Title: Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation
Abstract: Pediatric Blood & CancerVolume 64, Issue 2 p. 234-241 Research Article Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL-2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation Meng-Ju Li, Meng-Ju Li Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, TaiwanSearch for more papers by this authorHsi-Che Liu, Hsi-Che Liu Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, TaiwanSearch for more papers by this authorHsiu-Ju Yen, Hsiu-Ju Yen Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, TaiwanSearch for more papers by this authorTang-Her Jaing, Tang-Her Jaing Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorDong-Tsamn Lin, Dong-Tsamn Lin Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorChao-Ping Yang, Chao-Ping Yang Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorKai-Hsin Lin, Kai-Hsin Lin Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorIou-Jih Hung, Iou-Jih Hung Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorShiann-Tarng Jou, Shiann-Tarng Jou Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorMeng-Yao Lu, Meng-Yao Lu Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorChih-Cheng Hsiao, Chih-Cheng Hsiao Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanSearch for more papers by this authorChing-Tien Peng, Ching-Tien Peng Division of Pediatric Hematology & Oncology, China Medical University Children's Hospital, Taichung, Taiwan Department of Biotechnology, Asia University, Wufeng, Taichung, TaiwanSearch for more papers by this authorTai-Tsung Chang, Tai-Tsung Chang Department of Pediatrics, E-Da Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShih-Chung Wang, Shih-Chung Wang Department of Pediatrics, Changhua Christian Hospital, Changhua, TaiwanSearch for more papers by this authorMing-Tsan Lin, Ming-Tsan Lin Department of Pediatrics, Changhua Christian Hospital, Changhua, TaiwanSearch for more papers by this authorJiann-Shiuh Chen, Jiann-Shiuh Chen Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanSearch for more papers by this authorTe-Kau Chang, Te-Kau Chang Department of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanSearch for more papers by this authorGiun-Yi Hung, Giun-Yi Hung Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, TaiwanSearch for more papers by this authorKang-Hsi Wu, Kang-Hsi Wu Division of Pediatric Hematology & Oncology, China Medical University Children's Hospital, Taichung, TaiwanSearch for more papers by this authorYung-Li Yang, Yung-Li Yang Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorHsiu-Hao Chang, Hsiu-Hao Chang Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorShih-Hsiang Chen, Shih-Hsiang Chen Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorTing-Chi Yeh, Ting-Chi Yeh Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, TaiwanSearch for more papers by this authorChao-Neng Cheng, Chao-Neng Cheng Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanSearch for more papers by this authorPei-Chin Lin, Pei-Chin Lin Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShyh-Shin Chiou, Shyh-Shin Chiou Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorJiunn-Ming Sheen, Jiunn-Ming Sheen Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanSearch for more papers by this authorShin-Nan Cheng, Shin-Nan Cheng Department of Pediatrics, Tungs' Taichung Metro Harbor Hospital, Taichung, TaiwanSearch for more papers by this authorShu-Huey Chen, Shu-Huey Chen Department of Pediatrics, Taipei Medical University–Shuang Ho Hospital, Taipei, TaiwanSearch for more papers by this authorYu-Hsiang Chang, Yu-Hsiang Chang Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanSearch for more papers by this authorWan-Ling Ho, Wan-Ling Ho Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanSearch for more papers by this authorYu-Hua Chao, Yu-Hua Chao Department of Pediatrics, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, TaiwanSearch for more papers by this authorRong-Long Chen, Rong-Long Chen Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanSearch for more papers by this authorBow-Wen Chen, Bow-Wen Chen Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanSearch for more papers by this authorJinn-Li Wang, Jinn-Li Wang Department of Pediatrics, Wanfang Hospital Taipei Medical University, Taipei, TaiwanSearch for more papers by this authorYuh-Lin Hsieh, Yuh-Lin Hsieh Department of Pediatrics, Cathay General Hospital, Taipei, TaiwanSearch for more papers by this authorYu-Mei Liao, Yu-Mei Liao Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShang-Hsien Yang, Shang-Hsien Yang Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, TaiwanSearch for more papers by this authorWan-Hui Chang, Wan-Hui Chang Childhood Cancer Foundation, Taipei, TaiwanSearch for more papers by this authorYu-Mei Y. Chao, Yu-Mei Y. Chao Childhood Cancer Foundation, Taipei, TaiwanSearch for more papers by this authorDer-Cherng Liang, Corresponding Author Der-Cherng Liang [email protected] Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, Taiwan Correspondence Der-Cherng Liang, Department of Pediatrics, Mackay Memorial Hospital, 92, Sec. 2, Chung-San N. Rd, Taipei 10449, Taiwan. Email: [email protected] for more papers by this author Meng-Ju Li, Meng-Ju Li Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, TaiwanSearch for more papers by this authorHsi-Che Liu, Hsi-Che Liu Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, TaiwanSearch for more papers by this authorHsiu-Ju Yen, Hsiu-Ju Yen Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, TaiwanSearch for more papers by this authorTang-Her Jaing, Tang-Her Jaing Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorDong-Tsamn Lin, Dong-Tsamn Lin Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorChao-Ping Yang, Chao-Ping Yang Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorKai-Hsin Lin, Kai-Hsin Lin Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorIou-Jih Hung, Iou-Jih Hung Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorShiann-Tarng Jou, Shiann-Tarng Jou Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorMeng-Yao Lu, Meng-Yao Lu Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorChih-Cheng Hsiao, Chih-Cheng Hsiao Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanSearch for more papers by this authorChing-Tien Peng, Ching-Tien Peng Division of Pediatric Hematology & Oncology, China Medical University Children's Hospital, Taichung, Taiwan Department of Biotechnology, Asia University, Wufeng, Taichung, TaiwanSearch for more papers by this authorTai-Tsung Chang, Tai-Tsung Chang Department of Pediatrics, E-Da Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShih-Chung Wang, Shih-Chung Wang Department of Pediatrics, Changhua Christian Hospital, Changhua, TaiwanSearch for more papers by this authorMing-Tsan Lin, Ming-Tsan Lin Department of Pediatrics, Changhua Christian Hospital, Changhua, TaiwanSearch for more papers by this authorJiann-Shiuh Chen, Jiann-Shiuh Chen Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanSearch for more papers by this authorTe-Kau Chang, Te-Kau Chang Department of Pediatrics, Taichung Veterans General Hospital, Taichung, TaiwanSearch for more papers by this authorGiun-Yi Hung, Giun-Yi Hung Department of Pediatrics, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, TaiwanSearch for more papers by this authorKang-Hsi Wu, Kang-Hsi Wu Division of Pediatric Hematology & Oncology, China Medical University Children's Hospital, Taichung, TaiwanSearch for more papers by this authorYung-Li Yang, Yung-Li Yang Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorHsiu-Hao Chang, Hsiu-Hao Chang Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanSearch for more papers by this authorShih-Hsiang Chen, Shih-Hsiang Chen Department of Hematology–Oncology, Chang Gung Children's Hospital–Linkou, Taoyuan, TaiwanSearch for more papers by this authorTing-Chi Yeh, Ting-Chi Yeh Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, TaiwanSearch for more papers by this authorChao-Neng Cheng, Chao-Neng Cheng Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanSearch for more papers by this authorPei-Chin Lin, Pei-Chin Lin Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShyh-Shin Chiou, Shyh-Shin Chiou Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorJiunn-Ming Sheen, Jiunn-Ming Sheen Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanSearch for more papers by this authorShin-Nan Cheng, Shin-Nan Cheng Department of Pediatrics, Tungs' Taichung Metro Harbor Hospital, Taichung, TaiwanSearch for more papers by this authorShu-Huey Chen, Shu-Huey Chen Department of Pediatrics, Taipei Medical University–Shuang Ho Hospital, Taipei, TaiwanSearch for more papers by this authorYu-Hsiang Chang, Yu-Hsiang Chang Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanSearch for more papers by this authorWan-Ling Ho, Wan-Ling Ho Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei City, TaiwanSearch for more papers by this authorYu-Hua Chao, Yu-Hua Chao Department of Pediatrics, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung, TaiwanSearch for more papers by this authorRong-Long Chen, Rong-Long Chen Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanSearch for more papers by this authorBow-Wen Chen, Bow-Wen Chen Division of Pediatric Hematology and Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, TaiwanSearch for more papers by this authorJinn-Li Wang, Jinn-Li Wang Department of Pediatrics, Wanfang Hospital Taipei Medical University, Taipei, TaiwanSearch for more papers by this authorYuh-Lin Hsieh, Yuh-Lin Hsieh Department of Pediatrics, Cathay General Hospital, Taipei, TaiwanSearch for more papers by this authorYu-Mei Liao, Yu-Mei Liao Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSearch for more papers by this authorShang-Hsien Yang, Shang-Hsien Yang Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, TaiwanSearch for more papers by this authorWan-Hui Chang, Wan-Hui Chang Childhood Cancer Foundation, Taipei, TaiwanSearch for more papers by this authorYu-Mei Y. Chao, Yu-Mei Y. Chao Childhood Cancer Foundation, Taipei, TaiwanSearch for more papers by this authorDer-Cherng Liang, Corresponding Author Der-Cherng Liang [email protected] Department of Pediatrics, Mackay Memorial Hospital, Mackay Medical College, Taipei, Taiwan Correspondence Der-Cherng Liang, Department of Pediatrics, Mackay Memorial Hospital, 92, Sec. 2, Chung-San N. Rd, Taipei 10449, Taiwan. Email: [email protected] for more papers by this author First published: 03 October 2016 https://doi.org/10.1002/pbc.26142Citations: 16 Meng-Ju Li, Hsi-Che Liu, and Hsiu-Ju Yen contributed equally to this article. [This article was corrected on 3 November 2016 because an abbreviation in the article title needed to be spelled out.] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background Reinduction therapy has improved the outcomes in children with acute lymphoblastic leukemia (ALL). We sought to determine the optimal course(s) of reinduction therapy for standard-risk (SR, or "low-risk" in other groups) patients. Also, we evaluated outcomes using triple intrathecal therapy without cranial radiation (CrRT) for central nervous system (CNS) preventive therapy. Procedure From 2002 to 2012, all newly diagnosed children with ALL in Taiwan were enrolled in Taiwan Pediatric Oncology Group ALL-2002 protocol. SR patients were randomized to receive single or double reinduction courses. The patients enrolled before 2009 received CrRT, while those enrolled later did not. The Kaplan–Meier method was used to estimate survival rates and the difference between two groups was compared by the two-sided log-rank test. Results In 1,366 eligible patients, the 5-year overall survival (OS) was 81.6 ± 1.1% (standard error) and 5-year event-free survival (EFS) was 74.3 ± 1.2%. In SR patients, the 5-year OS for one and two reinduction courses was 91.6 ± 2.1% and 93.7 ± 1.8%, respectively, and the 5-year EFS was 85.2 ± 2.7% and 89.8 ± 2.3%, respectively. There were no significant differences in survival between these two groups. Patients with MLL or BCR-ABL1 had the worst outcomes: 5-year EFS was 23.4 and 31.8% and 5-year OS was 28.6 and 44.7%, respectively. There was no significant difference in CNS relapse or survival between the era with or without CrRT. Conclusions For SR patients, one-course reinduction was adequate. Triple intrathecal therapy alone successfully prevented CNS relapse. Citing Literature Supporting Information Filename Description pbc26142-sup-0001-Figure.tif2.6 MB Supplementary Figure S1. Road map of treatment regimens by risk groups pbc26142-sup-0002-TableS1.docx20.2 KB Supplementary Table S1. Treatment protocols of TPOG ALL-2002 SR pbc26142-sup-0003-TableS2.docx19.7 KB Supplementary Table S2. Treatment protocols of TPOG ALL-2002 HR pbc26142-sup-0004-TableS3.docx18.7 KB Supplementary Table S3. Treatment protocols of TPOG ALL-2002 VHR pbc26142-sup-0005-TableS4.docx17.6 KB Supplementary Table S4. Comparison of regimens in reinduction therapy Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume64, Issue2February 2017Pages 234-241 RelatedInformation
Publication Year: 2016
Publication Date: 2016-10-03
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 19
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot