 'were': [164, 201, 210, 267], 'transduced': [165, 219, 240, 249], 'lentivirus': [168], 'containing': [169], 'either': [170], 'an': [171, 225, 255, 285], 'empty': [172], 'multicloning': [173], 'site': [174], '(control)': [175], 'chimera.': [179, 236], 'Transduction': [180], 'confirmed': [182], 'by': [183], 'presence': [185, 214], 'positive': [188], 'epifluorescent': [189], 'signal': [190], 'immunoblots': [192, 209], 'showing': [193], 'chimeric': [197], 'protein.': [198], 'Microarray': [199, 222], 'data': [200], 'evaluated': [202], 'while': [208], 'analyzed': [211], 'cells.': [220], 'Results:': [221], 'showed': [224], 'increase': [226, 256, 286], 'transcripts': [229], 'cells': [231, 239, 248], 'stably': [232], 'expressing': [233], 'Compared': [237], 'control': [243], 'lentivirus,': [244], 'HeLa': [245], 'Huh-7': [247], 'on': [259], 'immunoblots.': [260], 'Levels': [261], 'loading': [264], 'control,': [265], 'actin,': [266], 'equivalent,': [268], 'indicating': [269], 'equal': [270], 'levels': [271], 'examined': [274], 'samples.': [276], 'Conclusion:': [277], 'Expression': [278], 'AURKA.': [288], 'Upregulation': [289], 'turn,': [293], 'may': [294], 'be': [295], 'subsequent': [298], 'formation': [300], 'This': [303], 'finding': [304], 'further': [305], 'supports': [306], "chimera's": [309], 'role': [310], 'pathogenesis': [313], 'provides': [317], 'potential': [319], 'target': [321], 'disease': [324], 'effective': [328], 'treatment': [329], 'besides': [330], 'surgery.': [331], 'Citation': [332], 'Format:': [333], 'Irene': [334], 'Isabel': [335], 'P.': [336, 351], 'Lim,': [337], 'Emily': [338], 'A.': [339], 'Greene-Colozzi,': [340], 'Jennifer': [341], 'M.': [342, 348], 'Murphy,': [343], 'Todd': [344], 'E.': [345], 'Heaton,': [346], 'Sanford': [347], 'Simon,': [349], 'Michael': [350], 'LaQuaglia.': [352], 'increases': [355], 'carcinoma.': [363], '[abstract].': [364], 'In:': [365], 'Proceedings': [366], '106th': [369], 'Annual': [370], 'Meeting': [371], 'American': [374], 'Association': [375], 'Cancer': [377, 387], 'Research;': [378], '2015': [379], 'Apr': [380], '18-22;': [381], 'Philadelphia,': [382], 'PA.': [383], 'Philadelphia': [384], '(PA):': [385], 'AACR;': [386], 'Res': [388], '2015;75(15': [389], 'Suppl):Abstract': [390], 'nr': [391], 'LB-214.': [392], 'doi:10.1158/1538-7445.AM2015-LB-214': [393]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2561277036', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:38:50.685399', 'created_date': '2017-01-06'}