Publication Information

{'id': 'https://openalex.org/W2525472300', 'doi': 'https://doi.org/10.1016/j.jalz.2006.05.871', 'title': 'P2–034: Deletion of genes responsible for vesicular transport in yeast causes mislocalization and enhanced toxicity of α–synuclein', 'display_name': 'P2–034: Deletion of genes responsible for vesicular transport in yeast causes mislocalization and enhanced toxicity of α–synuclein', 'publication_year': 2006, 'publication_date': '2006-07-01', 'ids': {'openalex': 'https://openalex.org/W2525472300', 'doi': 'https://doi.org/10.1016/j.jalz.2006.05.871', 'mag': '2525472300'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jalz.2006.05.871', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108427512', 'display_name': 'Alzheimer s & Dementia', 'issn_l': '1552-5260', 'issn': ['1552-5260', '1552-5279'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040441896', 'display_name': 'Piotr Zabrocki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Piotr Zabrocki', 'raw_affiliation_strings': ['K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003998241', 'display_name': 'Klaartje Pellens', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Klaartje Pellens', 'raw_affiliation_strings': ['K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108245784', 'display_name': 'Fred Van Leuven', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Fred Van Leuven', 'raw_affiliation_strings': ['K.U. Leuven, Experimental Genetics Group, Heverlee-Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'K.U. Leuven, Experimental Genetics Group, Heverlee-Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026407068', 'display_name': 'Joris Winderickx', 'orcid': 'https://orcid.org/0000-0003-3133-7733'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Joris G. Winderickx', 'raw_affiliation_strings': ['K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'K.U. Leuven, Functional Biology, Heverlee-Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5040441896'], 'corresponding_institution_ids': ['https://openalex.org/I99464096'], 'apc_list': {'value': 4000, 'currency': 'USD', 'value_usd': 4000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '2', 'issue': '3S_Part_8', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13127', 'display_name': 'Biotin and Related Studies', 'score': 0.9106, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vesicular-transport-protein', 'display_name': 'Vesicular Transport Proteins', 'score': 0.8713415}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.63820153}, {'id': 'https://openalex.org/keywords/vesicular-transport-proteins', 'display_name': 'Vesicular Transport Proteins', 'score': 0.5599834}, {'id': 'https://openalex.org/keywords/axoplasmic-transport', 'display_name': 'Axoplasmic transport', 'score': 0.51935875}, {'id': 'https://openalex.org/keywords/synuclein', 'display_name': 'Synuclein', 'score': 0.43356782}, {'id': 'https://openalex.org/keywords/escrt', 'display_name': 'ESCRT', 'score': 0.42288792}], 'concepts': [{'id': 'https://openalex.org/C167019083', 'wikidata': 'https://www.wikidata.org/wiki/Q4082043', 'display_name': 'Vesicular transport protein', 'level': 4, 'score': 0.8713415}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.6986857}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.67764944}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64953303}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.63820153}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.60316783}, {'id': 'https://openalex.org/C2910636507', 'wikidata': 'https://www.wikidata.org/wiki/Q4082043', 'display_name': 'Vesicular Transport Proteins', 'level': 5, 'score': 0.5599834}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.5455392}, {'id': 'https://openalex.org/C70192387', 'wikidata': 'https://www.wikidata.org/wiki/Q792602', 'display_name': 'Axoplasmic transport', 'level': 2, 'score': 0.51935875}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.4990387}, {'id': 'https://openalex.org/C2777916540', 'wikidata': 'https://www.wikidata.org/wiki/Q24767155', 'display_name': 'Synuclein', 'level': 5, 'score': 0.43356782}, {'id': 'https://openalex.org/C143876685', 'wikidata': 'https://www.wikidata.org/wiki/Q22327705', 'display_name': 'ESCRT', 'level': 4, 'score': 0.42288792}, {'id': 'https://openalex.org/C2781449126', 'wikidata': 'https://www.wikidata.org/wiki/Q288591', 'display_name': 'Alpha-synuclein', 'level': 4, 'score': 0.41978222}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.41474837}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2952127}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.20154852}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.11993912}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.105110645}, {'id': 'https://openalex.org/C2777867350', 'wikidata': 'https://www.wikidata.org/wiki/Q7908031', 'display_name': 'Vacuolar protein sorting', 'level': 4, 'score': 0.0951471}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jalz.2006.05.871', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S108427512', 'display_name': 'Alzheimer s & Dementia', 'issn_l': '1552-5260', 'issn': ['1552-5260', '1552-5279'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4381295388', 'https://openalex.org/W2744528944', 'https://openalex.org/W2184283965', 'https://openalex.org/W2115478133', 'https://openalex.org/W2093528538', 'https://openalex.org/W2091594158', 'https://openalex.org/W2068288334', 'https://openalex.org/W2042752875', 'https://openalex.org/W2021810154', 'https://openalex.org/W1530609782'], 'abstract_inverted_index': {'α–Synuclein': [0], 'is': [1, 16, 61], 'a': [2, 33, 47, 51, 62], 'small': [3], 'pre–synaptic': [4], 'protein': [5, 54], 'involved': [6, 125], 'in': [7, 37, 55, 79, 97, 126], 'the': [8, 56, 90, 94, 161, 168], 'pathology': [9], 'of': [10, 14, 35, 71, 93, 133, 142, 149, 167, 172], 'Parkinson.': [11], 'The': [12], 'function': [13], 'α–synuclein': [15, 36, 45, 84, 134, 150, 184], 'still': [17], 'unclear': [18], 'but': [19], 'was': [20], 'recently': [21], 'suggested': [22], 'to': [23, 31, 76, 89, 123, 151, 177, 185], 'be': [24, 124], 'important': [25], 'for': [26, 147], 'vesicular': [27, 38, 41, 73, 127, 152, 187], 'transport.': [28, 128], 'In': [29], 'order': [30], 'define': [32], 'role': [34], 'transport': [39, 153, 188], 'and': [40, 85, 164, 179], 'pathways,': [42], 'we': [43], 'expressed': [44], 'as': [46, 50], 'native': [48, 83], 'or': [49, 121], 'GFP–tagged': [52], 'fusion': [53], 'yeast': [57, 66, 100, 113], 'Saccharomyces': [58], 'cerevisiae.': [59], 'This': [60], 'suitable': [63], 'model': [64], 'since': [65], 'expresses': [67], 'many': [68], 'functional': [69], 'orthologues': [70], 'mammalian': [72, 80], 'proteins.': [74], 'Similar': [75], 'its': [77], 'localization': [78], 'cells,': [81], 'both': [82], 'α–synuclein–GFP': [86], 'were': [87], 'bound': [88], 'cytoplasmic': [91], 'side': [92], 'plasma': [95], 'membrane': [96], 'wild': [98], 'type': [99], 'cells': [101], '(Zabrocki': [102], 'et': [103], 'al.,': [104], 'FEBS': [105], 'J.,': [106], '272,': [107], '1386–1400,': [108], '2005).': [109], 'We': [110, 129, 144], 'screened': [111], 'mutant': [112], 'strains': [114], 'lacking': [115], 'different': [116, 186], 'proteins': [117, 166, 174], 'that': [118, 136], 'are': [119, 175], 'proven': [120], 'suspected': [122], 'observed': [130], 'distinct': [131], 'patterns': [132], 'mislocalization,': [135], 'often': [137], 'coincided': [138], 'with': [139], 'enhanced': [140], 'toxicity': [141], 'α–synuclein.': [143], 'provide': [145], 'evidence': [146], 'connections': [148], 'involving': [154], 'ESCRT': [155], 'I,': [156], 'II,': [157], 'III': [158], 'complexes,': [159], 'SNAREs,': [160], 'HOPS': [162], 'complex': [163], 'typical': [165], 'Golgi': [169], 'complex.': [170], 'Many': [171], 'these': [173], 'related': [176], 'endosomal': [178], 'ubiquitin–dependent': [180], 'transport,': [181], 'which': [182], 'links': [183], 'systems.': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2525472300', 'counts_by_year': [], 'updated_date': '2024-12-10T12:45:04.838447', 'created_date': '2016-10-07'}