Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2529861061', 'doi': 'https://doi.org/10.3389/fphar.2016.00370', 'title': 'A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)', 'display_name': 'A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)', 'publication_year': 2016, 'publication_date': '2016-10-13', 'ids': {'openalex': 'https://openalex.org/W2529861061', 'doi': 'https://doi.org/10.3389/fphar.2016.00370', 'mag': '2529861061', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27790143', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5062061'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2016.00370', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2016.00370/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2016.00370/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5074856959', 'display_name': 'Dale G. Deutsch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I59553526', 'display_name': 'Stony Brook University', 'ror': 'https://ror.org/05qghxh33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I59553526']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Dale G. Deutsch', 'raw_affiliation_strings': ['Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA', 'institution_ids': ['https://openalex.org/I59553526']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5074856959'], 'corresponding_institution_ids': ['https://openalex.org/I59553526'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 5.981, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 80, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '7', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anandamide', 'display_name': 'Anandamide', 'score': 0.9887688}, {'id': 'https://openalex.org/keywords/amide', 'display_name': 'Amide', 'score': 0.42875677}], 'concepts': [{'id': 'https://openalex.org/C2781144285', 'wikidata': 'https://www.wikidata.org/wiki/Q21113274', 'display_name': 'Fatty acid amide hydrolase', 'level': 5, 'score': 0.9972781}, {'id': 'https://openalex.org/C2779783865', 'wikidata': 'https://www.wikidata.org/wiki/Q410228', 'display_name': 'Anandamide', 'level': 5, 'score': 0.9887688}, {'id': 'https://openalex.org/C46721173', 'wikidata': 'https://www.wikidata.org/wiki/Q368952', 'display_name': 'Endocannabinoid system', 'level': 3, 'score': 0.81315947}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5490291}, {'id': 'https://openalex.org/C2776834966', 'wikidata': 'https://www.wikidata.org/wiki/Q4082494', 'display_name': 'Fatty acid-binding protein', 'level': 3, 'score': 0.5118684}, {'id': 'https://openalex.org/C543025807', 'wikidata': 'https://www.wikidata.org/wiki/Q61476', 'display_name': 'Fatty acid', 'level': 2, 'score': 0.50765455}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4852824}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43174866}, {'id': 'https://openalex.org/C2778439535', 'wikidata': 'https://www.wikidata.org/wiki/Q188777', 'display_name': 'Amide', 'level': 2, 'score': 0.42875677}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32424462}, {'id': 'https://openalex.org/C148001335', 'wikidata': 'https://www.wikidata.org/wiki/Q421237', 'display_name': 'Cannabinoid receptor', 'level': 4, 'score': 0.15710756}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05827838}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.049749285}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.04622951}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2016.00370', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2016.00370/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/e613cf4a7ac34e73b411fdebb522c48e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5062061', 'pdf_url': 'https://europepmc.org/articles/pmc5062061?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062061', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27790143', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fphar.2016.00370', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fphar.2016.00370/pdf', 'source': {'id': 'https://openalex.org/S132108250', 'display_name': 'Frontiers in Pharmacology', 'issn_l': '1663-9812', 'issn': ['1663-9812'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337347', 'funder_display_name': 'National Institute on Drug Abuse', 'award_id': '035923'}], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W1166458116', 'https://openalex.org/W1506141559', 'https://openalex.org/W1552423677', 'https://openalex.org/W1597904490', 'https://openalex.org/W1636945110', 'https://openalex.org/W1655239155', 'https://openalex.org/W1779184235', 'https://openalex.org/W1867730965', 'https://openalex.org/W1965657265', 'https://openalex.org/W1969338731', 'https://openalex.org/W1969762460', 'https://openalex.org/W1971721792', 'https://openalex.org/W1974783801', 'https://openalex.org/W1977182580', 'https://openalex.org/W1982429227', 'https://openalex.org/W1987120082', 'https://openalex.org/W1989073099', 'https://openalex.org/W1993018268', 'https://openalex.org/W1994470497', 'https://openalex.org/W1994764339', 'https://openalex.org/W1996767019', 'https://openalex.org/W1999822120', 'https://openalex.org/W2003594380', 'https://openalex.org/W2004610487', 'https://openalex.org/W2008818829', 'https://openalex.org/W2009864558', 'https://openalex.org/W2010557865', 'https://openalex.org/W2011607679', 'https://openalex.org/W2013276134', 'https://openalex.org/W2014306399', 'https://openalex.org/W2014848216', 'https://openalex.org/W2018780060', 'https://openalex.org/W2020678194', 'https://openalex.org/W2023364037', 'https://openalex.org/W2025367112', 'https://openalex.org/W2027991357', 'https://openalex.org/W2030187929', 'https://openalex.org/W2032888644', 'https://openalex.org/W2036994641', 'https://openalex.org/W2041074139', 'https://openalex.org/W2045985680', 'https://openalex.org/W2048070459', 'https://openalex.org/W2051621327', 'https://openalex.org/W2056402911', 'https://openalex.org/W2057443816', 'https://openalex.org/W2062173041', 'https://openalex.org/W2062861484', 'https://openalex.org/W2065241852', 'https://openalex.org/W2068979924', 'https://openalex.org/W2074220154', 'https://openalex.org/W2080157613', 'https://openalex.org/W2081617846', 'https://openalex.org/W2082493917', 'https://openalex.org/W2083371696', 'https://openalex.org/W2084493354', 'https://openalex.org/W2084652074', 'https://openalex.org/W2087723063', 'https://openalex.org/W2091962365', 'https://openalex.org/W2092637194', 'https://openalex.org/W2094241280', 'https://openalex.org/W2102976517', 'https://openalex.org/W2108656555', 'https://openalex.org/W2116707337', 'https://openalex.org/W2118908661', 'https://openalex.org/W2118977407', 'https://openalex.org/W2146761165', 'https://openalex.org/W2157400187', 'https://openalex.org/W2169269177', 'https://openalex.org/W2182085115', 'https://openalex.org/W2284863152', 'https://openalex.org/W2295029605', 'https://openalex.org/W2344859037', 'https://openalex.org/W2395516892', 'https://openalex.org/W2399086220', 'https://openalex.org/W2413960885'], 'related_works': ['https://openalex.org/W4380301580', 'https://openalex.org/W3192640716', 'https://openalex.org/W3092599270', 'https://openalex.org/W2085176527', 'https://openalex.org/W2075772925', 'https://openalex.org/W2065675074', 'https://openalex.org/W2042999271', 'https://openalex.org/W2001441318', 'https://openalex.org/W1970077719', 'https://openalex.org/W1964967443'], 'abstract_inverted_index': {'This': [0], 'perspective': [1], 'was': [2, 33], 'adapted': [3], 'from': [4, 150], 'a': [5, 26, 99], 'Career': [6], 'Achievement': [7], 'Award': [8], 'talk': [9], 'given': [10], 'at': [11], 'the': [12, 30, 52, 106, 112, 137, 146, 158, 163, 203], 'International': [13], 'Cannabinoid': [14], 'Research': [15], 'Society': [16], 'Symposium': [17], 'in': [18, 29, 86, 157, 209], 'Bukovina,': [19], 'Poland': [20], 'on': [21], 'June': [22], '27,': [23], '2016.': [24], 'As': [25], 'biochemist': [27], 'working': [28], 'neurosciences,': [31], 'I': [32], 'always': [34], 'fascinated': [35], 'with': [36, 237], 'neurotransmitter': [37], 'inactivation.': [38], 'In': [39], '1993': [40], 'we': [41, 118], 'identified': [42, 162], 'an': [43, 129], 'enzyme': [44, 53], 'activity': [45], 'that': [46, 66, 70, 123, 133, 168, 176], 'breaks': [47], 'down': [48], 'anandamide.': [49], 'We': [50, 59, 161], 'called': [51, 57], 'anandamide': [54, 172, 213], 'amidase,': [55], 'now': [56], 'FAAH.': [58, 174], 'and': [60, 119, 189, 197, 226], 'other': [61], 'laboratories': [62], 'developed': [63], 'FAAH': [64, 155], 'inhibitors': [65, 84], 'were': [67, 85, 192], 'useful': [68], 'reagents': [69], 'also': [71, 191], 'proved': [72], 'to': [73, 103, 173, 178, 194], 'have': [74, 121, 222], 'beneficial': [75], 'physiological': [76], 'effects': [77], 'and,': [78, 95], 'until': [79], 'recently,': [80], 'new': [81], 'generations': [82], 'of': [83, 202], 'clinical': [87], 'trials.': [88], 'Nearly': [89], 'all': [90], 'neurotransmitters': [91], 'are': [92], 'water': [93], 'soluble': [94], 'as': [96, 165, 234], 'such,': [97], 'require': [98, 229], 'transmembrane': [100], 'protein': [101], 'transporter': [102], 'pass': [104], 'through': [105], 'lipid': [107], 'membrane': [108], 'for': [109, 127, 239], 'inactivation': [110], 'inside': [111], 'cell.': [113], 'However,': [114], 'using': [115], 'model': [116], 'systems,': [117], 'others': [120], 'shown': [122], 'this': [124, 198], 'is': [125, 143], 'unnecessary': [126], 'anandamide,': [128, 170], 'uncharged': [130], 'hydrophobic': [131], 'molecule': [132], 'readily': [134], 'diffuses': [135], 'across': [136], 'cellular': [138], 'membrane.': [139], 'Interestingly,': [140], 'its': [141, 151, 184], 'uptake': [142], 'driven': [144], 'by': [145, 154, 205], 'concentration': [147], 'gradient': [148], 'resulting': [149], 'breakdown': [152], 'mainly': [153], 'localized': [156], 'endoplasmic': [159], 'reticulum.': [160], 'FABPs': [164, 179, 196, 216], 'intracellular': [166], 'carriers': [167], '"solubilize"': [169], 'transporting': [171], 'Compounds': [175], 'bind': [177, 195], 'block': [180], 'AEA': [181], 'breakdown,': [182], 'raising': [183, 212], 'level.': [185], 'The': [186], 'cannabinoids': [187], '(THC': [188], 'CBD)': [190], 'discovered': [193], 'may': [199, 217], 'be': [200, 218], 'one': [201], 'mechanisms': [204], 'which': [206], 'CBD': [207], 'works': [208], 'childhood': [210], 'epilepsy,': [211], 'levels.': [214], 'Targeting': [215], 'advantageous': [219], 'since': [220], 'they': [221], 'some': [223], 'tissue': [224], 'specificity': [225], 'do': [227], 'not': [228], 'reactive': [230], 'serine': [231], 'hydrolase': [232], 'inhibitors,': [233], 'does': [235], 'FAAH,': [236], 'potential': [238], 'off-target': [240], 'reactions.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2529861061', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-14T00:22:04.582519', 'created_date': '2016-10-21'}