Title: Multipotent perivascular mesenchymal stem cells in the human brain
Abstract:K questions in adult stem cell biology revolve around origin, tissue home and physiological role of adult stem cell populations. Mesenchymal stem cells (MSC) have remained elusive with regard to their...K questions in adult stem cell biology revolve around origin, tissue home and physiological role of adult stem cell populations. Mesenchymal stem cells (MSC) have remained elusive with regard to their in vivo physiology. Recent observations suggest that almost all adult tissues contain mesenchymal-like progenitors in a perivascular niche. Those cells can differentiate into mesodermal cell types and may even be endowed with tissue specific differentiation capacities. We have isolated and characterized a previously unrecognized progenitor cell population in the adult human brain. This cell population exhibits characteristics of mesenchymal stem cells (CD105, CD90, CD73, CD29) but in its native state does not express hematopoetic (CD34, CD45), endothelial (CD31), microglial (CD14, CD11b), glial and neuronal progenitor markers (GFAP, O4). We demonstrate at a clonal level, that the progenitors have true multilineage potential not only towards a mesodermal but also neuroectodermal phenotype and can differentiate into neurons. Thus, the vasculature in the adult human brain contains progenitor cells with multilineage capacity that may represent a reservoir that can be exploited in attempts to repair the damaged or diseased brain.Read More
Publication Year: 2013
Publication Date: 2013-07-06
Language: en
Type: article
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