Publication Information

{'id': 'https://openalex.org/W2554776677', 'doi': 'https://doi.org/10.18632/oncotarget.13458', 'title': 'EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction', 'display_name': 'EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction', 'publication_year': 2016, 'publication_date': '2016-11-19', 'ids': {'openalex': 'https://openalex.org/W2554776677', 'doi': 'https://doi.org/10.18632/oncotarget.13458', 'mag': '2554776677', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27907909', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5356756'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13458', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13458&path%5B%5D=42688', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13458&path%5B%5D=42688', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036829075', 'display_name': 'Nesaretnam Barr Kumarakulasinghe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Nesaretnam Barr Kumarakulasinghe', 'raw_affiliation_strings': ['Department of Haematology-Oncology, National University Cancer Institute, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology-Oncology, National University Cancer Institute, Singapore', 'institution_ids': ['https://openalex.org/I4210103786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043061995', 'display_name': 'Nicholas Syn', 'orcid': 'https://orcid.org/0000-0002-6343-176X'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Nicholas Syn', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Cancer Institute, Singapore', 'Yong Loo Lin School of Medicine, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Yong Loo Lin School of Medicine, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Department of Haematology-Oncology, National University Cancer Institute, Singapore', 'institution_ids': ['https://openalex.org/I4210103786']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026312862', 'display_name': 'Yu Yang Soon', 'orcid': 'https://orcid.org/0000-0002-1995-2170'}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Yu Yang Soon', 'raw_affiliation_strings': ['Department of Radiation Oncology, National University Cancer Institute, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiation Oncology, National University Cancer Institute, Singapore', 'institution_ids': ['https://openalex.org/I4210103786']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085404684', 'display_name': 'Atasha Asmat', 'orcid': 'https://orcid.org/0000-0001-5355-155X'}, 'institutions': [{'id': 'https://openalex.org/I2802408685', 'display_name': 'Tan Tock Seng Hospital', 'ror': 'https://ror.org/032d59j24', 'country_code': 'SG', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802408685']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Atasha Asmat', 'raw_affiliation_strings': ['Department of General Surgery, Tan Tock Seng Hospital, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Tan Tock Seng Hospital, Singapore', 'institution_ids': ['https://openalex.org/I2802408685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003119794', 'display_name': 'Huili Zheng', 'orcid': 'https://orcid.org/0000-0002-3976-0088'}, 'institutions': [{'id': 'https://openalex.org/I2802250162', 'display_name': 'Health Promotion Board', 'ror': 'https://ror.org/01xkzjp97', 'country_code': 'SG', 'type': 'government', 'lineage': ['https://openalex.org/I1291357265', 'https://openalex.org/I2802250162']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Huili Zheng', 'raw_affiliation_strings': ['National Registry of Diseases Office, Health Promotion Board, Singapore'], 'affiliations': [{'raw_affiliation_string': 'National Registry of Diseases Office, Health Promotion Board, Singapore', 'institution_ids': ['https://openalex.org/I2802250162']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112038876', 'display_name': 'En Yun Loy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802250162', 'display_name': 'Health Promotion Board', 'ror': 'https://ror.org/01xkzjp97', 'country_code': 'SG', 'type': 'government', 'lineage': ['https://openalex.org/I1291357265', 'https://openalex.org/I2802250162']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'En Yun Loy', 'raw_affiliation_strings': ['National Registry of Diseases Office, Health Promotion Board, Singapore'], 'affiliations': [{'raw_affiliation_string': 'National Registry of Diseases Office, Health Promotion Board, Singapore', 'institution_ids': ['https://openalex.org/I2802250162']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113935384', 'display_name': 'Brendan Pang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150261', 'display_name': 'National University Health System', 'ror': 'https://ror.org/05tjjsh18', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Brendan Pang', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Pathology, National University Health System, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, National University Health System, Singapore', 'institution_ids': ['https://openalex.org/I4210150261']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032293215', 'display_name': 'Ross A. Soo', 'orcid': 'https://orcid.org/0000-0002-3053-3997'}, 'institutions': [{'id': 'https://openalex.org/I4210103786', 'display_name': 'National University Cancer Institute, Singapore', 'ror': 'https://ror.org/025yypj46', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I4210103786', 'https://openalex.org/I4210150261']}, {'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': True, 'raw_author_name': 'Ross Andrew Soo', 'raw_affiliation_strings': ['Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'Department of Haematology-Oncology, National University Cancer Institute, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Haematology-Oncology, National University Cancer Institute, Singapore', 'institution_ids': ['https://openalex.org/I4210103786']}, {'raw_affiliation_string': 'Cancer Science Institute of Singapore, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5032293215'], 'corresponding_institution_ids': ['https://openalex.org/I4210103786', 'https://openalex.org/I165932596'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.882, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.917078, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '51', 'first_page': '85542', 'last_page': '85550'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/egfr-inhibitors', 'display_name': 'EGFR Inhibitors', 'score': 0.5915136}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6680367}, {'id': 'https://openalex.org/C2777506169', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'EGFR inhibitors', 'level': 4, 'score': 0.5915136}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.59003794}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.49778652}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4943502}, {'id': 'https://openalex.org/C167135981', 'wikidata': 'https://www.wikidata.org/wiki/Q2146302', 'display_name': 'Retrospective cohort study', 'level': 2, 'score': 0.42149997}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39395776}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3342893}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29851714}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.29529738}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.18095544}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10360271}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000069347', 'descriptor_name': 'Erlotinib Hydrochloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016009', 'descriptor_name': 'Chi-Square Distribution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016208', 'descriptor_name': 'Databases, Factual', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069347', 'descriptor_name': 'Erlotinib Hydrochloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017567', 'descriptor_name': 'Karnofsky Performance Status', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054328', 'descriptor_name': 'Proton Pump Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018570', 'descriptor_name': 'Risk Assessment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012846', 'descriptor_name': 'Singapore', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13458', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13458&path%5B%5D=42688', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5356756', 'pdf_url': 'https://europepmc.org/articles/pmc5356756?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356756', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27907909', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13458', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13458&path%5B%5D=42688', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.64, 'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1548923518', 'https://openalex.org/W1584673858', 'https://openalex.org/W1966714873', 'https://openalex.org/W1968151389', 'https://openalex.org/W1971211622', 'https://openalex.org/W2002056663', 'https://openalex.org/W2002795751', 'https://openalex.org/W2010896123', 'https://openalex.org/W2018708014', 'https://openalex.org/W2026603557', 'https://openalex.org/W2028754167', 'https://openalex.org/W2034287995', 'https://openalex.org/W2043696829', 'https://openalex.org/W2061817827', 'https://openalex.org/W2080081537', 'https://openalex.org/W2082576263', 'https://openalex.org/W2084340355', 'https://openalex.org/W2100116917', 'https://openalex.org/W2111662961', 'https://openalex.org/W2114291028', 'https://openalex.org/W2129360604', 'https://openalex.org/W2143555751', 'https://openalex.org/W2156849452', 'https://openalex.org/W2161821474', 'https://openalex.org/W2162724777', 'https://openalex.org/W2164844879', 'https://openalex.org/W2166084034', 'https://openalex.org/W2185481272', 'https://openalex.org/W2258868302', 'https://openalex.org/W2267994443', 'https://openalex.org/W2410680960', 'https://openalex.org/W2590062141', 'https://openalex.org/W4240064739'], 'related_works': ['https://openalex.org/W4385955473', 'https://openalex.org/W2994288809', 'https://openalex.org/W2350587855', 'https://openalex.org/W2155835698', 'https://openalex.org/W2094337488', 'https://openalex.org/W2077224613', 'https://openalex.org/W2076096978', 'https://openalex.org/W2047730886', 'https://openalex.org/W2044028228', 'https://openalex.org/W1984834769'], 'abstract_inverted_index': {'//': [0], 'Nesaretnam': [1], 'Barr': [2], 'Kumarakulasinghe': [3], '1,': [4, 9, 40], '*': [5, 12, 113], ',': [6, 13, 18, 22, 26, 31, 36], 'Nicholas': [7], 'Syn': [8], '2,': [10, 34], '3,': [11], 'Yu': [14], 'Yang': [15], 'Soon': [16], '4': [17, 74], 'Atasha': [19], 'Asmat': [20], '5': [21, 84], 'Huili': [23], 'Zheng': [24], '6': [25, 30, 94], 'En': [27], 'Yun': [28], 'Loy': [29], 'Brendan': [32], 'Pang': [33], '7': [35, 104], 'Ross': [37, 127], 'Andrew': [38, 128], 'Soo': [39], '2': [41, 51], '1': [42], 'Department': [43, 75, 85, 105], 'of': [44, 55, 59, 67, 71, 76, 86, 97, 106, 202, 215, 225, 333, 358], 'Haematology-Oncology,': [45], 'National': [46, 57, 69, 79, 95, 108], 'University': [47, 58, 70, 80, 109], 'Cancer': [48, 52, 81], 'Institute,': [49, 82], 'Singapore': [50, 61, 73, 83, 93, 103, 112], 'Science': [53], 'Institute': [54], 'Singapore,': [56, 60, 72], '3': [62], 'Yong': [63], 'Loo': [64], 'Lin': [65], 'School': [66], 'Medicine,': [68], 'Radiation': [77], 'Oncology,': [78], 'General': [87], 'Surgery,': [88], 'Tan': [89], 'Tock': [90], 'Seng': [91], 'Hospital,': [92], 'Registry': [96], 'Diseases': [98], 'Office,': [99], 'Health': [100, 110], 'Promotion': [101], 'Board,': [102], 'Pathology,': [107], 'System,': [111], 'These': [114], 'authors': [115, 124], 'have': [116, 386], 'contributed': [117], 'equally': [118], 'to': [119, 377], 'this': [120, 216], 'work': [121], 'as': [122, 353], 'co-first': [123], 'Correspondence': [125], 'to:': [126], 'Soo,': [129], 'email:': [130], '[email protected]': [131], 'Keywords:': [132], 'gefitinib,': [133], 'erlotinib,': [134], 'drug-drug': [135, 218], 'interactions,': [136], 'NSCLC,': [137], 'gastric': [138, 172, 208], 'acid': [139, 173], 'suppression': [140], 'Received:': [141], 'August': [142], '19,': [143, 151], '2016': [144, 148, 152], 'Accepted:': [145], 'October': [146], '27,': [147], 'Published:': [149], 'November': [150], 'ABSTRACT': [153], 'Background:': [154], 'Erlotinib': [155], 'and': [156, 164, 182, 200, 206, 302, 324, 327, 360, 370, 405], 'gefitinib': [157, 339], 'are': [158, 187], 'weak': [159], 'base': [160], 'drugs': [161], 'whose': [162], 'absorption': [163], 'clinical': [165, 213], 'efficacy': [166], 'may': [167], 'be': [168, 402], 'impaired': [169], 'by': [170, 364], 'concomitant': [171], 'suppressive': [174], '(AS)': [175], 'therapy,': [176], 'yet': [177], 'proton': [178], 'pump': [179], 'inhibitors': [180], '(PPIs)': [181], 'histamine-2': [183], 'receptor': [184], 'antagonists': [185], '(H2As)': [186], 'widely': [188], 'indicated': [189, 292], 'in': [190, 221, 284, 304, 394, 408], 'non-small': [191], 'cell': [192], 'lung': [193], 'cancer': [194], '(NSCLC)': [195], 'patients': [196, 305, 335], 'for': [197, 340], 'the': [198, 212, 238, 356, 395], 'prevention': [199], 'treatment': [201], 'erlotinib-induced': [203], 'gastrointestinal': [204], 'injury': [205], 'corticosteroid-associated': [207], 'irritation.': [209], 'We': [210], 'assessed': [211, 375], 'relevance': [214], 'potential': [217], 'interaction': [219], '(DDI)': [220], 'a': [222, 409], 'retrospective': [223, 330], 'cohort': [224], 'EGFR': [226, 341], '-mutant': [227, 342], 'NSCLC': [228, 344], 'patients.': [229], 'Results:': [230], 'The': [231], 'AS': [232, 241, 294, 359, 378, 382], 'usage': [233, 295], 'rate': [234], 'was': [235, 296, 348], '35%.': [236], 'In': [237], 'overall': [239, 396], 'cohort,': [240], 'users': [242], 'did': [243, 384], 'not': [244, 385], 'experience': [245], 'poorer': [246, 300], 'OS': [247, 301, 391], '(HR:': [248], '1.47,': [249], '95%': [250, 268], 'CI:': [251, 269], '0.92': [252], '–': [253, 271], '2.35,': [254], 'P': [255, 273], '=': [256, 266, 274], '0.10;': [257], 'median,': [258, 276], '11.4': [259], 'versus': [260, 278], '17.5': [261], 'months)': [262, 280], 'or': [263, 309, 338], 'PFS': [264, 303, 393], '(HR': [265], '1.37,': [267], '0.89': [270], '2.12,': [272], '0.16;': [275], '7.6': [277], '8.7': [279], 'compared': [281], 'with': [282, 298, 318], 'non-users': [283], 'multivariate': [285], 'Cox': [286], 'regression': [287], 'analysis.': [288], 'However,': [289], 'subgroup': [290, 399], 'analyses': [291], 'that': [293], 'associated': [297], 'significantly': [299], 'who': [306], 'had': [307], 'fewer': [308], 'milder': [310], 'comorbidities': [311], '(Charlson': [312], 'comorbidity': [313], 'index': [314], '≤': [315], '2),': [316], 'those': [317], 'Karnofsky': [319], 'performance': [320], 'status': [321], '<': [322], '90,': [323], 'never-smokers.': [325], 'Materials': [326], 'Methods:': [328], 'A': [329], 'database': [331], 'analysis': [332], '157': [334], 'given': [336], 'erlotinib': [337], 'advanced': [343], 'from': [345], 'two': [346], 'institutions': [347], 'conducted.': [349], 'Patients': [350], 'were': [351, 374], 'classified': [352], 'AS-users': [354], 'if': [355], 'periods': [357], 'anti-EGFR': [361], 'therapy': [362, 383], 'overlapped': [363], '≥': [365], '30%.': [366], 'Overall': [367], 'survival': [368, 372], '(OS)': [369], 'progression-free': [371], '(PFS)': [373], 'according': [376], 'usage.': [379], 'Conclusions:': [380], 'Concomitant': [381], 'an': [387], 'adverse': [388], 'impact': [389], 'on': [390], 'and/or': [392], 'cohort.': [397, 412], 'Our': [398], 'findings': [400], 'should': [401], 'regarded': [403], 'exploratory': [404], 'require': [406], 'replication': [407], 'large': [410], 'prospective': [411]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2554776677', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-08T14:26:28.137953', 'created_date': '2016-11-30'}