Title: Tu1224 Prevention of Subsequent Stricture Formation After Esophageal Endoscopic Submucosal Dissection Using Conditioned Medium Obtained From Amnion-Derived Mesenchymal Stem Cell Culture
Abstract: Endoscopic submucosal dissection (ESD) for esophageal cancer has been widely accepted in last decade; however, it often causes postoperative stricture when over three fourths the circumference of the esophagus is dissected, and lowers quality of life for patients. Although steroid is generally used to prevent the stricture by expecting anti-inflammatory actions, complications and side effects are of concern. Mesenchymal stem cells (MSCs) have been reported to be a valuable cell source in regenerative medicine, and large amounts of MSCs can be noninvasively isolated from human amnion, which is discarded after delivery. Moreover, conditioned medium (CM) obtained from MSCs has been reported to inhibit inflammation in several animal models. In this study, we evaluated whether CM obtained from amnion MSC culture (MSC-CM) could prevent the stricture after large esophageal ESD.
Publication Year: 2016
Publication Date: 2016-05-01
Language: en
Type: article
Indexed In: ['crossref']
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