Title: Treatment Satisfaction Of Osteoporosis Medication In Postmenopausal Women Of Korea; Results From The Study Of Osteoporosis Medication Adherence And Satisfaction In Postmenopausal Women
Abstract: We investigated clinical features, medication adherence, treatment satisfaction, and quality of life in postmenopausal osteoporosis(PMO) women with osteoporosis medication. Satisfaction to osteoporosis medication in postmenopausal women is important. Here we report on the treatment satisfaction of osteoporosis medication in PMO women. This was a multi-centered, cross-sectional, and observational study. Postmenopausal women prescribed with osteoporosis medications for 1 to 12 months were enrolled at 28 general hospitals from March 2013 to July 2014. Treatment satisfaction was measured with 4 domains of Treatment Satisfaction Questionnaire for Medication(TSQM): effectiveness, side effects, convenience, and global satisfaction. Potential factors related to TSQM collected by medical chart review were age, comorbidities, osteoporosis, fracture, treatment period, GI protectants, treatment pattern, and number of gastrointestinal risk factors(GI RFs). Also, dental surgical procedure, smoking, and adherence were collected through patient’s survey as the potential associating factors. A total of 1,804 patients were analyzed. The TSQM means were 56.1±11.8 in effectiveness, 64.2±22.5 in side-effects, 63.0±12.7 in convenience, and 53.8±15.3 in global satisfaction. Associations with higher effectiveness, convenience, and global satisfaction were shown in HRT use compared to BPP use, adherence compared to non-adherence, no dental surgical procedure compared to dental surgical procedure, greater number of GI RFs. In addition, SERM use compared to BPP use was related with convenience and global satisfaction; longer treatment period was related with effectiveness and global satisfaction. GI protectants use compared to non-use were associated with global satisfaction. Also, the convenience was related with 2 more factors: age and comorbidities. All these associations were statistically significant(p<0.05). Side-effect was not related to any of the factors. Treatment pattern, adherence, treatment period, number of GI RFs, age, comorbidities, GI protectants use, and dental surgical procedure were related to treatment satisfaction in PMO patients. These factors should be considered to increase the treatment satisfaction in PMO patients.