Publication Information

{'id': 'https://openalex.org/W2529219523', 'doi': 'https://doi.org/10.4103/2231-4040.191428', 'title': 'Anticancer, antioxidant potential and profiling of polyphenolic compounds of Wrightia tinctoria Roxb. (R.Br.) bark', 'display_name': 'Anticancer, antioxidant potential and profiling of polyphenolic compounds of Wrightia tinctoria Roxb. (R.Br.) bark', 'publication_year': 2016, 'publication_date': '2016-01-01', 'ids': {'openalex': 'https://openalex.org/W2529219523', 'doi': 'https://doi.org/10.4103/2231-4040.191428', 'mag': '2529219523', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27833897', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5052944'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4103/2231-4040.191428', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764715273', 'display_name': 'Journal of Advanced Pharmaceutical Technology amp Research', 'issn_l': '0976-2094', 'issn': ['0976-2094', '2231-4040'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320448', 'host_organization_name': 'Medknow', 'host_organization_lineage': ['https://openalex.org/P4310318547', 'https://openalex.org/P4310320448'], 'host_organization_lineage_names': ['Wolters Kluwer', 'Medknow'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.4103/2231-4040.191428', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080348997', 'display_name': 'Nishat Fatima', 'orcid': 'https://orcid.org/0000-0002-1607-5803'}, 'institutions': [{'id': 'https://openalex.org/I189949046', 'display_name': 'Integral University', 'ror': 'https://ror.org/039zd5s34', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I189949046']}, {'id': 'https://openalex.org/I280994', 'display_name': "King George's Medical University", 'ror': 'https://ror.org/00gvw6327', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I280994']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Nishat Fatima', 'raw_affiliation_strings': ["Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India; Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India."], 'affiliations': [{'raw_affiliation_string': "Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India; Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.", 'institution_ids': ['https://openalex.org/I189949046', 'https://openalex.org/I280994']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036554710', 'display_name': 'Mohammad Kaleem Ahmad', 'orcid': 'https://orcid.org/0000-0001-9447-0908'}, 'institutions': [{'id': 'https://openalex.org/I280994', 'display_name': "King George's Medical University", 'ror': 'https://ror.org/00gvw6327', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I280994']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Mohammad Kaleem Ahmad', 'raw_affiliation_strings': ["Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India."], 'affiliations': [{'raw_affiliation_string': "Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India.", 'institution_ids': ['https://openalex.org/I280994']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058690236', 'display_name': 'Jamal Akhtar Ansari', 'orcid': 'https://orcid.org/0000-0002-1467-6226'}, 'institutions': [{'id': 'https://openalex.org/I189949046', 'display_name': 'Integral University', 'ror': 'https://ror.org/039zd5s34', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I189949046']}, {'id': 'https://openalex.org/I280994', 'display_name': "King George's Medical University", 'ror': 'https://ror.org/00gvw6327', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I280994']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Jamal Akhtar Ansari', 'raw_affiliation_strings': ["Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India; Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India."], 'affiliations': [{'raw_affiliation_string': "Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India; Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.", 'institution_ids': ['https://openalex.org/I189949046', 'https://openalex.org/I280994']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038420905', 'display_name': 'Zulfıqar Ali', 'orcid': 'https://orcid.org/0000-0003-3902-5152'}, 'institutions': [{'id': 'https://openalex.org/I189949046', 'display_name': 'Integral University', 'ror': 'https://ror.org/039zd5s34', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I189949046']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Zulfiqar Ali', 'raw_affiliation_strings': ['Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.', 'institution_ids': ['https://openalex.org/I189949046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028147750', 'display_name': 'Abdul Rahman Khan', 'orcid': 'https://orcid.org/0000-0002-6798-453X'}, 'institutions': [{'id': 'https://openalex.org/I189949046', 'display_name': 'Integral University', 'ror': 'https://ror.org/039zd5s34', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I189949046']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Abdul Rahman Khan', 'raw_affiliation_strings': ['Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Integral University, Lucknow, Uttar Pradesh, India.', 'institution_ids': ['https://openalex.org/I189949046']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046149999', 'display_name': 'Abbas Ali Mahdi', 'orcid': 'https://orcid.org/0000-0002-8580-9911'}, 'institutions': [{'id': 'https://openalex.org/I280994', 'display_name': "King George's Medical University", 'ror': 'https://ror.org/00gvw6327', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I280994']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Abbas Ali Mahdi', 'raw_affiliation_strings': ["Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India."], 'affiliations': [{'raw_affiliation_string': "Department of Biochemistry, Natural Products Research Laboratory, King George's Medical University, Lucknow, Uttar Pradesh, India.", 'institution_ids': ['https://openalex.org/I280994']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 500, 'currency': 'USD', 'value_usd': 500, 'provenance': 'doaj'}, 'apc_paid': {'value': 500, 'currency': 'USD', 'value_usd': 500, 'provenance': 'doaj'}, 'fwci': 0.384, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.852115, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '7', 'issue': '4', 'first_page': '159', 'last_page': '159'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10225', 'display_name': 'Antimicrobial Properties of Essential Oils in Foods', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1106', 'display_name': 'Food Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10225', 'display_name': 'Antimicrobial Properties of Essential Oils in Foods', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1106', 'display_name': 'Food Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12721', 'display_name': 'Research on Moringa Oleifera', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10035', 'display_name': 'Antioxidants and Free Radicals in Health and Disease', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antioxidant-properties', 'display_name': 'Antioxidant Properties', 'score': 0.557061}], 'concepts': [{'id': 'https://openalex.org/C70899900', 'wikidata': 'https://www.wikidata.org/wiki/Q290439', 'display_name': 'Polyphenol', 'level': 3, 'score': 0.80680716}, {'id': 'https://openalex.org/C133446333', 'wikidata': 'https://www.wikidata.org/wiki/Q38681', 'display_name': 'Bark (sound)', 'level': 2, 'score': 0.6724731}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.6502068}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.59720373}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.49689606}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.3787144}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2331231}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.11318034}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10342997}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4103/2231-4040.191428', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764715273', 'display_name': 'Journal of Advanced Pharmaceutical Technology amp Research', 'issn_l': '0976-2094', 'issn': ['0976-2094', '2231-4040'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320448', 'host_organization_name': 'Medknow', 'host_organization_lineage': ['https://openalex.org/P4310318547', 'https://openalex.org/P4310320448'], 'host_organization_lineage_names': ['Wolters Kluwer', 'Medknow'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5052944', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052944', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27833897', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4103/2231-4040.191428', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764715273', 'display_name': 'Journal of Advanced Pharmaceutical Technology amp Research', 'issn_l': '0976-2094', 'issn': ['0976-2094', '2231-4040'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320448', 'host_organization_name': 'Medknow', 'host_organization_lineage': ['https://openalex.org/P4310318547', 'https://openalex.org/P4310320448'], 'host_organization_lineage_names': ['Wolters Kluwer', 'Medknow'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W154375584', 'https://openalex.org/W1936749636', 'https://openalex.org/W1972385110', 'https://openalex.org/W1981989535', 'https://openalex.org/W1998752256', 'https://openalex.org/W2090102281', 'https://openalex.org/W2114004260', 'https://openalex.org/W2139669634', 'https://openalex.org/W2164572791', 'https://openalex.org/W2212612964', 'https://openalex.org/W2260835883', 'https://openalex.org/W2263274623', 'https://openalex.org/W2950662762'], 'related_works': ['https://openalex.org/W2906979421', 'https://openalex.org/W2752881976', 'https://openalex.org/W2408130919', 'https://openalex.org/W2389493751', 'https://openalex.org/W2358168693', 'https://openalex.org/W2350469908', 'https://openalex.org/W2187037766', 'https://openalex.org/W1972060131', 'https://openalex.org/W1964952272', 'https://openalex.org/W1964659357'], 'abstract_inverted_index': {'Wrightia': [0], 'tinctoria': [1, 39, 234], 'Roxb.': [2], '(R.Br.)': [3], 'is': [4], 'an': [5], 'Ayurvedic': [6], 'remedy,': [7], 'ethnomedically': [8], 'used': [9], 'in': [10, 129, 142, 210], 'the': [11, 24, 74, 202, 228], 'treatment': [12], 'of': [13, 37, 53, 162, 175, 204, 220, 232], 'various': [14], 'ailments.': [15], 'The': [16, 102, 158], 'present': [17], 'work': [18], 'was': [19, 55, 77, 97, 164, 188], 'carried': [20], 'out': [21], 'to': [22, 166], 'evaluate': [23], 'anticancer': [25], 'and': [26, 34, 59, 69, 85, 119, 131, 139, 145, 155, 183, 193, 208, 224], 'antioxidant': [27, 75], 'activity': [28, 52, 84, 187, 231], 'as': [29, 31, 148], 'well': [30], 'total': [32, 159], 'phenolic': [33, 95, 160], 'phytochemical': [35], 'contents': [36], 'W.': [38, 233], 'bark': [40, 176], 'methanolic': [41], 'extract': [42, 177], '(WTBM)': [43], 'by': [44, 63, 79, 99, 150], 'high-performance': [45], 'liquid': [46], 'chromatography': [47], '(HPLC)-diode': [48], 'array': [49], 'detector.': [50], 'Antiproliferative': [51], 'WTBM': [54, 106, 134, 163, 216], 'evaluated': [56], 'against': [57, 111], 'MDA-MB-231': [58, 112, 144], 'MCF-7': [60, 120, 146], 'cancer': [61, 127, 222], 'cells': [62, 128, 147, 223], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [64], 'bromide': [65], 'assay,': [66, 154], 'colony': [67, 137], 'formation,': [68], 'Hoechst': [70, 156], 'staining.': [71, 157], 'In': [72], 'addition,': [73], 'potential': [76, 229], 'determined': [78], '2,2-diphenyl-1-picrylhydrazyl': [80], '(DPPH)': [81], 'radical': [82, 90, 185], 'scavenging': [83, 186], '2,2-': [86], 'azino-bis-3-ethylbenzothiazoline-6-sulfonic': [87], 'acid': [88, 170], '(ABTS)': [89], 'cation': [91], 'decolorization': [92], 'assay.': [93], 'Total': [94], 'content': [96, 161], 'assessed': [98], 'Folin-Ciocalteu': [100], 'method.': [101], 'results': [103], 'demonstrated': [104, 214], 'that': [105, 215], 'exhibited': [107], 'significant': [108], 'antiproliferative': [109], 'effect': [110], '(IC50': [113, 121], '=': [114, 122], '88.9': [115], '±': [116, 124, 190, 195], '1.27': [117], 'μg/ml)': [118, 126], '45.71': [123], '7.74': [125], 'time-': [130], 'dose-dependent': [132], 'manner.': [133], 'significantly': [135, 217], 'suppresses': [136], 'formation': [138], 'induces': [140], 'apoptosis': [141], 'both': [143], 'evident': [149], 'morphological': [151], 'assessment,': [152], 'clonogenic': [153], 'found': [165], 'be': [167], '30.3': [168], 'gallic': [169, 205], 'equivalent': [171], 'mg/g': [172], 'dry': [173], 'weight': [174], 'while': [178], 'IC50': [179], 'value': [180], 'for': [181], 'DPPH': [182], 'ABTS': [184], '72.2': [189], '2.8': [191], 'μg/ml': [192], '45.16': [194], '1.95': [196], 'μg/ml,': [197], 'respectively.': [198], 'HPLC': [199], 'analysis': [200], 'showed': [201], 'presence': [203], 'acid,': [206], 'rutin,': [207], 'quercetin': [209], 'WTBM.': [211], 'These': [212], 'findings': [213], 'inhibited': [218], 'proliferation': [219], 'breast': [221], 'induced': [225], 'apoptosis,': [226], 'suggesting': [227], 'chemopreventive': [230], 'bark.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2529219523', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-18T03:10:33.603737', 'created_date': '2016-10-14'}