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'University': [81, 113, 145, 177, 897], 'Rochester': [83, 115, 147, 179, 899], 'School': [84, 116, 148, 180], 'Medicine': [86, 118, 150, 182], 'Dentistry,': [88, 120, 152, 184], 'NY.': [89, 121, 153, 185], ',': [90, 122], 'PaivanasNicholas': [92], 'Paivanas': [93], 'SternJessica': [124], 'Stern': [125], 'VidulaHimabindu': [156], 'Vidula': [157], 'Originally': [186, 1646], 'published9': [187], 'Dec': [188], '2016https://doi.org/10.1161/CIRCHEARTFAILURE.116.003665Circulation:': [189], 'Failure.': [191], '2016;9:e003665IntroductionDrug': [192], 'rash': [193, 257, 289], 'with': [194, 215, 258, 285, 290, 304, 314, 339, 366, 392, 398, 442, 455, 512, 530, 565, 581, 621, 659, 784, 821, 841, 861, 937, 988, 1101, 1295, 1420, 1423, 1474, 1530], 'eosinophilia': [195, 259, 291], 'systemic': [197, 261, 293], 'symptoms': [198, 602], 'is': [199, 226, 232, 251, 884], 'a': [200, 252, 269, 387, 399, 468, 531, 731, 812, 826, 986, 1098, 1212, 1248, 1388, 1418, 1472, 1517, 1535, 1614], 'type': [201], 'IVb': [202], 'delayed': [203, 558], 'hypersensitivity': [204], 'reaction': [205], 'characterized': [206], 'by': [207, 333, 825, 1200], 'cutaneous': [208], 'eruption,': [209], 'eosinophilia,': [210], 'fever,': [211, 939], 'lymphadenopathy,': [212], 'hepatitis,': [214], 'potential': [216, 833], 'involvement': [217], 'heart,': [220], 'lungs,': [221], 'kidneys.': [223], 'The': [224], 'pathophysiology': [225], 'not': [227], 'completely': [228], 'understood,': [229], 'yet': [230], 'it': [231], 'thought': [233], 'that': [234], 'inciting': [235], 'medications': [236], 'may': [237], 'directly': [238], 'stimulate': [239], 'T': [240, 793, 1410], 'cells': [241, 794], 'via': [242], 'T-cell': [244, 798], 'receptor.': [245], 'necrotizing': [247, 1020, 1195, 1527], 'eosinophilic': [248, 989, 1021, 1196, 1293, 1528], 'myocarditis': [249, 441, 620, 990, 1197, 1294, 1529], '(ANEM)': [250, 1612], 'severe': [253, 645], 'complication': [254], 'drug': [256, 288, 1203], 'symptoms.': [262, 519], 'ANEM': [263, 718, 729, 842, 875], 'has': [264, 854], 'an': [265, 305, 521, 1201, 1205], 'unknown': [266], 'incidence,': [267], 'but': [268, 426, 858], 'reported': [270, 808], 'mortality': [271, 873], '>50%': [273], 'average': [275], 'survival': [276], '<4': [278], 'days.1Case': [279], 'PresentationA': [280], '21-year-old': [281], 'previously': [282], 'healthy': [283], 'woman': [284, 936], 'skin': [286], 'biopsy–proven': [287], 'symptoms,': [294], 'related': [295], 'minocycline': [297], 'use': [298, 1095, 1285], 'for': [299, 395, 405, 412, 834, 839, 1019, 1251, 1327], 'acne': [300], 'treated': [302, 391], 'recently': [303], 'oral': [306, 535], 'steroid': [307], 'taper,': [308], 'presented': [309], 'emergency': [312, 364], 'department': [313, 365], '4': [315, 471], 'days': [316, 397, 548], 'worsening': [318], 'chest': [319], 'pain': [320], 'dyspnea.': [322], 'Shortly': [323], 'after': [324, 549], 'arrival,': [325], 'she': [326, 460, 494, 508, 600], 'suffered': [327], 'pulseless': [328], 'electric': [329], 'activity': [330, 1521], 'arrest': [331], 'followed': [332, 824], '25': [334], 'minutes': [335], 'cardiopulmonary': [337], 'resuscitation': [338], 'return': [340], 'spontaneous': [342], 'circulation.': [343], 'After': [344], 'arrest,': [345], 'echocardiogram': [346], 'showed': [347, 552], 'severely': [348], 'depressed': [349], 'ejection': [350, 486, 553, 585], 'fraction,': [351], 'because': [353], 'refractory': [355], 'cardiogenic': [356, 1296, 1329], 'shock,': [357, 1297, 1330], 'mechanical': [358, 815, 845], 'support': [359, 817, 847], 'was': [360, 384, 390, 410, 461, 474, 509], 'instituted': [361], 'in': [362, 429, 568, 577, 758, 1069, 1096, 1150, 1288, 1387, 1471, 1522], 'venous-arterial': [367], 'extracorporeal': [368, 496, 654], 'membrane': [369, 497, 655, 852, 1093], 'oxygenation': [370, 498, 656, 853, 1094], 'using': [371, 811, 843], 'right': [373, 377], 'femoral': [374], 'vein': [375], 'axillary': [378], 'artery.': [379], 'Left': [380, 1380], 'ventricle': [381], '(LV)': [382], 'sump': [383], 'placed': [385], 'through': [386], 'trans-septal': [388], 'approach.She': [389], 'high-dose': [393, 743], 'methylprednisolone': [394], '5': [396, 650, 662], 'slow': [400, 532], 'taper': [401, 533], 'maintenance': [403], 'dose': [404], 'presumed': [406], 'myocarditis.': [407], 'Intravenous': [408], 'immunoglobulin': [409], 'administered': [411], '3': [413], 'days.': [414], 'Peripheral': [415], 'eosinophil': [416, 450, 631, 994, 1533], 'count': [417], 'decreased': [418], 'from': [419, 489], '1.6': [420], '(9.4%)': [421], '0.03': [423], 'thousand/μL': [424], '(0.2%)': [425], 'without': [427], 'improvement': [428, 567, 576, 660], 'LV': [430, 578, 584, 588], 'function.': [431], 'Endomyocardial': [432, 1148], 'biopsy': [433, 615], 'on': [434, 463, 477, 500], 'hospital': [435, 501, 505, 550], 'day': [436, 502, 506], '8': [437], 'revealed': [438], 'diffuse': [439, 618], 'active': [440, 619], 'coagulative': [443, 622], 'myocyte': [444, 623], 'necrosis': [445, 624], 'mixed': [447, 628], 'infiltrate,': [448, 629], 'including': [449, 537, 630], 'clusters': [451, 632], '(Figure': [452, 595], '1),': [453], 'consistent': [454], 'ANEM.': [456], 'Given': [457, 720, 869], 'these': [458], 'findings,': [459], 'started': [462, 476], 'antithymocyte': [464, 822], 'globulin': [465, 790, 823], 'received': [467], 'total': [469], 'doses.': [472], 'She': [473, 560], 'also': [475], 'cyclosporine,': [478, 538], 'mycophenolate': [479, 539, 762], 'mofetil,': [480, 540], 'standard': [482, 709], 'antimicrobial': [483], 'prophylaxis.': [484], 'Her': [485], 'fraction': [487, 554, 586], 'improved': [488], '17%': [490], '27%,': [492], 'tolerated': [495], 'explant': [499, 657], '16.': [503], 'On': [504], '63,': [507], 'discharged': [510], 'home': [511], 'New': [513], 'York': [514], 'Association': [516], 'class': [517], 'III': [518], 'As': [520], 'outpatient,': [522], 'angiotensin-converting': [523], 'enzyme': [524, 1651], 'inhibitor': [525], 'β-blocker': [527], 'were': [528], 'continued': [529], 'immunosuppression,': [536, 707, 880], 'methylprednisolone.': [542], 'Cardiac': [543], 'magnetic': [544], 'resonance': [545], 'imaging': [546, 643], '16': [547], 'discharge': [551], '27%': [555], 'no': [557, 803], 'enhancement.': [559], 'completed': [561], 'outpatient': [562], 'cardiac': [563, 837], 'rehabilitation': [564], 'significant': [566], 'exercise': [569], 'tolerance.': [570], 'Serial': [571], 'echocardiograms': [572], 'have': [573, 736, 747, 780, 806], 'shown': [574], 'progressive': [575], 'systolic': [579], 'function,': [580], 'normalization': [582, 666], 'longitudinal': [589, 692], 'strain': [590, 642], 'over': [591], 'subsequent': [592], '1-year': [593], 'follow-up': [594], '2).': [596], 'At': [597], '18-month': [598], 'follow-up,': [599], 'denies': [601], 'heart': [604, 696, 710, 1210], 'failure.Download': [605], 'figureDownload': [606, 638], 'PowerPointFigure': [607, 639], '1.': [608], 'Hematoxylin': [609], 'eosin': [611], 'stain': [612], 'endomyocardial': [614], 'sample': [616], 'demonstrating': [617, 644], '(solid': [625], 'arrows)': [626], '(open': [633], 'arrow;': [634], 'original': [635], 'magnification': [636], '×40).Download': [637], '2.': [640], 'Longitudinal': [641], 'left': [646], 'ventricular': [647], 'dysfunction': [648], 'at': [649, 661, 667], 'd': [651], 'status': [652], 'post': [653], '(A)': [658], 'mo': [663], '(B)': [664], '1': [668], 'y': [669], '(C).': [670], 'A2C': [671], 'indicates': [672], 'apical': [673, 676, 681], '2-chamber;': [674], 'A4C,': [675], '4-chamber;': [677], 'ANT,': [678], 'anterior;': [679], 'ApLAX,': [680], 'long-axis;': [682, 701], 'AVC;': [683], 'aortic': [684], 'valve': [685], 'closure;': [686], 'FR,': [687], 'frame': [688], 'rate;': [689, 697], 'GLPS,': [690], 'global': [691], 'peak': [693], 'strain;': [694], 'HR,': [695], 'INF,': [698], 'inferior;': [699], 'LAX,': [700], 'SEPT,': [703], 'septum.DiscussionMechanical': [704], 'circulatory': [705, 816, 846], 'support,': [706], 'failure': [711], 'medical': [712], 'therapies': [713], 'are': [714], 'basis': [716], 'treatment.1–4': [719], 'absence': [722], 'randomized': [724], 'control': [725], 'trials': [726], 'guide': [728], 'therapy,': [730], 'variety': [732], 'immunosuppression': [734, 820, 828, 864, 1016], 'regimens': [735], 'been': [737, 748, 782, 807, 855], 'used.': [738], 'Initial': [739, 1362], 'therapy': [740, 1018], 'generally': [741], 'involves': [742], 'steroids.': [744], 'Additional': [745], 'agents': [746], 'used,': [749], 'such': [750, 862], 'as': [751, 865, 1017, 1204, 1247, 1516], 'cyclosporine': [752], 'inhibit': [754], 'transcription': [755], 'cytokines': [757], 'T-helper': [759], 'lymphocytes': [760], 'decrease': [764, 770], 'T-': [765], 'B-cell': [767], 'proliferation': [768], 'antibody': [771], 'production.': [772], 'Antihistamines,': [773], 'azathioprine,': [774], 'intravenous': [775], 'immunoglobulin,': [776], 'rituximab,': [777], 'plasmapheresis': [779], 'all': [781], 'used': [783, 856], 'varying': [785], 'degrees': [786], 'success.': [788], 'Antithymocyte': [789], 'targets': [791], 'effector': [792], 'leads': [796], 'depletion.': [799], 'To': [800], 'our': [801, 866], 'knowledge,': [802], 'other': [804], 'cases': [805], 'successfully': [810], 'strategy': [813], 'potent': [819], 'prolonged': [827], 'taper.ConclusionsThis': [829], 'case': [830, 996, 1213, 1536], 'demonstrates': [831], 'meaningful': [835], 'long-term': [836], 'recovery': [838], 'patients': [840], 'early': [844], 'aggressive': [849], 'immunosuppression.': [850], 'Extracorporeal': [851, 1092, 1157, 1413], 'previously,': [857], 'only': [859], 'rarely': [860], 'intensive': [863], 'patient': [867, 987], 'required.': [868], 'exceptionally': [871], 'high': [872], 'uncertainty': [877], 'about': [878], 'ideal': [879], 'more': [881], 'mechanistic': [882], 'research': [883], 'needed': [885], 'understand': [887], 'maladaptive': [889], 'immune': [890], 'responses.DisclosuresNone.FootnotesCorrespondence': [891], 'MS,': [896, 914], 'Medical': [900], 'Center,': [901], '601': [902], 'Elmwood': [903], 'Ave,': [904], 'Box': [905], '679T,': [906], 'Rochester,': [907], 'NY': [908], '14642.': [909], 'E-mail': [910], '[email': [911], 'protected]References1.': [912], 'Sabatine': [913], 'Poh': [915], 'KK,': [916], 'Mega': [917], 'JL,': [918], 'Shepard': [919], 'JA,': [920, 953], 'Stone': [921], 'JR,': [922], 'Frosch': [923], 'MP.': [924], 'Case': [925, 932, 1219, 1395, 1433, 1542], 'records': [926], 'Massachusetts': [929], 'General': [930], 'Hospital.': [931], '36-2007.': [933], 'A': [934, 1237, 1432, 1506], '31-year-old': [935], 'rash,': [938], 'hypotension.N': [941], 'Engl': [942], 'J': [943, 1232], 'Med.': [944, 1026], '2007;': [945], '357:2167–2178.': [946], 'doi:': [947, 967, 1005, 1029], '10.1056/NEJMcpc079030.CrossrefMedlineGoogle': [948], 'Scholar2.': [949], 'Bourgeois': [950], 'GP,': [951], 'Cafardi': [952], 'Groysman': [954], 'V,': [955], 'Hughey': [956], 'LC.A': [957], 'review': [958, 1100], 'DRESS-associated': 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'Mieghem': [1139], 'N': [1140, 1407], 'Uil': [1143], 'C': [1144], 'Safety': [1146], 'Biopsy': [1149], 'New-Onset': [1151], 'Failure': [1154, 1658], 'Requiring': [1155], 'Veno-Arterial': [1156], 'Membrane': [1158, 1414], 'Oxygenation,': [1159], 'Circulation:': [1160, 1577], 'Failure,': [1162, 1579], '14:8,': [1163], '1-Aug-2021.': [1167, 1226], 'Beck-da-Silva': [1168], 'L,': [1169, 1341], 'Maulaz': [1170], 'Schvartzman': [1172], 'P,': [1173, 1183, 1347], 'Oliveira': [1174], 'F,': [1175], 'Stifft': [1176], 'Astigarraga': [1178], 'Kronfeld': [1180], 'Rudzínski': [1182], 'Galyavich': [1184], 'Nistor': [1186], 'Tardo': [1188], 'D': [1189, 1279], 'Vervaat': [1191], 'F': [1192], 'possibly': [1198], 'triggered': [1199], 'antimigraine': [1202], 'uncommon': [1206], 'cause': [1207], 'acute': [1209, 1328, 1526], 'failure:': [1211], 'report,': [1214, 1537], 'European': [1215, 1538], 'Journal': [1217, 1540], '-': [1218, 1541], 'Reports,': [1220, 1396, 1543], '10.1093/ehjcr/ytab286,': [1221], '5:8,': [1222], 'Martins': [1227], 'Marto': [1229], 'Johnson': [1231], 'Graber': [1234], 'E': [1235, 1282], 'Review': [1238], 'Systemic': [1240, 1426], 'Minocycline': [1241, 1246], 'Side': [1242], 'Effects': [1243], 'Topical': [1245], 'Safer': [1249], 'Alternative': [1250], 'Treating': [1252], 'Acne': [1253], 'Rosacea,': [1255], 'Antibiotics,': [1256], '10.3390/antibiotics10070757,': [1257], '10:7,': [1258], '(757)': [1259], 'Bohné': [1260], 'Chung': [1262], 'Tigges': [1264], 'E,': [1265, 1455, 1588], 'Schalk': [1268], 'H,': [1269, 1311, 1451, 1496, 1598], 'Waddell': [1270], 'Schenker': [1272], 'Willems': [1274], 'S,': [1275, 1551, 1553], 'Klingel': [1276], 'K,': [1277, 1313, 1453, 1498, 1590], 'Kivelitz': [1278], 'Bahlmann': [1281], '(2020)': [1283, 1323, 1359, 1379, 1411], 'Short-term': [1284], '“ECMELLA”': [1287], 'context': [1290], 'fulminant': [1292], 'BMC': [1298], 'Cardiovascular': [1299], 'Disorders,': [1300], '10.1186/s12872-020-01808-3,': [1301], '20:1,': [1302], '1-Dec-2020.': [1306], 'Ni': [1307], 'hIci': [1308], 'Boardman': [1310], 'Baig': [1312], 'Stafford': [1314], 'Cernei': [1316], 'Bodger': [1318], 'Westaby': [1321], 'devices': [1326], 'Cochrane': [1331], 'Database': [1332], 'Systematic': [1334], 'Reviews,': [1335], '10.1002/14651858.CD013002.pub2,': [1336], '2020:6': [1337], 'Kociol': [1338], 'Fang': [1342], 'Moslehi': [1344], 'Pang': [1346], 'Sabe': [1348], 'Shah': [1350], 'Sims': [1352], 'Thiene': [1354], 'G': [1355], 'Vardeny': [1357], 'Recognition': [1360], 'Fulminant': [1365, 1429, 1468], 'Myocarditis,': [1366], 'Circulation,': [1367], '141:6,': [1368], '(e69-e92),': [1369], '11-Feb-2020.': [1373], 'Brener': [1374], 'M': [1375, 1462, 1557, 1560, 1600], 'Ravalli': [1377], 'Ventricular': [1381], 'Cavity': [1382], 'Obliteration': [1383], 'Patient': [1389, 1419, 1473], 'Classic': [1391], 'Hodgkin': [1392], 'Lymphoma,': [1393], 'JACC:': [1394], '10.1016/j.jaccas.2019.10.046,': [1397], '2:2,': [1398], '(210-215),': [1399], '1-Feb-2020.': [1403], 'Seree-aphinan': [1404], 'Assanangkornchai': [1406], 'Nilmoje': [1409], 'Prolonged': [1412], 'Oxygenation': [1415], 'In': [1417], 'Drug': [1421], 'Reaction': [1422], 'Eosinophilia': [1424], 'Symptoms': [1427], 'Syndrome-associated': [1428], '–': [1431], 'Report': [1434], 'Literature': [1436], 'Review,': [1437], 'International,': [1439], '10.17925/HI.2020.14.2.112,': [1440], '14:2,': [1441], '(112),': [1442], '.': [1443], 'Tagawa': [1444], 'Nakamura': [1446], 'Y,': [1447, 1449, 1457], 'Okura': [1448], 'Nanba': [1450], 'Kishi': [1452], 'Akashi': [1454], 'Ochiai': [1456], 'Asai': [1458], 'Y': [1459], 'Chinushi': [1461], '(2019)': [1463], 'Successful': [1464], 'Treatment': [1465], 'Ulcerative': [1475], 'Colitis': [1476], 'Using': [1477], 'Steroid': [1478], 'Therapy': [1479], 'Percutaneous': [1481], 'Cardiopulmonary': [1482], 'Support,': [1483], 'Internal': [1484], '10.2169/internalmedicine.1528-18,': [1486], '58:8,': [1487], '(1111-1118),': [1488], '15-Apr-2019.': [1492], 'Kakino': [1493], 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