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'have': [353, 1024], 'led': [354], 'myriad': [357], 'devices,': [359, 379, 446], 'including': [360, 578, 1197], 'different': [361], 'filters,': [362], 'proximal': [363, 643, 1221], 'occluders,': [364], 'combination': [366], 'rinse': [368], 'aspirators—all': [370], 'GuardWire': [374], 'device': [375, 1056, 1067, 1083, 1405, 1765], 'other': [377, 649, 887, 1096, 1490], 'approved': [378, 401], 'arguing': [380], 'that': [381, 628, 658, 976, 995, 1038, 1109, 1350], 'it': [382, 991, 1099, 1383, 1398, 1426], 'no': [384, 481, 1036, 1106, 1493], 'longer': [385, 482, 872], 'ethical': [386], 'perform': [388], 'EPD.': [395, 857], 'Many': [396], 'technologies': [397], 'noninferiority': [399], 'received': [404], 'Administration': [408], 'approval': [409], 'marketing': [411], 'United': [414, 463, 728, 1701], 'States—without': [415], 'challenging': [416], 'findings': [418], 'performing': [424, 1440], 'study': [426, 660, 696, 845, 934, 957, 1286], 'arm.Yet,': [433], 'despite': [434], 'level': [436], 'recommendation,': [438], 'improved': [441], 'profile': [442, 541], 'available': [444, 483, 545], 'marketed': [445], 'has': [454], 'fallen': [455], 'as': [457, 459, 639, 819, 965, 1074, 1253, 1275], 'low': [458, 904], '21%': [460], 'States,': [464], 'according': [465], 'National': [468, 684, 912, 1711, 2153], 'Data': [470, 686, 914, 1713, 1875, 1899, 2155], 'Registry.7': [471], 'many': [475], 'marketing,': [485], 'operators': [487, 1320], 'more': [489], 'selective': [490], 'alternative': [497, 567], 'strategies': [498, 568, 1230], 'treatment': [501, 1116], 'lesions.There': [504], 'numerous': [506], 'reasons': [507], 'explain': [509], 'decline': [511], 'devices.': [516, 837], 'First,': [517], 'current': [518, 2413], 'cumbersome': [522], 'add': [524], 'complexity': [525, 1152], 'procedure.': [528], 'Second,': [529, 902], 'they': [530, 617], 'not': [532, 548, 559, 663, 740, 758, 936, 959, 1362, 1501], 'suitable': [533], 'every': [535], 'case': [536], 'anatomic': [539], 'limitations.': [542], 'Third,': [543, 932], 'EPDs': [546], 'bullet': [549], 'proof': [550], 'prevention': [553], 'free': [560], 'complications.': [562], 'Fourth,': [563], 'over': [564], 'time,': [565], 'simpler': [566], 'reduce': [570], 'practice,': [577], 'direct': [582, 966, 1237, 1934], 'stenting8': [583], 'undersizing': [585], 'stents': [586, 593, 1989], 'higher': [588, 879], 'stent/lesion': [589], 'length': [590], 'ratio,9': [591], 'special': [592], 'nitinol': [596, 1244], 'mesh,10': [597], 'stents,': [599], 'laser': [601, 1241, 2083], 'atherectomy.11': [602], 'None': [603], 'approaches': [606], 'well-designed': [611], 'clinical': [613, 1120, 1937, 2194], 'trial,': [614, 654], 'even': [615], 'though': [616], 'gained': [618], 'popularity': [619], 'among': [620], 'operators.': [621], 'Finally,': [622, 955, 1301], 'there': [623, 770, 1104], 'skepticism': [625], 'disbelief': [627], 'apply': [633, 1126], 'lesions,': [637, 703, 873, 1194, 1226], 'such': [638, 964, 1073, 1252], 'in-stent': [640, 1228], 'restenosis': [641], 'anastomosis,': [646, 1224], 'limitations': [650], 'notion': [656], 'do': [662], 'support': [664], 'routine': [665, 1450], 'interventions.In': [672], 'this': [673, 793, 843, 1498], 'issue': [674], 'Circulation:': [676, 2388], 'Interventions,': [678, 2390, 2449], 'al12': [681], 'Registry': [687, 689, 915, 917, 1708, 2156], 'CathPCI': [688, 916, 1707, 2157], 'conduct': [691], 'large': [693], 'retrospective': [694], 'observational': [695, 844], '49': [698, 2146], '325': [699, 2147], 'who': [704, 853, 862, 870], 'treated': [706, 855, 1941], 'between': [711, 895], 'years': [713, 766, 811], '2005': [714], '2009.': [716], 'Their': [717], 'corroborate': [719], 'previously': [721], 'reported': [722], 'underuse': [723], 'States': [729], '21%,': [732], 'when': [733, 893, 1098, 1403, 1439, 1457], 'one': [734, 1107], 'third': [735], 'centers': [738], 'did': [739, 935, 958], '5.6%': [747], '>50%': [751], 'PCI.': [754], 'Surprisingly,': [755], 'reduced': [761], 'after': [764, 1031, 1644], '3': [765, 810, 1182, 2464], 'follow-up.': [768], 'Moreover,': [769], 'adjusted': [774], 'risk': [775, 1144, 1176], 'no-reflow,': [777], 'dissection': [778, 1086], 'perforation,': [780], 'short-term': [786], 'follow-up': [787, 922], 'EPD.Although': [792], 'registry': [794, 2080], 'largest': [797], 'all-comers': [798], 'cohort': [799], 'mortality': [813], 'data,': [814], "study's": [816], 'limitations,': [818], 'illustrated': [820], 'authors,': [823], 'preclude': [824], 'drawing': [825], 'definitive': [826, 1422], 'conclusions': [827], 'on': [828, 924, 1050, 1118, 1140, 1172, 1358, 1834, 1936, 1946], 'safety': [833], 'Among': [838], 'deficiencies': [841], 'selection': [848, 1053, 1133], 'bias': [849], 'primarily': [860, 987], 'presented': [863], 'acute': [865, 1189, 2093], 'syndrome': [867, 1191, 2404], 'had': [871], 'translated': [875], 'lesions': [877, 1415], 'burden': [881], 'degenerative': [883, 945, 1195], 'score.': [884], 'confounders': [888], 'difficult': [890], 'adjust': [892], 'comparing': [894], 'non-EPD': [900], 'group.': [901], 'quality': [905], 'data': [908, 1423], 'source': [909], 'from': [910, 1021, 1463, 1470, 1482, 1650, 1705, 2327], 'lacked': [918], 'consistent': [919], 'biomarkers': [920], 'collection,': [921], 'outcomes': [923, 2134], 'majority': [926], 'patients,': [929, 990], 'monitoring.': [931], 'assess': [937], 'morphology,': [939], 'volume,': [941], 'score,': [946], 'be': [951, 993, 1137, 1162, 1234, 1261, 1273, 1309, 1369, 1375], 'correlated': [952], 'outcome.13': [954], 'detail': [960], 'procedural': [962], 'techniques,': [963], 'stenting,8': [967], 'stent': [968, 1239, 2036], 'undersizing,9': [969], 'pre-emptive': [974], 'vasodilators,14': [975], 'may': [977, 1260], 'affect': [978], 'event': [982, 1344, 1379], 'rates.Because': [983], 'higher-risk': [989], 'could': [992], 'argued': [994], 'beneficial': [999], 'patient': [1003, 1052], 'population': [1004, 1012], 'equates': [1006], 'lower-risk': [1011], 'use.Overall,': [1015], 'studies': [1016], 'examining': [1017], 'collected': [1020], 'shown': [1025], 'wide': [1027], 'incidence': [1028], 'intervention.15': [1033], 'There': [1034], 'doubt': [1037], 'can': [1040, 1272, 1374, 1416], 'debris.': [1045], 'Its': [1046], 'benefits,': [1047], 'however,': [1048, 1373], 'rely': [1049], 'appropriate': [1051, 1322], 'proper': [1055, 1115], 'use—both': [1057], 'require': [1060], 'familiarity': [1061, 1305], 'experience': [1063, 1303], 'specific': [1066], 'potential': [1071], 'complications,': [1072], 'misuse': [1079], 'device,': [1082], 'entrapment,': [1084], 'perforation': [1088], 'coronary.13,16Like': [1094], 'interventions,': [1097], 'comes': [1100], 'intervention,': [1103, 1130], 'size': [1108], 'fits': [1110], 'all.': [1111], 'Selection': [1112], 'based': [1117, 1139, 1171], 'presentation': [1121], 'morphology': [1124, 1266], 'should': [1125, 1136, 1288, 1308, 1318], 'also': [1127], 'tailored': [1138], 'degree': [1142, 1174], 'facilitation': [1149], 'anatomy': [1155], 'safely.': [1159], 'It': [1160], 'would': [1161], 'helpful': [1163, 1262], 'if': [1164], 'decision': [1166], 'using': [1168, 2217, 2269], 'embolization.': [1179], 'We': [1180], 'suggest': [1181], 'levels': [1183], 'recommendations:High:': [1185], 'In': [1186, 1209], 'thrombus-containing': [1193], 'lipid–containing': [1199, 1269], 'optical': [1202, 1254], 'coherence': [1203, 1255], 'tomography': [1204, 1256], 'near-infrared': [1206, 1258], 'spectroscopy/intravascular': [1207], 'ultrasound.Intermediate:': [1208], 'focal': [1210, 1414], 'lesion,': [1211], 'calcified': [1212], 'torturous': [1214], 'anatomy,': [1215], 'borderline': [1217], 'landing': [1218], 'zone.Low:': [1219], 'For': [1220], 'fibrotic': [1225], 'restenosis.Alternative': [1229], 'include': [1236], 'stenting,': [1238], 'undersizing,': [1240], 'atherectomy,': [1242], 'mesh': [1245], 'covered': [1247], 'stents.': [1248], 'Intracoronary': [1249], 'imaging': [1250], 'modalities,': [1251], 'spectroscopy,': [1259], 'stratify': [1264], 'guidance': [1276], 'need': [1279, 1447], 'intervention.': [1284], 'Future': [1285], 'take': [1289, 1434], 'factors': [1291], 'heterogeneous': [1294], 'nature': [1295], 'disease': [1298], 'into': [1299], 'consideration.': [1300], 'operator': [1302], 'addressed': [1310], 'interventional': [1312], 'programs,': [1313], 'continued': [1315], 'education': [1316], 'activities': [1317], 'train': [1319], 'devices.The': [1326], 'analogous': [1331], 'seat': [1337, 1351, 1391, 1436], 'belt,': [1338], 'prevents': [1340], 'injury': [1341], 'car': [1347], 'accident.': [1348], 'Myths': [1349], 'belts': [1352], 'needed': [1354], 'while': [1356, 1393], 'driving': [1357], 'highway': [1360], 'city': [1365], 'proven': [1367], 'wrong.': [1370], 'belts,': [1372], 'hazardous': [1376], 'fire.': [1381], 'Yet,': [1382], 'law': [1386], 'always': [1388], 'wear': [1389], 'belt': [1392, 1437], 'driving.': [1394], 'Similarly,': [1395], 'EPD,': [1397], 'hard': [1400], 'predict': [1402], 'will': [1406], 'catastrophic': [1409], 'event.': [1410], 'Sometimes,': [1411], 'result': [1417], 'Until': [1421], 'proves': [1424], 'otherwise,': [1425], 'too': [1428, 1431], 'early': [1429], 'risky': [1432], 'off': [1438], 'interventions': [1441, 1886], 'lesions;': [1444], 'therefore,': [1445], 'consider': [1449], 'appropriate.DisclosuresDr': [1458], 'reports': [1460, 1492], 'personal': [1461, 1480], 'fees': [1462, 1481], 'Biotronik,': [1464], 'Medtronic,': [1465], 'Abbott': [1467], 'Vascular;': [1468], 'grants': [1469, 1478], 'Medicines': [1472], 'Company': [1473], 'Edwards': [1475], 'Lifesciences;': [1476], 'AstraZeneca,': [1483], 'Boston': [1484], 'Scientific,': [1485], 'Biosensors': [1487], 'International.': [1488], 'author': [1491], 'conflicts.FootnotesThe': [1494], 'opinions': [1495], 'expressed': [1496], 'article': [1499], 'necessarily': [1502], 'those': [1503], 'editors': [1506], 'Heart': [1511, 1830, 1950, 2471], 'Association.Correspondence': [1512], 'MD,': [1516], '110': 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