Publication Information

{'id': 'https://openalex.org/W2528137095', 'doi': None, 'title': 'Chapter 16 Chk1 and Chk2 as Checkpoint Targets', 'display_name': 'Chapter 16 Chk1 and Chk2 as Checkpoint Targets', 'publication_year': 2009, 'publication_date': '2009-01-01', 'ids': {'openalex': 'https://openalex.org/W2528137095', 'mag': '2528137095'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://link.springer.com/chapter/10.1007/978-1-60761-178-3_16', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100764107', 'display_name': 'Haiying Zhang', 'orcid': 'https://orcid.org/0000-0002-7158-2373'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Haiying Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108457558', 'display_name': 'Zhan Xiao', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zhan Xiao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045320763', 'display_name': 'Tom Sowin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tom Sowin', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chek1', 'display_name': 'CHEK1', 'score': 0.9176062}, {'id': 'https://openalex.org/keywords/checkpoint-kinase-2', 'display_name': 'Checkpoint Kinase 2', 'score': 0.81665224}], 'concepts': [{'id': 'https://openalex.org/C50001416', 'wikidata': 'https://www.wikidata.org/wiki/Q17861750', 'display_name': 'CHEK1', 'level': 5, 'score': 0.9176062}, {'id': 'https://openalex.org/C2910325170', 'wikidata': 'https://www.wikidata.org/wiki/Q14912280', 'display_name': 'Checkpoint Kinase 2', 'level': 5, 'score': 0.81665224}, {'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.793193}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.7599487}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.7449065}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.5245469}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.4931454}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48842588}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46777028}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.41245297}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3950945}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32673365}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12759584}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://link.springer.com/chapter/10.1007/978-1-60761-178-3_16', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 100, 'referenced_works': ['https://openalex.org/W104764535', 'https://openalex.org/W1488639892', 'https://openalex.org/W1752089945', 'https://openalex.org/W1903850103', 'https://openalex.org/W1965140423', 'https://openalex.org/W1966249371', 'https://openalex.org/W1969210627', 'https://openalex.org/W1972185917', 'https://openalex.org/W1975245003', 'https://openalex.org/W1976558883', 'https://openalex.org/W1979986967', 'https://openalex.org/W1982305402', 'https://openalex.org/W1986539944', 'https://openalex.org/W1986557026', 'https://openalex.org/W1988876917', 'https://openalex.org/W1990120645', 'https://openalex.org/W1990850872', 'https://openalex.org/W1991949196', 'https://openalex.org/W1995758795', 'https://openalex.org/W1996505651', 'https://openalex.org/W1997759534', 'https://openalex.org/W2000980666', 'https://openalex.org/W2003842525', 'https://openalex.org/W2017275179', 'https://openalex.org/W2018579586', 'https://openalex.org/W2023724309', 'https://openalex.org/W2028044172', 'https://openalex.org/W2029304297', 'https://openalex.org/W2042028505', 'https://openalex.org/W2045647925', 'https://openalex.org/W2045894986', 'https://openalex.org/W2047383934', 'https://openalex.org/W2048451721', 'https://openalex.org/W2049877855', 'https://openalex.org/W2050348418', 'https://openalex.org/W2051744391', 'https://openalex.org/W2055687679', 'https://openalex.org/W2057650437', 'https://openalex.org/W2062830810', 'https://openalex.org/W2063882503', 'https://openalex.org/W2070831760', 'https://openalex.org/W2074889730', 'https://openalex.org/W2075707444', 'https://openalex.org/W2076314401', 'https://openalex.org/W2076324577', 'https://openalex.org/W2077569993', 'https://openalex.org/W2079017691', 'https://openalex.org/W2082507134', 'https://openalex.org/W2084796662', 'https://openalex.org/W2086218417', 'https://openalex.org/W2087697646', 'https://openalex.org/W2088231104', 'https://openalex.org/W2091782725', 'https://openalex.org/W2095946344', 'https://openalex.org/W2095986441', 'https://openalex.org/W2102653975', 'https://openalex.org/W2105592350', 'https://openalex.org/W2106622937', 'https://openalex.org/W2108979392', 'https://openalex.org/W2110386799', 'https://openalex.org/W2110687570', 'https://openalex.org/W2111131079', 'https://openalex.org/W2111403239', 'https://openalex.org/W2111758853', 'https://openalex.org/W2114205900', 'https://openalex.org/W2116326380', 'https://openalex.org/W2119186872', 'https://openalex.org/W2120921507', 'https://openalex.org/W2121446363', 'https://openalex.org/W2125003296', 'https://openalex.org/W2128994729', 'https://openalex.org/W2129753373', 'https://openalex.org/W2131833681', 'https://openalex.org/W2134547388', 'https://openalex.org/W2140730373', 'https://openalex.org/W2143330861', 'https://openalex.org/W2145339037', 'https://openalex.org/W2147971204', 'https://openalex.org/W2148964728', 'https://openalex.org/W2149013144', 'https://openalex.org/W2153812820', 'https://openalex.org/W2153953411', 'https://openalex.org/W2154141161', 'https://openalex.org/W2158648773', 'https://openalex.org/W2158669039', 'https://openalex.org/W2158696238', 'https://openalex.org/W2167857691', 'https://openalex.org/W2171131568', 'https://openalex.org/W2171439401', 'https://openalex.org/W2253128172', 'https://openalex.org/W2290363779', 'https://openalex.org/W2316582027', 'https://openalex.org/W2324773916', 'https://openalex.org/W2329294870', 'https://openalex.org/W2337836213', 'https://openalex.org/W2341475099', 'https://openalex.org/W2402214665', 'https://openalex.org/W2415353577', 'https://openalex.org/W2416730013', 'https://openalex.org/W2604362717'], 'related_works': ['https://openalex.org/W3132677335', 'https://openalex.org/W3089617720', 'https://openalex.org/W3081554319', 'https://openalex.org/W2960474771', 'https://openalex.org/W2804858811', 'https://openalex.org/W2803556357', 'https://openalex.org/W2772278187', 'https://openalex.org/W2770695743', 'https://openalex.org/W2415744544', 'https://openalex.org/W2225210933', 'https://openalex.org/W2166827161', 'https://openalex.org/W2158616790', 'https://openalex.org/W2109614413', 'https://openalex.org/W2071088216', 'https://openalex.org/W2063393084', 'https://openalex.org/W2030124682', 'https://openalex.org/W1979803759', 'https://openalex.org/W1594035260', 'https://openalex.org/W1498579066', 'https://openalex.org/W1484740038'], 'abstract_inverted_index': {'DNA': [0, 13, 25], 'damage': [1], 'checkpoint': [2, 28], 'response': [3], 'is': [4], 'initiated': [5], 'to': [6, 52, 79], 'arrest': [7, 69], 'cell': [8, 47], 'cycle': [9], 'progression': [10], 'so': [11], 'that': [12], 'repair': [14], 'can': [15], 'take': [16], 'place': [17], 'and,': [18], 'thereby,': [19], 'prevents': [20], 'accumulation': [21], 'and': [22, 31, 42, 67, 96, 106], 'propagation': [23], 'of': [24, 45, 83, 87], 'damage.': [26], 'In': [27], 'response,': [29], 'Chk1': [30, 50, 84], 'Chk2': [32, 59, 102], 'have': [33, 89], 'major': [34, 74], 'roles,': [35], 'primarily': [36], 'in': [37, 40], 'arresting': [38], 'cells': [39], 'S': [41, 66], 'G2': [43, 68], 'phase': [44], 'the': [46, 54, 80, 99], 'cycle.': [48], 'However,': [49], 'appears': [51], 'be': [53], 'more': [55], 'critical': [56], 'player,': [57], 'with': [58], 'playing': [60], 'an': [61], 'acces-': [62], 'sory': [63], 'role.': [64], 'Since': [65], 'are': [70], 'pro-survival': [71], 'events,': [72], 'a': [73], 'effort': [75], 'has': [76], 'been': [77], 'devoted': [78], 'devel-': [81], 'opment': [82], 'inhibitors,': [85], 'some': [86], 'which': [88], 'en-': [90], 'tered': [91], 'clinical': [92], 'trials': [93], 'as': [94], 'chemo-': [95], 'radio-sensitizers.': [97], 'On': [98], 'other': [100], 'hand,': [101], 'potentiates': [103], 'p53-dependent': [104], 'apoptosis,': [105], 'inhibitors': [107], 'targeting': [108], 'this': [109], 'kinase': [110], 'may': [111], 'afford': [112], 'protection': [113], 'against': [114], 'normal': [115], 'tissue': [116], 'injury': [117], 'during': [118], 'cancer': [119], 'therapy.': [120]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2528137095', 'counts_by_year': [], 'updated_date': '2024-12-08T03:00:04.109027', 'created_date': '2016-10-14'}