Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2522145043', 'doi': 'https://doi.org/10.1111/1751-2980.12408', 'title': 'MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease', 'display_name': 'MicroRNAs as biomarkers and regulators of nonalcoholic fatty liver disease', 'publication_year': 2016, 'publication_date': '2016-09-15', 'ids': {'openalex': 'https://openalex.org/W2522145043', 'doi': 'https://doi.org/10.1111/1751-2980.12408', 'mag': '2522145043', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27628945'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/1751-2980.12408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135107853', 'display_name': 'Journal of Digestive Diseases', 'issn_l': '1751-2972', 'issn': ['1751-2972', '1751-2980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014644688', 'display_name': 'Xiao Lin Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao Lin Liu', 'raw_affiliation_strings': ['Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I2801518579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045829991', 'display_name': 'Hai Cao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hai Xia Cao', 'raw_affiliation_strings': ['Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I2801518579']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101713846', 'display_name': 'Jian‐Gao Fan', 'orcid': 'https://orcid.org/0000-0002-8618-6402'}, 'institutions': [{'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Jian Gao Fan', 'raw_affiliation_strings': ['Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology and Center for Fatty Liver, XinHua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China', 'institution_ids': ['https://openalex.org/I2801518579']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5101713846'], 'corresponding_institution_ids': ['https://openalex.org/I2801518579'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.594, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.613982, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '17', 'issue': '11', 'first_page': '708', 'last_page': '715'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11765', 'display_name': 'Circular RNAs in diseases', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nonalcoholic-steatohepatitis', 'display_name': 'Nonalcoholic steatohepatitis', 'score': 0.5006101}], 'concepts': [{'id': 'https://openalex.org/C2776954865', 'wikidata': 'https://www.wikidata.org/wiki/Q1546498', 'display_name': 'Nonalcoholic fatty liver disease', 'level': 4, 'score': 0.8780957}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.78760517}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.78070885}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.50755584}, {'id': 'https://openalex.org/C3018708256', 'wikidata': 'https://www.wikidata.org/wiki/Q1546498', 'display_name': 'Nonalcoholic steatohepatitis', 'level': 5, 'score': 0.5006101}, {'id': 'https://openalex.org/C2778772119', 'wikidata': 'https://www.wikidata.org/wiki/Q6058862', 'display_name': 'Fatty liver', 'level': 3, 'score': 0.4704465}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.4526536}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43113482}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.4246564}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14771885}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13382298}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.12637931}], 'mesh': [{'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D065626', 'descriptor_name': 'Non-alcoholic Fatty Liver Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065626', 'descriptor_name': 'Non-alcoholic Fatty Liver Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065626', 'descriptor_name': 'Non-alcoholic Fatty Liver Disease', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D065626', 'descriptor_name': 'Non-alcoholic Fatty Liver Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/1751-2980.12408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135107853', 'display_name': 'Journal of Digestive Diseases', 'issn_l': '1751-2972', 'issn': ['1751-2972', '1751-2980'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27628945', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81270491 and 81470840'}], 'datasets': [], 'versions': [], 'referenced_works_count': 80, 'referenced_works': ['https://openalex.org/W1440460151', 'https://openalex.org/W144423133', 'https://openalex.org/W1485267747', 'https://openalex.org/W1544572219', 'https://openalex.org/W1545606694', 'https://openalex.org/W1555170732', 'https://openalex.org/W1825697469', 'https://openalex.org/W1923097273', 'https://openalex.org/W1928264125', 'https://openalex.org/W1928422586', 'https://openalex.org/W1935382102', 'https://openalex.org/W1963683487', 'https://openalex.org/W1967972402', 'https://openalex.org/W1978346362', 'https://openalex.org/W1980867561', 'https://openalex.org/W1984468543', 'https://openalex.org/W1984499494', 'https://openalex.org/W1989277040', 'https://openalex.org/W1989429848', 'https://openalex.org/W1993553259', 'https://openalex.org/W1999787016', 'https://openalex.org/W2001927173', 'https://openalex.org/W2004882752', 'https://openalex.org/W2007131306', 'https://openalex.org/W2009423035', 'https://openalex.org/W2014980326', 'https://openalex.org/W2016307947', 'https://openalex.org/W2019900254', 'https://openalex.org/W2025049635', 'https://openalex.org/W2027744584', 'https://openalex.org/W2030354790', 'https://openalex.org/W2033374739', 'https://openalex.org/W2038153203', 'https://openalex.org/W2041466968', 'https://openalex.org/W2042981158', 'https://openalex.org/W2045376844', 'https://openalex.org/W2047257800', 'https://openalex.org/W2047967134', 'https://openalex.org/W2048091871', 'https://openalex.org/W2054504536', 'https://openalex.org/W2059613020', 'https://openalex.org/W2063885268', 'https://openalex.org/W2064227724', 'https://openalex.org/W2065612971', 'https://openalex.org/W2088543680', 'https://openalex.org/W2090073925', 'https://openalex.org/W2096364245', 'https://openalex.org/W2102901373', 'https://openalex.org/W2104745602', 'https://openalex.org/W2107943478', 'https://openalex.org/W2108272027', 'https://openalex.org/W2111718356', 'https://openalex.org/W2117316556', 'https://openalex.org/W2119144998', 'https://openalex.org/W2128304272', 'https://openalex.org/W2134896806', 'https://openalex.org/W2135608471', 'https://openalex.org/W2139342290', 'https://openalex.org/W2141269207', 'https://openalex.org/W2145377399', 'https://openalex.org/W2157085831', 'https://openalex.org/W2163241101', 'https://openalex.org/W2167729033', 'https://openalex.org/W216833258', 'https://openalex.org/W2174904675', 'https://openalex.org/W2216686873', 'https://openalex.org/W2222334274', 'https://openalex.org/W2259715960', 'https://openalex.org/W2260144515', 'https://openalex.org/W2263796657', 'https://openalex.org/W2277108569', 'https://openalex.org/W2309174028', 'https://openalex.org/W2312845632', 'https://openalex.org/W2337397486', 'https://openalex.org/W2338974767', 'https://openalex.org/W2340023004', 'https://openalex.org/W2397243787', 'https://openalex.org/W2404854535', 'https://openalex.org/W2416046723', 'https://openalex.org/W270759187'], 'related_works': ['https://openalex.org/W4393935533', 'https://openalex.org/W4285728697', 'https://openalex.org/W4283818330', 'https://openalex.org/W3003636062', 'https://openalex.org/W2899389750', 'https://openalex.org/W2804007807', 'https://openalex.org/W2402526617', 'https://openalex.org/W2312762963', 'https://openalex.org/W2294522312', 'https://openalex.org/W2063941454'], 'abstract_inverted_index': {'Nonalcoholic': [0], 'fatty': [1], 'liver': [2], 'disease': [3, 8, 24, 99, 104], '(NAFLD)': [4], 'is': [5, 31], 'a': [6, 32, 70], 'complicated': [7], 'affected': [9], 'by': [10], 'the': [11, 19, 23, 37, 59, 94, 98, 101, 111, 126, 134, 157], 'interaction': [12], 'of': [13, 22, 39, 58, 69, 73, 97, 103, 119, 128, 136, 159], 'environmental': [14], 'and': [15, 41, 52, 80, 100, 124, 143, 152], 'genetic': [16], 'factors;': [17], 'however,': [18], 'precise': [20], 'pathogenesis': [21, 38, 158], 'has': [25], 'not': [26], 'been': [27], 'fully': [28], 'determined.': [29], 'There': [30], 'need': [33], 'to': [34, 42, 156], 'better': [35], 'understand': [36], 'NAFLD': [40, 120], 'identify': [43], 'non-invasive': [44], 'diagnostic': [45], 'modalities.': [46], 'Recent': [47], 'advances': [48], 'in': [49, 62, 85, 140, 149], 'systematic': [50], 'biology': [51], 'epigenetics': [53], 'have': [54], 'improved': [55], 'our': [56], 'understanding': [57], 'genotype-phenotype': [60], 'relationships': [61], 'NAFLD.': [63, 160], 'MicroRNAs': [64], '(miRNAs)': [65], 'are': [66, 77], 'important': [67], 'regulators': [68], 'wide': [71], 'range': [72], 'biological': [74], 'processes.': [75], 'MiRNAs': [76], 'extremely': [78], 'stable': [79], 'protect': [81], 'from': [82], 'RNAase-mediated': [83], 'degradation': [84], 'body': [86], 'fluids,': [87], 'making': [88], 'them': [89], 'attractive': [90], 'candidate': [91], 'biomarkers': [92, 118], 'for': [93, 125], 'early': [95], 'detection': [96], 'monitoring': [102], 'progression.': [105], 'In': [106], 'this': [107], 'review,': [108], 'we': [109, 132], 'summarized': [110], 'current': [112], 'knowledge': [113], 'on': [114], 'miRNAs': [115, 137], 'as': [116, 146, 148], 'potential': [117], 'at': [121], 'different': [122], 'stages': [123], 'prognosis': [127], 'advanced': [129], 'diseases.': [130], 'Furthermore,': [131], 'discussed': [133], 'implications': [135], 'that': [138], 'functioning': [139], 'lipid': [141], 'metabolism': [142], 'hepatic': [144, 150], 'steatosis': [145], 'well': [147], 'inflammation': [151], 'fibrosis': [153], 'with': [154], 'regard': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2522145043', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2025-01-13T04:29:44.491862', 'created_date': '2016-09-30'}