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'transpeptidase(γ-GTP)を組織化学的に検討し,血清γ-GTP値と比較した結果,胆管閉塞時の血清γ-GTP上昇には,肝小葉内γ-GTP活性増加と著明な胆管増殖が関係する事がわかった.肝内γ-GTPの電顕的検討を,先天性胆道閉鎖症3例,肝外胆管閉塞ラットで行い,胆管閉塞時の肝内γ-GTPの超微形態的局在状態を初めて明らかにした.胆管閉塞時,肝小葉内では,γ-GTPの増加した毛細胆管,肝細胞において,γ-GTPの毛細胆管腔,Disse腔への流出が起り,グリソン鞘では,γ-GTPの増加した増殖胆管で,γ-GTPの内腔への流出,増殖胆管周囲小血管への流出が起る事を示唆する所見も得られた.': [1]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2527529581', 'counts_by_year': [], 'updated_date': '2024-09-14T18:25:05.067550', 'created_date': '2016-10-07'}