Publication Information

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1356, 1859, 2172], 'for': [17, 43, 65, 85, 99, 119, 130, 148, 165, 198, 218, 240, 260, 274, 294, 305, 323, 340, 373, 541, 691, 736, 772, 784, 913, 939, 1074, 1122, 1154, 1183, 1215, 1217, 1239, 1336, 1369, 1393, 1461, 1551, 1619, 1633, 1648, 1704, 1715, 1733, 1886, 1897, 1910, 1981, 2043, 2100, 2126, 2322], 'treatment': [18, 468, 2223, 2354], 'multiple': [20, 472, 1304, 2142, 2179, 2274, 2356], 'myeloma:': [21], 'A': [22, 1124, 1390, 1458, 2190, 2226, 2256], 'propensity': [23, 607, 907], 'matched': [24, 608, 930, 1018], 'study': [25, 646, 1575, 1811, 1847, 1977, 2191], '1,790': [27], 'patients': [28, 1024, 1129, 1134, 1138, 1218, 1253, 1306, 1314, 1324, 1599, 1851, 1889, 1899, 2176], 'John': [29, 32, 204, 207, 1994], 'C.': [30, 33, 205, 208, 1995], 'Reneau,': [31, 206], 'Reneau': [34, 209], 'Department': [35, 52, 157, 177, 210, 227, 332, 352], 'Internal': [37, 212, 2015], 'Medicine,': [38, 213, 2016], 'Mayo': [39, 61, 76, 92, 110, 126, 144, 161, 181, 214, 236, 251, 267, 285, 301, 319, 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2027], 'and': [59, 80, 114, 234, 255, 289, 413, 417, 429, 436, 455, 469, 493, 510, 534, 553, 624, 633, 651, 661, 666, 700, 730, 733, 753, 769, 802, 859, 877, 886, 922, 926, 966, 994, 1028, 1047, 1060, 1069, 1088, 1116, 1135, 1146, 1164, 1175, 1272, 1323, 1361, 1374, 1385, 1396, 1405, 1432, 1442, 1453, 1464, 1482, 1494, 1534, 1562, 1604, 1635, 1641, 1669, 1689, 1929, 1935, 1941, 1954, 1961, 1978, 1987, 2010, 2028, 2038, 2144, 2169, 2173, 2214, 2229, 2266, 2320, 2326], 'Informatics,': [60, 235, 2029], 'authorHolly': [70, 245], 'van': [71, 74, 246, 249], 'Houten,': [72, 247], 'Holly': [73, 248, 1999], 'Houten': [75, 250], 'Clinic': [77, 111, 252, 286, 2035], 'Robert': [78, 112, 253, 287, 2036], 'D.': [79, 113, 254, 288, 2037], 'Patricia': [81, 115, 256, 290, 2039], 'E.': [82, 116, 257, 291, 2040], 'Kern': [83, 117, 258, 292, 2041], 'Center': [84, 118, 259, 293, 2042], 'the': [86, 120, 261, 295, 431, 441, 465, 479, 483, 538, 579, 587, 594, 597, 616, 641, 657, 727, 756, 773, 777, 808, 825, 837, 841, 896, 916, 920, 923, 936, 955, 959, 967, 999, 1002, 1017, 1051, 1104, 1161, 1168, 1211, 1346, 1351, 1419, 1475, 1488, 1498, 1530, 1552, 1557, 1568, 1580, 1593, 1620, 1662, 1684, 1687, 1691, 1694, 1700, 1734, 1757, 1800, 1815, 1823, 1827, 1833, 1845, 1881, 1913, 1932, 1944, 1948, 1952, 1964, 1973, 1976, 1982, 1985, 1988, 1991, 2044, 2081, 2101, 2111, 2123, 2127, 2145, 2167, 2186, 2193, 2222, 2247, 2298, 2353], 'Science': [87, 121, 262, 296, 2045], 'Care': [90, 124, 265, 299, 2048], 'Delivery,': [91, 125, 266, 300, 2049], 'Minnesota': [95, 270, 2071], 'OptumLabs,': [96, 271], 'Cambridge,': [97, 272, 2055], 'MassachusettsSearch': [98, 273], 'authorLindsey': [104, 279], 'R.': [105, 108, 280, 283, 2003], 'Sangaralingham,': [106, 281], 'Lindsey': [107, 282, 2002], 'Sangaralingham': [109, 284], 'authorFrancis': [135, 310], 'K.': [136, 139, 311, 314, 2006], 'Buadi,': [137, 312], 'Francis': [138, 313, 2005], 'Buadi': [140, 315], 'Division': [141, 316], 'Hematology,': [143, 318, 2059], 'authorAmir': [153, 328], 'Lerman,': [154, 329], 'Amir': [155, 330, 2008], 'Lerman': [156, 331], 'Cardiovascular': [159, 179, 334, 354, 2066], 'Diseases,': [160, 180, 335, 355, 2067], 'authorJoerg': [170, 345], 'Herrmann,': [171, 187, 346, 362], 'Corresponding': [172, 347], 'Author': [173, 348, 1926], 'Joerg': [174, 186, 349, 361, 1917, 2011], 'Herrmann': [175, 350, 1918], '[email protected]': [176, 351], 'MinnesotaCorrespondence': [184, 359], 'to:': [185, 360], 'MD,': [188, 363], '200': [189, 364], 'First': [190, 365, 379], 'St.': [191, 366], 'SW,': [192, 367], 'MN': [194, 369], '55905.': [195, 370], 'E-mail:': [196, 371], '[email protected]': [197, 372], 'author': [203, 378, 2125], 'published:': [380], '04': [381], 'November': [382], '2016': [383], 'https://doi.org/10.1002/ajh.24599Citations:': [384], '14': [385, 1119, 1198], 'Conflict': [386], 'interest:': [388], 'Authors': [389], 'report': [390], 'no': [391, 1207, 1341, 1378, 1414, 1469], 'conflicts': [392], 'interest.': [394], 'AboutSectionsPDF': [395], 'ToolsRequest': [396], 'permissionExport': [397], 'citationAdd': [398], 'to': [399, 421, 444, 545, 566, 686, 742, 760, 823, 835, 911, 1355, 1426, 1510, 1630, 1666, 1702, 1713, 1722, 1747, 1825, 1907, 1912, 1971, 2122, 2185], 'favoritesTrack': [400], 'citation': [401], 'ShareShare': [402], 'Give': [403], 'accessShare': [404, 407], 'full': [405, 1969], 'text': [406], 'full-text': [408, 423, 447], 'accessPlease': [409], 'review': [410, 2228], 'our': [411, 1538, 1574, 1810], 'Terms': [412, 435], 'Conditions': [414, 437], 'Use': [416], 'check': [418], 'box': [419], 'below': [420, 443], 'share': [422, 445], 'version': [424, 448, 1109, 1118, 2083], 'article.I': [426], 'have': [427, 475, 517, 1508, 1616], 'read': [428], 'accept': [430], 'Wiley': [432], 'Online': [433], 'Library': [434], 'UseShareable': [439], 'LinkUse': [440], 'link': [442], 'a': [446, 461, 574, 605, 634, 678, 716, 928, 951, 1155, 1255, 1275, 1316, 1326, 1649, 1678, 1785, 1863, 2294], 'article': [451], 'your': [453], 'friends': [454], 'colleagues.': [456], 'Learn': [457], 'more.Copy': [458], 'URL': [459], 'Share': [460], 'linkShare': [462], 'onFacebookTwitterLinkedInRedditWechat': [463], 'To': [464, 997], 'Editor:': [466], 'The': [467, 817, 844, 1094, 1178, 1190, 1903, 1916, 1966, 2095], 'outcomes': [470, 1835, 2321], 'myeloma': [473, 1305, 2143, 2180, 2275], '(MM)': [474], 'changed': [476], 'significantly': [477, 1805], 'over': [478, 628], 'past': [480], 'decade': [481], 'introduction': [484], 'novel': [486, 2148, 2295], 'agents': [487], 'including': [488, 1520], 'immunomodulatory': [489], 'drugs': [490], 'like': [491, 496, 1372, 1906], 'proteasome': [494, 1623, 1637, 2254, 2350], 'inhibitors': [495, 1638], '1.': [498, 904], 'In': [499], 'view': [500], 'these': [502, 1837], 'developments,': [503], 'side': [504], 'effects,': [505], 'especially': [506], 'those': [507, 1273, 1424, 1548, 1789], 'profound': [509], 'enduring': [511], 'impact': [512, 1828, 2146], 'such': [513], 'as': [514, 889, 891, 958, 970, 1042, 1566, 1611, 1697, 1699, 1856, 1894], 'cardiovascular': [515, 1596, 1614, 2324], 'toxicities,': [516], 'gained': [518], 'increased': [519, 527, 1448], 'significance.': [520], 'Lenalidomide': [521], 'has': [522, 559, 1673], 'been': [523, 561, 1617, 1674], 'associated': [524, 2218, 2252, 2347], 'an': [526, 687, 1512], 'thromboembolism,': [530], 'angina,': [531], 'atrial': [532], 'fibrillation,': [533], 'bradycardia': [535], '2,': [536], 'whereas': [537], 'labeling': [539], 'information': [540, 2108], 'was': [543, 707, 821, 1185, 1197, 1206, 1247, 1339, 1377, 1412, 1567, 1919], 'updated': [544], 'include': [546], 'precautions': [547], 'regarding': [548, 596], 'possible': [549, 1717, 1782], 'heart': [550, 1300, 1320, 1330, 1571, 2250, 2260], 'failure': [551, 1301, 1321, 1331, 1572, 2251, 2261], '(HF)': [552], 'QT': [554], 'prolongation,': [555], 'even': [556, 1871], 'though': [557, 1203, 1528, 1872], '“causality': [558], 'not': [560, 572, 1447, 1710, 1731, 1756, 1861, 2098], 'established.”': [562], 'Indeed,': [563], 'in': [564, 578, 807, 895, 900, 915, 1010, 1013, 1050, 1160, 1167, 1210, 1294, 1303, 1345, 1350, 1418, 1423, 1472, 1474, 1502, 1537, 1556, 1573, 1598, 1643, 1878, 1888, 1900, 1975, 2080, 2141, 2175, 2221, 2263, 2273, 2297, 2318, 2352], 'contrast': [565], 'post-marking': [567], 'reports,': [568], 'two': [569], 'meta-analyses': [570, 1506], 'did': [571], 'show': [573, 1511], 'statistically': [575, 649, 1342, 1415, 1869], 'significant': [576, 1208, 1343, 1379, 1416, 1470], 'increase': [577, 1471], 'rate': [580, 1212], 'all-grade': [582], 'or': [583, 694, 721, 763, 810, 857, 862, 1044, 1090, 1310, 1755, 1769, 1795, 2103], 'high-grade': [584], 'cardiotoxicities': [585, 600], 'use': [588], '3,': [591, 1522], '4.': [592, 1523], 'Given': [593], 'controversy': [595], 'bortezomib,': [602, 1311], 'we': [603, 1005, 1739, 1751], 'conducted': [604], 'retrospective,': [606], 'analysis': [609, 897, 931, 2258], 'administrative': [611], 'claims': [612, 771], 'data': [613, 626, 647, 1039, 1049, 1587, 1628, 1743, 1818, 1974, 1986, 1992, 2165], 'based': [614, 934], 'on': [615, 627, 935, 1605, 1741, 1819, 1832, 1890, 2166], 'OptumLabs': [617, 1909], 'Data': [618, 1914], 'Warehouse,': [619], 'which': [620, 1676, 1821], 'includes': [621], 'inpatient,': [622], 'outpatient,': [623], 'pharmacy': [625, 734], '100': [629, 1098], 'million': [630], 'privately': [631], 'insured': [632], 'number': [635, 1180, 1192], 'Medicare': [637], 'Advantage': [638], 'enrollees': [639], 'throughout': [640], 'United': [642, 1558], 'States': [643, 1559], '5.': [644], 'All': [645, 671, 1839], 'were': [648, 704, 766, 782, 847, 947, 1030, 1040, 1078, 1101, 1120, 1130, 1152, 1445, 1545, 1730, 2182], 'de-identified': [650], 'accessed': [652], 'using': [653, 804, 832, 1103], 'techniques': [654], 'compliant': [655], 'Insurance': [659], 'Portability': [660], 'Accountability': [662], 'Act': [663], '1996': [665], 'Institutional': [667], 'Review': [668], 'Board': [669], 'regulations.': [670], 'adults': [672], '≥18': [673], 'years': [674, 1159, 1166, 1174], 'age': [676], 'diagnosis': [679, 853, 885, 1257, 1277, 1318, 1328], 'MM': [681, 1601, 1695, 1850, 1898], 'within': [682, 942], '12': [683, 724, 739, 757, 774], 'months': [684, 725, 740, 758, 775], 'prior': [685, 741, 759, 1256, 1276, 1317, 1327], 'index': [688, 728, 780, 820], 'chemotherapy': [689, 729, 744, 749, 781], 'claim': [690], 'either': [692], 'between': [696, 919, 1016, 1023, 1252, 1491], 'January': [697], '1,': [698], '2008': [699], 'December': [701], '31,': [702], '2014': [703], 'eligible;': [705], 'dexamethasone': [706, 2174], 'part': [708], 'both': [710], 'regimens.': [711], 'Additional': [712, 2074], 'inclusion': [713], 'criteria': [714], 'included': [715], 'clean': [717], 'period': [718], '(no': [719], 'bortezomib)': [722], 'before': [726], 'continuous': [731], 'medical': [732], 'enrollment': [735], 'at': [737, 1080, 1602], 'least': [738], 'first': [743, 761, 1081, 1949], 'administration.': [745], 'Patients': [746, 1077, 1151], 'receiving': [747], 'other': [748], '(thalidomide,': [750], 'carfilzomib,': [751, 1086], 'pomalidomide,': [752], 'doxorubicin)': [754], 'during': [755, 840], 'administration': [765], 'excluded.': [767], 'Inpatient': [768], 'outpatient': [770, 863], 'preceding': [776], 'date': [778], 'reviewed': [783, 1732], 'evidence': [785], 'coronary': [787, 867, 870, 980, 1370], 'artery': [788, 871, 981], 'disease,': [789, 792, 795, 982, 985, 988], 'peripheral': [790, 983], 'vascular': [791, 984], 'diabetes,': [793, 986], 'renal': [794, 987], 'HF,': [796, 855, 989], 'hyperlipidemia,': [797, 990], 'hypertension,': [798, 991], 'myocardial': [799], 'infarction': [800], '(MI),': [801], 'arrhythmia': [803, 858, 1422], 'ICD-9': [805, 833, 884], 'codes': [806, 834, 888, 893], 'primary': [809, 851], 'secondary': [811], 'diagnoses': [812], '(Supporting': [813, 1142, 1357, 1381, 1401, 1428, 1449, 1478, 1541], 'Information': [814, 902, 1143, 1148, 1358, 1363, 1382, 1387, 1402, 1407, 1429, 1434, 1450, 1455, 1479, 1484, 1542, 2073, 2076, 2092], 'Table': [815, 903, 1149, 1359, 1383, 1403, 1430, 1451, 1480, 1543], '1).': [816], 'Charlson/Deyo': [818, 995], 'comorbidity': [819, 829], 'used': [822, 894, 906, 1121], 'assess': [824, 998], "patient's": [826], 'overall': [827], 'baseline': [828, 842, 917, 1603, 1796], 'burden': [830, 1594], 'identify': [836], '17': [838], 'conditions': [839], 'period.': [843], 'outcome': [845, 1048], 'measures': [846], '(1)': [848], 'hospitalization': [849, 1214, 1243, 1302, 1536], 'discharge': [852], 'MI,': [856, 992, 1394], '(2)': [860], 'inpatient': [861], 'procedures': [864, 1371], 'percutaneous': [866], 'intervention': [868], '(PCI),': [869], 'bypass': [872], '(CABG),': [873], 'pacemaker': [874], '(PM)': [875], 'implantation,': [876], 'automatic': [878], 'implantable': [879], 'cardioverter': [880], 'defibrillator': [881], '(AICD)': [882], 'implantation.': [883], 'procedure': [887], 'well': [890, 1698], 'CPT': [892], 'are': [898, 1501, 1588, 1664], 'available': [899], 'Supporting': [901, 1147, 1362, 1386, 1406, 1433, 1454, 1483, 2072, 2075, 2091], 'We': [905], 'score': [908], '(PS)': [909], 'matching': [910, 1003, 1034, 1141, 1672], 'adjust': [912], 'imbalances': [914], 'covariates': [918, 1015, 1718], 'group': [925, 1163, 1170, 1353, 1477], 'performed': [927], 'one-to-one': [929], 'without': [932, 1274, 1325], 'replacement': [933], 'estimated': [937], 'PS': [938, 1033, 1140, 1671], 'each': [940, 943, 1075], 'patient': [941, 1539, 1728], 'group.': [944], 'Propensity': [945], 'scores': [946], 'computed': [948, 1102], 'modeling': [950], 'logistic': [952], 'regression,': [953], 'dependent': [956], 'variable': [957], 'odds': [960], 'being': [962, 1711, 1841], 'treated': [963, 1025, 1219, 1307, 2183], 'independent': [968], 'variables': [969], 'age,': [971], 'gender,': [972], 'race,': [973], 'year': [974], 'drug': [976, 1083], 'initiation,': [977], 'history': [978], 'arrhythmia,': [993, 1462], 'index.': [996], 'success': [1000], 'procedure,': [1004], 'measured': [1006], 'standardized': [1007], 'differences': [1008, 1380, 1490], '(measured': [1009], 'percentage': [1011], 'points)': [1012], 'observed': [1014], 'groups.': [1019], 'Differences': [1020], 'that': [1021, 1507, 1529, 1719, 1783, 1849, 1867], 'existed': [1022], 'eliminated': [1031], 'after': [1032, 1139], '(<10%': [1035], 'denotes': [1036], 'balance).': [1037], 'Baseline': [1038], 'presented': [1041], 'frequencies': [1043], 'mean': [1045], 'values': [1046], 'form': [1052], 'Kaplan–Meier': [1054], 'curves': [1055], 'unadjusted': [1057], 'events': [1058, 1519, 1831], 'rates': [1059, 1096, 1531], 'Cox': [1061], 'proportional': [1062], 'hazard': [1063, 1066], 'models': [1064], 'ratios': [1067], '(HR)': [1068], '95%': [1070, 1232, 1267, 1287], 'confidence': [1071], 'intervals': [1072], '(CI)': [1073], 'outcome.': [1076], 'censored': [1079], 'event,': [1082], 'switch': [1084], '(bortezomib,': [1085], 'lenalidomide,': [1087], 'doxorubicin),': [1089], 'end': [1091], 'enrollment.': [1093], 'event': [1095], 'per': [1097], 'patient-years': [1099], '(PY)': [1100], 'person-year': [1105], 'method.': [1106], 'SAS': [1107], 'software': [1108], '9.3': [1110], '(SAS': [1111], 'Institute': [1112], 'Inc,': [1113], 'Cary,': [1114], 'NC)': [1115], 'Stata': [1117], 'analyses.': [1123], 'total': [1125], '2,452': [1127], 'unique': [1128], 'identified,': [1131], '895': [1132, 1136], 'Fig.': [1144, 1235, 1270, 1290, 1364, 1388, 1408, 1435, 1456, 1485], '1': [1145, 2130], '2).': [1150], 'followed': [1153], 'median': [1156, 1179, 1191], '1.2': [1158], '1.3': [1165], '(interquartile': [1171, 1187, 1199], 'range': [1172, 1188, 1200], '0.56–2.29': [1173], '0.64–2.55,': [1176], 'respectively).': [1177], 'refills': [1182], '9': [1186], '4–18).': [1189], 'injections': [1194], '5–24).': [1201], 'Even': [1202], 'higher,': [1204, 1876], 'there': [1205, 1376, 1411], 'difference': [1209, 1344, 1417], 'HF': [1216, 1242, 1259, 1279, 1521, 1535, 1760, 1794], 'compared': [1222, 1354, 1578, 1857], '(3.52/100': [1225], 'PY': [1226, 1261, 1281, 1561], 'vs.': [1227, 1262, 1282], '2.17/100': [1228], 'PY,': [1229, 1264, 1284, 1564], 'HR': [1230, 1265, 1285], '1.54,': [1231], 'CI': [1233, 1268, 1288], '0.84–2.82,': [1234], '1A).': [1236], 'Similar': [1237], 'results': [1238, 1400, 1500, 1663], 'exposure': [1246], 'noted': [1248], 'upon': [1249], 'further': [1250], 'stratification': [1251], '(12.09/100': [1260], '9.76/100': [1263], '1.11,': [1266], '0.46–2.70,': [1269], '1B)': [1271], '(2.31/100': [1280], '1.22/100': [1283], '2.00,': [1286], '0.87–4.64,': [1289], '1C).': [1291], 'Figure': [1292], '1Open': [1293], 'figure': [1295], 'viewerPowerPoint': [1296], 'Event-free': [1297], 'survival': [1298, 1834, 2140], 'from': [1299], 'all-comers': [1312], '(A),': [1313], '(B),': [1322], '(C)': [1332], '(P': [1333], '=': [1334], 'NS': [1335], 'all).': [1337], 'There': [1338], 'also': [1340, 1413, 1446, 1467, 1877], 'MI': [1349, 1533], '3': [1360, 1384, 1404, 1431, 1452, 1481, 2204, 2268], '2A).': [1365], 'Similarly,': [1366], 'when': [1367], 'evaluating': [1368], 'PCI': [1373], 'CABG': [1375, 1397], '2B).': [1389], 'combined': [1391, 1459], 'endpoint': [1392, 1460], 'PCI,': [1395], 'yielded': [1398], 'similar': [1399], '2C).': [1409], 'Finally,': [1410, 1750, 1809], 'exposed': [1425], '3A).': [1436], 'Rates': [1437], 'implantation': [1439], 'PM': [1441], 'AICD': [1443, 1465], 'devices': [1444], '3B).': [1457], 'PM,': [1463], 'placement': [1466], 'showed': [1468], '3C).': [1486], 'Despite': [1487], 'well-known': [1489], 'real': [1492], 'world': [1493], 'clinical': [1495, 2188], 'trial': [1496], 'data,': [1497], 'current': [1499, 1735, 1846], 'agreement': [1503], 'previous': [1505], 'failed': [1509], 'association': [1513], 'adverse': [1517, 1723], 'cardiac': [1518, 1724, 1770, 1797, 1830, 2345], 'It': [1524, 1780], 'is': [1525, 1608, 1781, 1868, 1874, 1892, 1896, 2097], 'note': [1527], 'population': [1540, 1555, 1576, 1583, 1696], '3)': [1544], 'higher': [1546, 1791, 1806, 1870], 'than': [1547, 2116], 'reported': [1549, 2262], 'elsewhere': [1550], 'general': [1553, 1581, 1882], 'adult': [1554, 1582], '(0.816/100': [1560], '0.931/100': [1563], 'respectively)': [1565], 'incidence': [1569], '(12.7%)': [1577], '(2.1%)': [1584], '6.': [1585], 'These': [1586], 'worth': [1589], 'exploring': [1590], 'further,': [1591], 'defining': [1592], 'diseases': [1597], 'therapy.': [1606], 'This': [1607], 'particularly': [1609], 'pertinent': [1610], 'concerns': [1612], 'toxicity': [1615, 2346], 'raised': [1618], 'second': [1621], 'generation': [1622], 'inhibitor': [1624], 'carfilzomib': [1625], 'post-approval': [1627], 'yet': [1629], 'be': [1631, 1804, 2078, 2120], 'acquired': [1632], 'ixazomib': [1634], '(marizomib,': [1639], 'oprozomib,': [1640], 'delanzomib)': [1642], 'various': [1644], 'phases': [1645], 'development': [1647], 'wide': [1650], 'array': [1651], 'malignancies': [1653], 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