Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2537384127', 'doi': 'https://doi.org/10.1080/09637486.2016.1244661', 'title': 'A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation', 'display_name': 'A randomised, double-blind, placebo-controlled clinical study: the effects of a synbiotic, Lepicol, in adults with chronic, functional constipation', 'publication_year': 2016, 'publication_date': '2016-10-24', 'ids': {'openalex': 'https://openalex.org/W2537384127', 'doi': 'https://doi.org/10.1080/09637486.2016.1244661', 'mag': '2537384127', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27776217'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/09637486.2016.1244661', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S58312864', 'display_name': 'International Journal of Food Sciences and Nutrition', 'issn_l': '0963-7486', 'issn': ['0963-7486', '1465-3478'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043063398', 'display_name': 'Sally Cudmore', 'orcid': 'https://orcid.org/0000-0002-3131-7428'}, 'institutions': [{'id': 'https://openalex.org/I4210152051', 'display_name': 'Atlantia Food Clinical Trials', 'ror': 'https://ror.org/03ynpnz81', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210152051']}, {'id': 'https://openalex.org/I4210141138', 'display_name': 'APC Microbiome Institute', 'ror': 'https://ror.org/03f2ct267', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210141138']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Sally Cudmore', 'raw_affiliation_strings': ['APC Microbiome Institute, University College Cork, Cork, Ireland;', 'Atlantia Food Clinical Trials, Cork, Ireland;'], 'affiliations': [{'raw_affiliation_string': 'Atlantia Food Clinical Trials, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210152051']}, {'raw_affiliation_string': 'APC Microbiome Institute, University College Cork, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210141138', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043952619', 'display_name': 'Andrea Doolan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210152051', 'display_name': 'Atlantia Food Clinical Trials', 'ror': 'https://ror.org/03ynpnz81', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210152051']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Andrea Doolan', 'raw_affiliation_strings': ['Atlantia Food Clinical Trials, Cork, Ireland;'], 'affiliations': [{'raw_affiliation_string': 'Atlantia Food Clinical Trials, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210152051']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057930637', 'display_name': 'Seán Lacey', 'orcid': 'https://orcid.org/0000-0003-3005-6294'}, 'institutions': [{'id': 'https://openalex.org/I4210100923', 'display_name': 'Munster Technological University', 'ror': 'https://ror.org/013xpqh61', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100923']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Seán Lacey', 'raw_affiliation_strings': ['Department of Mathematics, Cork Institute of Technology, Cork, Ireland;'], 'affiliations': [{'raw_affiliation_string': 'Department of Mathematics, Cork Institute of Technology, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210100923']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5069986091', 'display_name': 'Fergus Shanahan', 'orcid': 'https://orcid.org/0000-0003-0467-0936'}, 'institutions': [{'id': 'https://openalex.org/I4210152051', 'display_name': 'Atlantia Food Clinical Trials', 'ror': 'https://ror.org/03ynpnz81', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210152051']}, {'id': 'https://openalex.org/I4210141138', 'display_name': 'APC Microbiome Institute', 'ror': 'https://ror.org/03f2ct267', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210141138']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}, {'id': 'https://openalex.org/I2802396013', 'display_name': 'Cork University Hospital', 'ror': 'https://ror.org/04q107642', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802396013']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Fergus Shanahan', 'raw_affiliation_strings': ['APC Microbiome Institute, University College Cork, Cork, Ireland;', 'Atlantia Food Clinical Trials, Cork, Ireland;', 'Cork University Hospital, School of Medicine, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Atlantia Food Clinical Trials, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210152051']}, {'raw_affiliation_string': 'APC Microbiome Institute, University College Cork, Cork, Ireland;', 'institution_ids': ['https://openalex.org/I4210141138', 'https://openalex.org/I27577105']}, {'raw_affiliation_string': 'Cork University Hospital, School of Medicine, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I2802396013', 'https://openalex.org/I27577105']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5043063398'], 'corresponding_institution_ids': ['https://openalex.org/I4210152051', 'https://openalex.org/I4210141138', 'https://openalex.org/I27577105'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.992, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.910675, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '68', 'issue': '3', 'first_page': '366', 'last_page': '377'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10365', 'display_name': 'Gastrointestinal motility and disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10365', 'display_name': 'Gastrointestinal motility and disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2715', 'display_name': 'Gastroenterology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12089', 'display_name': 'Intestinal and Peritoneal Adhesions', 'score': 0.976, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12489', 'display_name': 'Microbial Metabolites in Food Biotechnology', 'score': 0.9756, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/laxative', 'display_name': 'Laxative', 'score': 0.85248536}, {'id': 'https://openalex.org/keywords/functional-constipation', 'display_name': 'Functional constipation', 'score': 0.745461}, {'id': 'https://openalex.org/keywords/prebiotic', 'display_name': 'Prebiotic', 'score': 0.45541078}, {'id': 'https://openalex.org/keywords/placebo-group', 'display_name': 'Placebo group', 'score': 0.45010963}], 'concepts': [{'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.86106414}, {'id': 'https://openalex.org/C2780661987', 'wikidata': 'https://www.wikidata.org/wiki/Q217972', 'display_name': 'Laxative', 'level': 3, 'score': 0.85248536}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84249324}, {'id': 'https://openalex.org/C2781112942', 'wikidata': 'https://www.wikidata.org/wiki/Q178436', 'display_name': 'Constipation', 'level': 2, 'score': 0.7562394}, {'id': 'https://openalex.org/C2779642851', 'wikidata': 'https://www.wikidata.org/wiki/Q5508805', 'display_name': 'Functional constipation', 'level': 3, 'score': 0.745461}, {'id': 'https://openalex.org/C3017955636', 'wikidata': 'https://www.wikidata.org/wiki/Q178436', 'display_name': 'Chronic constipation', 'level': 3, 'score': 0.6432741}, {'id': 'https://openalex.org/C108797546', 'wikidata': 'https://www.wikidata.org/wiki/Q204015', 'display_name': 'Defecation', 'level': 2, 'score': 0.5847383}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5812578}, {'id': 'https://openalex.org/C2779951463', 'wikidata': 'https://www.wikidata.org/wiki/Q7268788', 'display_name': 'Quality of life (healthcare)', 'level': 2, 'score': 0.5378195}, {'id': 'https://openalex.org/C2775980262', 'wikidata': 'https://www.wikidata.org/wiki/Q218870', 'display_name': 'Prebiotic', 'level': 2, 'score': 0.45541078}, {'id': 'https://openalex.org/C3017583242', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Placebo group', 'level': 4, 'score': 0.45010963}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.43464127}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.43418062}, {'id': 'https://openalex.org/C1862650', 'wikidata': 'https://www.wikidata.org/wiki/Q186005', 'display_name': 'Physical therapy', 'level': 1, 'score': 0.42942703}, {'id': 'https://openalex.org/C2780255968', 'wikidata': 'https://www.wikidata.org/wiki/Q1816730', 'display_name': 'Probiotic', 'level': 3, 'score': 0.41972718}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.39690953}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.07113731}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003248', 'descriptor_name': 'Constipation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004043', 'descriptor_name': 'Dietary Fiber', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D007444', 'descriptor_name': 'Inulin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D019936', 'descriptor_name': 'Probiotics', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D058616', 'descriptor_name': 'Synbiotics', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003248', 'descriptor_name': 'Constipation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003672', 'descriptor_name': 'Defecation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003672', 'descriptor_name': 'Defecation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004043', 'descriptor_name': 'Dietary Fiber', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007444', 'descriptor_name': 'Inulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019936', 'descriptor_name': 'Probiotics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011788', 'descriptor_name': 'Quality of Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058616', 'descriptor_name': 'Synbiotics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/09637486.2016.1244661', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S58312864', 'display_name': 'International Journal of Food Sciences and Nutrition', 'issn_l': '0963-7486', 'issn': ['0963-7486', '1465-3478'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27776217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W134147560', 'https://openalex.org/W1479822772', 'https://openalex.org/W1490141590', 'https://openalex.org/W1742607873', 'https://openalex.org/W1893993890', 'https://openalex.org/W1966250447', 'https://openalex.org/W1967828768', 'https://openalex.org/W1971889126', 'https://openalex.org/W1972889877', 'https://openalex.org/W1981331700', 'https://openalex.org/W2018628066', 'https://openalex.org/W2027490473', 'https://openalex.org/W2035066683', 'https://openalex.org/W2048335298', 'https://openalex.org/W2049421425', 'https://openalex.org/W2051720609', 'https://openalex.org/W2056304431', 'https://openalex.org/W2080472404', 'https://openalex.org/W2087434656', 'https://openalex.org/W2089084311', 'https://openalex.org/W2102635366', 'https://openalex.org/W2119545769', 'https://openalex.org/W2133091139', 'https://openalex.org/W2137160419', 'https://openalex.org/W2145469804', 'https://openalex.org/W4213072300', 'https://openalex.org/W60453086'], 'related_works': ['https://openalex.org/W3188252153', 'https://openalex.org/W2997597874', 'https://openalex.org/W2917202268', 'https://openalex.org/W2900295547', 'https://openalex.org/W2527580960', 'https://openalex.org/W2441580825', 'https://openalex.org/W2412058508', 'https://openalex.org/W2264709033', 'https://openalex.org/W2083748765', 'https://openalex.org/W2020918128'], 'abstract_inverted_index': {'The': [0], 'study': [1], 'objective': [2], 'was': [3, 150], 'to': [4, 36, 42, 137, 144], 'evaluate': [5], 'the': [6, 70, 108, 115, 138, 158], 'safety': [7], 'and': [8, 15, 78, 127, 148], 'effects': [9], 'of': [10, 59, 65, 101, 125, 134, 141], 'Lepicol®': [11], '(pysllium': [12], 'fibre,': [13], 'inulin': [14], '5': [16], 'probiotic': [17], 'strains)': [18], 'in': [19, 69, 99, 114, 123, 130, 154, 157], 'adults': [20], 'with': [21, 32, 62, 87, 107, 132], 'chronic,': [22], 'functional': [23, 33], 'constipation': [24, 34, 142], 'during': [25], 'a': [26, 145, 151], '4': [27, 105], 'week': [28, 84, 92], 'intervention.': [29], '69': [30], 'subjects': [31], 'according': [35], 'Rome': [37], 'III': [38], 'criteria': [39], 'were': [40], 'randomised': [41], 'receive': [43], 'Lepicol': [44, 71, 116, 159], '(n': [45, 50], '=': [46, 51], '35)': [47], 'or': [48], 'placebo': [49, 74, 82], '34)': [52], 'daily.': [53], 'Both': [54, 94], 'groups': [55, 95], 'had': [56, 120], 'improved': [57, 143], 'frequency': [58], 'bowel': [60, 67], 'movements,': [61], 'an': [63], 'increase': [64, 129], '1.082': [66], 'movements': [68], 'group': [72], 'over': [73], 'after': [75, 83], 'one': [76], 'week,': [77], '1.079': [79], 'more': [80], 'than': [81], '2,': [85], 'but': [86], 'no': [88], 'significant': [89, 97, 152], 'difference': [90], 'at': [91, 104], '4.': [93], 'showed': [96], 'improvements': [98], 'quality': [100, 133], 'life': [102, 135], 'scores': [103], 'weeks,': [106], 'average': [109], 'score': [110], 'being': [111], '12.033%': [112], 'better': [113], 'group,': [117], 'which': [118], 'also': [119], '15.2%': [121], 'improvement': [122], 'intensity': [124], 'symptoms': [126], '28.5%': [128], 'satisfaction': [131], 'compared': [136], 'placebo.': [139], 'Symptoms': [140], 'greater': [146], 'degree': [147], 'there': [149], 'reduction': [153], 'laxative': [155], 'use': [156], 'group.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2537384127', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-12-12T18:57:20.378094', 'created_date': '2016-10-28'}