Title: Commentary to ‘Gonadal dysgenesis in disorders of sex development (DSD): Diagnosis and surgical management’
Abstract: Just as disorders of sex development (DSD) represent a spectrum of disorders of varying phenotypic abnormality, so do the associated gonads, which may vary from phenotypic and histologic normalcy to complete dysgenesis. The authors nicely delineate genetic (gonadoblastoma gene on Y chromosome) and histologic markers for gonadal malignancy risk. Response to commentary to ‘Gonadal dysgenesis in disorders of sex development (DSD): Diagnosis and surgical management’Journal of Pediatric UrologyVol. 13Issue 1PreviewWe acknowledge that gonadal management of DSD patients, like many other DSD-related issues, is controversial. Bilateral gonadectomy in children with DSD conditions with known high germ cell cancer (GCC) risk is indeed a safe option, but at a significant price in terms of need for puberty induction and subsequent hormone replacement therapy, and definite loss of fertility. For patient and parent counseling procedures it is regrettable that reliable figures on gonadal GCC risk in many DSD conditions are either lacking or at best roughly known. Full-Text PDF
Publication Year: 2016
Publication Date: 2016-11-04
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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