Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2523184587', 'doi': 'https://doi.org/10.1016/j.jmb.2016.09.018', 'title': 'Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination', 'display_name': 'Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination', 'publication_year': 2016, 'publication_date': '2016-09-25', 'ids': {'openalex': 'https://openalex.org/W2523184587', 'doi': 'https://doi.org/10.1016/j.jmb.2016.09.018', 'mag': '2523184587', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27678051', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5115946'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2016.09.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5115946?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006996873', 'display_name': 'Anthony DiBello', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anthony DiBello', 'raw_affiliation_strings': ['Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103216612', 'display_name': 'Ajit B. Datta', 'orcid': 'https://orcid.org/0000-0001-9695-4228'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ajit B. Datta', 'raw_affiliation_strings': ['Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103224776', 'display_name': 'Xiangbin Zhang', 'orcid': 'https://orcid.org/0000-0002-8240-4919'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiangbin Zhang', 'raw_affiliation_strings': ['Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060002881', 'display_name': 'Cynthia Wolberger', 'orcid': 'https://orcid.org/0000-0001-8578-2969'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Cynthia Wolberger', 'raw_affiliation_strings': ['Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biophysics and Biophysical Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5060002881'], 'corresponding_institution_ids': ['https://openalex.org/I145311948'], 'apc_list': {'value': 4250, 'currency': 'USD', 'value_usd': 4250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.475, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '428', 'issue': '23', 'first_page': '4639', 'last_page': '4650'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ubiquitin-conjugating-enzyme', 'display_name': 'Ubiquitin-conjugating enzyme', 'score': 0.7748122}, {'id': 'https://openalex.org/keywords/rnf4', 'display_name': 'RNF4', 'score': 0.75976646}, {'id': 'https://openalex.org/keywords/ubiquitin-protein-ligases', 'display_name': 'Ubiquitin-Protein Ligases', 'score': 0.732022}], 'concepts': [{'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.8898716}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.88910484}, {'id': 'https://openalex.org/C182561583', 'wikidata': 'https://www.wikidata.org/wiki/Q7876535', 'display_name': 'Ubiquitin-conjugating enzyme', 'level': 5, 'score': 0.7748122}, {'id': 'https://openalex.org/C138599941', 'wikidata': 'https://www.wikidata.org/wiki/Q18031158', 'display_name': 'RNF4', 'level': 5, 'score': 0.75976646}, {'id': 'https://openalex.org/C2908868211', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin-Protein Ligases', 'level': 5, 'score': 0.732022}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.51258796}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5041388}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4864504}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.45409152}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.414329}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39927742}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.35332447}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17443198}, {'id': 'https://openalex.org/C24284526', 'wikidata': 'https://www.wikidata.org/wiki/Q204785', 'display_name': 'Zinc finger', 'level': 4, 'score': 0.14852801}], 'mesh': [{'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D025841', 'descriptor_name': 'Small Ubiquitin-Related Modifier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025841', 'descriptor_name': 'Small Ubiquitin-Related Modifier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jmb.2016.09.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S46058472', 'display_name': 'Journal of Molecular Biology', 'issn_l': '0022-2836', 'issn': ['0022-2836', '1089-8638'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5115946', 'pdf_url': 'https://europepmc.org/articles/pmc5115946?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115946', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27678051', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5115946', 'pdf_url': 'https://europepmc.org/articles/pmc5115946?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'GM109102'}], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1526095797', 'https://openalex.org/W1547431965', 'https://openalex.org/W1559325314', 'https://openalex.org/W1831346262', 'https://openalex.org/W1945378141', 'https://openalex.org/W1964909962', 'https://openalex.org/W1965146753', 'https://openalex.org/W1976169230', 'https://openalex.org/W1979019144', 'https://openalex.org/W1982004004', 'https://openalex.org/W1984881591', 'https://openalex.org/W1992063298', 'https://openalex.org/W2001701156', 'https://openalex.org/W2003434224', 'https://openalex.org/W2007588515', 'https://openalex.org/W2008646773', 'https://openalex.org/W2010053735', 'https://openalex.org/W2015291446', 'https://openalex.org/W2017178787', 'https://openalex.org/W2019304455', 'https://openalex.org/W2023265964', 'https://openalex.org/W2024238110', 'https://openalex.org/W2026875361', 'https://openalex.org/W2027792462', 'https://openalex.org/W2028003321', 'https://openalex.org/W2028111548', 'https://openalex.org/W2029709752', 'https://openalex.org/W2029794768', 'https://openalex.org/W2036231949', 'https://openalex.org/W2036806530', 'https://openalex.org/W2041517382', 'https://openalex.org/W2044287615', 'https://openalex.org/W2045174330', 'https://openalex.org/W2047705460', 'https://openalex.org/W2055161360', 'https://openalex.org/W2056139483', 'https://openalex.org/W2059698383', 'https://openalex.org/W2060870400', 'https://openalex.org/W2060875411', 'https://openalex.org/W2061671463', 'https://openalex.org/W2074704372', 'https://openalex.org/W2078870259', 'https://openalex.org/W2081120309', 'https://openalex.org/W2083272521', 'https://openalex.org/W2094153604', 'https://openalex.org/W2100200896', 'https://openalex.org/W2106246537', 'https://openalex.org/W2108423991', 'https://openalex.org/W2109311268', 'https://openalex.org/W2119301405', 'https://openalex.org/W2130901904', 'https://openalex.org/W2131079894', 'https://openalex.org/W2135988226', 'https://openalex.org/W2136128861', 'https://openalex.org/W2136623638', 'https://openalex.org/W2138057005', 'https://openalex.org/W2144114582', 'https://openalex.org/W2146497742', 'https://openalex.org/W2147542927', 'https://openalex.org/W2147917253', 'https://openalex.org/W2166440816', 'https://openalex.org/W2171687207', 'https://openalex.org/W2320253565', 'https://openalex.org/W2398731353', 'https://openalex.org/W2416333604', 'https://openalex.org/W243680554', 'https://openalex.org/W4210757594', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4248285230', 'https://openalex.org/W34474889', 'https://openalex.org/W295190513', 'https://openalex.org/W2797773019', 'https://openalex.org/W2523184587', 'https://openalex.org/W2383178712', 'https://openalex.org/W2356902701', 'https://openalex.org/W2121772170', 'https://openalex.org/W1993442317', 'https://openalex.org/W1964924844'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2523184587', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-09T17:22:32.851429', 'created_date': '2016-09-30'}