Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2522179353', 'doi': 'https://doi.org/10.1128/aac.00838-16', 'title': 'Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae', 'display_name': 'Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae', 'publication_year': 2016, 'publication_date': '2016-10-01', 'ids': {'openalex': 'https://openalex.org/W2522179353', 'doi': 'https://doi.org/10.1128/aac.00838-16', 'mag': '2522179353', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27503655', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5038245'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00838-16', 'pdf_url': 'https://aac.asm.org/content/aac/60/10/6425.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aac.asm.org/content/aac/60/10/6425.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030280540', 'display_name': 'Pranita D. Tamma', 'orcid': 'https://orcid.org/0000-0002-4143-6324'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pranita D. Tamma', 'raw_affiliation_strings': ['Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102865102', 'display_name': 'Yanjie Huang', 'orcid': 'https://orcid.org/0000-0002-9536-9622'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yanjie Huang', 'raw_affiliation_strings': ['Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050729266', 'display_name': 'Belita N. A. Opene', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Belita N. A. Opene', 'raw_affiliation_strings': ['Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076726611', 'display_name': 'Patricia J. Simner', 'orcid': 'https://orcid.org/0000-0001-6134-151X'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patricia J. Simner', 'raw_affiliation_strings': ['Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.301, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.999597, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '60', 'issue': '10', 'first_page': '6425', 'last_page': '6429'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13849', 'display_name': 'Outbreak of Cronobacter sakazakii Infections', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ertapenem', 'display_name': 'Ertapenem', 'score': 0.96497893}, {'id': 'https://openalex.org/keywords/doripenem', 'display_name': 'Doripenem', 'score': 0.9189379}, {'id': 'https://openalex.org/keywords/carbapenem', 'display_name': 'Carbapenem', 'score': 0.8564354}, {'id': 'https://openalex.org/keywords/carbapenem-resistant-enterobacteriaceae', 'display_name': 'Carbapenem-resistant enterobacteriaceae', 'score': 0.82585156}, {'id': 'https://openalex.org/keywords/carbapenemases', 'display_name': 'Carbapenemases', 'score': 0.572534}, {'id': 'https://openalex.org/keywords/enterobacteriaceae', 'display_name': 'Enterobacteriaceae', 'score': 0.510114}], 'concepts': [{'id': 'https://openalex.org/C2778368673', 'wikidata': 'https://www.wikidata.org/wiki/Q553220', 'display_name': 'Ertapenem', 'level': 5, 'score': 0.96497893}, {'id': 'https://openalex.org/C2777821550', 'wikidata': 'https://www.wikidata.org/wiki/Q411552', 'display_name': 'Doripenem', 'level': 5, 'score': 0.9189379}, {'id': 'https://openalex.org/C2776685102', 'wikidata': 'https://www.wikidata.org/wiki/Q410897', 'display_name': 'Carbapenem', 'level': 3, 'score': 0.8564354}, {'id': 'https://openalex.org/C2779375183', 'wikidata': 'https://www.wikidata.org/wiki/Q421670', 'display_name': 'Meropenem', 'level': 4, 'score': 0.8515996}, {'id': 'https://openalex.org/C2775992322', 'wikidata': 'https://www.wikidata.org/wiki/Q5037837', 'display_name': 'Carbapenem-resistant enterobacteriaceae', 'level': 5, 'score': 0.82585156}, {'id': 'https://openalex.org/C2778910516', 'wikidata': 'https://www.wikidata.org/wiki/Q380136', 'display_name': 'Enterobacteriaceae', 'level': 4, 'score': 0.79761606}, {'id': 'https://openalex.org/C2779631663', 'wikidata': 'https://www.wikidata.org/wiki/Q425152', 'display_name': 'Imipenem', 'level': 4, 'score': 0.759038}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7439467}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5167934}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.42615157}, {'id': 'https://openalex.org/C2777058267', 'wikidata': 'https://www.wikidata.org/wiki/Q132592', 'display_name': 'Klebsiella pneumoniae', 'level': 4, 'score': 0.42558378}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.14836767}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.14370844}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.09503329}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06725663}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015780', 'descriptor_name': 'Carbapenems', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015780', 'descriptor_name': 'Carbapenems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004755', 'descriptor_name': 'Enterobacteriaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012372', 'descriptor_name': 'ROC Curve', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001618', 'descriptor_name': 'beta-Lactamases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00838-16', 'pdf_url': 'https://aac.asm.org/content/aac/60/10/6425.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5038245', 'pdf_url': 'https://europepmc.org/articles/pmc5038245?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038245', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27503655', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.00838-16', 'pdf_url': 'https://aac.asm.org/content/aac/60/10/6425.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.42, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 6, 'referenced_works': ['https://openalex.org/W1128749024', 'https://openalex.org/W2065337857', 'https://openalex.org/W2131192097', 'https://openalex.org/W2141917952', 'https://openalex.org/W2160777220', 'https://openalex.org/W2266477129'], 'related_works': ['https://openalex.org/W4282834160', 'https://openalex.org/W3118931395', 'https://openalex.org/W2595667698', 'https://openalex.org/W2522250029', 'https://openalex.org/W2285087135', 'https://openalex.org/W2184417017', 'https://openalex.org/W2002728592', 'https://openalex.org/W1991087639', 'https://openalex.org/W1971861707', 'https://openalex.org/W1720517915'], 'abstract_inverted_index': {'Carbapenemase-producing': [0], '(CP)': [1], 'Enterobacteriaceae': [2, 12], 'are': [3], 'largely': [4], 'responsible': [5], 'for': [6, 30], 'the': [7], 'rapid': [8], 'spread': [9], 'of': [10, 26, 44, 53], 'carbapenem-resistant': [11], '(CRE).': [13], 'Distinguishing': [14], 'CP-CRE': [15, 61], 'from': [16, 62], 'non-CP-CRE': [17, 63], 'has': [18], 'important': [19], 'infection': [20], 'control': [21], 'implications.': [22], 'In': [23], 'a': [24], 'cohort': [25], '198': [27], 'CRE': [28], 'isolates,': [29], 'isolates': [31], 'that': [32], 'remained': [33], 'susceptible': [34], 'or': [35], 'intermediate': [36], 'to': [37, 59], 'some': [38], 'carbapenem': [39], 'antibiotics,': [40], 'an': [41], 'ertapenem': [42], 'MIC': [43], '0.5': [45], 'μg/ml': [46, 55], 'and': [47, 50], 'meropenem,': [48], 'imipenem,': [49], 'doripenem': [51], 'MICs': [52], '2': [54], 'were': [56], 'best': [57], 'able': [58], 'distinguish': [60], 'isolates.': [64]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2522179353', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-13T12:51:17.488604', 'created_date': '2016-09-30'}