Title: Analysis of Activity of Mannan-Binding Lectin, an Initiator of the Lectin Pathway of the Complement System
Abstract: Chapter 14 Analysis of Activity of Mannan-Binding Lectin, an Initiator of the Lectin Pathway of the Complement System Steffen Thiel, Steffen ThielSearch for more papers by this author Steffen Thiel, Steffen ThielSearch for more papers by this author Book Editor(s):Barbara Detrick, Barbara Detrick Johns Hopkins University, School of Medicine, Baltimore, MarylandSearch for more papers by this authorJohn L. Schmitz, John L. Schmitz University of North Carolina, School of Medicine, Chapel Hill, North CarolinaSearch for more papers by this authorRobert G. Hamilton, Robert G. Hamilton Johns Hopkins University, School of Medicine, Baltimore, MarylandSearch for more papers by this author First published: 27 January 2016 https://doi.org/10.1128/9781555818722.ch14 AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Abstract The innate immune system has traditionally been described as the first line of the body's defense against invasive pathogens. Such a response then leads to an inflammatory response which may also include coagulation. Activation of the innate immune response is mediated by pattern recognition molecules, which may be membrane-bound (e.g., cell-associated Toll-like receptors, NOD-like receptors, and RIG-I-like receptors) or soluble proteins. Recognition of foreign or altered structures in the body by some of the soluble pattern recognition receptors may lead to activation of the complement system and thus trigger one of the innate antimicrobial defense mechanisms. Such complement-activating soluble pattern recognition molecules include the collectins (lectins, i.e., carbohydrate-binding proteins, that use a collagen helix for stabilization of the molecule), i.e., mannan-binding lectin (MBL, also known as mannose-binding lectin), collectin K1 (CL-K1), and collectin L1 (CL-L1), and the ficolins (proteins that contain a fibrinogen-like domain and use a collagen helix for stabilization of the molecule), i.e., H-ficolin, L-ficolin, and M-ficolin (1, 2). Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition RelatedInformation
Publication Year: 2016
Publication Date: 2016-01-27
Language: en
Type: book-chapter
Indexed In: ['crossref']
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