Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2530970334', 'doi': 'https://doi.org/10.18632/oncotarget.12647', 'title': 'Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells', 'display_name': 'Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells', 'publication_year': 2016, 'publication_date': '2016-10-13', 'ids': {'openalex': 'https://openalex.org/W2530970334', 'doi': 'https://doi.org/10.18632/oncotarget.12647', 'mag': '2530970334', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27779109', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5354843'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12647', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12647&path%5B%5D=40064', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12647&path%5B%5D=40064', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004456284', 'display_name': 'Dong Pan', 'orcid': 'https://orcid.org/0000-0003-2067-6983'}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dong Pan', 'raw_affiliation_strings': ['Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'University of Chinese Academy of Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Chinese Academy of Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I4210165038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003775716', 'display_name': 'Yaxiong Chen', 'orcid': 'https://orcid.org/0000-0002-2903-6723'}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yaxiong Chen', 'raw_affiliation_strings': ['Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102254599', 'display_name': 'Yarong Du', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yarong Du', 'raw_affiliation_strings': ['Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101047461', 'display_name': 'Zhenxin Ren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenxin Ren', 'raw_affiliation_strings': ['Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103010592', 'display_name': 'Xiaoman Li', 'orcid': 'https://orcid.org/0000-0002-2296-5677'}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210165038', 'display_name': 'University of Chinese Academy of Sciences', 'ror': 'https://ror.org/05qbk4x57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210165038']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoman Li', 'raw_affiliation_strings': ['Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'University of Chinese Academy of Sciences, Beijing, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Chinese Academy of Sciences, Beijing, China', 'institution_ids': ['https://openalex.org/I4210165038']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101460086', 'display_name': 'Burong Hu', 'orcid': 'https://orcid.org/0000-0003-0156-9154'}, 'institutions': [{'id': 'https://openalex.org/I4210131271', 'display_name': 'Institute of Modern Physics', 'ror': 'https://ror.org/03x8rhq63', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210131271']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Burong Hu', 'raw_affiliation_strings': ['Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu, China', 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences & Key Laboratory of Space Radiobiology of Gansu Province, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China', 'institution_ids': ['https://openalex.org/I4210131271', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu, China', 'institution_ids': ['https://openalex.org/I3923682']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.249, 'has_fulltext': False, 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.683517, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '8', 'issue': '3', 'first_page': '4422', 'last_page': '4435'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/radioresistance', 'display_name': 'Radioresistance', 'score': 0.8466707}, {'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.533048}, {'id': 'https://openalex.org/keywords/cell-plasticity', 'display_name': 'Cell Plasticity', 'score': 0.509475}], 'concepts': [{'id': 'https://openalex.org/C58962609', 'wikidata': 'https://www.wikidata.org/wiki/Q2353022', 'display_name': 'Radioresistance', 'level': 3, 'score': 0.8466707}, {'id': 'https://openalex.org/C2984488660', 'wikidata': 'https://www.wikidata.org/wiki/Q530471', 'display_name': 'Chinese academy of sciences', 'level': 3, 'score': 0.5961774}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.551331}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.49675947}, {'id': 'https://openalex.org/C81729549', 'wikidata': 'https://www.wikidata.org/wiki/Q4649475', 'display_name': 'A549 cell', 'level': 3, 'score': 0.48467758}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.462685}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.43383062}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.41191897}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36892733}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.3447538}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.21918634}, {'id': 'https://openalex.org/C191935318', 'wikidata': 'https://www.wikidata.org/wiki/Q148', 'display_name': 'China', 'level': 2, 'score': 0.20523366}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18397471}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16693321}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.1012359}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011836', 'descriptor_name': 'Radiation Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050720', 'descriptor_name': 'Retinoblastoma-Like Protein p107', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000072283', 'descriptor_name': 'A549 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050720', 'descriptor_name': 'Retinoblastoma-Like Protein p107', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12647', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12647&path%5B%5D=40064', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5354843', 'pdf_url': 'https://europepmc.org/articles/pmc5354843?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354843', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27779109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12647', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12647&path%5B%5D=40064', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.59, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1268281962', 'https://openalex.org/W1501446652', 'https://openalex.org/W1503137832', 'https://openalex.org/W1590109449', 'https://openalex.org/W1863403460', 'https://openalex.org/W1966248949', 'https://openalex.org/W1971708895', 'https://openalex.org/W1974468502', 'https://openalex.org/W1975232516', 'https://openalex.org/W1979878315', 'https://openalex.org/W1981095724', 'https://openalex.org/W1991102099', 'https://openalex.org/W1995086523', 'https://openalex.org/W2002104092', 'https://openalex.org/W2007201884', 'https://openalex.org/W2009000841', 'https://openalex.org/W2009231929', 'https://openalex.org/W2010251891', 'https://openalex.org/W2011006143', 'https://openalex.org/W2013170090', 'https://openalex.org/W2017830084', 'https://openalex.org/W2025031749', 'https://openalex.org/W2028483534', 'https://openalex.org/W2030857870', 'https://openalex.org/W2031146595', 'https://openalex.org/W2036048970', 'https://openalex.org/W2040257851', 'https://openalex.org/W2060446375', 'https://openalex.org/W2065247841', 'https://openalex.org/W2065289282', 'https://openalex.org/W2072255720', 'https://openalex.org/W2081403346', 'https://openalex.org/W2081736214', 'https://openalex.org/W2092788984', 'https://openalex.org/W2101733145', 'https://openalex.org/W2103405053', 'https://openalex.org/W2103983684', 'https://openalex.org/W2107038650', 'https://openalex.org/W2111131204', 'https://openalex.org/W2127362646', 'https://openalex.org/W2128368447', 'https://openalex.org/W2129695120', 'https://openalex.org/W2130201056', 'https://openalex.org/W2131620064', 'https://openalex.org/W2134257943', 'https://openalex.org/W2138342865', 'https://openalex.org/W2141410747', 'https://openalex.org/W2149672704', 'https://openalex.org/W2154251974', 'https://openalex.org/W2159405962', 'https://openalex.org/W2162939320', 'https://openalex.org/W2163216399', 'https://openalex.org/W2165928290', 'https://openalex.org/W2165948908', 'https://openalex.org/W2170554811', 'https://openalex.org/W2171634093', 'https://openalex.org/W2180427602', 'https://openalex.org/W2358970259', 'https://openalex.org/W2917837889'], 'related_works': ['https://openalex.org/W3029267387', 'https://openalex.org/W2902329290', 'https://openalex.org/W2603251817', 'https://openalex.org/W2151182744', 'https://openalex.org/W2128056428', 'https://openalex.org/W2107880877', 'https://openalex.org/W2089826616', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473', 'https://openalex.org/W2024490794'], 'abstract_inverted_index': {'//': [0], 'Dong': [1], 'Pan': [2], '1,': [3, 20, 25], '2': [4, 21, 61], ',': [5, 9, 13, 17, 22], 'Yaxiong': [6], 'Chen': [7], '1': [8, 12, 16, 27], 'Yarong': [10], 'Du': [11], 'Zhenxin': [14], 'Ren': [15], 'Xiaoman': [18], 'Li': [19], 'Burong': [23, 97], 'Hu': [24], '3': [26, 70], 'Key': [28, 43], 'Laboratory': [29, 44], 'of': [30, 37, 40, 45, 48, 52, 57, 63, 66, 74, 77, 142, 155, 199, 216, 220, 241, 248, 257, 265, 286, 312, 335], 'Heavy': [31], 'Ion': [32], 'Radiation': [33, 75], 'Biology': [34], 'and': [35, 82, 86, 147, 157, 197, 251, 270, 282, 292, 341, 350], 'Medicine': [36, 76], 'Chinese': [38, 55, 64], 'Academy': [39, 56, 65], 'Sciences': [41, 88], '&': [42], 'Space': [46], 'Radiobiology': [47], 'Gansu': [49], 'Province,': [50], 'Institute': [51], 'Modern': [53], 'Physics,': [54], 'Sciences,': [58, 67], 'Lanzhou,': [59], 'China': [60, 69, 94], 'University': [62], 'Beijing,': [68], 'Collaborative': [71], 'Innovation': [72], 'Center': [73], 'Jiangsu': [78], 'Higher': [79], 'Education': [80], 'Institutions': [81], 'School': [83], 'for': [84], 'Radiological': [85], 'Interdisciplinary': [87], '(RAD-X),': [89], 'Soochow': [90], 'University,': [91], 'Suzhou,': [92], 'Jiangsu,': [93], 'Correspondence': [95], 'to:': [96], 'Hu,': [98], 'email:': [99], '[email protected]': [100], 'Keywords:': [101], 'three': [102], 'dimensional': [103, 124], 'cultured': [104, 167, 290, 338], 'cells,': [105], 'radioresistance,': [106], 'methylation,': [107], 'promoter,': [108], 'RBL1': [109, 227, 249, 258, 266, 287, 313], 'Received:': [110], 'August': [111], '04,': [112], '2016    ': [113, 117], 'Accepted:': [114], 'September': [115], '29,': [116], 'Published:': [118], 'October': [119], '13,': [120], '2016': [121], 'ABSTRACT': [122], 'Three': [123], '(3D)': [125], 'culture': [126, 133], 'in': [127, 144, 152, 168, 177, 204, 230, 237, 253, 260, 279, 319, 344], 'vitro': [128], 'is': [129, 148, 303], 'a': [130, 328], 'new': [131, 329], 'cell': [132, 194, 200, 221, 339], 'model': [134, 340], 'that': [135, 164, 192], 'more': [136, 172], 'closely': [137], 'mimics': [138], 'the': [139, 143, 153, 181, 193, 211, 217, 246, 254, 268, 272, 304, 309, 323, 333, 336], 'physiology': [140], 'features': [141, 334], 'vivo': [145], 'environment': [146], 'being': [149], 'used': [150], 'widely': [151], 'field': [154], 'medical': [156], 'biological': [158], 'research.': [159], 'It': [160], 'has': [161], 'been': [162], 'demonstrated': [163], 'cancer': [165, 348], 'cells': [166, 176, 207, 233, 236, 294, 321], '3D': [169, 205, 231, 261, 289, 320, 337], 'matrices': [170], 'are': [171, 208], 'radioresistant': [173], 'compared': [174, 234], 'with': [175, 235], 'monolayer': [178], '(2D).': [179], 'However,': [180], 'mechanisms': [182], 'causing': [183], 'this': [184], 'difference': [185], 'remain': [186], 'largely': [187], 'unclear.': [188], 'Here': [189], 'we': [190], 'found': [191], 'cycle': [195, 201, 222], 'distribution': [196], 'expression': [198, 256, 311], 'regulation': [202, 223], 'genes': [203, 224], 'A549': [206, 232, 262, 281, 291], 'different': [209], 'from': [210], '2D.': [212, 238], 'The': [213, 239], 'higher': [214], 'levels': [215], 'promotor': [218, 250, 317], 'methylation': [219, 318], 'such': [225], 'as': [226], 'were': [228], 'observed': [229], 'treatments': [240], 'irradiation': [242, 278], 'or': [243], '5-Aza-CdR': [244], 'activated': [245], 'demethylation': [247], 'resulted': [252], 'increased': [255], 'only': [259], 'cells.': [263, 284], 'Inhibition': [264], 'enhanced': [267], 'radioresistance': [269], 'decreased': [271], 'G2/M': [273], 'phase': [274], 'arrest': [275], 'induced': [276], 'by': [277], '2D': [280], 'MCF7': [283, 293], 'Overexpression': [285], 'sensitized': [288], 'to': [295, 299, 307, 315], 'irradiation.': [296], 'Taken': [297], 'together,': [298], 'our': [300], 'knowledge,': [301], 'it': [302], 'first': [305], 'time': [306], 'revealthat': [308], 'low': [310], 'due': [314], 'itself': [316], 'enhances': [322], 'radioresistance.': [324], 'Our': [325], 'finding': [326], 'sheds': [327], 'light': [330], 'on': [331], 'understanding': [332], 'its': [342], 'application': [343], 'basic': [345], 'research': [346], 'into': [347], 'radiotherapy': [349], 'medcine': [351], 'development.': [352]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2530970334', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-13T15:17:49.725648', 'created_date': '2016-10-21'}