Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2560149946', 'doi': 'https://doi.org/10.1080/13880209.2016.1257642', 'title': 'Effect of berberine on PPAR<sub>α</sub>-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV', 'display_name': 'Effect of berberine on PPAR<sub>α</sub>-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV', 'publication_year': 2016, 'publication_date': '2016-12-07', 'ids': {'openalex': 'https://openalex.org/W2560149946', 'doi': 'https://doi.org/10.1080/13880209.2016.1257642', 'mag': '2560149946', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27927051', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6130450'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/13880209.2016.1257642', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/13880209.2016.1257642?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.1080/13880209.2016.1257642?needAccess=true', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102970015', 'display_name': 'Hongmei Qiu', 'orcid': 'https://orcid.org/0000-0003-2878-7389'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongmei Qiu', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027261156', 'display_name': 'Yang‐Che Wu', 'orcid': 'https://orcid.org/0000-0003-3058-832X'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Wu', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100322864', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0001-8599-7249'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Quanhua Wang', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100722907', 'display_name': 'Changqing Liu', 'orcid': 'https://orcid.org/0000-0002-1059-6528'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Changqing Liu', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102173875', 'display_name': 'Lai Xue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lai Xue', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100370939', 'display_name': 'Hong Wang', 'orcid': 'https://orcid.org/0000-0002-6192-3082'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Wang', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101785639', 'display_name': 'Qin Wu', 'orcid': 'https://orcid.org/0000-0001-5264-9926'}, 'institutions': [{'id': 'https://openalex.org/I182386381', 'display_name': 'Zunyi Medical University', 'ror': 'https://ror.org/00g5b0g93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I182386381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qin Wu', 'raw_affiliation_strings': ['Department of Pharmacology, Key Laboratory for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Guizhou, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Key Laboratory for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Guizhou, P.R. China', 'institution_ids': ['https://openalex.org/I182386381']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101748275', 'display_name': 'Qingsong Jiang', 'orcid': 'https://orcid.org/0000-0002-4163-6799'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingsong Jiang', 'raw_affiliation_strings': ['Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, P.R. China;', 'institution_ids': ['https://openalex.org/I87780372']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2085, 'currency': 'GBP', 'value_usd': 2557, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.978, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.764708, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '55', 'issue': '1', 'first_page': '227', 'last_page': '232'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12059', 'display_name': 'Therapeutic Potential of Berberine Alkaloids', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12059', 'display_name': 'Therapeutic Potential of Berberine Alkaloids', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13971', 'display_name': 'Chemistry and Biology of Antitumor Antibiotics', 'score': 0.9884, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11064', 'display_name': 'Antiplatelet Therapy in Cardiovascular Disease', 'score': 0.9741, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.5617058}, {'id': 'https://openalex.org/keywords/berberine', 'display_name': 'Berberine', 'score': 0.477328}], 'concepts': [{'id': 'https://openalex.org/C2780116568', 'wikidata': 'https://www.wikidata.org/wiki/Q176525', 'display_name': 'Berberine', 'level': 2, 'score': 0.9361964}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.89898944}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.68961763}, {'id': 'https://openalex.org/C2778326061', 'wikidata': 'https://www.wikidata.org/wiki/Q1761022', 'display_name': 'Enos', 'level': 4, 'score': 0.59011984}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5750017}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5698828}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.5617058}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5224423}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.45704252}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40919155}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37747657}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.33136672}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.29780388}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23468128}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2144976}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19547316}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.1869021}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.10004291}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D001599', 'descriptor_name': 'Berberine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001599', 'descriptor_name': 'Berberine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047493', 'descriptor_name': 'PPAR alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D061251', 'descriptor_name': 'Primary Cell Culture', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/13880209.2016.1257642', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/13880209.2016.1257642?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/3f4fb4ad73ce49e0a94b60bb5eab4a84', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6130450', 'pdf_url': 'https://europepmc.org/articles/pmc6130450?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130450', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27927051', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1080/13880209.2016.1257642', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.1080/13880209.2016.1257642?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.63, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1583375002', 'https://openalex.org/W1763082601', 'https://openalex.org/W1963649307', 'https://openalex.org/W1969266723', 'https://openalex.org/W1977589606', 'https://openalex.org/W1981691650', 'https://openalex.org/W1982353281', 'https://openalex.org/W1985500659', 'https://openalex.org/W1990315857', 'https://openalex.org/W1997738990', 'https://openalex.org/W2008978505', 'https://openalex.org/W2011500206', 'https://openalex.org/W2021903200', 'https://openalex.org/W2024929104', 'https://openalex.org/W2035522294', 'https://openalex.org/W2045999552', 'https://openalex.org/W2051938600', 'https://openalex.org/W2076553098', 'https://openalex.org/W2085503736', 'https://openalex.org/W2088129332', 'https://openalex.org/W2095946347', 'https://openalex.org/W2112964143', 'https://openalex.org/W2130600499', 'https://openalex.org/W2136319476', 'https://openalex.org/W2137948074', 'https://openalex.org/W2140115160', 'https://openalex.org/W2163883963', 'https://openalex.org/W2173017159', 'https://openalex.org/W2411186166', 'https://openalex.org/W2417343424', 'https://openalex.org/W2439642275'], 'related_works': ['https://openalex.org/W4385728725', 'https://openalex.org/W4377242443', 'https://openalex.org/W3150803062', 'https://openalex.org/W2985843621', 'https://openalex.org/W2528788296', 'https://openalex.org/W2382211266', 'https://openalex.org/W2374508672', 'https://openalex.org/W2351576280', 'https://openalex.org/W1990933410', 'https://openalex.org/W1589733092'], 'abstract_inverted_index': {'The': [0], 'available': [1], 'treatments': [2], 'for': [3], 'the': [4, 45, 51, 71, 76, 114, 126, 158, 192, 215, 232], 'abnormal': [5], 'proliferation': [6, 77, 121, 223], 'of': [7, 47, 53, 160, 194, 218], 'vascular': [8], 'smooth': [9], 'muscle': [10], 'cells': [11], '(VSMCs)': [12], 'are': [13], 'still': [14], 'dismal.': [15], 'Berberine': [16, 187], 'has': [17], 'been': [18], 'demonstrated': [19], 'to': [20], 'possess': [21], 'extensive': [22], 'medicine': [23], 'activity,': [24], 'yet': [25], 'relatively': [26], 'little': [27], 'is': [28], 'known': [29], 'about': [30], 'its': [31, 56], 'effect': [32, 52], 'on': [33, 59, 220], 'VSMCs': [34, 48, 67, 120, 198, 226], 'proliferation.': [35], 'Many': [36], 'studies': [37], 'showed': [38], 'that': [39], 'PPARα': [40, 161], 'and': [41, 55, 75, 82, 86, 94, 108, 131, 145, 164, 181], 'NO': [42, 98, 109, 182], 'participated': [43], 'in': [44, 62, 148, 172, 197, 224], 'process': [46], 'proliferation.To': [49], 'evaluate': [50], 'berberine': [54, 142, 219], 'possible': [57], 'influence': [58], 'PPARα-NO': [60, 233], 'pathway': [61], 'angiotensin': [63, 195, 221], 'IV-stimulated': [64], 'VSMCs.The': [65], 'primary': [66], 'were': [68, 89, 203], 'cultured': [69, 225], 'with': [70, 174], 'tissue': [72], 'explants': [73], 'method,': [74], 'was': [78, 102, 111, 122, 139], 'characterized': [79], 'by': [80, 91, 124, 141, 205], 'MTT': [81], 'protein': [83, 133, 165], 'content.': [84], 'Protein': [85], 'mRNA': [87, 163, 177], 'expression': [88, 159], 'measured': [90, 103, 112], 'Western': [92], 'blot': [93], 'real-time': [95], 'RT-PCR,': [96], 'respectively.': [97], 'synthase': [99], '(NOS)': [100], 'activity': [101, 180], 'using': [104, 113], 'a': [105, 149], 'spectrophotometric': [106], 'assay,': [107], 'concentration': [110, 183], 'Griess': [115], 'assay.Angiotensin': [116], 'IV': [117, 156, 196], '(0.1': [118], 'nmol/L)-induced': [119], 'evidenced': [123], 'increasing': [125], 'optical': [127], 'density': [128], 'at': [129, 162, 188, 227], 'A490': [130], 'total': [132], 'content': [134], '(p': [135, 152, 167, 184, 199, 210], '<': [136, 153, 168, 185, 200, 211], '0.01),': [137], 'which': [138, 170, 202], 'inhibited': [140], '(10,': [143], '30': [144, 189], '100': [146], 'μmol/L)': [147, 209], 'concentration-dependent': [150], 'manner': [151], '0.05).': [154], 'Angiotensin': [155], 'decreased': [157], 'level': [166], '0.05),': [169, 201], 'occurred': [171], 'parallel': [173], 'declining': [175], 'eNOS': [176], 'expression,': [178], 'NOS': [179], '0.01).': [186], 'μmol/L': [190], 'reversed': [191], 'effects': [193, 217], 'abolished': [204], 'MK': [206], '886': [207], '(0.3': [208], '0.05).The': [212], 'results': [213], 'support': [214], 'therapeutic': [216], 'IV-induced': [222], 'least': [228], 'partially': [229], 'through': [230], 'targeting': [231], 'signalling': [234], 'pathway.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2560149946', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-14T00:19:46.103606', 'created_date': '2016-12-16'}