Title: Earlier work seems to suggest that overexpression of uncoupling protein 1 would be anti-inflammatory. However, new findings show that expression of uncoupling protein 1 in aortic smooth muscle cells of mice increases reactive oxygen species, activates the renin-angiotensin system, elevates blood pressure, and worsens atherosclerosis.
Abstract: Earlier work seems to suggest that overexpression of uncoupling protein 1 would be anti-inflammatory. However, newfindings show that expression of uncoupling protein 1 in aortic smooth muscle cells of mice increases reactive oxygenspecies, activates the renin-angiotensin system, elevates blood pressure, and worsens atherosclerosis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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