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'abstract_inverted_index': {'<h3>Background</h3>': [0], 'Our': [1], 'previous': [2], 'study': [3], 'showed': [4, 321, 380], 'that': [5, 322, 364, 381], 'suppression': [6], 'of': [7, 16, 47, 99, 157, 186, 195, 222, 244, 262, 292, 299, 326, 390, 411, 438, 448, 459], 'peroxisome': [8], 'proliferator-activated': [9], 'receptor-gamma': [10], 'coactivator-1β': [11], '(PGC-1β)': [12], 'alleviated': [13], 'the': [14, 43, 193, 323, 445], 'secretion': [15], 'matrix': [17], 'metalloproteinase': [18], '(MMP)-3': [19], 'from': [20], 'fibroblast-like': [21], 'synoviocytes': [22], 'and': [23, 45, 64, 85, 95, 105, 108, 131, 138, 165, 169, 180, 192, 213, 241, 246, 264, 276, 290, 340, 350, 398, 452], 'inhibited': [24], 'osteoclastogenesis': [25], 'in': [26, 37, 53, 120, 128, 183, 219, 306, 356, 365, 419, 426], 'vitro.': [27], 'However,': [28], 'little': [29], 'was': [30, 72, 78, 101, 111, 122, 250, 303, 335, 386, 431], 'known': [31], 'about': [32], 'PGC-1β': [33, 49, 118, 362, 371, 414], 'with': [34, 50, 59, 124, 163, 201, 271, 337, 358, 367], 'joint': [35, 51, 273, 421], 'destruction': [36, 52, 422], 'RA': [38, 54, 61, 121, 187, 223, 231], 'patients.': [39, 55], '<h3>Objectives</h3>': [40], 'To': [41], 'investigate': [42], 'expression': [44, 119], 'correlation': [46], 'synovial': [48, 166, 351, 360, 369, 397, 412], '<h3>Methods</h3>': [56], 'Eighty-one': [57], 'patients': [58, 232, 255, 284, 308, 311, 357, 366], 'active': [60], 'were': [62, 142, 268, 353], 'recruited': [63], 'followed': [65], 'up': [66], 'for': [67, 83, 88, 330, 396, 444], 'one': [68, 106, 287], 'year.': [69], 'Serum': [70, 349], 'MMP3': [71], 'detected': [73], 'by': [74, 80, 433], 'ELISA.': [75], 'Synovial': [76], 'tissue': [77], 'obtained': [79], 'closed-needle': [81], 'biopsy': [82], 'H&E': [84], 'immunohistochemistry': [86], 'staining': [87, 127], 'PGC-1β,': [89], 'MMP-3,': [90], 'CD3,': [91], 'CD20,': [92], 'CD38,': [93], 'CD68': [94], 'CD15.': [96], 'X-ray': [97], 'assessment': [98], 'hand/wrist': [100], 'repeated': [102], 'at': [103, 239], 'baseline': [104, 240], 'year': [107, 288], 'radiographic': [109, 295, 333, 392], 'progression': [110, 334, 393], 'defined': [112], 'as': [113, 173, 175], 'TSS≥0.5': [114], 'unit.': [115], '<h3>Results</h3>': [116], '(1)': [117], 'observed': [123], 'intense': [125], 'nuclear': [126], 'lining': [129, 158, 245, 263, 300, 327, 361, 370, 383, 413], 'cells': [130, 134, 160, 198, 212, 249, 267, 302, 329, 385], 'sublining': [132, 184, 196, 220, 247, 265], 'inflammatory': [133], '(including': [135], 'macrophages,': [136], 'lymphocytes': [137], 'plasma': [139, 215], 'cells)': [140], 'which': [141], 'significantly': [143, 161, 199, 251, 269, 304, 354], 'higher': [144, 252, 305, 355], 'than': [145, 253, 309, 363], 'osteoarthritis': [146], '(OA)': [147], 'or': [148], 'orthopedic': [149], 'arthropathies': [150], '(Orth.A,': [151], 'Fig.': [152, 258, 374, 407], '1A).': [153], '(2)': [154], 'The': [155, 297], 'percentage': [156, 194, 243, 298], 'PGC-1β+': [159, 197, 248, 266, 301, 328, 384], 'correlated': [162, 200, 270], 'serum': [164, 399], 'MMP-3': [167, 352, 400, 425], '(<i>r</i>=0.394': [168], '0.376,': [170], 'both': [171], '<i>P</i><0.01),': [172], 'well': [174], 'CRP,': [176, 202], 'ESR,': [177, 203], 'CD15+': [178], 'neutrophils': [179], 'CD68+': [181, 217], 'macrophages': [182, 218], 'area': [185, 221], 'synovium': [188, 224], '(<i>r</i>=0.266–0.356,': [189], 'all': [190, 226, 280], '<i>P</i><0.05),': [191], 'total': [204], 'synovitis': [205], 'score,': [206], 'CD3+': [207], 'T': [208], 'cells,': [209, 216], 'CD20+': [210], 'B': [211], 'CD38+': [214], '(<i>r</i>=0.225-0.428,': [225], '<i>P</i><0.05).': [227, 281], '(3)': [228], 'Forty-three': [229], '(53%)': [230], 'had': [233, 285, 294], 'erosive': [234], 'disease': [235], '(2013': [236], 'EULAR': [237], 'definition)': [238], 'their': [242], 'non-erosive': [254], '(both': [256, 372], '<i>P</i><0.05,': [257, 373], '1B).': [259], 'Both': [260], 'percentages': [261], 'mTSS,': [272], 'space': [274], 'narrowing': [275], 'erosion': [277], 'subscore': [278], '(<i>r</i>=0.228-0.261,': [279], '(4)': [282], 'Thirty-nine': [283], 'finished': [286], 'follow-up': [289], '23%': [291], 'them': [293], 'progression.': [296], 'progressive': [307], 'non-progressive': [310], '[83%': [312], '(79%–91%)': [313], 'vs': [314], '75%': [315], '(65%–82%),': [316], '<i>P</i>=0.002].': [317], 'ROC': [318], 'curve': [319], 'analysis': [320, 379], 'tradeoff': [324], 'value': [325], 'predicting': [331], '1-year': [332, 391], '78%': [336], 'sensitivity': [338], '89%': [339], 'specificity': [341], '70%': [342], '(AUC=0.833,': [343], '95%': [344, 403], 'CI:': [345, 404], '0.689–0.978,': [346], '<i>P</i>=0.003).': [347], '(5)': [348], 'high': [359, 382], 'low': [368], '1C–E).': [375], 'Multivariate': [376], 'logistic': [377], 'regression': [378], 'a': [387], 'significant': [388], 'predictor': [389], 'after': [394], 'adjustment': [395], '(OR:': [401], '15.002,': [402], '1.43–156.698,': [405], '<i>P</i>=0.024,': [406], '1C).': [408], '<h3>Conclusions</h3>': [409], 'Overexpression': [410], 'might': [415], 'play': [416], 'important': [417], 'roles': [418], 'aggravating': [420], 'through': [423], 'upregulating': [424], 'RA.': [427], '<h3>Acknowledgement</h3>': [428], 'This': [429], 'work': [430], 'supported': [432], 'National': [434], 'Natural': [435, 454], 'Science': [436, 455], 'Foundation': [437, 456], 'China': [439], '(81471597),': [440], 'Specialized': [441], 'Research': [442], 'Fund': [443], 'Doctoral': [446], 'Program': [447], 'Higher': [449], 'Education': [450], '(20130171110075)': [451], 'Guangdong': [453], '(2014A030313074).': [457], '<h3>Disclosure': [458], 'Interest</h3>': [460], 'None': [461], 'declared': [462]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2556672908', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-12T11:27:40.691868', 'created_date': '2016-11-30'}