Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2548552719', 'doi': 'https://doi.org/10.18632/oncotarget.13121', 'title': 'Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE−/− mice', 'display_name': 'Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE−/− mice', 'publication_year': 2016, 'publication_date': '2016-11-04', 'ids': {'openalex': 'https://openalex.org/W2548552719', 'doi': 'https://doi.org/10.18632/oncotarget.13121', 'mag': '2548552719', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27821816', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5363520'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13121', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13121&path%5B%5D=41588', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13121&path%5B%5D=41588', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101995282', 'display_name': 'Juan Peng', 'orcid': 'https://orcid.org/0000-0002-0754-3054'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Juan Peng', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025085694', 'display_name': 'Qin Yang', 'orcid': 'https://orcid.org/0000-0001-8690-4809'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qin Yang', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004831893', 'display_name': 'Afang Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'A-Fang Li', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103040078', 'display_name': 'Rongqing Li', 'orcid': 'https://orcid.org/0009-0003-6202-9407'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rong-Qing Li', 'raw_affiliation_strings': ['Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013012861', 'display_name': 'Wang Zuo', 'orcid': 'https://orcid.org/0000-0002-7365-7834'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zuo Wang', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039905441', 'display_name': 'Lu‐Shan Liu', 'orcid': 'https://orcid.org/0000-0003-0234-5574'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lu-Shan Liu', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052916268', 'display_name': 'Zhong Ren', 'orcid': 'https://orcid.org/0000-0003-0848-7354'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhong Ren', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034300226', 'display_name': 'Xi‐Long Zheng', 'orcid': 'https://orcid.org/0000-0002-0889-1827'}, 'institutions': [{'id': 'https://openalex.org/I56478863', 'display_name': 'Libin Cardiovascular Institute of Alberta', 'ror': 'https://ror.org/02qthww36', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I56478863']}, {'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CA', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Xi-Long Zheng', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, Calgary, Alberta, Canada', 'Health Sciences Center, Calgary, Alberta, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, Calgary, Alberta, Canada', 'institution_ids': ['https://openalex.org/I56478863', 'https://openalex.org/I168635309']}, {'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}, {'raw_affiliation_string': 'Health Sciences Center, Calgary, Alberta, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088695928', 'display_name': 'Xiao‐Qing Tang', 'orcid': 'https://orcid.org/0000-0002-3518-9275'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Qing Tang', 'raw_affiliation_strings': ['. Department of Physiology & Institute of Neuroscience, Medical School, University of South China, Hengyang, PRC, China'], 'affiliations': [{'raw_affiliation_string': '. Department of Physiology & Institute of Neuroscience, Medical School, University of South China, Hengyang, PRC, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100380152', 'display_name': 'Guohua Li', 'orcid': 'https://orcid.org/0000-0002-9073-3907'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guo-Hua Li', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079853956', 'display_name': 'Zhi-Han Tang', 'orcid': 'https://orcid.org/0000-0001-8191-7950'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zhi-Han Tang', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100750965', 'display_name': 'Zhi‐Sheng Jiang', 'orcid': 'https://orcid.org/0000-0002-9044-3491'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Sheng Jiang', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052724806', 'display_name': 'Dangheng Wei', 'orcid': 'https://orcid.org/0000-0002-2588-0943'}, 'institutions': [{'id': 'https://openalex.org/I91935597', 'display_name': 'University of South China', 'ror': 'https://ror.org/03mqfn238', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I91935597']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dang-Heng Wei', 'raw_affiliation_strings': ['. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China'], 'affiliations': [{'raw_affiliation_string': '. Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan, China', 'institution_ids': ['https://openalex.org/I91935597']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5079853956'], 'corresponding_institution_ids': ['https://openalex.org/I91935597'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.323, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 76, 'citation_normalized_percentile': {'value': 0.904359, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '7', 'issue': '47', 'first_page': '76423', 'last_page': '76436'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9602, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase and Carbon Monoxide Research', 'score': 0.9223, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apolipoprotein-e', 'display_name': 'Apolipoprotein E', 'score': 0.54098994}, {'id': 'https://openalex.org/keywords/cytoprotection', 'display_name': 'Cytoprotection', 'score': 0.493562}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.7063105}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.6496626}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.62189347}, {'id': 'https://openalex.org/C57089818', 'wikidata': 'https://www.wikidata.org/wiki/Q424728', 'display_name': 'Apolipoprotein E', 'level': 3, 'score': 0.54098994}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5186074}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34825778}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34539244}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34333527}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29063275}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.26251954}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21330193}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.21201733}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.14429036}], 'mesh': [{'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D050197', 'descriptor_name': 'Atherosclerosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D050197', 'descriptor_name': 'Atherosclerosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050197', 'descriptor_name': 'Atherosclerosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D050197', 'descriptor_name': 'Atherosclerosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061307', 'descriptor_name': 'Human Umbilical Vein Endothelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D061307', 'descriptor_name': 'Human Umbilical Vein Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058226', 'descriptor_name': 'Plaque, Atherosclerotic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058226', 'descriptor_name': 'Plaque, Atherosclerotic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D058226', 'descriptor_name': 'Plaque, Atherosclerotic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13121', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13121&path%5B%5D=41588', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5363520', 'pdf_url': 'https://europepmc.org/articles/pmc5363520?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363520', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27821816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.13121', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13121&path%5B%5D=41588', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.65, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1171241794', 'https://openalex.org/W1964866117', 'https://openalex.org/W1976573435', 'https://openalex.org/W1985538633', 'https://openalex.org/W1988747541', 'https://openalex.org/W1991324547', 'https://openalex.org/W1996144099', 'https://openalex.org/W1997998180', 'https://openalex.org/W2004336032', 'https://openalex.org/W2005463129', 'https://openalex.org/W2013177932', 'https://openalex.org/W2016726636', 'https://openalex.org/W2017335473', 'https://openalex.org/W2035166160', 'https://openalex.org/W2040151622', 'https://openalex.org/W2057865864', 'https://openalex.org/W2064741210', 'https://openalex.org/W2076062022', 'https://openalex.org/W2086731358', 'https://openalex.org/W2088918448', 'https://openalex.org/W2099288717', 'https://openalex.org/W2119515848', 'https://openalex.org/W2120897623', 'https://openalex.org/W2141284336', 'https://openalex.org/W2151313069', 'https://openalex.org/W2151485523', 'https://openalex.org/W2161431688', 'https://openalex.org/W2166670116', 'https://openalex.org/W2173450677'], 'related_works': ['https://openalex.org/W3151903987', 'https://openalex.org/W3150996080', 'https://openalex.org/W3149538430', 'https://openalex.org/W3141893332', 'https://openalex.org/W2498134948', 'https://openalex.org/W2382353027', 'https://openalex.org/W2324929766', 'https://openalex.org/W2082972770', 'https://openalex.org/W2005626592', 'https://openalex.org/W18792685'], 'abstract_inverted_index': {'//': [0, 119, 123, 127], 'Juan': [1], 'Peng': [2], '1,*': [3, 7, 11], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44], 'Qin': [5], 'Yang': [6], 'A-Fang': [9], 'Li': [10, 14, 38], 'Rong-Qing': [13], '1': [15, 19, 23, 27, 39, 43, 47, 51, 347, 379], 'Zuo': [17], 'Wang': [18], 'Lu-Shan': [21], 'Liu': [22], 'Zhong': [25], 'Ren': [26], 'Xi-Long': [29], 'Zheng': [30], '2': [31, 157], 'Xiao-Qing': [33], 'Tang': [34, 42], '3': [35], 'Guo-Hua': [37], 'Zhi-Han': [41, 116], 'Zhi-Sheng': [45, 120], 'Jiang': [46], 'and': [48, 75, 203, 225, 238, 257, 273, 284, 300, 326, 389], 'Dang-Heng': [49, 124], 'Wei': [50], '1.': [52], 'Institute': [53, 81, 99], 'of': [54, 61, 65, 73, 82, 86, 96, 100, 105, 162, 170, 199, 223, 228, 344, 354, 367, 371, 376, 394], 'Cardiovascular': [55, 80], 'Disease,': [56], 'Key': [57], 'Lab': [58], 'for': [59, 402], 'Arteriosclerology': [60], 'Hunan': [62], 'Province,': [63], 'University': [64, 85, 104], 'South': [66, 106], 'China,': [67, 107], 'Hengyang,': [68, 108], 'Hunan,': [69], 'China': [70, 110], '2.': [71], 'Department': [72, 95], 'Biochemistry': [74], 'Molecular': [76], 'Biology,': [77], 'The': [78, 84, 168, 369], 'Libin': [79], 'Alberta,': [83, 92], 'Calgary,': [87, 91], 'Health': [88], 'Sciences': [89], 'Center,': [90], 'Canada': [93], '3.': [94], 'Physiology': [97], '&': [98], 'Neuroscience,': [101], 'Medical': [102], 'School,': [103], 'PRC,': [109], '*': [111], 'Co-first': [112], 'author': [113], 'Correspondence': [114], 'to:': [115], 'Tang,': [117], 'email:': [118, 122, 126], 'Jiang,': [121], 'Wei,': [125], 'Keywords': [128], ':': [129, 139, 144, 149], 'TET2,': [130], 'autophagy,': [131, 385], 'endothelial': [132, 185, 190, 309, 318, 332, 383], 'cells,': [133], 'inflammation,': [134], 'atherosclerosis,': [135], 'Pathology': [136], 'Section': [137], 'Received': [138], 'June': [140], '08,': [141], '2016': [142, 147, 152], 'Accepted': [143], 'October': [145], '21,': [146], 'Published': [148], 'November': [150], '04,': [151], 'Abstract': [153], 'Tet': [154], 'methylcytosine': [155], 'dioxygenase': [156], '(TET2)': [158], 'mediates': [159], 'the': [160, 197, 307, 330, 341, 345, 352, 365, 374, 377], 'conversion': [161], '5-methylcytosine': [163], '(5mC)': [164], 'to': [165, 351, 382], '5-hydroxymethylcytosine': [166], '(5hmC).': [167], 'loss': [169], 'TET2': [171, 183, 200, 213, 233, 260, 321, 334, 361, 372, 395], 'is': [172], 'associated': [173], 'with': [174, 219, 262, 288, 306], 'advanced': [175], 'atherosclerotic': [176, 217, 278, 285], 'lesions.': [177, 279], 'Our': [178], 'previous': [179], 'study': [180, 195], 'showed': [181], 'that': [182, 312, 360], 'improves': [184], 'cell': [186, 191, 245, 319, 384], 'function': [187], 'by': [188, 294, 339], 'enhancing': [189], 'autophagy.': [192, 320], 'Accordingly,': [193], 'this': [194], 'determined': [196], 'role': [198], 'in': [201, 230, 267, 277, 329], 'atherosclerosis': [202], 'potential': [204], 'mechanisms.': [205], 'In': [206], 'ApoE': [207, 268], '−/−': [208, 269], 'mice': [209, 270], 'fed': [210], 'high-fat': [211], 'diet,': [212], 'overexpression': [214, 234, 335], 'markedly': [215], 'decreased': [216, 226, 271], 'lesions': [218, 286], 'uniformly': [220], 'increased': [221, 274], 'level': [222, 227, 343], '5hmC': [224, 272], '5mC': [229, 275], 'genomic': [231], 'DNA.': [232], 'also': [235], 'promoted': [236], 'autophagy': [237, 281, 325], 'downregulated': [239, 363], 'inflammation': [240, 302, 355], 'factors,': [241], 'such': [242], 'as': [243], 'vascular': [244], 'adhesion': [246, 250], 'molecule': [247, 251], '1,': [248, 252, 256], 'intercellular': [249], 'monocyte': [253], 'chemotactic': [254], 'protein': [255], 'interleukin-1.': [258], 'Consistently,': [259], 'knockdown': [261], 'small': [263], 'hairpin': [264], 'RNA': [265], '(shRNA)': [266], 'levels': [276], 'Meanwhile,': [280], 'was': [282, 362], 'inhibited': [283, 317], 'progressed': [287], 'an': [289], 'unstable': [290], 'lesion': [291], 'phenotype': [292], 'characterized': [293], 'large': [295], 'lipid': [296], 'core,': [297], 'macrophage': [298], 'accumulation,': [299], 'upregulated': [301], 'factor': [303, 391], 'expression.': [304], 'Experiments': [305], 'cultured': [308], 'cells': [310], 'revealed': [311], 'oxidized': [313], 'low-density': [314], 'lipoprotein': [315], '(ox-LDL)': [316], 'shRNA': [322], 'strengthened': [323], 'impaired': [324, 386], 'autophagic': [327, 387], 'flux': [328], 'ox-LDL-treated': [331], 'cells.': [333], 'reversed': [336], 'these': [337], 'effects': [338], 'decreasing': [340], 'methylation': [342, 375], 'Beclin': [346, 378], 'promoter,': [348, 380], 'which': [349], 'contributed': [350], 'downregulation': [353, 370], 'factors.': [356], 'Overall,': [357], 'we': [358], 'identified': [359], 'during': [364], 'pathogenesis': [366], 'atherosclerosis.': [368, 404], 'promotes': [373], 'leading': [381], 'flux,': [388], 'inflammatory': [390], 'upregulation.': [392], 'Upregulation': [393], 'may': [396], 'be': [397], 'a': [398], 'novel': [399], 'therapeutic': [400], 'strategy': [401], 'treating': [403]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2548552719', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-09-19T07:46:24.725556', 'created_date': '2016-11-11'}