Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2556222602', 'doi': 'https://doi.org/10.1038/srep37024', 'title': 'Quantifying side-chain conformational variations in protein structure', 'display_name': 'Quantifying side-chain conformational variations in protein structure', 'publication_year': 2016, 'publication_date': '2016-11-15', 'ids': {'openalex': 'https://openalex.org/W2556222602', 'doi': 'https://doi.org/10.1038/srep37024', 'mag': '2556222602', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27845406', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5109468'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37024', 'pdf_url': 'https://www.nature.com/articles/srep37024.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep37024.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047497779', 'display_name': 'Zhichao Miao', 'orcid': 'https://orcid.org/0000-0002-5777-9815'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}, {'id': 'https://openalex.org/I4210128885', 'display_name': "Architecture et Réactivité de l'arN", 'ror': 'https://ror.org/03xmjtz19', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210128885', 'https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Zhichao Miao', 'raw_affiliation_strings': ['Architecture et Réactivité de l′ARN, Université de Strasbourg, Institut de biologie moléculaire et cellulaire du CNRS, Strasbourg, 67000, France'], 'affiliations': [{'raw_affiliation_string': 'Architecture et Réactivité de l′ARN, Université de Strasbourg, Institut de biologie moléculaire et cellulaire du CNRS, Strasbourg, 67000, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I68947357', 'https://openalex.org/I4210128885']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045938742', 'display_name': 'Yang Cao', 'orcid': 'https://orcid.org/0000-0002-1925-2123'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4391768003', 'display_name': 'State Key Laboratory of Biotherapy', 'ror': 'https://ror.org/00x43yy22', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768003']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Cao', 'raw_affiliation_strings': ['Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610014, China'], 'affiliations': [{'raw_affiliation_string': 'Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610014, China', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4391768003']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 0.95, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/side-chain', 'display_name': 'Side chain', 'score': 0.52538663}, {'id': 'https://openalex.org/keywords/chain', 'display_name': 'Chain (unit)', 'score': 0.47396442}], 'concepts': [{'id': 'https://openalex.org/C204921945', 'wikidata': 'https://www.wikidata.org/wiki/Q899689', 'display_name': 'Side chain', 'level': 3, 'score': 0.52538663}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.49230945}, {'id': 'https://openalex.org/C199185054', 'wikidata': 'https://www.wikidata.org/wiki/Q552299', 'display_name': 'Chain (unit)', 'level': 2, 'score': 0.47396442}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.41546872}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.40249395}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.2876547}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19418404}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.154261}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.11814776}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C1276947', 'wikidata': 'https://www.wikidata.org/wiki/Q333', 'display_name': 'Astronomy', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37024', 'pdf_url': 'https://www.nature.com/articles/srep37024.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109468', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27845406', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37024', 'pdf_url': 'https://www.nature.com/articles/srep37024.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1515226261', 'https://openalex.org/W1575141465', 'https://openalex.org/W1838872057', 'https://openalex.org/W1948887231', 'https://openalex.org/W1989690293', 'https://openalex.org/W2002651564', 'https://openalex.org/W2003237067', 'https://openalex.org/W2011301426', 'https://openalex.org/W2011658408', 'https://openalex.org/W2055043387', 'https://openalex.org/W2057965088', 'https://openalex.org/W2063223774', 'https://openalex.org/W2072404529', 'https://openalex.org/W2084703708', 'https://openalex.org/W2095750235', 'https://openalex.org/W2103589755', 'https://openalex.org/W2105732409', 'https://openalex.org/W2106383417', 'https://openalex.org/W2109683504', 'https://openalex.org/W2109801072', 'https://openalex.org/W2120459111', 'https://openalex.org/W2121268822', 'https://openalex.org/W2121583326', 'https://openalex.org/W2130479394', 'https://openalex.org/W2132629607', 'https://openalex.org/W2153153865', 'https://openalex.org/W2158714788', 'https://openalex.org/W2161151688', 'https://openalex.org/W2166317516', 'https://openalex.org/W2168375512', 'https://openalex.org/W2177731497', 'https://openalex.org/W2180229411', 'https://openalex.org/W2222702281', 'https://openalex.org/W2315624362', 'https://openalex.org/W2413979151'], 'related_works': ['https://openalex.org/W4280529929', 'https://openalex.org/W3158858967', 'https://openalex.org/W2914661072', 'https://openalex.org/W2897673755', 'https://openalex.org/W2748952813', 'https://openalex.org/W2556222602', 'https://openalex.org/W2390279801', 'https://openalex.org/W2358668433', 'https://openalex.org/W2013326634', 'https://openalex.org/W2003932717'], 'abstract_inverted_index': {'Abstract': [0], 'Protein': [1], 'side-chain': [2, 12, 27, 42, 78, 103, 112, 128], 'conformation': [3, 113], 'is': [4, 14, 81, 115], 'closely': [5, 82], 'related': [6, 83], 'to': [7, 84, 87, 98, 122], 'their': [8], 'biological': [9], 'functions.': [10], 'The': [11, 107], 'prediction': [13, 114, 129], 'a': [15, 117], 'key': [16], 'step': [17], 'in': [18, 31, 105], 'protein': [19, 21, 32, 111], 'design,': [20], 'docking': [22], 'and': [23, 36, 53, 59, 74, 92], 'structure': [24], 'optimization.': [25], 'However,': [26], 'polymorphism': [28], 'comprehensively': [29], 'exists': [30], 'as': [33], 'various': [34], 'types': [35, 101], 'has': [37], 'been': [38, 50], 'long': [39], 'overlooked': [40], 'by': [41], 'prediction.': [43], 'But': [44], 'such': [45], 'conformational': [46, 79], 'variations': [47, 58], 'have': [48], 'not': [49, 116], 'quantitatively': [51], 'studied': [52], 'the': [54, 77, 85, 124], 'correlations': [55], 'between': [56], 'these': [57], 'residue': [60], 'features': [61], 'are': [62], 'vague.': [63], 'Here,': [64], 'we': [65], 'performed': [66], 'statistical': [67], 'analyses': [68, 95], 'on': [69], 'large': [70], 'scale': [71], 'data': [72], 'sets': [73], 'found': [75], 'that': [76, 110], 'flexibility': [80], 'exposure': [86], 'solvent,': [88], 'degree': [89], 'of': [90, 102, 127], 'freedom': [91], 'hydrophilicity.': [93], 'These': [94], 'allowed': [96], 'us': [97, 121], 'quantify': [99], 'different': [100], 'variabilities': [104], 'PDB.': [106], 'results': [108], 'underscore': [109], 'single-answer': [118], 'problem,': [119], 'leading': [120], 'reconsider': [123], 'assessment': [125], 'approaches': [126], 'programs.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2556222602', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-13T04:29:38.884639', 'created_date': '2016-11-30'}