Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate–A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome

Name: Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate–A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome
Uploaded: 2017-01-01
Torleiv Svendsen; Eylert Brodtkorb; Arne Reimers; Espen Molden; Erik Sætre; Svein I. Johannessen; Cecilie Johannessen Landmark
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253], 'The': [18, 263], 'purpose': [19], 'of': [20, 80, 100, 104, 106, 110, 120, 132, 142, 162, 181, 213, 224, 231, 233, 260, 272], 'this': [21], 'study': [22, 55], 'was': [23, 122, 134, 144, 183, 190, 209, 226, 255], 'to': [24, 37, 74, 87, 218, 267], 'evaluate': [25], 'therapeutic': [26], 'monitoring': [28], '(TDM)': [29], 'data': [30, 64, 76, 154], 'in': [31, 42, 47, 70, 72, 112, 149, 211, 220, 257], 'Norway': [32, 113], 'relate': [34], 'variability': [36, 141, 148, 223], 'clinical': [38, 45, 75, 153], 'tolerability': [41], 'long-term': [44], 'setting': [46], 'patients': [48, 82, 95, 111, 160, 239], 'with': [49, 146, 166, 240], 'refractory': [50], 'epilepsy.': [51, 170], 'This': [52], 'retrospective': [53], 'observational': [54], 'included': [56], 'TDM-data': [57, 92], 'from': [58, 65, 77, 93, 157], 'the': [59, 66, 107, 163, 178, 214, 229, 245, 261], 'main': [60], 'laboratories': [61], 'population': [63], 'Norwegian': [67], 'Prescription': [68], 'Database': [69], 'Norway,': [71], 'addition': [73], 'medical': [78], 'records': [79], 'adult': [81, 159], 'using': [83, 114], 'ESL': [84, 121, 133, 143, 182, 189, 225], 'for': [85, 98, 270], 'up': [86], 'three': [88], 'years,': [89], 'whenever': [90], 'possible.': [91], '168': [94], 'were': [96, 155, 203], 'utilized': [97], 'assessment': [99], 'consisting': [103], '71%': [105], 'total': [108], 'number': [109], 'ESL,': [115], '2011-14.': [116], 'Median': [117], 'daily': [118], 'dose': [119], '800': [123], 'mg': [124], '(range': [125, 137], '400–1600': [126], 'mg),': [127], 'median': [129], 'serum': [130], 'concentration': [131], '53': [135], 'μmol/L': [136], '13–132': [138], 'μmol/L).': [139], 'Inter-patient': [140], 'extensive,': [145], '25-fold': [147], 'concentration/dose': [150], 'ratios.': [151], 'Additional': [152], 'available': [156], '104': [158], 'out': [161], '168,': [164], 'all': [165], 'resistant': [168, 242], 'focal': [169, 243], 'After': [171], '1,': [172], '2': [173], '3': [175], 'years': [176], 'follow-up,': [177], 'retention': [179, 247], 'rate': [180, 248], '83%,': [184], '72%': [185], '64%,': [187], 'respectively.': [188], 'generally': [191], 'well': [192], 'tolerated': [193], 'as': [194], 'add-on': [195], 'treatment,': [196], 'but': [197], 'sedation,': [198], 'cognitive': [199], 'impairment': [200], 'hyponatremia': [202], 'reported.': [204], 'Hyponatremia': [205, 254], '(sodium': [206], '<137': [207], 'mmol/L)': [208], 'present': [210, 264], '36%': [212], 'patients,': [215], 'lead': [217], 'discontinuation': [219], 'three.': [221], 'Pharmacokinetic': [222], 'extensive': [227], 'demonstration': [230], 'usefulness': [232], 'TDM': [234, 275], 'requires': [235], 'further': [236], 'studies.': [237], 'In': [238], 'Epilepsy,': [244], 'high': [246], 'indicated': [249], 'good': [250], 'observed': [256], 'one': [258], 'third': [259], 'patients.': [262], 'results': [265], 'point': [266], 'need': [269], 'individualization': [271], 'treatment': [273], 'may': [276], 'be': [277], 'useful.': [278]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2560685728', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-08-21T19:06:26.803064', 'created_date': '2016-12-16'}
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