Publication Information

{'id': 'https://openalex.org/W2554276404', 'doi': 'https://doi.org/10.1155/2016/1985750', 'title': 'Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature', 'display_name': 'Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2554276404', 'doi': 'https://doi.org/10.1155/2016/1985750', 'mag': '2554276404', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28003999', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5150123'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/1985750', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/1985750.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://downloads.hindawi.com/journals/bmri/2016/1985750.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046464395', 'display_name': 'Salvatore Serravalle', 'orcid': 'https://orcid.org/0000-0003-1304-614X'}, 'institutions': [{'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}, {'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Salvatore Serravalle', 'raw_affiliation_strings': ['Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043213284', 'display_name': 'Salvatore Nicola Bertuccio', 'orcid': 'https://orcid.org/0000-0002-5428-6716'}, 'institutions': [{'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}, {'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Salvatore N. Bertuccio', 'raw_affiliation_strings': ['Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071715614', 'display_name': 'Annalisa Astolfi', 'orcid': 'https://orcid.org/0000-0002-2732-0747'}, 'institutions': [{'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}, {'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Annalisa Astolfi', 'raw_affiliation_strings': ['Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', '“Giorgio Prodi” Cancer Research Center, University of Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294']}, {'raw_affiliation_string': '“Giorgio Prodi” Cancer Research Center, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035339293', 'display_name': 'Fraia Melchionda', 'orcid': 'https://orcid.org/0000-0002-6339-8576'}, 'institutions': [{'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}, {'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fraia Melchionda', 'raw_affiliation_strings': ['Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074034025', 'display_name': 'Andrea Pession', 'orcid': 'https://orcid.org/0000-0002-0379-9562'}, 'institutions': [{'id': 'https://openalex.org/I4210097083', 'display_name': 'Policlinico S.Orsola-Malpighi', 'ror': 'https://ror.org/00t4vnv68', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097083']}, {'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Pession', 'raw_affiliation_strings': ['Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Pediatric Hematology and Oncology, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046464395'], 'corresponding_institution_ids': ['https://openalex.org/I4210097083', 'https://openalex.org/I9360294'], 'apc_list': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'USD', 'value_usd': 2400, 'provenance': 'doaj'}, 'fwci': 0.553, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.800887, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '2016', 'issue': None, 'first_page': '1', 'last_page': '6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/decitabine', 'display_name': 'Decitabine', 'score': 0.9410572}, {'id': 'https://openalex.org/keywords/demethylating-agent', 'display_name': 'Demethylating agent', 'score': 0.857666}, {'id': 'https://openalex.org/keywords/azacitidine', 'display_name': 'Azacitidine', 'score': 0.5203273}, {'id': 'https://openalex.org/keywords/epigenetic-therapy', 'display_name': 'Epigenetic Therapy', 'score': 0.438614}], 'concepts': [{'id': 'https://openalex.org/C2780235182', 'wikidata': 'https://www.wikidata.org/wiki/Q1181878', 'display_name': 'Decitabine', 'level': 5, 'score': 0.9410572}, {'id': 'https://openalex.org/C2779277951', 'wikidata': 'https://www.wikidata.org/wiki/Q5255196', 'display_name': 'Demethylating agent', 'level': 5, 'score': 0.857666}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.7691974}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.6552832}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57142586}, {'id': 'https://openalex.org/C2776239401', 'wikidata': 'https://www.wikidata.org/wiki/Q416451', 'display_name': 'Azacitidine', 'level': 5, 'score': 0.5203273}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.51481265}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4670984}, {'id': 'https://openalex.org/C2780737395', 'wikidata': 'https://www.wikidata.org/wiki/Q18353741', 'display_name': 'Epigenetic therapy', 'level': 5, 'score': 0.438614}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32552582}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.30884862}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.188443}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.18726748}], 'mesh': [{'descriptor_ui': 'D001216', 'descriptor_name': 'Asparagine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001217', 'descriptor_name': 'Aspartate-Ammonia Ligase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D054218', 'descriptor_name': 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D054218', 'descriptor_name': 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001216', 'descriptor_name': 'Asparagine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001217', 'descriptor_name': 'Aspartate-Ammonia Ligase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077209', 'descriptor_name': 'Decitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054218', 'descriptor_name': 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054218', 'descriptor_name': 'Precursor T-Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/1985750', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/1985750.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/225c40b546594dca839231bd3d02946a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5150123', 'pdf_url': 'https://europepmc.org/articles/pmc5150123?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11585/610764', 'pdf_url': 'https://cris.unibo.it/bitstream/11585/610764/2/1985750.pdf', 'source': {'id': 'https://openalex.org/S4306402579', 'display_name': 'Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210117483', 'host_organization_name': 'Istituto di Ematologia di Bologna', 'host_organization_lineage': ['https://openalex.org/I4210117483'], 'host_organization_lineage_names': ['Istituto di Ematologia di Bologna'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11392/2411995', 'pdf_url': 'https://sfera.unife.it/bitstream/11392/2411995/1/Biomed%20Res%20Int_2016.pdf', 'source': {'id': 'https://openalex.org/S4306400369', 'display_name': 'Institutional Research Information System University of Ferrara (University of Ferrara)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I201324441', 'host_organization_name': 'University of Ferrara', 'host_organization_lineage': ['https://openalex.org/I201324441'], 'host_organization_lineage_names': ['University of Ferrara'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150123', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28003999', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1155/2016/1985750', 'pdf_url': 'http://downloads.hindawi.com/journals/bmri/2016/1985750.pdf', 'source': {'id': 'https://openalex.org/S1010394304', 'display_name': 'BioMed Research International', 'issn_l': '2314-6133', 'issn': ['2314-6133', '2314-6141'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319869', 'host_organization_name': 'Hindawi Publishing Corporation', 'host_organization_lineage': ['https://openalex.org/P4310319869'], 'host_organization_lineage_names': ['Hindawi Publishing Corporation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1520363931', 'https://openalex.org/W1968369969', 'https://openalex.org/W1976955442', 'https://openalex.org/W2001161985', 'https://openalex.org/W2007240193', 'https://openalex.org/W2020634404', 'https://openalex.org/W2024968355', 'https://openalex.org/W2041512814', 'https://openalex.org/W2045999295', 'https://openalex.org/W2086155728', 'https://openalex.org/W2148133242', 'https://openalex.org/W2292046663', 'https://openalex.org/W2516491046'], 'related_works': ['https://openalex.org/W4238188575', 'https://openalex.org/W3180148659', 'https://openalex.org/W2568485457', 'https://openalex.org/W2403102032', 'https://openalex.org/W2168834251', 'https://openalex.org/W2127289529', 'https://openalex.org/W2109710744', 'https://openalex.org/W2046447413', 'https://openalex.org/W2005926589', 'https://openalex.org/W137194296'], 'abstract_inverted_index': {'T-Acute': [0], 'Lymphoblastic': [1], 'Leukemia': [2], '(T-ALL)': [3], 'remains': [4], 'a': [5, 11], 'subgroup': [6, 189], 'of': [7, 24, 48, 73, 85, 131, 169, 183, 190, 199], 'pediatric': [8], 'ALL,': [9], 'with': [10, 106, 115, 150, 192], 'lower': [12], 'response': [13, 36], 'to': [14, 31, 37, 52, 58, 81, 112, 197], 'standard': [15], 'chemotherapy.': [16, 38], 'Some': [17], 'recent': [18], 'studies': [19], 'established': [20], 'the': [21, 71, 82, 90, 113, 122, 128, 132, 139, 143, 147, 151, 158, 170, 188, 200, 210], 'fundamental': [22], 'role': [23], 'epigenetic': [25, 83], 'aberrations': [26], 'such': [27], 'as': [28], 'DNA': [29], 'hypermethylation,': [30], 'influence': [32], "patients'": [33], 'outcome': [34], 'and': [35, 50, 88, 108, 185], 'Moreover,': [39], 'L-asparaginase': [40, 78, 107, 159, 184], 'is': [41, 79], 'an': [42, 179], 'important': [43], 'chemotherapeutic': [44], 'agent': [45, 153], 'for': [46], 'treatment': [47, 114, 149], 'ALL': [49], 'resistance': [51], 'this': [53, 175], 'drug': [54], 'has': [55], 'been': [56], 'linked': [57], 'ASNS': [59, 86, 116, 123, 144, 171, 194, 201, 217], 'expression,': [60, 146], 'which': [61], 'can': [62, 92], 'be': [63, 93], 'silenced': [64], 'through': [65], 'methylation.': [66], 'Therefore,': [67], 'we': [68, 100, 119, 135], 'tested': [69], 'whether': [70, 89], 'sensitivity': [72, 91, 160, 208], 'T-ALL': [74, 103, 163, 191], 'cell': [75, 104, 164, 212], 'lines': [76, 105, 165, 213], 'towards': [77], 'correlated': [80, 109], 'status': [84, 130], 'gene': [87, 145], 'modified': [94], 'by': [95, 167, 215], 'concurrent': [96], 'demethylating': [97, 140, 152], 'treatment.': [98], 'Hence': [99], 'treated': [101], 'different': [102, 110], 'responses': [111], 'expression.': [117, 218], 'Then': [118], 'demonstrated': [120], 'that': [121], 'expression': [124, 195], 'was': [125], 'dependent': [126], 'on': [127, 142], 'methylation': [129], 'promoter.': [133], 'Finally': [134], 'showed': [136], 'that,': [137], 'despite': [138], 'effect': [141], 'combined': [148], 'Decitabine': [154, 186], 'could': [155], 'synergistically': [156], 'improve': [157], 'in': [161, 187, 209], 'those': [162], 'characterized': [166, 214], 'hypermethylation': [168, 198], 'gene.': [172], 'In': [173], 'conclusion,': [174], 'preclinical': [176], 'study': [177], 'identified': [178], 'unexpected': [180], 'synergistic': [181], 'activity': [182], 'low': [193], 'due': [196], 'promoter,': [202], 'while': [203], 'it': [204], 'did': [205], 'not': [206], 'restore': [207], 'resistant': [211], 'higher': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2554276404', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-11T15:08:43.599757', 'created_date': '2016-11-30'}