Publication Information

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'https://openalex.org/W2172829973', 'https://openalex.org/W2200781451', 'https://openalex.org/W2213559942', 'https://openalex.org/W2216772075', 'https://openalex.org/W2224640355', 'https://openalex.org/W2310326452', 'https://openalex.org/W2469754149', 'https://openalex.org/W2486832766', 'https://openalex.org/W990987308'], 'related_works': ['https://openalex.org/W2980421756', 'https://openalex.org/W2389923937', 'https://openalex.org/W2386858378', 'https://openalex.org/W2380273283', 'https://openalex.org/W2369640577', 'https://openalex.org/W2363047424', 'https://openalex.org/W2354064740', 'https://openalex.org/W2347280302', 'https://openalex.org/W1849276116', 'https://openalex.org/W1571263303'], 'abstract_inverted_index': {'A': [0, 244, 2863], 'subgroup': [1, 245], 'of': [2, 44, 56, 71, 79, 87, 111, 116, 178, 203, 246, 288, 300, 315, 323, 331, 355, 360, 422, 447, 545, 781, 788, 878, 906, 915, 940, 973, 1025, 1051, 1079, 1105, 1136, 1160, 1198, 1223, 1229, 1254, 1278, 1287, 1333, 1419, 1429, 1435, 1516, 1540, 1570, 1616, 1640, 1774, 1795, 1830, 1889, 1961, 1986, 1991, 2009, 2043, 2088, 2118, 2142, 2201, 2238, 2280, 2288, 2305, 2430, 2443, 2467, 2500, 2529, 2557, 2583, 2595, 2601, 2620, 2628, 2674, 2789, 2821, 2833, 2837, 2964, 2973, 2992, 3001, 3112, 3143, 3149, 3175, 3180, 3253, 3284, 3387, 3431, 3537, 3549, 3558, 3568, 3578, 3609, 3653, 3666, 3697, 3727, 3731, 3747, 3773, 3835, 3948, 3986, 3994, 4000, 4009, 4040], 'breast': [3, 46, 60, 214, 242, 247, 290, 304, 458, 486, 496, 650, 665, 693, 746, 765, 782, 814, 984, 1013, 1857, 2431, 2437, 2511, 2586, 2611, 2669, 2738, 2793, 2846, 3275], 'cancers': [4, 248, 2432], 'has': [5, 249, 1432, 1690, 1840, 2062, 2258, 3713], 'several': [6, 250], 'metabolic': [7, 13, 218, 226, 251, 257, 462, 470, 489, 527, 2698, 2787, 2802, 2827], 'compartments.': [8, 252], 'The': [9, 69, 253, 313, 642, 1015, 1274], 'mechanisms': [10, 254], 'by': [11, 255, 769, 1004, 1071, 1180, 1231, 1313, 1396, 1481, 1536, 1546, 2011, 2150, 2177, 2533, 3105, 3163, 3428, 3556, 3649, 3737, 3777, 3917], 'which': [12, 256, 1157, 1225, 1431, 1648, 2365, 2878, 2899, 2919, 2949, 3206, 3271, 3434, 3921, 3929, 3935, 4005], 'compartmentalization': [14, 219, 258, 463, 2735, 2803], 'develop': [15, 259], 'in': [16, 38, 41, 74, 84, 150, 186, 192, 213, 260, 282, 285, 318, 328, 394, 430, 436, 457, 492, 543, 589, 610, 630, 649, 656, 690, 764, 785, 813, 912, 975, 982, 1393, 1400, 1478, 1485, 1521, 1614, 1711, 1746, 1856, 1909, 1930, 1968, 2018, 2036, 2066, 2139, 2236, 2265, 2285, 2361, 2364, 2375, 2427, 2436, 2502, 2509, 2559, 2590, 2597, 2609, 2701, 2737, 2792, 2801, 2806, 2813, 2845, 2904, 3017, 3109, 3169, 3226, 3297, 3300, 3309, 3312, 3324, 3327, 3338, 3344, 3347, 3355, 3381, 3406, 3419, 3424, 3467, 3478, 3486, 3519, 3582, 3594, 3612, 3629, 3635, 3645, 3679, 3735, 3782, 3791, 3809, 3812, 3837, 3855, 3862, 3878, 3891, 3898, 3943, 3950, 3962, 3981, 4002, 4014, 4138], 'tumors': [17, 261, 494, 2616, 4058, 4079, 4084, 4106, 4127, 4141], 'are': [18, 262, 767, 1158, 2682, 2782, 3161, 3272, 3282, 3695], 'poorly': [19, 263, 1837], 'characterized.': [20, 264, 1838], 'TP53': [21, 265, 1605, 2227], 'inducible': [22, 266, 1517], 'glycolysis': [23, 33, 267, 277, 542, 600, 605, 821, 832, 907, 941, 1052, 1070, 1106, 1138, 1571, 1607, 1698, 1890, 1964, 2119, 2165, 2229, 2444, 2468, 2602, 3445, 3538, 3552, 3667], 'and': [24, 34, 62, 66, 81, 89, 100, 113, 121, 134, 145, 169, 220, 230, 268, 278, 306, 310, 325, 333, 344, 357, 365, 378, 389, 413, 464, 474, 537, 547, 616, 619, 628, 647, 698, 717, 760, 822, 833, 847, 852, 908, 942, 980, 1053, 1083, 1107, 1139, 1196, 1252, 1276, 1298, 1305, 1311, 1331, 1360, 1427, 1444, 1542, 1572, 1608, 1646, 1744, 1766, 1782, 1801, 1804, 1833, 1853, 1891, 1912, 1925, 1965, 2016, 2073, 2094, 2120, 2153, 2166, 2180, 2230, 2336, 2358, 2407, 2433, 2445, 2469, 2507, 2546, 2603, 2625, 2635, 2715, 2745, 2762, 2795, 2826, 2839, 2858, 2864, 2892, 2907, 2929, 2947, 2981, 3003, 3007, 3019, 3039, 3076, 3086, 3133, 3147, 3159, 3188, 3199, 3265, 3280, 3307, 3360, 3369, 3389, 3572, 3659, 3675, 3690, 3693, 3817, 3872, 3894, 3933, 3969, 3991, 4026, 4031, 4070, 4118], 'apoptosis': [25, 269, 823, 834, 1140, 1609, 1868, 1966, 1990, 2015, 2072, 2086, 2167, 2231, 2446, 2604, 3403, 3885, 3916, 3949, 4012], 'regulator': [26, 270, 824, 939, 1050, 1104, 1141, 1569, 1610, 1888, 1967, 2117, 2168, 2232, 2466], '(TIGAR)': [27, 271, 825, 1142, 1611, 2169, 2233], 'is': [28, 35, 272, 279, 526, 807, 903, 909, 996, 1007, 1019, 1164, 1177, 1220, 1421, 1634, 1735, 1785, 1836, 1851, 1859, 1907, 2136, 2301, 2330, 2373, 2401, 2424, 2613, 2867, 2879, 2900, 2920, 2950, 3207, 3435, 3534, 3564, 3573, 3662, 3701, 3745, 3775, 3922, 4006], 'a': [29, 199, 224, 238, 273, 443, 468, 482, 508, 937, 1048, 1074, 1102, 1165, 1567, 1671, 1886, 2063, 2115, 2362, 2464, 2799, 2868, 3062, 3208, 3223, 3248, 3378, 3400, 3436, 3457, 3502, 3535, 3626, 3739, 3758, 3859, 3888, 3895, 3939, 4007], 'bisphosphatase': [30, 73, 274, 317, 1023, 1075, 1988], 'that': [31, 275, 1076, 1169, 1291, 1299, 2260, 2810, 2882, 2923, 3211, 3803], 'reduces': [32, 276, 1077, 1822, 1867, 2040, 2085, 3212], 'highly': [36, 280, 533, 910, 2425, 2741], 'expressed': [37, 281, 911, 2426], 'carcinoma': [39, 61, 75, 119, 133, 155, 187, 215, 283, 305, 319, 363, 377, 399, 431, 459, 535, 538, 645, 1659, 1919, 1931, 1970, 1994, 2021, 2038, 2045, 2434, 2814, 2847, 3021, 3031, 3043, 3056, 3068, 3091, 3117, 3170, 3181, 3201, 3356, 3364, 3520, 3583, 3595, 3685, 3708, 3827, 3856, 3879, 3910, 4061, 4109], 'cells': [40, 76, 92, 120, 138, 156, 188, 216, 284, 320, 336, 364, 382, 400, 432, 460, 536, 539, 588, 646, 741, 1395, 1480, 1660, 1932, 1995, 2039, 2097, 2145, 2172, 2203, 2282, 2308, 2379, 2435, 2744, 2747, 2815, 3032, 3044, 3057, 3069, 3092, 3118, 3124, 3171, 3182, 3202, 3216, 3233, 3299, 3311, 3326, 3346, 3357, 3365, 3373, 3397, 3421, 3453, 3466, 3475, 3493, 3498, 3511, 3521, 3571, 3584, 3596, 3614, 3622, 3686, 3709, 3767, 3787, 3790, 3821, 3828, 3857, 3865, 3880, 3911, 3953, 3964, 3983, 4028, 4033, 4045, 4062, 4095, 4110, 4149], 'the': [42, 54, 85, 109, 176, 286, 298, 329, 353, 420, 786, 879, 913, 997, 1022, 1026, 1144, 1199, 1227, 1255, 1282, 1294, 1334, 1361, 1397, 1417, 1445, 1482, 1538, 1543, 1772, 1828, 1849, 1962, 2041, 2140, 2286, 2366, 2428, 2581, 2593, 2598, 2786, 2831, 2880, 2901, 2921, 2941, 2956, 2962, 2971, 2999, 3046, 3089, 3095, 3110, 3141, 3150, 3259, 3385, 3547, 3565, 3607, 3654, 3725, 3748, 4037], 'majority': [43, 287, 914, 2141, 2429], 'human': [45, 289, 493, 692, 916, 983, 1016, 1522, 1845, 2510, 2610, 2702, 3255], 'cancers.': [47, 291], 'Hence': [48, 292, 3546], 'we': [49, 293, 2842, 2969, 3011, 3139, 3246, 3605], 'set': [50, 294], 'out': [51, 295], 'to': [52, 105, 296, 349, 663, 762, 1021, 1173, 1235, 1402, 1425, 1487, 1652, 1656, 1693, 1843, 1863, 2283, 2717, 2764, 2824, 2910, 3005, 3034, 3059, 3071, 3082, 3094, 3183, 3203, 3218, 3235, 3576, 3716, 3720, 3826, 3840, 3874, 3882, 3915, 3960, 3966, 3979], 'determine': [53, 297], 'effects': [55, 299, 1434, 1826, 2788, 2832, 2963, 3000, 3715], 'TIGAR': [57, 94, 117, 140, 153, 184, 204, 211, 234, 301, 338, 361, 384, 397, 428, 448, 455, 478, 981, 995, 1010, 1017, 1068, 1436, 1531, 1637, 1688, 1700, 1734, 1760, 1775, 1796, 1821, 1839, 1866, 1906, 2010, 2034, 2061, 2084, 2135, 2207, 2261, 2277, 2300, 2329, 2352, 2400, 2423, 2508, 2534, 2584, 2596, 2790, 2811, 2834, 2844, 2849, 2871, 2893, 2934, 2938, 2965, 2987, 3002, 3029, 3054, 3113, 3115, 3164, 3176, 3279, 3291, 3353, 3361, 3423, 3455, 3477, 3500, 3550, 3580, 3592, 3610, 3624, 3683, 3706, 3728, 3789, 3831, 3836, 3853, 3876, 3968, 4030, 4047, 4139], 'expression': [58, 78, 212, 302, 322, 456, 1303, 1515, 1689, 1701, 2619, 2791, 2812, 2860, 2972, 3174, 3293, 3320, 3341, 3354, 3557, 3588, 3601, 3677, 3700, 3971, 3975, 3985, 4088], 'on': [59, 181, 303, 425, 1281, 1708, 1742, 1776, 1827, 2585, 2785, 2835, 2966, 3009, 3551, 3615, 3729], 'fibroblast': [63, 135, 307, 379, 818, 3616], 'glycolytic': [64, 130, 308, 374, 534, 1001, 1027, 1167, 1534, 1544, 2742, 3750, 3860], 'phenotype': [65, 227, 309, 471, 3861], 'tumor': [67, 182, 190, 208, 221, 311, 426, 434, 452, 465, 587, 657, 667, 696, 783, 1415, 1916, 2367, 2588, 2722, 2769], 'growth.': [68, 183, 209, 312, 427, 453], 'overexpression': [70, 185, 314, 429, 1426, 1914, 2850, 2935, 2988, 3168, 3518, 3581, 3611, 3834, 3854, 3877], 'this': [72, 179, 316, 423, 1987], 'induces': [77, 321, 1011, 1989, 2014, 2816], 'enzymes': [80, 324], 'transporters': [82, 326], 'involved': [83, 327], 'catabolism': [86, 330, 1639, 1829, 2906], 'lactate': [88, 146, 170, 229, 332, 390, 414, 473, 530, 855, 1645, 2838, 2869, 2874, 2884, 3008, 3040, 3083, 3087, 3108, 3134, 3189, 3505, 3524, 3541, 3569, 3719, 3961], 'glutamine.': [90, 334], 'Carcinoma': [91, 137, 335, 381, 757, 3372, 3396], 'overexpressing': [93, 118, 139, 154, 337, 362, 383, 398, 3030, 3055, 3116, 3422, 3454, 3476, 3499, 3623, 3684, 3707, 3788, 3822, 4029, 4046, 4140], 'have': [95, 141, 339, 385, 606, 660, 1300, 1649, 2355, 2440, 2579, 2617, 3061, 3222, 3288, 3829], 'higher': [96, 340, 3027, 3447, 3946, 4086], 'oxygen': [97, 341, 873, 1779, 2554, 3013], 'consumption': [98, 342, 874, 1780, 3014, 3024], 'rates': [99, 343, 2087, 2442, 2600, 3015, 3025, 3577, 3947, 4013], 'ATP': [101, 345, 1783, 3191, 3227, 3238], 'levels': [102, 346, 1078, 1549, 2532, 3228, 3239, 3542, 4051, 4099, 4153], 'when': [103, 347, 3080, 3126, 3405], 'exposed': [104, 348, 3033, 3058, 3070, 3081, 3093, 3197, 3217, 3234, 3825, 3873, 3881], 'glutamine,': [106, 350, 1647, 3035, 3185], 'lactate,': [107, 351, 3036, 3184], 'or': [108, 352, 2804, 3037, 3084, 3107, 3186, 3268, 3768, 3869, 3942], 'combination': [110, 354, 3944], 'glutamine': [112, 231, 356, 475, 2840, 2905, 2909, 2925, 3006, 3038, 3060, 3072, 3085, 3106, 3132, 3187], 'lactate.': [114, 358], 'Coculture': [115, 359], 'fibroblasts': [122, 149, 366, 393, 648, 688, 770, 784, 2712, 2759, 3256, 3376, 3409, 3427, 3634, 3646, 3680, 3736, 3754, 3783, 3838, 3848, 3871, 3901], 'compared': [123, 367, 3041, 3462, 3489, 3507, 3632, 3795, 3845, 4052, 4100, 4142, 4154], 'with': [124, 152, 162, 194, 223, 228, 368, 396, 406, 438, 467, 472, 529, 540, 601, 1697, 1705, 1713, 1737, 1918, 1927, 2206, 2605, 2740, 2748, 2819, 2933, 2952, 3042, 3128, 3258, 3366, 3375, 3408, 3426, 3444, 3446, 3463, 3490, 3508, 3539, 3620, 3633, 3668, 3682, 3703, 3705, 3757, 3764, 3785, 3796, 3819, 3846, 3870, 3887, 3900, 3972, 4016, 4053, 4059, 4101, 4107, 4143, 4155], 'control': [125, 369, 1312, 3018, 3047, 3067, 3090, 3123, 3198, 3464, 3491, 3509, 3636, 3765, 3797, 3815, 3847, 4032, 4078, 4126], 'cocultures': [126, 370, 3637], 'induce': [127, 157, 207, 371, 401, 451], 'more': [128, 372, 3913], 'pronounced': [129, 373], 'differences': [131, 375], 'between': [132, 376, 532, 644, 3814], 'cells.': [136, 380, 2848, 3022, 3771], 'reduced': [142, 386, 541, 3322, 3370, 3459, 3504, 3523, 3599, 3672, 3702, 3830, 3842, 3973, 4011, 4049, 4097, 4151], 'glucose': [143, 164, 387, 408, 1358, 1442, 1657, 2825, 3129, 3843], 'uptake': [144, 388, 1707, 1740, 3418, 3442, 3448, 3461, 3488, 3631, 3644, 3661, 3670, 3844], 'production.': [147, 391], 'Conversely,': [148, 392, 1530, 2914], 'coculture': [151, 395, 3249, 3301, 3313, 3328, 3348, 3407, 3425, 3468, 3704, 3798, 3816, 3818, 3899, 4015], 'HIF': [158, 402], '(hypoxia-inducible': [159, 403], 'factor)': [160, 404], 'activation': [161, 405, 1392, 1428, 1477, 1929, 3730, 3811], 'increased': [163, 166, 195, 407, 410, 439, 2359, 3104, 3173, 3190, 3237, 3295, 3367, 3450, 3678, 3776, 3967, 4133], 'uptake,': [165, 409], '6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3': [167, 411], '(PFKFB3),': [168, 412], 'dehydrogenase-A': [171, 415], 'expression.': [172, 416], 'We': [173, 417, 2808, 3195, 3415, 3722], 'also': [174, 418, 607, 2137, 2204, 2872, 3172, 3398, 3522], 'studied': [175, 419, 2970, 3012, 3140, 3416, 3606], 'effect': [177, 421, 1773, 1855, 2582, 3548, 3608, 3726], 'enzyme': [180, 424, 1028, 1168, 2881, 2903, 2922], 'increases': [189, 433, 1533, 1767, 1915], 'growth': [191, 222, 435, 466, 668, 697, 1917, 2589], 'vivo': [193, 437], 'proliferation': [196, 440, 2304, 2607, 3368], 'rates.': [197, 441], 'However,': [198, 442, 2255, 2576, 3231], 'catalytically': [200, 444], 'inactive': [201, 445], 'variant': [202, 446], 'did': [205, 449], 'not': [206, 450, 3103, 3221, 3495], 'Therefore,': [210, 454], 'promotes': [217, 461], 'mitochondrial': [225, 469, 881, 1768, 1777, 1834, 2621, 2626, 2675, 2888, 2967, 2993, 3918, 3931], 'catabolism.': [232, 476], 'Targeting': [233, 477, 581], 'warrants': [235, 479], 'consideration': [236, 480], 'as': [237, 481, 1073, 1143, 1644, 1699, 3743, 3938], 'potential': [239, 483], 'therapy': [240, 484], 'for': [241, 485, 507, 1293, 1658, 1670, 2303, 2332, 2403, 2562, 2887, 3028], 'cancer.': [243, 487, 1014], 'Multiple': [488, 2697], 'compartments': [490, 2699], 'exist': [491, 2700], 'including': [495], 'cancer': [497, 549, 603, 651, 666, 747, 766, 810, 815, 976, 1394, 1479, 1717, 1846, 1858, 2067, 2092, 2438, 2503, 2563, 2587, 2612, 2670, 2679, 2719, 2739, 2746, 2766, 2794, 3276], '(1.DeNicola': [498, 1661], 'G.M.': [499, 1662], 'Cantley': [500, 1663], 'L.C.': [501, 1664], "Cancer's": [502, 1665], 'fuel': [503, 1666], 'choice:': [504, 1667], 'new': [505, 1668], 'flavors': [506, 1669], 'picky': [509, 1672], 'eater.Mol.': [510, 1673], 'Cell.': [511, 1674, 2338, 2409], '2015;': [512, 634, 1675], '60:': [513, 1676], '514-523Abstract': [514, 1677], 'Full': [515, 517, 707, 709, 796, 798, 947, 949, 1058, 1060, 1112, 1114, 1208, 1210, 1264, 1266, 1343, 1345, 1577, 1579, 1623, 1625, 1678, 1680, 1896, 1898, 2125, 2127, 2190, 2192, 2245, 2247, 2342, 2344, 2413, 2415, 2474, 2476], 'Text': [516, 518, 708, 710, 797, 799, 948, 950, 1059, 1061, 1113, 1115, 1209, 1211, 1265, 1267, 1344, 1346, 1578, 1580, 1624, 1626, 1679, 1681, 1897, 1899, 2126, 2128, 2191, 2193, 2246, 2248, 2343, 2345, 2414, 2416, 2475, 2477], 'PDF': [519, 711, 800, 951, 1062, 1116, 1212, 1268, 1347, 1581, 1627, 1682, 1900, 2129, 2194, 2249, 2346, 2417, 2478], 'PubMed': [520, 637, 712, 752, 801, 952, 990, 1063, 1117, 1152, 1213, 1269, 1348, 1369, 1409, 1453, 1494, 1582, 1628, 1683, 1755, 1814, 1901, 1980, 2029, 2079, 2130, 2195, 2250, 2295, 2347, 2418, 2479, 2517, 2541, 2571, 2642, 2692, 2729, 2776], 'Scopus': [521, 638, 713, 753, 802, 953, 991, 1064, 1118, 1153, 1214, 1270, 1349, 1370, 1410, 1454, 1495, 1583, 1629, 1684, 1756, 1815, 1902, 1981, 2030, 2080, 2131, 2196, 2251, 2296, 2348, 2419, 2480, 2518, 2542, 2572, 2643, 2693, 2730, 2777], '(109)': [522, 1685], 'Google': [523, 596, 640, 715, 755, 804, 955, 993, 1066, 1120, 1155, 1216, 1272, 1351, 1372, 1412, 1456, 1497, 1528, 1585, 1631, 1686, 1758, 1817, 1904, 1983, 2032, 2082, 2133, 2198, 2253, 2298, 2350, 2421, 2482, 2520, 2544, 2574, 2645, 2695, 2732, 2779], 'Scholar).': [524, 597, 641, 756, 805, 994, 1067, 1217, 1273, 1413, 1529, 1632, 1687, 1759, 1818, 1905, 1984, 2033, 2083, 2134, 2199, 2254, 2299, 2351, 2422, 2575, 2696, 2733, 2780], 'There': [525, 2781], 'coupling': [528], 'transfer': [531, 2713, 2760], 'models': [544], 'vulvar': [546], 'colon': [548], '(2.Sonveaux': [550], 'P.': [551, 1596, 2218, 2314, 2385], 'Végran': [552], 'F.': [553, 624, 676, 1380, 1465, 1594, 2216, 2648, 2709, 2756], 'Schroeder': [554], 'T.': [555, 678, 1499], 'Wergin': [556], 'M.C.': [557], 'Verrax': [558], 'J.': [559, 791, 1127, 1148, 1356, 1405, 1440, 1490, 1501, 1727, 1731, 1936, 1942, 1946, 1954, 1956, 1975, 2001, 2163, 2537, 2662], 'Rabbani': [560], 'Z.N.': [561], 'De': [562], 'Saedeleer': [563], 'C.J.': [564], 'Kennedy': [565], 'K.M.': [566], 'Diepart': [567], 'C.': [568, 1503, 2159, 2320, 2391], 'Jordan': [569], 'B.F.': [570], 'Kelley': [571], 'M.J.': [572], 'Gallez': [573], 'B.': [574, 1950, 2050], 'Wahl': [575], 'M.L.': [576], 'Feron': [577], 'O.': [578, 1129], 'Dewhirst': [579], 'M.W.': [580, 728], 'lactate-fueled': [582], 'respiration': [583, 2152, 2179], 'selectively': [584], 'kills': [585], 'hypoxic': [586], 'mice.J.': [590], 'Clin.': [591], 'Invest.': [592], '2008;': [593], '118:': [594], '3930-3942PubMed': [595], 'High': [598, 1514], 'stromal': [599, 2686, 2743], 'low': [602, 2441, 2599], 'cell': [604, 758, 811, 1302, 1715, 1748, 1805, 1920, 2068, 2090, 2148, 2175, 2263, 3277], 'been': [608, 661, 1650, 1691, 1841], 'described': [609, 2580], 'breast,': [611], 'ovarian,': [612], 'prostate,': [613], 'bladder,': [614], 'head': [615], 'neck': [617], 'carcinomas,': [618], 'sarcomas': [620], '(3.Martinez-Outschoorn': [621], 'U.E.': [622, 2652, 2705, 2752], 'Sotgia': [623, 2708, 2755], 'Lisanti': [625, 2665, 2706, 2753], 'M.P.': [626, 772, 2666, 2707, 2754], 'Caveolae': [627], 'signalling': [629], 'cancer.Nat.': [631, 2636], 'Rev.': [632, 2637], 'Cancer.': [633, 2638], '15:': [635], '225-237Crossref': [636], '(162)': [639], 'interactions': [643], 'play': [652], 'an': [653, 904, 1221, 3663, 3923], 'important': [654], 'role': [655, 972, 1960, 2065, 2499, 2594, 2800], 'progression.': [658], 'Fibroblasts': [659, 3351, 3618, 3824], 'shown': [662, 1651, 1692, 2259], 'promote': [664, 695, 745], '(4.Orimo': [669], 'A.': [670, 726, 923, 1034, 1088, 1185, 1187, 1241, 1243, 1320, 1322, 1378, 1463, 1553, 1600, 1604, 1872, 2101, 2222, 2226, 2450, 2656, 2664], 'Gupta': [671], 'P.B.': [672], 'Sgroi': [673], 'D.C.': [674, 2633], 'Arenzana-Seisdedos': [675], 'Delaunay': [677], 'Naeem': [679], 'R.': [680, 736, 931, 1042, 1096, 1191, 1247, 1326, 1354, 1390, 1438, 1475, 1511, 1513, 1561, 1592, 1602, 1880, 2109, 2214, 2224, 2270, 2458, 2658], 'Carey': [681], 'V.J.': [682], 'Richardson': [683, 731], 'A.L.': [684, 732], 'Weinberg': [685, 737], 'R.A.': [686, 738, 2316, 2387], 'Stromal': [687], 'present': [689], 'invasive': [691], 'carcinomas': [694, 919], 'angiogenesis': [699], 'through': [700, 1971, 2070, 2955], 'elevated': [701, 1423], 'SDF-1/CXCL12': [702], 'secretion.Cell.': [703], '2005;': [704], '121:': [705], '335-348Abstract': [706], '(3020)': [714], 'Scholar)': [716, 2646], 'metastasis': [718], '(5.Karnoub': [719], 'A.E.': [720], 'Dash': [721], 'A.B.': [722], 'Vo': [723], 'A.P.': [724], 'Sullivan': [725], 'Brooks': [727], 'Bell': [729], 'G.W.': [730], 'Polyak': [733], 'K.': [734, 921, 929, 1032, 1040, 1086, 1094, 1551, 1559, 1870, 1878, 2099, 2107, 2324, 2395, 2448, 2456, 2523], 'Tubo': [735], 'Mesenchymal': [739], 'stem': [740, 2378], 'within': [742], 'tumour': [743], 'stroma': [744], 'metastasis.Nature.': [748], '2007;': [749, 793, 1366, 1450], '449:': [750], '557-563Crossref': [751], '(2606)': [754], 'invasiveness': [759], 'resistance': [761, 3886], 'chemotherapy': [763], 'induced': [768, 1606, 2228, 2989, 3352, 3362, 3858, 3884, 3945], '(6.Shekhar': [771], 'Santner': [773], 'S.': [774, 1507, 1948, 2007, 2268, 2660], 'Carolin': [775], 'K.A.': [776], 'Tait': [777], 'L.': [778, 1189, 1245, 1324, 1374, 1376, 1459, 1461, 1505, 1952, 1958, 1997, 2548], 'Direct': [779], 'involvement': [780], 'modulation': [787], 'tamoxifen': [789, 3883, 3980, 4017], 'sensitivity.Am.': [790], 'Pathol.': [792, 986, 2513], '170:': [794], '1546-1560Abstract': [795], '(91)': [803], 'It': [806, 1006, 1633], 'unknown': [808, 1008, 1635, 1786], 'how': [809], 'metabolism': [812, 977, 1359, 1443, 1835, 2504, 2889, 3145], 'modulates': [816, 1638], 'adjacent': [817, 2685], 'metabolism.': [819, 3617], 'TP53-induced': [820, 831, 1137, 1963], '2The': [826], 'abbreviations': [827], 'used': [828, 3247], 'are:': [829], 'TIGAR,': [830, 936, 1047, 1101, 1566, 1885, 2114, 2463, 3987], 'regulator;': [835], 'PFKFB,': [836], '6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase;': [837], 'Fru-2,6-P2,': [838], 'fructose': [839, 1171, 1174, 1233, 1236], '2,6-bisphosphate;': [840], 'PFK-1,': [841], 'phosphofructokinase-1;': [842], 'OXPHOS,': [843, 3010, 4010], 'oxidative': [844, 2629], 'phosphorylation;': [845], 'MCT1': [846, 3586, 3600], '-2,': [848], 'monocarboxylate': [849, 2853], 'transporter': [850, 877, 2854, 3561], '1': [851, 2896, 2979, 2985, 3562], '2;': [853], 'LDH-B,': [854], 'dehydrogenase': [856, 2875], 'B;': [857], 'GLS1,': [858], 'glutaminase': [859, 2895], '1;': [860, 866, 871], 'PGC1,': [861], 'peroxisome': [862, 2974], 'proliferator-activated': [863, 2975], 'receptor': [864, 2976], 'coactivator': [865, 2978], 'NRF1,': [867], 'nuclear': [868, 2982], 'respiratory': [869, 2983], 'factor': [870, 2984, 3733], 'OCR,': [872], 'rate;': [875], 'TOMM20,': [876], 'outer': [880], 'membrane': [882, 1769], 'member': [883], '20;': [884], '3PO,': [885], '3-(3-': [886], 'pyridinyl)-1-(4-pyridinyl)-2-propen-1-one;': [887], '2-NBDG,': [888], '2-(N-(7-nitrobenz-2-': [889], 'oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose': [890], '(fluorescent': [891], '2-deoxyglucose);': [892], 'HIF,': [893], 'hypoxia-inducible': [894, 3732], 'factor;': [895], 'RFP,': [896], 'red': [897], 'fluorescent': [898, 3438], 'protein;': [899], 'PI,': [900], 'propidium': [901], 'iodide.': [902], 'inhibitor': [905, 1222, 3210], 'breast-invasive': [917], 'ductal': [918], '(7.Bensaad': [920, 1031, 1085, 1550, 1869, 2098, 2447], 'Tsuruta': [922, 1033, 1087, 1552, 1871, 2100, 2449], 'Selak': [924, 1035, 1089, 1554, 1873, 2102, 2451], 'M.A.': [925, 1036, 1090, 1555, 1588, 1874, 2103, 2210, 2452], 'Vidal': [926, 1037, 1091, 1556, 1875, 2104, 2453], 'M.N.': [927, 1038, 1092, 1557, 1590, 1876, 2105, 2212, 2454], 'Nakano': [928, 1039, 1093, 1558, 1877, 2106, 2455], 'Bartrons': [930, 1041, 1095, 1190, 1246, 1325, 1389, 1474, 1560, 1601, 1879, 2108, 2223, 2457], 'Gottlieb': [932, 1043, 1097, 1562, 1881, 2110, 2459], 'E.': [933, 1044, 1098, 1132, 1563, 1882, 2111, 2274, 2460], 'Vousden': [934, 1045, 1099, 1564, 1791, 1883, 2112, 2327, 2398, 2461, 2526], 'K.H.': [935, 1046, 1100, 1565, 1792, 1884, 2113, 2328, 2399, 2462, 2527], 'p53-inducible': [938, 1049, 1103, 1568, 1887, 2116, 2465], 'apoptosis.Cell.': [943, 1054, 1108, 1573, 1892, 2121, 2470], '2006;': [944, 1055, 1109, 1574, 1893, 2122, 2471], '126:': [945, 1056, 1110, 1575, 1894, 2123, 2472], '107-120Abstract': [946, 1057, 1111, 1576, 1895, 2124, 2473], '(1564)': [954, 1065, 1119, 1584, 1903, 2132, 2481], 'Scholar,': [956, 1121, 1352, 1457, 1586, 2483, 2521, 2545], '8.Won': [957, 2484], 'K.Y.': [958, 2485], 'Lim': [959, 2486], 'S.J.': [960, 2487], 'Kim': [961, 963, 2488, 2490], 'G.Y.': [962, 2489], 'Y.W.': [964, 2491], 'Han': [965, 2492], 'S.A.': [966, 2493], 'Song': [967, 2494], 'J.Y.': [968, 2495], 'Lee': [969, 2313, 2384, 2496], 'D.K.': [970, 2497], 'Regulatory': [971, 2498], 'p53': [974, 2501], 'via': [978, 2505], 'SCO2': [979, 2506], 'cancer.Hum.': [985, 2512], '2012;': [987, 1811, 2187, 2514, 2568, 2639, 2689], '43:': [988, 2515], '221-228Crossref': [989, 2516], '(88)': [992, 2519], 'only': [998], 'known': [999], 'phosphatase': [1000], 'modulator': [1002], 'regulated': [1003], 'TP53.': [1005], 'if': [1009, 1636, 2796], 'aggressive': [1012, 2817, 3363], 'gene': [1018], 'similar': [1020], 'domain': [1024, 3262], '6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase': [1029, 1284, 1518], '(PFKFB)': [1030], 'decreases': [1069, 2262], 'functioning': [1072], 'intracellular': [1080, 2530], 'fructose-2,6-bisphosphate': [1081], '(Fru-2,6-P2)': [1082], '2,3-bisphosphoglycerate': [1084, 1146], '9.Gerin': [1122], 'I.': [1123], 'Noël': [1124], 'G.': [1125, 1733, 2003, 2550], 'Bolsée': [1126], 'Haumont': [1128], 'Van': [1130], 'Schaftingen': [1131], 'Bommer': [1133], 'G.T.': [1134], 'Identification': [1135], 'phosphoglycolate-independent': [1145], 'phosphatase.Biochem.': [1147], '2014;': [1149, 2076, 2726, 2773], '458:': [1150], '439-448Crossref': [1151], '(34)': [1154, 2297], 'Scholar),': [1156], 'regulators': [1159], 'glycolysis.': [1161, 3451, 3545, 3579, 3673, 3698], 'Phosphofructokinase-1': [1162], '(PFK-1)': [1163], 'key': [1166], 'converts': [1170, 2883, 2908], '6-phosphate': [1172, 1237], '1,6-bisphosphate.': [1175], 'PFK-1': [1176, 1230, 1541], 'allosterically': [1178], 'activated': [1179], 'Fru-2,6-P2': [1181, 1219, 1279, 1420, 1548, 3213, 4050, 4098, 4152], '(10.Okar': [1182, 1238, 1317], 'D.A.': [1183, 1239, 1318], 'Manzano': [1184, 1240, 1319, 1377, 1462, 1603, 2225], 'Navarro-Sabatè': [1186, 1242, 1321], 'Riera': [1188, 1244, 1323], 'Lange': [1192, 1248, 1327], 'A.J.': [1193, 1249, 1328], 'PFK-2/FBPase-2:': [1194, 1250, 1329], 'maker': [1195, 1251, 1330], 'breaker': [1197, 1253, 1332], 'essential': [1200, 1256, 1335], 'biofactor': [1201, 1257, 1336], 'fructose-2,6-bisphosphate.Trends': [1202, 1258, 1337], 'Biochem.': [1203, 1259, 1338], 'Sci.': [1204, 1260, 1339, 1809], '2001;': [1205, 1261, 1340], '26:': [1206, 1262, 1341], '30-35Abstract': [1207, 1263, 1342], '(286)': [1215, 1271, 1350], 'Also,': [1218, 2592], 'fructose-1,6-bisphosphatase,': [1224], 'opposes': [1226], 'activity': [1228, 1309, 1539, 1765], 'converting': [1232, 3718], '1,6-bisphosphate': [1234], 'synthesis': [1275, 2926, 3383], 'breakdown': [1277], 'depends': [1280], 'bifunctional': [1283], 'isoenzymes,': [1285], 'products': [1286], 'four': [1288], 'genes': [1289], '(PFKFB1–4)': [1290], 'code': [1292], 'different': [1295, 1307, 1314], 'PFKFB': [1296], 'isoenzymes': [1297], 'distinct': [1301], 'patterns': [1304], 'display': [1306], 'kinase/bisphosphatase': [1308], 'ratios': [1310], 'protein': [1315, 2857, 3587], 'kinases': [1316], '11.Bartrons': [1353], 'Caro': [1355, 1439], 'Hypoxia,': [1357, 1441], "Warburg's": [1362, 1446], 'effect.J.': [1363, 1447], 'Bioenerg.': [1364, 1448], 'Biomembr.': [1365, 1449], '39:': [1367, 1451], '223-229Crossref': [1368, 1452], '(201)': [1371, 1455], 'Scholar12.Novellasdemunt': [1373], 'Bultot': [1375, 1460], 'Ventura': [1379, 1464], 'Rosa': [1381, 1466], 'J.L.': [1382, 1467], 'Vertommen': [1383, 1468], 'D.': [1384, 1469, 2312, 2322, 2383, 2393, 2650], 'Rider': [1385, 1470], 'M.H.': [1386, 1471], 'Navarro-Sabate': [1387, 1472], 'À.': [1388, 1473, 1598, 2220], 'PFKFB3': [1391, 1476, 3209, 3281, 3318, 3339, 3674, 3692], 'p38/MK2': [1398, 1483], 'pathway': [1399, 1484, 1973], 'response': [1401, 1486], 'stress': [1403, 1488], 'stimuli.Biochem.': [1404, 1489], '2013;': [1406, 1491, 1752, 2026, 2292, 2339, 2410], '452:': [1407, 1492], '531-543Crossref': [1408, 1493], '(62)': [1411, 1496], 'In': [1414, 1819, 1861, 3851, 3907], 'cells,': [1416, 2680, 2720, 2767, 3270, 4004], 'concentration': [1418], 'generally': [1422], 'due': [1424], 'PFKFB3,': [1430], 'opposite': [1433, 3289, 3714], '(11.Bartrons': [1437], '12.Novellasdemunt': [1458], 'Scholar13.Atsumi': [1498], 'Chesney': [1500], 'Metz': [1502], 'Leng': [1504], 'Donnelly': [1506], 'Makita': [1508], 'Z.': [1509], 'Mitchell': [1510], 'Bucala': [1512], '(iPFK-2;': [1519], 'PFKFB3)': [1520], 'cancers.Cancer': [1523], 'Res.': [1524, 2024, 2075], '2002;': [1525], '62:': [1526], '5881-5887PubMed': [1527], 'depletion': [1532], 'flux': [1535, 1545, 2954], 'increasing': [1537, 1547, 2953], '14.Peña-Rico': [1587], 'Calvo-Vidal': [1589, 2211], 'Villalonga-Planells': [1591, 2213], 'Martínez-Soler': [1593, 2215], 'Giménez-Bonafé': [1595, 2217], 'Navarro-Sabaté': [1597, 2219], 'Tortosa': [1599, 2221], 'knockdown': [1612, 2208, 2234], 'results': [1613, 2235], 'radiosensitization': [1615, 2237], 'glioma': [1617, 2171, 2202, 2239, 2281], 'cells.Radiother.': [1618, 2240], 'Oncol.': [1619, 1976, 2241], '2011;': [1620, 2242], '101:': [1621, 2243], '132-139Abstract': [1622, 2244], '(59)': [1630, 2252], 'other': [1641, 1831], 'substrates': [1642, 1832], 'such': [1643], 'be': [1653, 1694, 3554], 'alternate': [1654], 'catabolites': [1655, 2823], 'inversely': [1695, 1703, 3574], 'associated': [1696, 1704], 'was': [1702, 2931, 3294, 3321, 3342, 3647, 3805], '2-deoxyglucose': [1706, 3417, 3439, 3655], 'PET': [1709], 'scans': [1710], 'subjects': [1712], 'non-small': [1714, 1747, 2089], 'lung': [1716, 1749, 2091], '(15.Zhou': [1718], 'X.': [1719, 1729, 1999], 'Xie': [1720], 'W.': [1721, 2056, 2318, 2389], 'Li': [1722, 2049, 2055], 'Q.': [1723, 1944], 'Zhang': [1724, 1726, 1945], 'Y.': [1725, 1938, 1940], 'Zhao': [1728, 1998], 'Liu': [1730, 1937], 'Huang': [1732], 'correlated': [1736], 'maximal': [1738], 'standardized': [1739], 'value': [1741], 'FDG-PET': [1743], 'survival': [1745, 2069, 2360], 'cancer.PLoS': [1750], 'ONE.': [1751], '8:': [1753], 'e80576Crossref': [1754], '(20)': [1757], 'regulates': [1761, 2278], 'hexokinase': [1762], '2': [1763, 2855], '(HK2)': [1764], 'potential,': [1770], 'but': [1771, 1824, 2681, 3130, 3833], 'metabolism,': [1778], 'rates,': [1781], 'generation': [1784, 3192], '(16.Cheung': [1787], 'E.C.': [1788, 2310, 2381, 2525], 'Ludwig': [1789], 'R.L.': [1790], 'Mitochondrial': [1793, 3152], 'localization': [1794], 'under': [1797], 'hypoxia': [1798, 3794], 'stimulates': [1799], 'HK2': [1800], 'lowers': [1802], 'ROS': [1803, 2531], 'death.Proc.': [1806], 'Natl.': [1807], 'Acad.': [1808], 'U.S.A.': [1810], '109:': [1812], '20491-20496Crossref': [1813], '(171)': [1816], 'sum,': [1820, 3852], 'glycolysis,': [1823, 1865, 3285], 'its': [1825, 1854], 'reported': [1842], 'mediate': [1844], 'aggressiveness,': [1847], 'although': [1848, 3286], 'mechanism': [1850], 'unclear,': [1852], 'unknown.': [1860, 2614], 'addition': [1862], 'reducing': [1864], 'overexpressed': [1908, 2138, 2843], 'nasopharyngeal': [1910, 1969], 'carcinoma,': [1911], 'genetic': [1913], 'growth,': [1921], 'colony': [1922], 'formation,': [1923], 'migration,': [1924], 'invasion': [1926], 'NFκB': [1928], '(17.Zhao': [1933], 'M.': [1934], 'Fan': [1935], 'Yu': [1939, 2051], 'Xu': [1941], 'Wen': [1943], 'Fu': [1947], 'Wang': [1949], 'Xiang': [1951], 'Feng': [1953], 'Wu': [1955, 2057], 'Yang': [1957], 'Oncogenic': [1959], 'NF-κB': [1972], 'modulation.Int.': [1974], '2016;': [1977], '48:': [1978], '756-764Crossref': [1979], '(16)': [1982], 'Knockdown': [1985, 2008], 'HepG2': [1992, 2019, 2037], 'hepatocellular': [1993, 2020, 2044], '(18.Ye': [1996], 'Lu': [2000], 'Qian': [2002], 'Zheng': [2004], 'J.C.': [2005], 'Ge': [2006], 'RNA': [2012], 'interference': [2013], 'autophagy': [2017, 2558], 'cells.Biochem.': [2022], 'Biophys.': [2023], 'Commun.': [2025], '437:': [2027], '300-306Crossref': [2028], '(37)': [2031], 'down-regulation': [2035, 3593], 'size': [2042], 'xenografts': [2046], '(19.Xie': [2047], 'J.M.': [2048], 'H.P.': [2052], 'Gao': [2053], 'Q.G.': [2054], 'H.R.': [2058], 'Qin': [2059], 'Z.H.': [2060], 'dual': [2064], 'regulating': [2071], 'autophagy.Cancer': [2074], '74:': [2077], '5127-5138Crossref': [2078], '(64)': [2081], 'H-1299': [2093], 'osteosarcoma': [2095], 'U2OS': [2096], 'glioblastomas,': [2143], 'protecting': [2144], 'from': [2146, 2173, 2684, 2927], 'starvation-induced': [2147, 2174], 'death': [2149, 2176], 'up-regulating': [2151, 2178], 'improving': [2154, 2181], 'cellular': [2155, 2182], 'redox': [2156, 2183], 'homeostasis': [2157], '(20.Wanka': [2158], 'Steinbach': [2160], 'J.P.': [2161], 'Rieger': [2162], 'Tp53-induced': [2164], 'protects': [2170], 'homeostasis.J.': [2184], 'Biol.': [2185, 2566, 2725, 2772], 'Chem.': [2186], '287:': [2188], '33436-33446Abstract': [2189], '(131)': [2197], 'Radiosensitization': [2200], 'occurs': [2205, 2736], '(14.Peña-Rico': [2209], 'another': [2256], 'study': [2257], 'viability': [2264], 'glioblastoma': [2266], '(21.Sinha': [2267], 'Ghildiyal': [2269], 'Mehta': [2271], 'V.S.': [2272], 'Sen': [2273], 'ATM-NFκB': [2275], 'axis-driven': [2276], 'sensitivity': [2279], 'radiomimetics': [2284], 'presence': [2287], 'TNFα.Cell': [2289], 'Death': [2290], 'Dis.': [2291], '4:': [2293], 'e615Crossref': [2294], 'required': [2302, 2331, 2402], 'small': [2306], 'intestine': [2307], '(22.Cheung': [2309, 2380], 'Athineos': [2311, 2382], 'Ridgway': [2315, 2386], 'Lambie': [2317, 2388], 'Nixon': [2319, 2390], 'Strathdee': [2321, 2392], 'Blyth': [2323, 2394], 'Sansom': [2325, 2396], 'O.J.': [2326, 2397], 'efficient': [2333, 2404], 'intestinal': [2334, 2377, 2405], 'regeneration': [2335, 2406], 'tumorigenesis.Dev.': [2337, 2408], '25:': [2340, 2411, 2727, 2774], '463-477Abstract': [2341, 2412], '(148)': [2349, 2420], 'null': [2353], 'mice': [2354], 'decreased': [2356, 2940, 3402, 3984], 'tumorigenesis': [2357], 'model': [2363, 3250], 'suppressor': [2368], 'adenomatous': [2369], 'polyposis': [2370], 'coli': [2371], '(APC)': [2372], 'deleted': [2374], 'LGR5+': [2376], 'frequently': [2439], '24.Bensaad': [2522], 'Cheung': [2524], 'Modulation': [2528], 'controls': [2535, 3955, 4054, 4090, 4102, 4144, 4156], 'autophagy.EMBO': [2536], '2009;': [2538], '28:': [2539], '3015-3026Crossref': [2540], '(309)': [2543, 2731, 2778], '25.Li': [2547], 'Ishdorj': [2549], 'Gibson': [2551], 'S.B.': [2552], 'Reactive': [2553], 'species': [2555], 'regulation': [2556], 'cancer:': [2560], 'implications': [2561], 'treatment.Free': [2564], 'Radic': [2565], 'Med.': [2567], '53:': [2569], '1399-1410Crossref': [2570], '(128)': [2573], 'no': [2577, 2783, 3482, 3806], 'reports': [2578], 'vivo.': [2591], 'high': [2606, 2618, 2749], 'observed': [2608], 'Breast': [2615], 'biogenesis': [2622, 2676, 2994], 'transcription': [2623, 3751], 'factors': [2624], 'markers': [2627, 2673, 2836, 2991, 3142, 3283, 3696], 'phosphorylation': [2630], '(OXPHOS)': [2631], '(26.Wallace': [2632], 'Mitochondria': [2634, 2667], '12:': [2640], '685-698Crossref': [2641], '(1590)': [2644], '(27.Sotgia': [2647], 'Whitaker-Menezes': [2649], 'Martinez-Outschoorn': [2651], 'Salem': [2653], 'A.F.': [2654], 'Tsirigos': [2655], 'Lamb': [2657], 'Sneddon': [2659], 'Hulit': [2661], 'Howell': [2663], '"fuel"': [2668], 'metabolism:': [2671], 'fifteen': [2672], 'label': [2677], 'epithelial': [2678], 'excluded': [2683], 'cells.Cell': [2687], 'Cycle.': [2688], '11:': [2690], '4390-4401Crossref': [2691], '(140)': [2694], 'malignancies': [2703], '(28.Martinez-Outschoorn': [2704, 2751], 'Catabolic': [2710, 2757], 'cancer-associated': [2711, 2758], 'energy': [2714, 2761], 'biomass': [2716, 2763], 'anabolic': [2718, 2765], 'fueling': [2721, 2768], 'growth.Semin.': [2723, 2770], 'Cancer': [2724, 2771], '47-60Crossref': [2728, 2775], 'Metabolic': [2734], 'OXPHOS': [2750, 3144, 3924, 3995], 'data': [2784], 'it': [2797], 'plays': [2798], 'heterogeneity': [2805], 'tumors.': [2807], 'hypothesize': [2809], 'disease': [2818], 'utilization': [2820], 'alternative': [2822], 'compartmentalization.': [2828], 'To': [2829, 2960, 2997, 3242], 'investigate': [2830, 2961, 2998, 3243], 'utilization,': [2841], 'up-regulated': [2851, 3162, 3585], 'moderately': [2852], '(MCT2)': [2856], 'mRNA': [2859, 3292, 3319, 3340], '(Fig.': [2861, 2890, 2912, 2936, 2944, 2995, 3052, 3165, 3177, 3193, 3229, 3240, 3305, 3332, 3349, 3358, 3394, 3413, 3472, 3515, 3530, 3589, 3602, 3641, 3687, 3710, 3800, 3849, 3905, 3956, 3976, 3996, 4022, 4055, 4080, 4091, 4103, 4128, 4145, 4157], '1,': [2862, 2945], 'B).': [2865], 'MCT2': [2866], 'importer.': [2870], 'up-regulates': [2873, 2894], 'B': [2876, 3689], '(LDH-B),': [2877], 'into': [2885, 3570, 4036], 'pyruvate': [2886], '1C)': [2891], '(GLS1)': [2897], 'modestly,': [2898], 'rate-limiting': [2902], 'glutamate': [2911, 2915, 2928], '1D).': [2913], 'ammonia': [2916], 'ligase': [2917], '(GLUL),': [2918], 'mediates': [2924], 'ammonia,': [2930], 'down-regulated': [2932], '1E).': [2937], 'markedly': [2939], 'NADP+/NADPH': [2942], 'ratio': [2943], 'F': [2946], 'G),': [2948], 'consistent': [2951], 'pentose': [2957], 'phosphate': [2958], 'pathway.': [2959], 'biogenesis,': [2968], 'γ': [2977], '(PGC1)': [2980], '(NRF1).': [2986], 'these': [2990], '2A).': [2996], 'exposure': [3004], '(OCR)': [3016], 'TIGAR-overexpressing': [3020, 3200, 3232, 3769, 3909, 3951, 4060, 4082, 4093, 4108, 4147], 'Oxygen': [3023], 'were': [3026, 3102, 3762, 3866, 3912, 4034, 4132], 'expressing': [3045], 'vector': [3048], '(p': [3049, 3073, 3098, 3135, 3302, 3314, 3329, 3391, 3410, 3469, 3512, 3527, 3638, 3779, 3902, 4019, 4067, 4074, 4115, 4122, 4135], '<': [3050, 3074, 3099, 3136, 3303, 3315, 3330, 3392, 3411, 3470, 3513, 3528, 3639, 3780, 3903, 4020, 4068, 4075, 4116, 4123, 4136], '0.05)': [3051, 3075, 3331, 3412, 3471, 3514, 3529, 3640, 3781, 3904, 4021, 4069, 4076, 4117, 4124, 4137], '2B).': [3053], '1.2-fold': [3063, 3627, 3841, 3889], 'greater': [3064, 3078, 4065, 4072, 4113, 4120], 'OCR': [3065, 3079, 3121], 'than': [3066, 3088, 3122, 3954, 4077, 4089, 4125], '1.5-fold': [3077, 3296, 4134], 'same': [3096], 'conditions': [3097, 3799], '0.05).': [3100, 3137], 'OCRs': [3101], 'absence': [3111], 'overexpression.': [3114], 'had': [3119, 3377, 3399, 3456, 3481, 3501, 3625, 4048, 4063, 4085, 4096, 4111, 4150], 'lower': [3120, 3540, 3544, 3669], '(0.8-fold)': [3125], 'cultured': [3127, 3763, 3867], 'without': [3131], 'Next,': [3138], 'MITONEET,': [3146, 3990], 'Transporter': [3148], 'Outer': [3151], 'Membrane': [3153], 'Member': [3154], '20': [3155], '(TOMM20).': [3156], 'Both': [3157], 'MITONEET': [3158, 4001], 'TOMM20': [3160, 3167, 3517, 4087], '2C).': [3166], '2D).': [3178], 'Exposure': [3179, 3959, 3978], '2E).': [3194], 'then': [3196], '3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one': [3204], '(3PO),': [3205], 'levels.': [3214], 'Control': [3215], '3PO': [3219, 3236], 'do': [3220], 'significant': [3224, 3336, 3484, 3807], 'change': [3225, 3808], '2F).': [3230, 3241], 'stromal-epithelial': [3244], 'interactions,': [3245], 'system': [3251], 'composed': [3252], '1)': [3254], 'immortalized': [3257], 'telomerase': [3260], 'catalytic': [3261], '(hTERT-BJ1': [3263], 'fibroblasts)': [3264], '2)': [3266], 'T47D': [3267, 3298, 3345, 3420, 3452, 3465, 3474, 3492, 3497, 3510, 3613, 3621, 3766, 3770, 3786, 3820, 3864, 3952, 4083, 4094, 4105], 'MCF7': [3269, 3310, 3325, 3963, 3982, 4003, 4027, 4148], 'well': [3273], 'established': [3274], 'lines.': [3278], 'they': [3287], 'effects.': [3290], '0.01)': [3304, 3393], '3A)': [3306], '1.6-fold': [3308, 3778], '0.05),': [3316], 'whereas': [3317], '1.9-fold': [3323, 3503, 3526], '3B).': [3333], 'No': [3334], 'statistically': [3335, 3483], 'difference': [3337, 3485], 'noted': [3343], '3A).': [3350], '3C),': [3359], 'apoptosis.': [3371], 'cocultured': [3374, 3619, 3681, 3784], '4.7-fold': [3379], 'increase': [3380, 3628], 'DNA': [3382], 'at': [3384], 'expense': [3386], 'G0-G1': [3388], 'G2-M': [3390], '3D).': [3395], '2-fold': [3401], 'rate': [3404], '3E).': [3414], 'measuring': [3429], 'fluorescence': [3430, 3652], '2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose': [3432], '(2-NBDG),': [3433], 'green': [3437, 3651], 'compound.': [3440], '2-NBDG': [3441, 3460, 3487, 3630, 3660], 'correlates': [3443], 'indicating': [3449, 3543, 3671], '1.3-fold': [3458, 4018], '4A).': [3473], 'homotypic': [3479, 3892], 'culture': [3480, 3893], '(data': [3494], 'shown).': [3496], 'production': [3506, 3525, 3533], '4B).': [3516], '4C).': [3531], 'Lactate': [3532], 'measure': [3536, 3665], 'can': [3553], 'phenocopied': [3555], 'TOMM20.': [3559], 'Monocarboxylate': [3560], '(MCT1)': [3563], 'main': [3566, 3749], 'importer': [3567], 'related': [3575], '4D).': [3590], 'Conversely': [3591], 'using': [3597, 3738], 'CRISPR-Cas9': [3598], '4E–F).': [3603], 'Next': [3604], '5A).': [3642], 'Glucose': [3643], 'measured': [3648], 'quantifying': [3650], 'compound': [3656], '2-NBDG.': [3657], '2-Deoxyglucose': [3658], 'additional': [3664], 'LDH-A': [3676, 3694], '5,': [3688], 'C).': [3691], 'LDH-B': [3699, 3712], '5C).': [3711], 'LDH-A,': [3717], 'pyruvate.': [3721], 'next': [3723], 'assessed': [3724], '(HIF)': [3734], 'HIF1A': [3740, 3744, 3759, 3774, 3810], 'luciferase': [3741, 3760], 'reporter': [3742, 3761], 'one': [3746], 'factors.': [3752], 'NIH3T3': [3753], 'stably': [3755], 'transfected': [3756], 'Activation': [3772], '0.5%': [3792], 'O2': [3793], '5D).': [3801], 'Note': [3802], 'there': [3804], 'normoxia': [3813], 'TIGAR.': [3823], 'expression,': [3832], 'led': [3839, 3965], '5E).': [3850], 'fibroblasts.': [3863], 'alone': [3868], 'tamoxifen.': [3875], 'reduction': [3890, 3897], '1.4-fold': [3896], '6A).': [3906], 'contrast,': [3908], 'sensitive': [3914], 'modulators.': [3919], 'Metformin,': [3920], 'complex': [3925], 'I': [3926], 'inhibitor,': [3927], 'doxycycline,': [3928], 'inhibits': [3930, 3936], 'translation,': [3932], 'ABT-199,': [3934], 'BCL2': [3937, 3970], 'single': [3940], 'agent': [3941], '6,': [3957, 3997], 'B–E).': [3958], 'MCT4': [3974], '6F).': [3977], 'BCL-XL,': [3988], 'BCL2,': [3989], 'labile': [3992], 'subunits': [3993], 'G–H).': [3998], 'Overexpression': [3999], 'marker': [4008], '6I).': [4023], 'MDA-MB-231,': [4024], 'T47D,': [4025], 'injected': [4035], 'mammary': [4038], 'gland': [4039], 'nude': [4041], 'female': [4042], 'mice.': [4043], 'MDA-MB-231': [4044, 4057], '7A).': [4056], '2.5-fold': [4064], 'volume': [4066, 4114], '2.4': [4071], 'weight': [4073, 4121], '7B).': [4081], '7C).': [4092], '7D).': [4104], '3.5-fold': [4112], '3.8-fold': [4119], '7E).': [4129], 'Mitotic': [4130], 'figures': [4131], '7F).': [4146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2548993203', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 11}], 'updated_date': '2024-12-15T12:47:26.722657', 'created_date': '2016-11-11'}