Title: Systems Chemical Biology: Integrating Medicinal Chemistry and Systems Biology for Drug Discovery
Abstract: Chemical biology represents the interface of chemistry and biology and aims to answer questions in biology at the molecular level using chemical techniques. Systems biology integrates the massive amounts of high-throughput omics data and computational modeling to understand the systems-level mechanisms of biological processes. Since their emergence, these two disciplines have largely evolved in parallel in the past two decades. Recently, there is an increasing need to integrate them to obtain a more complete picture of how small molecules affect biological systems as a whole, which leads to the emergence of a new field—systems chemical biology. Systems chemical biology approaches not only offer new unique insights into biological systems but also have important applications in biomedicine. In the article, we review the methodologies of systems chemical biology and discuss their impact on drug discovery and development.
Publication Year: 2016
Publication Date: 2016-11-26
Language: en
Type: book-chapter
Indexed In: ['crossref']
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