Title: Nonspecific microflora in patients associated with pulmonary multidrug-resistant tuberculosis
Abstract: <b>Introduction:</b> One of the main causes of low TB treatment outcome of pulmonary tuberculosis (PTB) is chronic nonspecific lung diseases (CNLD). <b>Aims and objectives:</b> to study the frequency and nature of nonspecific species in patients with multidrug-resistant TB (MDR-TB). <b>Methods:</b> 142 case histories of patients with PTB associated with CNLD treated in NTCC in last five years were analyzed. 93 patients with drug-sensitive M. tuberculosis (MTB) and 49 patients with MDR-TB were previously treated by antibiotics. Sputum samples were examined by smear microscopy and culture on MGIT and Lowenstein-Jensen medium for MTB and different media for nonmycobacterial species. <b>Results:</b> Among MDR-TB patients male (n=45, 91.8%) aged 25-44 years (n=34, 69.4%) dominated. Widespread lung infiltrates with destructions (n=19, 38.8%) and disseminations (n=18, 16.3%) dominated. Chronic destructive PTB was diagnosed in 14 cases (28.6%). The most bacterial agents detected were Candida (n=38, 77.6%), Streptococci (n=11, 22.4%) and Enterobacteriaceae (n=6, 12.2%). Nonspecific species co-occurred in 15 cases (30.6%) with prevalence of Candida as well (n=13, 86.7%). In 33.3% of cases Candida co-occurred with Streptococci (n=5). Candida in PTB patients with drug-sensitive MTB was found less often (n=57, 61.3%; p<0.05). <b>Conclusions:</b> In MDR-TB nonspecific microflora is associated with male gender, CNLD. It contributes on development of widespread pulmonary lesions with destruction and tendency of chronic course, and requires corrections. More frequent detection of Candida in MDR-TB patients can be interpreted as the result of antibiotic treatment in the past and presence by Fluoroquinolones, Aminoglycosides.
Publication Year: 2015
Publication Date: 2015-09-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 2
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