Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2530150164', 'doi': 'https://doi.org/10.18632/oncotarget.12631', 'title': 'A four-gene signature predicts survival in clear-cell renal-cell carcinoma', 'display_name': 'A four-gene signature predicts survival in clear-cell renal-cell carcinoma', 'publication_year': 2016, 'publication_date': '2016-10-13', 'ids': {'openalex': 'https://openalex.org/W2530150164', 'doi': 'https://doi.org/10.18632/oncotarget.12631', 'mag': '2530150164', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27779101', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5347726'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12631', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12631&path%5B%5D=40008', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12631&path%5B%5D=40008', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029911700', 'display_name': 'Jun Dai', 'orcid': 'https://orcid.org/0000-0001-5155-8838'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Dai', 'raw_affiliation_strings': ['Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087240172', 'display_name': 'Yuchao Lu', 'orcid': 'https://orcid.org/0000-0003-4523-2342'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuchao Lu', 'raw_affiliation_strings': ['Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026360799', 'display_name': 'Jinyu Wang', 'orcid': 'https://orcid.org/0000-0001-7162-9082'}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I4210114914', 'display_name': 'Prince of Wales Hospital', 'ror': 'https://ror.org/02827ca86', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1294586568', 'https://openalex.org/I4210114914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jinyu Wang', 'raw_affiliation_strings': ['Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong SAR, Hong Kong, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong SAR, Hong Kong, China', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I4210114914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042394520', 'display_name': 'Lili Yang', 'orcid': 'https://orcid.org/0000-0003-4274-4617'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lili Yang', 'raw_affiliation_strings': ['Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101497479', 'display_name': 'Yingyan Han', 'orcid': 'https://orcid.org/0000-0002-4129-0783'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingyan Han', 'raw_affiliation_strings': ['Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100347002', 'display_name': 'Ying Wang', 'orcid': 'https://orcid.org/0000-0001-8020-3622'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Wang', 'raw_affiliation_strings': ['Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084504259', 'display_name': 'Dan Yan', 'orcid': 'https://orcid.org/0000-0003-1424-1625'}, 'institutions': [{'id': 'https://openalex.org/I43922553', 'display_name': 'Wuhan University of Science and Technology', 'ror': 'https://ror.org/00e4hrk88', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I43922553']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dan Yan', 'raw_affiliation_strings': ['Department of Pathology, Medical College, Wuhan University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Medical College, Wuhan University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I43922553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101533098', 'display_name': 'Qiurong Ruan', 'orcid': 'https://orcid.org/0000-0002-7015-7666'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qiurong Ruan', 'raw_affiliation_strings': ['Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100767237', 'display_name': 'Shaogang Wang', 'orcid': 'https://orcid.org/0000-0002-3206-1495'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shaogang Wang', 'raw_affiliation_strings': ['Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5101533098'], 'corresponding_institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.243, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.92764, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '50', 'first_page': '82712', 'last_page': '82726'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10449', 'display_name': 'Renal Cell Carcinoma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10449', 'display_name': 'Renal Cell Carcinoma', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Molecular Mechanisms of Kidney Development and Disease', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-signature', 'display_name': 'Gene signature', 'score': 0.52633137}, {'id': 'https://openalex.org/keywords/renal-cell-carcinoma', 'display_name': 'Renal Cell Carcinoma', 'score': 0.498964}, {'id': 'https://openalex.org/keywords/tissue-microarray', 'display_name': 'Tissue microarray', 'score': 0.47093406}], 'concepts': [{'id': 'https://openalex.org/C2781278892', 'wikidata': 'https://www.wikidata.org/wiki/Q18556340', 'display_name': 'Clear cell renal cell carcinoma', 'level': 3, 'score': 0.7389687}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7148878}, {'id': 'https://openalex.org/C2779733811', 'wikidata': 'https://www.wikidata.org/wiki/Q5531562', 'display_name': 'Gene signature', 'level': 4, 'score': 0.52633137}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4821729}, {'id': 'https://openalex.org/C193270364', 'wikidata': 'https://www.wikidata.org/wiki/Q17141925', 'display_name': 'Tissue microarray', 'level': 3, 'score': 0.47093406}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.46962762}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.41470996}, {'id': 'https://openalex.org/C191935318', 'wikidata': 'https://www.wikidata.org/wiki/Q148', 'display_name': 'China', 'level': 2, 'score': 0.4104641}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39470005}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.37266284}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3229721}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20609087}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.15733248}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.13923785}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.07983166}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000081242', 'descriptor_name': 'B-Cell Lymphoma 3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011237', 'descriptor_name': 'Predictive Value of Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016016', 'descriptor_name': 'Proportional Hazards Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011755', 'descriptor_name': 'Pyrophosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011755', 'descriptor_name': 'Pyrophosphatases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046888', 'descriptor_name': 'Tissue Array Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12631', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12631&path%5B%5D=40008', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5347726', 'pdf_url': 'https://europepmc.org/articles/pmc5347726?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347726', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27779101', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.12631', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=12631&path%5B%5D=40008', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1512055001', 'https://openalex.org/W1721946128', 'https://openalex.org/W1862544240', 'https://openalex.org/W1896606537', 'https://openalex.org/W1968616420', 'https://openalex.org/W1971843650', 'https://openalex.org/W1984621921', 'https://openalex.org/W1999966467', 'https://openalex.org/W2010231082', 'https://openalex.org/W2018248081', 'https://openalex.org/W2019864071', 'https://openalex.org/W2027335142', 'https://openalex.org/W2029676176', 'https://openalex.org/W2032176596', 'https://openalex.org/W2034689459', 'https://openalex.org/W2034922964', 'https://openalex.org/W2037915750', 'https://openalex.org/W2045379023', 'https://openalex.org/W2046178435', 'https://openalex.org/W2050402493', 'https://openalex.org/W2055240558', 'https://openalex.org/W2068948572', 'https://openalex.org/W2075486945', 'https://openalex.org/W2085438634', 'https://openalex.org/W2097709626', 'https://openalex.org/W2100701400', 'https://openalex.org/W2108899869', 'https://openalex.org/W2116793145', 'https://openalex.org/W2117050434', 'https://openalex.org/W2119909954', 'https://openalex.org/W2126958361', 'https://openalex.org/W2129874753', 'https://openalex.org/W2132108310', 'https://openalex.org/W2141983633', 'https://openalex.org/W2143462939', 'https://openalex.org/W2149456801', 'https://openalex.org/W2161810908', 'https://openalex.org/W2161899881', 'https://openalex.org/W2164317031', 'https://openalex.org/W2164907150', 'https://openalex.org/W2165948908', 'https://openalex.org/W2183465597', 'https://openalex.org/W2213710063', 'https://openalex.org/W2339303388', 'https://openalex.org/W2388163742', 'https://openalex.org/W2427314951', 'https://openalex.org/W2460218705', 'https://openalex.org/W2911611736', 'https://openalex.org/W4242150417'], 'related_works': ['https://openalex.org/W4384497762', 'https://openalex.org/W4365385323', 'https://openalex.org/W4255321854', 'https://openalex.org/W3173240031', 'https://openalex.org/W3146426108', 'https://openalex.org/W3044672584', 'https://openalex.org/W3032319459', 'https://openalex.org/W2884617011', 'https://openalex.org/W2087724775', 'https://openalex.org/W2074517075'], 'abstract_inverted_index': {'//': [0], 'Jun': [1], 'Dai': [2], '1,': [3], '*': [4, 9, 126], ',': [5, 10, 14, 18, 22, 26, 30, 34], 'Yuchao': [6], 'Lu': [7], '2,': [8], 'Jinyu': [11], 'Wang': [12, 24, 36], '3': [13, 75], 'Lili': [15], 'Yang': [16], '4': [17, 25, 33, 95], 'Yingyan': [19], 'Han': [20], '1': [21, 38], 'Ying': [23], 'Dan': [27], 'Yan': [28], '5': [29, 112], 'Qiurong': [31, 137], 'Ruan': [32], 'Shaogang': [35, 141], '2': [37, 56], 'Cancer': [39], 'Biology': [40], 'Research': [41], 'Center,': [42], 'Tongji': [43, 45, 62, 64, 99, 101], 'Hospital,': [44, 63, 84, 100], 'Medical': [46, 65, 102, 116], 'College,': [47, 66, 103, 117], 'Huazhong': [48, 67, 104], 'University': [49, 68, 87, 105, 119], 'of': [50, 60, 69, 77, 82, 88, 97, 106, 114, 120, 176, 185, 205, 212, 228, 239, 260, 283, 301, 326, 348, 363], 'Science': [51, 70, 107, 121], 'and': [52, 58, 71, 79, 108, 122, 208, 225, 246, 288, 304, 331, 350], 'Technology,': [53, 72, 109, 123], 'Wuhan,': [54, 73, 110, 124], 'China': [55, 74, 94, 111, 125], 'Department': [57, 76, 113], 'Institute': [59, 96], 'Urology,': [61], 'Orthopaedics': [78], 'Traumatology,': [80], 'Prince': [81], 'Wales': [83], 'The': [85, 312], 'Chinese': [86], 'Hong': [89, 92], 'Kong': [90], 'SAR,': [91], 'Kong,': [93], 'Pathology,': [98, 115], 'Wuhan': [118], 'These': [127], 'authors': [128], 'have': [129], 'contributed': [130], 'equally': [131], 'to': [132, 189, 201, 217, 297, 354], 'this': [133], 'work': [134], 'Correspondence': [135], 'to:': [136], 'Ruan,': [138], 'email:': [139, 143], '[email protected]': [140], 'Wang,': [142], '[email protected]': [144], 'Keywords:': [145], 'ccRCC,': [146, 195, 349], 'prognosis,': [147], 'gene': [148], 'signature,': [149], 'tissue': [150, 213], 'microarray,': [151], 'bioinformatics': [152], 'Received:': [153], 'April': [154], '26,': [155], '2016': [156, 160, 164], 'Accepted:': [157], 'September': [158], '25,': [159], 'Published:': [161], 'October': [162], '13,': [163], 'ABSTRACT': [165], 'Clear-cell': [166], 'renal-cell': [167], 'carcinoma': [168, 179], '(ccRCC)': [169], 'is': [170], 'the': [171, 203, 219, 222, 226, 240, 252, 261, 276, 299, 305, 317, 340, 346, 361], 'most': [172], 'common': [173], 'pathological': [174], 'subtype': [175], 'renal': [177], 'cell': [178], '(RCC),': [180], 'accounting': [181], 'for': [182, 359], 'about': [183], '80%': [184], 'RCC.': [186], 'In': [187, 338], 'order': [188], 'find': [190], 'potential': [191], 'prognostic': [192, 236, 281, 324], 'biomarkers': [193], 'in': [194, 285], 'we': [196], 'presented': [197], 'a': [198, 235, 269], 'four-gene': [199, 253, 341], 'signature': [200, 254, 277, 342], 'evaluate': [202], 'prognosis': [204, 227, 362], 'ccRCC.': [206, 229, 286], 'SurvExpress': [207], 'immunohistochemical': [209], '(IHC)': [210], 'staining': [211, 267], 'microarrays': [214], 'were': [215, 295], 'used': [216], 'analyze': [218], 'association': [220, 300], 'between': [221], 'four': [223, 241, 262, 306], 'genes': [224, 242, 263], 'Data': [230], 'from': [231], 'TCGA': [232], 'dataset': [233], 'revealed': [234], 'prompt': [237], 'function': [238], '(PTEN,': [243], 'PIK3C2A,': [244], 'ITPA': [245], 'BCL3).': [247], 'Further': [248], 'discovery': [249], 'suggested': [250], 'that': [251, 275, 316], 'predicted': [255], 'survival': [256, 284, 347], 'better': [257], 'than': [258], 'any': [259], 'alone.': [264], 'Moreover,': [265], 'IHC': [266], 'demonstrated': [268], 'consistent': [270], 'result': [271], 'with': [272, 310, 345], 'TCGA,': [273], 'indicating': [274], 'was': [278, 321, 343], 'an': [279, 322], 'independent': [280, 323], 'factor': [282], 'Univariate': [287], 'multivariate': [289], 'Cox': [290], 'proportional': [291], 'hazard': [292], 'regression': [293], 'analysis': [294], 'conducted': [296], 'verify': [298], 'clinicopathological': [302], 'variables': [303], "genes'": [307], 'expression': [308], 'levels': [309], 'survival.': [311], 'results': [313], 'further': [314], 'testified': [315], 'risk': [318], '(four-gene': [319], 'signature)': [320], 'factors': [325], 'both': [327], 'Overall': [328], 'Survival': [329, 333], '(OS)': [330], 'Disease-free': [332], '(DFS)': [334], '(': [335], 'P': [336], '<0.05).': [337], 'conclusion,': [339], 'correlated': [344], 'therefore,': [351], 'may': [352], 'help': [353], 'provide': [355], 'significant': [356], 'clinical': [357], 'implications': [358], 'predicting': [360], 'patients.': [364]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2530150164', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-09-19T09:34:20.123736', 'created_date': '2016-10-21'}