Title: The Immune Response to DNP-poly-L-Lysine in Randomly Bred Guinea Pigs and Its Relation to Antigenic Competition
Abstract: This chapter elaborates the immune response to DNP (dinitrophenyl)-poly-L-lysine in randomly bred guinea pigs and its relation to antigenic competition. The ability of the same guinea pigs to respond to the various antigens was proved by tests. The DNP-p(Lys) conjugate inhibited the immune response toward the unrelated synthetic antigens in responders and nonresponders as well as to this conjugate. This finding led to investigate whether an immune response to DNP-p(Lys) could also be detected in what are commonly called nonresponder guinea pigs. The results obtained show that a certain degree of immune response toward DNP-p(Lys) could be detected also in the animals found negative by criteria of delayed type reactivity and PCA tests. This response was lower than in the positive reactants and was detectable by occurrence of hemagglutination titers, their specific inhibition by the DNP-mono Lys hapten, binding assays and complement deviation tests. These experiments showed that minimal immunizing doses of DNP-p(Lys) conjugate affected the immune response toward a large quantity of p(Tyr, Glu) only in animal responders to the conjugate
Publication Year: 1970
Publication Date: 1970-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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