Title: Synthesis and Pharmacological Activities of Some Thieno Pyridazine Derivatives Using 5-Amino-4-Ethoxycarbonyl Phenanthro(9,10-e)Theino(2,3-c)Pyridazine as a Starting Material
Abstract:amino-4-ethoxycarbonyl-phenanthro (9, 10-e)thieno(2,3-c)pyridazine 4 was prepared via reaction of pyridazine derivative 3 and ethyl chloroacetate. Reaction of 4 with chloroacetyl choride, potassium th...amino-4-ethoxycarbonyl-phenanthro (9, 10-e)thieno(2,3-c)pyridazine 4 was prepared via reaction of pyridazine derivative 3 and ethyl chloroacetate. Reaction of 4 with chloroacetyl choride, potassium thiocyanate afforded pyrimidothienopyridazine derivative 6. reaction of 4 with active methylene reagents namely, ethyl acetoacetate, ethyl benzoyl acetate, ethyl phenyl acetate, ethyl cyanoacetate and/or diethyl malonate gave pyridinothienopyridazine derivatives 16a-e respectively. The pharmacological screening should that many of these compounds have good activities. The structure assignments of the new compounds are based on chemical and spectroscopic evidence. The detailed synthesis, spectroscopic data, and pharmacological properties are reported. (Journal of American Science. 2010;6(10):151-159). (ISSN: 1545-1003).Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 2
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