Publication Information

{'id': 'https://openalex.org/W2521150622', 'doi': 'https://doi.org/10.1074/mcp.m116.059915', 'title': 'Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies', 'display_name': 'Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer′s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies', 'publication_year': 2016, 'publication_date': '2016-08-10', 'ids': {'openalex': 'https://openalex.org/W2521150622', 'doi': 'https://doi.org/10.1074/mcp.m116.059915', 'mag': '2521150622', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27507836', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5054339'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.059915', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/10/3126.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.mcponline.org/content/mcprot/15/10/3126.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050058929', 'display_name': 'Patrick Oeckl', 'orcid': 'https://orcid.org/0000-0002-7652-7023'}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Patrick Oeckl', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013860093', 'display_name': 'Fabian Metzger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Fabian Metzger', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011967294', 'display_name': 'Magdalena Nagl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Nagl', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080821885', 'display_name': 'Christine A. F. Von Arnim', 'orcid': 'https://orcid.org/0000-0002-8614-2223'}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christine A.F. von Arnim', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017687275', 'display_name': 'Steffen Halbgebauer', 'orcid': 'https://orcid.org/0000-0002-8711-5702'}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Steffen Halbgebauer', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086343406', 'display_name': 'Petra Steinacker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Petra Steinacker', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008484351', 'display_name': 'Albert C. Ludolph', 'orcid': 'https://orcid.org/0000-0002-5401-0904'}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Albert C. Ludolph', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071308068', 'display_name': 'Markus Otto', 'orcid': 'https://orcid.org/0000-0003-4273-4267'}, 'institutions': [{'id': 'https://openalex.org/I4210155144', 'display_name': 'University Hospital Ulm', 'ror': 'https://ror.org/05emabm63', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210155144']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Markus Otto', 'raw_affiliation_strings': ['Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Germany', 'institution_ids': ['https://openalex.org/I4210155144']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5071308068'], 'corresponding_institution_ids': ['https://openalex.org/I4210155144'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 6.13, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 106, 'citation_normalized_percentile': {'value': 0.884938, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '15', 'issue': '10', 'first_page': '3126', 'last_page': '3138'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synucleinopathies', 'display_name': 'Synucleinopathies', 'score': 0.90726906}, {'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.53539616}, {'id': 'https://openalex.org/keywords/amyloid-beta', 'display_name': 'Amyloid beta', 'score': 0.45809704}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.41325167}], 'concepts': [{'id': 'https://openalex.org/C2777440831', 'wikidata': 'https://www.wikidata.org/wiki/Q2376264', 'display_name': 'Synucleinopathies', 'level': 5, 'score': 0.90726906}, {'id': 'https://openalex.org/C2779651940', 'wikidata': 'https://www.wikidata.org/wiki/Q54196', 'display_name': 'Cerebrospinal fluid', 'level': 2, 'score': 0.8322537}, {'id': 'https://openalex.org/C2781449126', 'wikidata': 'https://www.wikidata.org/wiki/Q288591', 'display_name': 'Alpha-synuclein', 'level': 4, 'score': 0.62721854}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.53539616}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.4601631}, {'id': 'https://openalex.org/C2776156579', 'wikidata': 'https://www.wikidata.org/wiki/Q417667', 'display_name': 'Amyloid beta', 'level': 3, 'score': 0.45809704}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.43843225}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.4280627}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.41325167}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35784295}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32272714}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29232734}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.15791625}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007562', 'descriptor_name': 'Creutzfeldt-Jakob Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000134', 'qualifier_name': 'cerebrospinal fluid', 'is_major_topic': True}, {'descriptor_ui': 'D051846', 'descriptor_name': 'beta-Synuclein', 'qualifier_ui': 'Q000134', 'qualifier_name': 'cerebrospinal fluid', 'is_major_topic': True}, {'descriptor_ui': 'D051845', 'descriptor_name': 'gamma-Synuclein', 'qualifier_ui': 'Q000134', 'qualifier_name': 'cerebrospinal fluid', 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000134', 'qualifier_name': 'cerebrospinal fluid', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007562', 'descriptor_name': 'Creutzfeldt-Jakob Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003955', 'descriptor_name': 'Diagnostic Tests, Routine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051846', 'descriptor_name': 'beta-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051845', 'descriptor_name': 'gamma-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.059915', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/10/3126.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5054339', 'pdf_url': 'https://europepmc.org/articles/pmc5054339?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054339', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27507836', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m116.059915', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/10/3126.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.75, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320320300', 'funder_display_name': 'European Commission', 'award_id': '633190'}, {'funder': 'https://openalex.org/F4320320300', 'funder_display_name': 'European Commission', 'award_id': '246513'}, {'funder': 'https://openalex.org/F4320320300', 'funder_display_name': 'European Commission', 'award_id': '01ED1202A'}, {'funder': 'https://openalex.org/F4320320300', 'funder_display_name': 'European Commission', 'award_id': '01ED1203F'}, {'funder': 'https://openalex.org/F4320321114', 'funder_display_name': 'Bundesministerium für Bildung und Forschung', 'award_id': 'O1GI1007A'}, {'funder': 'https://openalex.org/F4320321114', 'funder_display_name': 'Bundesministerium für Bildung und Forschung', 'award_id': '01GM1103A'}], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1149606326', 'https://openalex.org/W1485683953', 'https://openalex.org/W1532754033', 'https://openalex.org/W1789015615', 'https://openalex.org/W1805697412', 'https://openalex.org/W1827206004', 'https://openalex.org/W1966449557', 'https://openalex.org/W1968251608', 'https://openalex.org/W1969243451', 'https://openalex.org/W1979591162', 'https://openalex.org/W1982125411', 'https://openalex.org/W1986656413', 'https://openalex.org/W1988094412', 'https://openalex.org/W2000445298', 'https://openalex.org/W2003260773', 'https://openalex.org/W2004373930', 'https://openalex.org/W2008560062', 'https://openalex.org/W2016722487', 'https://openalex.org/W2018633688', 'https://openalex.org/W2033132890', 'https://openalex.org/W2040203980', 'https://openalex.org/W2045044466', 'https://openalex.org/W2047206971', 'https://openalex.org/W2048422451', 'https://openalex.org/W2050676526', 'https://openalex.org/W2052151366', 'https://openalex.org/W2055863273', 'https://openalex.org/W2056499061', 'https://openalex.org/W2057784346', 'https://openalex.org/W2061118257', 'https://openalex.org/W2064132534', 'https://openalex.org/W2064197301', 'https://openalex.org/W2064681168', 'https://openalex.org/W2065338300', 'https://openalex.org/W2066170812', 'https://openalex.org/W2069860553', 'https://openalex.org/W2080148133', 'https://openalex.org/W2102572922', 'https://openalex.org/W2103986409', 'https://openalex.org/W2104889897', 'https://openalex.org/W2108060249', 'https://openalex.org/W2108865709', 'https://openalex.org/W2109326791', 'https://openalex.org/W2113435863', 'https://openalex.org/W2114836779', 'https://openalex.org/W2131365154', 'https://openalex.org/W2136557657', 'https://openalex.org/W2140732014', 'https://openalex.org/W2141091417', 'https://openalex.org/W2144707045', 'https://openalex.org/W2152543350', 'https://openalex.org/W2155980527', 'https://openalex.org/W2157905553', 'https://openalex.org/W2160719857', 'https://openalex.org/W2161486437', 'https://openalex.org/W2166609052', 'https://openalex.org/W2166789153', 'https://openalex.org/W2168386087', 'https://openalex.org/W2171081285', 'https://openalex.org/W2171285101', 'https://openalex.org/W2192217112', 'https://openalex.org/W2222784460', 'https://openalex.org/W2260519762', 'https://openalex.org/W2306559597', 'https://openalex.org/W2333105741', 'https://openalex.org/W2345993752', 'https://openalex.org/W2430794023', 'https://openalex.org/W5040294', 'https://openalex.org/W640170556', 'https://openalex.org/W902096590'], 'related_works': ['https://openalex.org/W4391406286', 'https://openalex.org/W4298261981', 'https://openalex.org/W4282825797', 'https://openalex.org/W4243519544', 'https://openalex.org/W3130859323', 'https://openalex.org/W3088492926', 'https://openalex.org/W2912544573', 'https://openalex.org/W2890336486', 'https://openalex.org/W2097206574', 'https://openalex.org/W2005385069'], 'abstract_inverted_index': {'α-Synuclein': [0, 312, 627, 807, 905], '(αSyn)': [1, 313, 628, 2060], 'is': [2, 55, 122, 140, 169, 277, 306, 314, 367, 436, 454, 483, 592, 621, 685, 720, 726, 756, 778, 829, 927, 932, 971, 1002, 1261, 1336, 1427, 1626, 1745, 4148], 'a': [3, 18, 80, 152, 229, 307, 315, 330, 393, 466, 543, 622, 686, 693, 784, 814, 912, 928, 1003, 1124, 1339, 1360, 1405, 1523, 1535, 1756, 1839, 1925, 2014, 2056, 2088, 2150, 2405, 2693, 2774, 3037, 3049, 3097, 3126, 3139, 3204, 3271, 3289, 3304, 3399, 3476, 4143, 4172], 'major': [4, 316], 'constituent': [5, 317, 759], 'of': [6, 67, 85, 119, 132, 252, 269, 318, 380, 398, 433, 446, 567, 584, 652, 654, 660, 699, 717, 760, 770, 776, 864, 886, 897, 990, 996, 1014, 1062, 1065, 1075, 1137, 1180, 1192, 1217, 1242, 1253, 1274, 1342, 1452, 1494, 1531, 1641, 1664, 1678, 1695, 1753, 1767, 1780, 1807, 1843, 1931, 2019, 2039, 2071, 2077, 2083, 2092, 2133, 2152, 2175, 2247, 2308, 2341, 2393, 2407, 2446, 2458, 2479, 2506, 2534, 2571, 2609, 2688, 2855, 3070, 3075, 3092, 3105, 3116, 3130, 3135, 3142, 3145, 3153, 3184, 3238, 3246, 3274, 3292, 3364, 3421, 3424, 3449, 3469, 3472, 3479, 3658, 3665, 3678, 3685, 3722, 3729, 3786, 3804, 3857, 3868, 3883, 3924, 3974, 3996, 4011, 4030, 4045, 4073, 4103, 4112, 4133, 4164, 4175, 4179, 4186, 4198, 4201, 4216, 4220], 'proteinaceous': [7, 319, 1293], 'aggregates': [8, 320, 1294], 'in': [9, 31, 35, 53, 72, 95, 97, 104, 124, 135, 145, 158, 162, 183, 191, 208, 255, 291, 295, 301, 321, 343, 347, 365, 385, 408, 410, 418, 438, 449, 459, 472, 476, 497, 505, 522, 570, 606, 610, 616, 696, 767, 787, 935, 968, 973, 993, 1000, 1113, 1144, 1165, 1199, 1292, 1295, 1309, 1470, 1529, 1543, 1587, 1593, 1634, 1645, 1658, 1668, 1783, 1809, 1818, 1866, 1872, 1923, 1928, 1942, 1969, 2009, 2013, 2023, 2046, 2051, 2131, 2149, 2193, 2336, 2345, 2363, 2419, 2421, 2434, 2468, 2484, 2488, 2574, 2606, 2636, 2682, 2719, 2782, 2835, 2860, 3036, 3059, 3096, 3109, 3147, 3288, 3358, 3394, 3428, 3849, 3929, 4036, 4095, 4106, 4131], 'neurodegenerative': [10, 322, 701, 789, 1114, 1297, 1597, 1624, 1659, 2136, 2153, 3436, 3930], 'diseases': [11, 36, 323, 348, 702, 719, 1298, 1625, 1660, 2137, 2154], 'such': [12, 324, 703, 845, 4116], 'as': [13, 286, 325, 601, 704, 813, 846, 911, 1118, 1142, 1197, 1363, 1408, 1868, 1885, 2067, 2108, 2110, 2653, 2807, 3121, 3234, 3317, 3362, 4117], 'Parkinson′s': [14, 326, 705], 'disease': [15, 187, 327, 501, 706, 970, 1024, 1039, 1090, 1311, 1545, 1820, 1890, 2169, 3437], '(PD)': [16, 328], 'and': [17, 24, 39, 50, 70, 92, 129, 161, 166, 178, 185, 199, 222, 257, 297, 300, 329, 336, 351, 362, 383, 405, 443, 475, 480, 492, 499, 513, 536, 572, 612, 615, 662, 665, 668, 692, 711, 724, 774, 780, 810, 827, 837, 868, 908, 1010, 1077, 1080, 1083, 1147, 1202, 1226, 1238, 1281, 1312, 1320, 1334, 1344, 1387, 1539, 1547, 1582, 1590, 1598, 1620, 1643, 1647, 1661, 1744, 1759, 1769, 1821, 1862, 1891, 1939, 2036, 2044, 2061, 2120, 2138, 2167, 2180, 2188, 2208, 2226, 2238, 2276, 2295, 2311, 2332, 2350, 2357, 2378, 2385, 2397, 2400, 2412, 2416, 2443, 2466, 2476, 2510, 2532, 2562, 2591, 2604, 2615, 2622, 2631, 2634, 2651, 2671, 2713, 2749, 2778, 2823, 2829, 2838, 2850, 2895, 2910, 3048, 3054, 3065, 3100, 3128, 3132, 3161, 3200, 3229, 3263, 3278, 3314, 3356, 3376, 3388, 3391, 3438, 3494, 3656, 3680, 3806, 3809, 3812, 3817, 3852, 3855, 3859, 3888, 3900, 3956, 4004, 4006, 4021, 4033, 4048, 4056, 4071, 4082, 4092, 4121, 4142, 4145, 4153, 4160, 4182, 4230], 'potential': [19, 331, 839, 1886], 'biomarker': [20, 280, 308, 332, 595, 623, 1005, 1143, 1198, 1674, 1781, 1870, 1926], 'candidate': [21, 281, 309, 333, 596, 624, 1006], 'for': [22, 63, 274, 310, 334, 376, 589, 625, 798, 816, 914, 1007, 1011, 1219, 1338, 1691, 1751, 1762, 1777, 1888, 1919, 2033, 2087, 2100, 2114, 2369, 2381, 2499, 2528, 2536, 2655, 2762, 2796, 2800, 2893, 3167, 3173, 3197, 3260, 3312, 3379, 3547, 3719, 3783, 3834, 3985, 4002, 4088, 4157, 4193, 4210, 4222], 'diagnosis': [23, 299, 335, 614, 725, 1009, 1146, 1201, 3471, 3721, 3785], 'treatment': [25, 337], 'effects.': [26, 338], 'However,': [27, 339, 1998], 'studies': [28, 340, 1108, 1159, 1237, 1619], 'about': [29, 47, 141, 341, 359, 455, 1250, 1267, 1622, 2185], 'αSyn': [30, 86, 121, 165, 254, 304, 342, 399, 435, 479, 569, 619, 755, 777, 799, 847, 887, 899, 926, 998, 1015, 1111, 1163, 1220, 1269, 1343, 1389, 1651, 1754, 1863, 2008, 2078, 2085, 2101, 2116, 2177, 2190, 2197, 2228, 2245, 3228, 3313, 3380, 3975, 3998, 4118, 4158], 'cerebrospinal': [32, 344, 937, 1041, 1138, 1193, 1496, 1588, 1810, 3360, 3925], 'fluid': [33, 345, 938, 1042, 1139, 1194, 1497, 1589, 1811, 3361, 3926], '(CSF)': [34, 346, 939, 1498], 'are': [37, 265, 349, 580, 764, 1169, 1222, 1284, 1290, 1468, 1585, 1591, 1865, 2079, 2098, 2417, 2833, 3426, 4034, 4093], 'inconsistent': [38, 350, 1243], 'mainly': [40, 352], 'based': [41, 353, 727, 3214, 4016, 4226], 'on': [42, 354, 728, 2441, 2692, 2725, 3159, 3215, 3832, 4017, 4227], 'immunological': [43, 355], 'assays.': [44, 356], 'Quantitative': [45, 357], 'information': [46, 358, 1621, 2184], 'β-synuclein': [48, 360, 1031, 1279], '(βSyn)': [49, 361, 1280], 'γ-synuclein': [51, 363, 1047, 1282], '(γSyn)': [52, 364, 2415], 'CSF': [54, 73, 96, 120, 159, 175, 233, 262, 366, 386, 409, 434, 473, 489, 547, 577, 1001, 1022, 1110, 1268, 1471, 1503, 1530, 1628, 1646, 1669, 1784, 1943, 2010, 2054, 2132, 2176, 2297, 2429, 2437, 3076, 3148, 3154, 3185, 3301, 3375, 3395, 3439, 3858, 3871, 3902, 4107], 'not': [56, 170, 189, 248, 368, 484, 503, 563, 1177, 1615, 1631, 2001, 4139, 4149], 'available.Here,': [57], 'we': [58, 246, 371, 561, 4064, 4122], 'present': [59, 123, 372, 437, 934, 972, 1291, 1469, 1586, 2028], 'an': [60, 278, 287, 373, 593, 602, 1258, 1364, 1409, 1541, 1746, 2030, 2427, 2661, 2726, 2888, 4043], 'alternative': [61, 288, 374, 603, 811, 895, 909, 1259, 1748], 'method': [62, 375, 1216, 1260, 2032, 2127, 3987], 'the': [64, 105, 125, 130, 136, 146, 377, 419, 439, 444, 450, 460, 697, 757, 768, 788, 898, 936, 994, 1012, 1119, 1172, 1215, 1240, 1251, 1254, 1275, 1453, 1495, 1502, 1662, 1679, 1760, 1778, 1844, 1856, 1920, 1929, 2020, 2024, 2034, 2047, 2084, 2115, 2126, 2140, 2189, 2209, 2394, 2637, 2771, 2851, 3063, 3068, 3071, 3122, 3133, 3216, 3235, 3247, 3256, 3275, 3409, 3416, 3450, 3666, 3683, 3720, 3730, 3784, 3800, 3823, 3850, 3853, 3865, 3878, 3977, 3986, 3990, 3997, 4007, 4018, 4052, 4074, 4110, 4128, 4191, 4214], 'simultaneous': [65, 378, 1765, 2035], 'quantification': [66, 379, 1063, 1096, 1694, 1752, 1766, 2038, 3117, 3198], 'αSyn,': [68, 176, 381, 490, 2041, 2375], 'βSyn': [69, 168, 177, 227, 382, 482, 491, 541, 1345, 1380, 1629, 1642, 1768, 2240, 4003], 'γSyn': [71, 179, 384, 493, 1425, 1527, 1644, 2043, 2187, 2225, 3230, 3315, 4005], 'by': [74, 172, 387, 486, 894, 1534, 1812, 1851, 1912, 1973, 2011, 2215, 2628, 3082, 3090, 3103, 3151, 3182, 3864, 3874, 3953, 4027, 4119], 'multiple': [75, 388, 1068, 1813], 'reaction': [76, 389, 656, 1069, 1683, 1814], 'monitoring': [77, 390, 1070, 1684, 1815], '(MRM)': [78, 391, 1687], 'with': [79, 155, 217, 232, 293, 303, 392, 469, 531, 546, 608, 618, 888, 1430, 1450, 1596, 1617, 1755, 2142, 2178, 2230, 2383, 2455, 2519, 2556, 2559, 2568, 2593, 2647, 2707, 2741, 2773, 3053, 3125, 3138, 3162, 3186, 3303, 3398, 3550, 3660], 'high': [81, 102, 117, 153, 230, 394, 416, 431, 467, 544, 1757, 2401, 4100], 'sequence': [82, 395, 1858, 2086, 2372, 2922, 4055], 'coverage': [83, 396], '(70%)': [84, 397], 'to': [87, 164, 289, 400, 478, 604, 722, 782, 842, 870, 1178, 1232, 1263, 1384, 1650, 1654, 1749, 1935, 2005, 2128, 2171, 2181, 2770, 3189, 3286, 3295, 3408, 3442, 3457, 3497, 3822, 3847, 3897, 3988, 4051, 4126, 4204], 'validate': [88, 401, 2172], 'previous,': [89, 402], 'ELISA-based': [90, 403], 'results': [91, 259, 404, 574, 1168, 2141, 2174], 'characterize': [93, 406, 2129], 'synucleins': [94, 407, 2130, 2148, 3146, 4211], 'more': [98, 411, 1672, 1840, 2089], 'detail.The': [99], 'MRM': [100, 414, 1771, 1913, 2012, 2031, 2246, 2784], 'has': [101, 415, 1381, 1630, 1772, 1914], 'sensitivity': [103, 417, 4020, 4156, 4192, 4209, 4229], 'low': [106, 420, 2021, 2048, 2347, 2490, 4113], 'pg/ml': [107, 421, 2025, 2049], 'range': [108, 422, 2050, 2406, 4102], '(3–30pg/ml': [109, 423], 'full-length': [110, 424, 2196], 'αSyn)': [111, 425], 'using': [112, 426, 1697, 2055, 2244, 2373, 2538, 2660, 2863, 3221, 3255, 3945, 3965, 4077, 4183], '200': [113, 427, 2052, 2366, 2444, 2587, 3293], 'μl': [114, 428, 2053, 2445, 2457, 2478, 2508, 2512, 2608, 2649], 'CSF.': [115, 429, 2194, 2656], 'A': [116, 430], 'portion': [118, 432], 'N-terminally': [126, 440], 'acetylated': [127, 441], 'form': [128, 442], 'concentration': [131, 445, 1234, 2022, 2212, 2241, 3124, 3231, 3237, 3267, 3291, 3306, 3393], 'unmodified': [133, 447, 2040, 2074], 'peptides': [134, 448, 1854, 2063, 2076, 2113, 2251, 2333, 2380, 2465, 2516, 2535, 2722, 3241, 3973, 4001, 4013, 4032, 4047, 4159, 4167, 4221], 'nonamyloid': [137, 451], 'component': [138, 452, 1072], 'region': [139, 453], '40%': [142, 456], 'lower': [143, 457, 1060, 3114], 'than': [144, 272, 458, 587, 1676], 'N-terminal': [147, 461, 1019, 2106], 'region.': [148, 462], 'Synuclein': [149, 463], 'concentrations': [150, 180, 235, 264, 464, 494, 549, 579, 1112, 1164, 1528, 1667, 2340, 2570, 3211, 4105], 'show': [151, 465], 'correlation': [154, 231, 468, 545, 3968], 'each': [156, 470, 1677, 2370, 2435, 2856, 3041, 4089], 'other': [157, 471, 843, 1272, 1623, 1892, 4057], '(r>0.80)': [160, 474], 'contrast': [163, 477], 'γSyn,': [167, 481, 2065, 2377], 'affected': [171, 485], 'blood': [173, 487], 'contamination.': [174, 488], 'were': [181, 495, 2233, 2256, 2307, 2334, 2360, 2439, 2453, 2497, 2517, 2601, 2658, 2690, 2723, 2780, 2806, 2848, 3057, 3207, 3212, 3309, 3385, 3405, 3413, 3454, 3886, 3904, 3951, 3983, 4014, 4025, 4086, 4224], 'increased': [182, 207, 496, 521, 1592, 4155, 4213], 'Alzheimer′s': [184, 498, 1023, 1544, 1819], 'Creutzfeldt-Jakob': [186, 500, 1038, 2168], 'but': [188, 502, 1224, 1612, 4212], 'altered': [190, 504], 'PD,': [192, 506, 1166, 2156], 'PD': [193, 218, 256, 507, 532, 571, 708, 1091, 1117, 3452], 'dementia': [194, 198, 508, 512, 709, 714, 1059, 1092, 1315, 1532, 3548, 3659], '(PDD),': [195, 509, 710], 'Lewy': [196, 510, 712, 761, 1057, 1313, 3661], 'body': [197, 511, 649, 713, 1058, 1314], 'atypical': [200, 514], 'parkinsonian': [201, 515], 'syndromes.': [202, 516], 'The': [203, 413, 517, 861, 1271, 1639, 2765, 2802, 3073, 3113, 3191, 3281, 4084, 4099, 4135], 'ratio': [204, 518, 1663, 3141, 3273], 'βSyn/αSyn': [205, 519], 'was': [206, 520, 1614, 2000, 2200, 2213, 2242, 2264, 2432, 2645, 2768, 2858, 3080, 3088, 3119, 3149, 3180, 3195, 3232, 3253, 3268, 3284, 3396, 3440, 3819, 3862, 3872, 3943, 3963], 'PDD': [209, 523, 3493], '(1.49': [210, 524], '±': [211, 220, 225, 525, 534, 539], '0.38,': [212, 526], 'p': [213, 239, 527, 553], '<': [214, 240, 528, 554], '0.05)': [215, 529], 'compared': [216, 530, 2139, 3952], '(1.11': [219, 533], '0.26)': [221, 535], 'controls': [223, 537], '(1.15': [224, 538], '0.28).': [226, 540], 'shows': [228, 542], 'tau': [234, 294, 548, 609, 1921, 3392], '(r': [236, 550], '=': [237, 243, 551, 557], '0.86,': [238, 552], '0.0001,': [241, 555], 'n': [242, 556], '125).In': [244], 'conclusion,': [245, 560], 'could': [247, 562], 'confirm': [249, 564, 1264], 'previous': [250, 565, 1265, 2173], 'observations': [251, 566], 'reduced': [253, 568, 1162, 4208], 'our': [258, 573], 'indicate': [260, 575], 'that': [261, 282, 576, 597, 831], 'synuclein': [263, 578, 1276, 1665, 4058, 4136], 'rather': [266, 581], 'general': [267, 582], 'markers': [268, 583], 'synaptic': [270, 585], 'degeneration': [271, 586], 'specific': [273, 588], 'synucleinopathies.': [275, 590, 772], 'βsyn': [276, 591], 'attractive': [279, 594], 'might': [283, 598, 833, 1670], 'be': [284, 599, 783, 892, 1179, 1385, 1671, 1689, 1936], 'used': [285, 600, 631, 1690, 1927, 2125, 2828, 3196], 'or': [290, 605, 849, 1849, 2321, 2450, 2843, 3446, 3840, 4196], 'combination': [292, 302, 607, 617], 'AD': [296, 611, 2166, 3797], 'CJD': [298, 613, 3818], 'it': [305, 620, 931, 1837, 1999], 'PDD.': [311, 626], 'available.': [369], 'Here,': [370], 'detail.': [412], '125).': [558], 'In': [559, 1835, 2094, 2425, 3040], '1The': [629], 'abbreviations': [630], 'are:': [632], 'αSynα-synucleinAcN-terminal': [633], 'acetylationaCSFartificial': [634], 'CSFADAlzheimer′s': [635], 'diseaseAlbserum': [636], 'albuminα1Chα1-antichymotrypsinα1Trα1-antitrypsinα2HSα2-HS-glycoproteinα2Mα2-macroglobulinβSynβ-synucleinCBScorticobasal': [637], 'syndromeCEcollision': [638], 'energyChPchoroid': [639], 'plexusCJDCreutzfeldt-Jakob': [640], 'diseaseCPceruloplasminCSFcerebrospinal': [641], 'fluidCURcurtain': [642], 'gasISinternal': [643], 'standardγSynγ-synucleinHSAhuman': [644], 'serum': [645, 1025, 1049, 2278, 3377, 3860], 'albuminHbhemoglobinHbbhemoglobin': [646], 'beta': [647, 1053, 3250, 3279], 'subunitHpxhemopexinIgimmunoglobulinLBDLewy': [648], 'dementiaLLOQlower': [650], 'limit': [651, 1061, 1064, 3115, 3134], 'quantificationLODlimit': [653], 'detectionMeOHmethanolMRMmultiple': [655], 'monitoringNACnon-Abeta': [657], 'componentNINCDS-ADRDANational': [658], 'Institute': [659, 1074, 3803], 'Neurological': [661, 1076, 3805], 'Communicative': [663, 1078, 3807], 'Disorders': [664, 670, 1079, 1085, 3808, 3814], "Stroke-Alzheimer's": [666, 1081, 3810], 'Disease': [667, 1082, 3811, 3949], 'Related': [669, 1084, 3813], 'AssociationO-GlcNAcO-linked': [671], 'β-N-acetylglucosaminePDParkinon′s': [672], 'diseasePDDPD': [673], 'dementiaPSAQprotein': [674], 'standard': [675, 1046, 1094, 1702, 2059, 2449, 2460, 3901], 'absolute': [676, 1095, 1693, 1703, 1726, 2037], 'quantificationPSPprogressive': [677], 'supranuclear': [678, 1098, 2160, 3724], 'palsyPTMpost-translational': [679], 'modificationQC': [680], 'samplequality': [681], 'control': [682, 1103], 'sampleTEABtriethylammonium': [683], 'bicarbonate.': [684, 1106], 'small': [687, 1174, 4199], '(14': [688], 'kDa)': [689], 'presynaptic': [690], 'protein': [691, 930, 1093, 1277, 1666, 1699, 1723, 1805, 1846, 1857, 1910, 1922, 2058, 2211, 2346, 2489, 4104], 'key': [694], 'player': [695], 'pathogenesis': [698, 995], 'several': [700, 1853, 2096, 4124], '(PD),': [707], '(LBD).': [715], 'None': [716], 'these': [718, 771], 'curable': [721], 'date': [723], 'clinical': [729, 1008, 3470], 'symptoms': [730], '(1.McCann': [731], 'H.': [732, 736, 1440, 1444, 1475, 1481, 1489, 3344, 3575, 3587, 3920], 'Stevens': [733], 'C.H.': [734], 'Cartwright': [735], 'Halliday': [737, 3609], 'G.M.': [738], 'α-Synucleinopathy': [739], 'phenotypes.Parkinsonism': [740], 'Relat.': [741], 'Disord.': [742, 1603, 3553], '2014;': [743, 1509, 1827], '20:': [744], 'S62-S70Abstract': [745], 'Full': [746, 1370, 1372, 1415, 1417, 1512, 1514, 1734, 1736, 1899, 1901], 'Text': [747, 1371, 1373, 1416, 1418, 1513, 1515, 1735, 1737, 1900, 1902], 'PDF': [748, 1374, 1419, 1516, 1738, 1903], 'PubMed': [749, 822, 878, 920, 984, 1153, 1208, 1329, 1375, 1420, 1461, 1517, 1607, 1739, 1830, 1904, 1993, 2544, 2903, 3370, 3488, 3559, 3672, 3737, 3792, 3936], 'Scopus': [750, 823, 879, 921, 985, 1154, 1209, 1330, 1376, 1421, 1462, 1518, 1608, 1740, 1831, 1905, 1994, 2545, 2904, 3371, 3489, 3560, 3673, 3738, 3793, 3937], '(226)': [751], 'Google': [752, 825, 881, 923, 987, 1156, 1211, 1332, 1378, 1423, 1464, 1520, 1610, 1742, 1833, 1907, 1996, 2547, 2906, 3373, 3491, 3562, 3675, 3740, 3795, 3939], 'Scholar).': [753, 882, 924, 988, 1212, 1379, 1424, 1465, 1521, 1834, 1908, 1997, 3374, 3676, 3796, 3837, 3940], 'Aggregated': [754], 'main': [758], 'bodies': [762], 'which': [763, 1933], 'histopathological': [765], 'hallmarks': [766], 'brain': [769], 'Oligomerization': [773], 'aggregation': [775, 836, 1390, 1426], 'neurotoxic': [779], 'thought': [781], 'causative': [785], 'factor': [786], 'process.': [790], 'Many': [791, 1107], 'post-translational': [792, 1100, 1883], 'modifications': [793, 1884], '(PTMs)': [794], 'have': [795], 'been': [796, 1382, 1632, 1775, 1917], 'described': [797, 2654, 2834], '(e.g.': [800], 'phosphorylation,': [801], 'oxidation)': [802], '(2.Beyer': [803, 901], 'K.': [804, 902, 1302, 3626], 'Ariza': [805, 903], 'A.': [806, 858, 904, 1473, 1554, 1574, 1709, 1711, 1959, 3523, 3525, 3624, 3630, 3765], 'posttranslational': [808, 906], 'modification': [809, 907, 1101], 'splicing': [812, 896, 910], 'trigger': [815, 913], 'neurodegeneration.Mol.': [817, 915], 'Neurobiol.': [818, 916], '2013;': [819, 875, 917, 1896, 3789], '47:': [820, 918, 3735], '509-524Crossref': [821, 919], '(95)': [824, 922], 'Scholar)': [826, 1333, 1611, 1743, 2548], 'there': [828, 1335], 'evidence': [830, 1337], 'PTMs': [832, 1850, 1864, 2097, 2384], 'influence': [834], 'its': [835, 991], 'toxic': [838], '(in': [840], 'addition': [841, 2505, 4197], 'mechanisms': [844], 'mutations': [848], 'metal': [850], 'ion': [851, 2803], 'binding)': [852], '(3.Lashuel': [853], 'H.A.': [854, 1881], 'Overk': [855], 'C.R.': [856], 'Oueslati': [857], 'Masliah': [859, 1354, 1399], 'E.': [860, 1349, 1355, 1394, 1400, 1479, 1560, 1564, 1797, 3541, 3608, 3634, 3713, 3775], 'many': [862], 'faces': [863], 'α-synuclein:': [865], 'from': [866, 2202, 2234, 2258, 2265, 2282, 2289, 2299, 2313, 3203], 'structure': [867], 'toxicity': [869], 'therapeutic': [871], 'target.Nat.': [872], 'Rev.': [873], 'Neurosci.': [874], '14:': [876], '38-48Crossref': [877], '(1024)': [880], 'Additionally,': [883, 1171], 'shorter': [884], 'forms': [885], 'unknown': [889], 'function': [890], 'can': [891, 1688], 'generated': [893], 'gene': [900], 'Although': [925], 'cytoplasmic': [929], 'also': [933, 1247, 1428, 4189], '(4.El-Agnaf': [940], 'O.M.A.': [941], 'Salem': [942, 1439], 'S.A.': [943], 'Paleologou': [944], 'K.E.': [945], 'Cooper': [946], 'L.J.': [947], 'Fullwood': [948], 'N.J.': [949], 'Gibson': [950], 'M.J.': [951, 2886, 3743], 'Curran': [952], 'M.D.': [953], 'Court': [954, 1716], 'J.A.': [955, 1487, 3642], 'Mann': [956, 2523], 'D.M.A.': [957], 'Ikeda': [958], 'S.': [959, 1438, 1793, 1953, 1963, 3517, 3604, 3638, 3907], 'Cookson': [960], 'M.R.': [961], 'Hardy': [962, 3613], 'J.': [963, 980, 1552, 1558, 1562, 1572, 1576, 1721, 1955, 2522, 3332, 3348, 3354, 3513, 3519, 3569, 3577, 3614, 3703, 3709, 3909], 'Allsop': [964], 'D.': [965, 1135, 1190, 1715, 3330, 3501, 3585, 3595, 3602, 3620, 3691], 'Alpha-synuclein': [966, 1882], 'implicated': [967], "Parkinson's": [969, 1145, 1200, 1310, 3365, 3474, 3551], 'extracellular': [974], 'biological': [975], 'fluids,': [976], 'including': [977, 2155], 'human': [978, 1048, 2277, 3359], 'plasma.FASEB': [979], '2003;': [981], '17:': [982], '1945-1947Crossref': [983], '(469)': [986], 'Because': [989], 'importance': [992], 'synucleinopathies,': [997], 'determination': [999, 1221, 1640, 1779], 'promising': [1004, 1869], 'development': [1013], 'modulating': [1016], 'drugs.': [1017], 'α-synuclein': [1018, 1140, 1195], 'acetylation': [1020], 'artificial': [1021, 2296], 'albumin': [1026, 1050, 2279], 'α1-antichymotrypsin': [1027], 'α1-antitrypsin': [1028], 'α2-HS-glycoprotein': [1029], 'α2-macroglobulin': [1030], 'corticobasal': [1032, 2163, 3787], 'syndrome': [1033, 2164], 'collision': [1034, 2914], 'energy': [1035], 'choroid': [1036], 'plexus': [1037], 'ceruloplasmin': [1040], 'curtain': [1043, 2813], 'gas': [1044, 2814, 2818, 2825], 'internal': [1045, 2068, 2459], 'hemoglobin': [1051, 1052, 2045, 3265, 3305], 'subunit': [1054], 'hemopexin': [1055], 'immunoglobulin': [1056], 'detection': [1066, 3136, 4111], 'methanol': [1067, 2328], 'non-Abeta': [1071], 'National': [1073], 'Association': [1086], 'O-linked': [1087], 'β-N-acetylglucosamine': [1088], 'Parkinon′s': [1089], 'progressive': [1097, 2159, 3723], 'palsy': [1099, 2161, 3725], 'quality': [1102], 'sample': [1104, 2016, 2431, 2452, 2689, 3051, 4090], 'triethylammonium': [1105, 2268], 'investigated': [1109, 1526, 1633], 'diseases,': [1115], 'especially': [1116], 'most': [1120], 'common': [1121, 2248], 'synucleinopathy': [1122], '(for': [1123], 'review,': [1125], 'see': [1126, 2472], 'ref': [1127], '(5.Parnetti': [1128, 1183], 'L.': [1129, 1184, 1957, 3465], 'Cicognola': [1130, 1185], 'C.': [1131, 1186, 1570, 1949, 1961, 3346, 3507, 3521, 3539, 3581], 'Eusebi': [1132, 1187], 'P.': [1133, 1188, 1786, 1788], 'Chiasserini': [1134, 1189], 'Value': [1136, 1191], 'species': [1141, 1196], 'prognosis.Biomark.': [1148, 1203], 'Med.': [1149, 1204], '2016;': [1150, 1205, 1990], '10:': [1151, 1206], '35-49Crossref': [1152, 1207], '(44)': [1155, 1210], 'Scholar)).': [1157], 'Most': [1158], 'observed': [1160, 1540, 4019], 'slightly': [1161], 'although': [1167, 1288], 'inconsistent.': [1170], 'reported': [1173], 'alterations': [1175], 'seem': [1176], 'diagnostic': [1181, 3545], 'relevance': [1182], 'To': [1213, 4060], 'date,': [1214], 'choice': [1218], 'immunoassays': [1223, 1750, 2179], 'antibodies': [1225], 'platforms': [1227], 'vary': [1228], 'considerably.': [1229], 'This': [1230], 'led': [1231], 'large': [1233], 'differences': [1235, 1246, 1817], 'between': [1236], 'hampers': [1239, 4109], 'interpretation': [1241], 'results.': [1244], 'These': [1245], 'raise': [1248], 'concern': [1249], 'selectivity': [1252, 1758, 4231], 'assays': [1255], 'and,': [1256], 'thus,': [1257], 'needed': [1262], 'observation': [1266], 'concentrations.': [1270], 'members': [1273], 'family,': [1278], '(γSyn),': [1283], 'less': [1285], 'well': [1286, 2109], 'studied': [1287], 'they': [1289], 'some': [1296], '(6.Galvin': [1299], 'J.E.': [1300, 3579], 'Uryu': [1301], 'Lee': [1303, 3627, 3766], 'V.M.': [1304], 'Trojanowski': [1305, 3651], 'J.Q.': [1306, 3652], 'Axon': [1307], 'pathology': [1308], 'hippocampus': [1316], 'contains': [1317], 'alpha-,': [1318], 'beta-,': [1319], 'gamma-synuclein.Proc.': [1321], 'Natl.': [1322], 'Acad.': [1323], 'Sci.': [1324], 'U.S.A.': [1325], '1999;': [1326], '96:': [1327], '13450-13455Crossref': [1328], '(368)': [1331], 'strong': [1340], 'interaction': [1341], '(7.Hashimoto': [1346, 1391], 'M.': [1347, 1351, 1353, 1392, 1396, 1398, 1483, 1713, 1717, 1795, 1803, 1879, 2524, 2874, 3322, 3499, 3571, 3654, 3707, 3759, 3761, 3779, 3922], 'Rockenstein': [1348, 1393], 'Mante': [1350, 1395], 'Mallory': [1352, 1397], 'beta-Synuclein': [1356, 1401], 'inhibits': [1357, 1388, 1402], 'alpha-synuclein': [1358, 1403, 3357], 'aggregation:': [1359, 1404], 'possible': [1361, 1406, 2002, 3993], 'role': [1362, 1407, 1657], 'anti-parkinsonian': [1365, 1410], 'factor.Neuron.': [1366, 1411], '2001;': [1367, 1412], '32:': [1368, 1413], '213-223Abstract': [1369, 1414], '(363)': [1377, 1422], 'shown': [1383, 1918, 4035], 'neuroprotective': [1386], 'associated': [1429, 1449, 3549], 'widespread': [1431], 'neurodegeneration': [1432, 1448], '(8.Ninkina': [1433], 'N.': [1434, 1951, 2872, 3537], 'Peters': [1435], 'O.': [1436], 'Millership': [1437], 'van': [1441], 'der': [1442], 'Putten': [1443], 'Buchman': [1445], 'V.L.': [1446], 'Gamma-synucleinopathy:': [1447], 'overexpression': [1451], 'mouse': [1454], 'protein.Hum.': [1455], 'Mol.': [1456], 'Genet.': [1457], '2009;': [1458], '18:': [1459], '1779-1794Crossref': [1460], '(88)': [1463], 'Both': [1466], 'proteins': [1467, 1584, 1680, 1696, 4115, 4137], '(9.Guldbrandsen': [1472], 'Vethe': [1474], 'Farag': [1476], 'Y.': [1477, 2526, 3509, 3640, 3689], 'Oveland': [1478], 'Garberg': [1480], 'Berle': [1482], 'Myhr': [1484], 'K-M': [1485], 'Opsahl': [1486], 'Barsnes': [1488], 'Berven': [1490], 'F.S.': [1491], 'In-depth': [1492], 'characterization': [1493, 1842, 1911, 2091], 'proteome': [1499, 1504], 'displayed': [1500], 'through': [1501], 'resource': [1505], '(CSF-PR).Mol.': [1506], 'Cell.': [1507, 1729, 1894], 'Proteomics.': [1508, 1730, 1895], '13:': [1510, 1828], '3152-3163Abstract': [1511], '(100)': [1519], 'Only': [1522], 'single': [1524, 3098, 3205], 'study': [1525, 3478, 3851], 'patients': [1533, 2134, 3425, 3433, 3453, 3798, 3839], 'qualitative': [1536], 'Western': [1537], 'blot': [1538], 'increase': [1542, 3296], '(AD)': [1546], 'LBD': [1548, 3495], '(10.Mukaetova-Ladinska': [1549], 'E.B.': [1550, 3644], 'Milne': [1551], 'Andras': [1553], 'Abdel-All': [1555], 'Z.': [1556, 3320], 'Cerejeira': [1557], 'Greally': [1559], 'Robson': [1561], 'Jaros': [1563], 'Perry': [1565, 3582, 3647], 'R.': [1566, 2880, 3503, 3527], 'McKeith': [1567, 3530], 'I.G.': [1568, 3565], 'Brayne': [1569], 'Xuereb': [1571], 'Cleghorn': [1573], 'Doherty': [1575], 'McIntosh': [1577], 'G.': [1578, 3338, 3610, 3693], 'Milton': [1579], 'I.': [1580, 3529, 3531, 3632, 3687, 3745], 'Alpha-': [1581], 'gamma-synuclein': [1583], 'aged': [1594], 'subjects': [1595], 'vascular': [1599], 'changes.Dement.': [1600], 'Geriatr.': [1601], 'Cogn.': [1602], '2008;': [1604], '26:': [1605, 2901], '32-42Crossref': [1606], '(33)': [1609], 'this': [1613, 3299], 'validated': [1616], 'further': [1618], 'missing.': [1627], 'neurological': [1635], 'disorders': [1636], 'so': [1637, 2003], 'far.': [1638], 'their': [1648, 1656, 3841, 4049, 4228], 'relation': [1649, 4050], 'would': [1652], 'help': [1653], 'clarify': [1655], 'meaningful': [1673], 'candidates': [1675, 1782, 1871], 'alone.': [1681], 'Multiple': [1682], 'mass': [1685, 2675, 2924], 'spectrometry': [1686], 'accurate,': [1692], 'stable-labeled': [1698, 2057, 2062], 'standards': [1700, 2356, 2396], '(protein': [1701], 'quantification,': [1704], 'PSAQ)': [1705], '(11.Brun': [1706], 'V.': [1707], 'Dupuis': [1708], 'Adrait': [1710], 'Marcellin': [1712], 'Thomas': [1714], 'Vandenesch': [1718], 'F.': [1719, 1947, 1965, 3646], 'Garin': [1720], 'Isotope-labeled': [1722], 'standards:': [1724], 'toward': [1725], 'quantitative': [1727], 'proteomics.Mol.': [1728], '2007;': [1731, 2541, 3554], '6:': [1732], '2139-2149Abstract': [1733], '(381)': [1741], 'excellent': [1747], 'ability': [1761], 'multiplexing,': [1763], 'i.e.': [1764], 'γSyn.': [1770], 'already': [1773], 'successfully': [1774, 1916], 'applied': [1776], '(12.Oeckl': [1785], 'Steinacker': [1787], 'von': [1789, 3914], 'Arnim': [1790, 3915], 'C.A.F.': [1791, 3916], 'Straub': [1792], 'Nagl': [1794], 'Feneberg': [1796], 'Weishaupt': [1798], 'J.H.': [1799, 3705], 'Ludolph': [1800, 3917], 'A.C.': [1801, 3918], 'Otto': [1802, 3921], 'Intact': [1804], 'analysis': [1806, 2218, 3091, 3104, 3316, 3856, 3942, 3962], 'ubiquitin': [1808], 'reveals': [1816], 'frontotemporal': [1822], 'lobar': [1823], 'degeneration.J.': [1824], 'Proteome': [1825, 1988], 'Res.': [1826, 1989], '4518-4525Crossref': [1829], '(28)': [1832], 'addition,': [1836, 2095, 2426], 'allows': [1838], 'detailed': [1841, 2090], 'whole': [1845], 'regarding': [1847], 'truncations': [1848], 'analyzing': [1852, 2896], 'across': [1855], 'after': [1859], 'proteolytic': [1860], 'digestion': [1861, 4129, 4173, 4207], 'discussion': [1867, 3981], 'synucleinopathies': [1873], '(13.Schmid': [1874], 'A.W.': [1875], 'Fauvet': [1876], 'B.': [1877, 2868, 2878, 3543, 3591, 3600, 3695, 3753], 'Moniatte': [1878], 'Lashuel': [1880], 'biomarkers': [1887, 3363], 'Parkinson': [1889], 'synucleinopathies.Mol.': [1893], '12:': [1897], '3543-3558Abstract': [1898], '(111)': [1906], 'Detailed': [1909], 'recently': [1915], 'CSF,': [1924, 2447], 'diagnostics': [1930], 'AD,': [1932], 'seems': [1934], 'predominantly': [1937], 'N-': [1938], 'C-terminally': [1940], 'truncated': [1941], '(14.Barthélemy': [1944], 'N.R.': [1945], 'Fenaille': [1946], 'Hirtz': [1948], 'Sergeant': [1950], 'Schraen-Maschke': [1952], 'Vialaret': [1954], 'Buée': [1956], 'Gabelle': [1958], 'Junot': [1960], 'Lehmann': [1962], 'Becher': [1964], 'Tau': [1966], 'Protein': [1967], 'Quantification': [1968], 'Human': [1970], 'Cerebrospinal': [1971], 'Fluid': [1972], 'Targeted': [1974], 'Mass': [1975], 'Spectrometry': [1976], 'at': [1977, 2339, 2352, 2501, 2639, 2738, 3062, 3067, 3155, 3168, 3174, 3298, 3415, 3877, 3890], 'High': [1978], 'Sequence': [1979], 'Coverage': [1980], 'Provides': [1981], 'Insights': [1982], 'into': [1983, 2564], 'Its': [1984], 'Primary': [1985], 'Structure': [1986], 'Heterogeneity.J.': [1987], '15:': [1991], '667-676Crossref': [1992], '(72)': [1995], 'far': [2004], 'quantitatively': [2006], 'measure': [2007], 'useful': [2015], 'volume': [2017], 'because': [2018], 'range.': [2026], 'We': [2027, 2124, 2145], 'here': [2029], 'βSyn,': [2042, 2186, 2224, 2376], '(βSyn,': [2064], 'PTMs)': [2066], 'standards.': [2069], 'Seven': [2070], 'eight': [2072], 'possible,': [2073], 'tryptic': [2075, 2515, 3972, 4031], 'included': [2080, 2099, 2433], 'covering': [2081], '70%': [2082], 'αSyn.': [2093], '(Ser87P,': [2102], 'Ser87O-GlcNAc,': [2103], 'Thr54P,': [2104], 'Thr54O-GlcNAc,': [2105], 'acetylation)': [2107], 'two': [2111], 'proteotypic': [2112, 3240], 'splice': [2117, 2386], 'variants': [2118, 2387], 'αSyn126': [2119], 'αSyn112': [2121], '(Fig.': [2122], '1).': [2123, 3244], 'without': [2135, 3055], 'ELISA': [2143, 3381, 3401], 'data.': [2144], 'then': [2146], 'measured': [2147], 'panel': [2151], 'PDD,': [2157], 'LBD,': [2158], '(PSP),': [2162], '(CBS),': [2165], '(CJD)': [2170], 'gain': [2182], 'new': [2183, 3038], 'peptide': [2191, 2847, 2857, 3206, 3252, 3979], 'pattern': [2192, 2854], 'Recombinant': [2195], '(purity': [2198], '>95%)': [2199, 2232], 'purchased': [2201, 2257, 2312], 'AJ': [2203], 'Roboscreen': [2204], 'GmbH': [2205], '(Leipzig,': [2206], 'Germany)': [2207], 'exact': [2210, 2239], 'determined': [2214, 2243, 3089, 3181, 3254, 3397, 3905], 'amino': [2216, 4053], 'acid': [2217, 2578, 2757, 4054], '(Alphalyse': [2219], 'A/S,': [2220], 'Odense,': [2221], 'Denmark).': [2222], 'Full-length': [2223], '15N-labeled': [2227], '(all': [2229], 'purity': [2231], 'rPeptide': [2235], '(Bogart,': [2236], 'GA)': [2237], 'peptides.': [2249, 4218], 'Synthetic': [2250], '(see': [2252, 2388, 2758, 3242, 3980], 'supplemental': [2253, 2389, 2422, 2473, 2759, 2839, 3429, 4037, 4096], 'Table': [2254, 2390, 2423, 2474, 2760, 2836, 2840, 3430, 4038, 4097], 'S1)': [2255, 2475], 'Thermo': [2259, 2314], 'Fisher': [2260, 2315, 2705], 'Scientific.': [2261], 'Trypsin/LysC': [2262, 2480], 'Mix': [2263], 'Promega': [2266], 'GmbH,': [2267, 2324], 'bicarbonate': [2269], '(TEAB),': [2270], 'ammonium': [2271, 2572, 2595], 'hydroxide': [2272], 'solution': [2273, 2462, 2481], '(LC-MS': [2274], 'grade)': [2275], '(HSA,': [2280], '#A3782)': [2281], 'Sigma,': [2283], 'solid': [2284, 2550], 'phase': [2285, 2551, 2709, 2715, 2743, 2751], 'cation': [2286, 2552], 'extraction': [2287, 2553], 'disks': [2288, 2554], '3M': [2290], '(#2251,': [2291], 'St.': [2292], 'Paul,': [2293], 'MN)': [2294], '(aCSF)': [2298], 'EcoCyte': [2300], 'Bioscience': [2301], '(Austin,': [2302], 'TX).': [2303], 'All': [2304, 3403, 3838, 3970], 'LC': [2305, 4062], 'solvents': [2306], 'LC-MS': [2309, 2337], 'grade': [2310], 'Scientific': [2316], '(DMSO,': [2317], 'formic': [2318, 2577, 2747, 2756, 4080], 'acid,': [2319, 2748, 4081], 'TFA)': [2320], 'Carl': [2322], 'Roth': [2323], 'Karlsruhe,': [2325], 'Germany': [2326], '(ACN,': [2327], '(MeOH),': [2329], 'water).': [2330], 'Proteins': [2331], 'dissolved': [2335], 'water': [2338, 2509], '100–500': [2342], 'μg/ml,': [2343], 'aliquoted': [2344], 'binding': [2348, 2491], 'tubes': [2349, 2492], 'stored': [2351, 2635, 3889], '−80': [2353, 3891], '°C.': [2354, 2503, 2641], 'Calibration': [2355], 'QC': [2358, 2402, 2430, 2451, 3046], 'samples': [2359, 2403, 2438, 2862, 3047, 3077, 3095, 3108, 3287, 3302, 3378, 3861, 4205], 'prepared': [2361, 2652], 'freshly': [2362], 'aCSF': [2364, 2650, 3187], 'containing': [2365, 2549], 'μg/ml': [2367], 'HSA': [2368, 4166, 4217], 'analytical': [2371, 2766, 3042], 'recombinant': [2374], 'synthetic': [2379], 'sequences': [2382], 'S1).': [2391], 'Concentrations': [2392], 'calibration': [2395, 2448, 3044, 3217, 3262], 'low,': [2398], 'medium': [2399], 'covered': [2404], '1.5–1310': [2408], 'pm': [2409, 2414], '(αSyn,': [2410], 'βSyn)': [2411], '40–2000': [2413], 'listed': [2418], 'detail': [2420], 'S1.': [2424], 'unspiked': [2428], 'sequence.': [2436, 3999], 'thawed': [2440], 'ice': [2442, 3160], 'mixed': [2454], '40': [2456, 2739], '(IS)': [2461], '(containing': [2463], 'labeled': [2464, 2797], '15N-αSyn': [2467], '0.5': [2469, 2733], 'm': [2470], 'TEAB,': [2471], '12': [2477, 3176], '(0.1': [2482], 'μg/μl': [2483], '100': [2485, 2511, 2735, 3480], 'mm': [2486, 2580, 2584, 2588, 2701, 2736], 'TEAB)': [2487], '(Sarstedt,': [2493], 'Nümbrecht,': [2494], 'Germany).': [2495], 'Samples': [2496, 2657, 3885], 'digested': [2498], '16h': [2500], '27': [2502, 4176], 'After': [2504], '700': [2507], '10%': [2513], 'TFA,': [2514, 2712], 'captured': [2518], 'STAGE-tips': [2520], '(15.Rappsilber': [2521], 'Ishihama': [2525], 'Protocol': [2527], 'micro-purification,': [2529], 'enrichment,': [2530], 'pre-fractionation': [2531], 'storage': [2533], 'proteomics': [2537, 2898], 'StageTips.Nat.': [2539], 'Protoc.': [2540], '2:': [2542], '1896-1906Crossref': [2543], '(2570)': [2546], '(activated': [2555], 'ACN),': [2557], 'washed': [2558], '0.2%': [2560], 'TFA': [2561, 2718], 'eluted': [2563], '24-Well': [2565], 'PCR': [2566], 'plates': [2567], 'increasing': [2569], 'acetate': [2573], '20%': [2575], 'ACN/0.5%': [2576], '(75': [2579], '→fraction': [2581, 2585, 2589], '1,': [2582], '125': [2583], '2,': [2586], '3)': [2590], 'finally': [2592], '5%': [2594], 'hydroxide/80%': [2596], 'ACN': [2597, 2612, 2619, 2625, 4202], '(fraction': [2598, 2613, 2620, 2626], '4).': [2599], 'Fractions': [2600], 'vacuum': [2602], 'dried': [2603], 'redissolved': [2605], '25': [2607, 2775], '0.1%': [2610, 2623], 'TFA/6%': [2611, 2618], '1': [2614, 4041], '3),': [2616], '0.5%': [2617], '2)': [2621], 'TFA/4%': [2624], '4)': [2627], 'thorough': [2629], 'mixing': [2630], 'sonication,': [2632], 'centrifuged': [2633, 3887], 'autosampler': [2638], '4': [2640], 'Serum': [2642], '(20': [2643], 'μl)': [2644], 'diluted': [2646, 3386], '180': [2648], 'analyzed': [2659, 3058], 'Agilent': [2662], '1260': [2663], 'HPLC': [2664], 'pump': [2665], '(Santa': [2666], 'Clara,': [2667], 'CA),': [2668], 'Eksigent': [2669, 2727], 'microLC200,': [2670], 'AB': [2672, 2678], 'Sciex': [2673], 'QTRAP6500': [2674, 2772], 'spectrometer': [2676], '(both': [2677], 'Sciex,': [2679], 'Framingham,': [2680], 'MA)': [2681], 'positive': [2683], 'ionization': [2684], 'mode.': [2685], 'Twenty': [2686], 'microliters': [2687], 'loaded': [2691], 'C18': [2694], 'PepMap100,': [2695], '5': [2696, 2700], 'μm,': [2697, 2732], '0.3': [2698], '×': [2699, 2734], 'trap': [2702], 'column': [2703, 2737, 2767, 4067], '(Thermo': [2704], 'Scientific)': [2706], 'mobile': [2708, 2714, 2742, 2750, 4075], 'A:': [2710, 2744], '0.05%': [2711, 2717], 'B:': [2716, 2752], 'MeOH.': [2720], 'Afterward,': [2721], 'separated': [2724], 'HALO': [2728], 'Fused-core': [2729], 'C18,': [2730], '2.7': [2731], '°C': [2740, 3892, 4177, 4181], '4%': [2745, 2753], 'DMSO/0.1%': [2746], 'DMSO/96%': [2754], 'ACN/0.1%': [2755], 'S2': [2761], 'gradient': [2763], 'settings).': [2764], 'connected': [2769], 'μm': [2776], 'electrode': [2777], 'data': [2779], 'acquired': [2781, 2849], 'scheduled': [2783], 'mode': [2785], '(retention': [2786], 'time': [2787, 2791], 'window': [2788], '40–120s,': [2789], 'scan': [2790], '0.2–0.4s,': [2792], 'dwell': [2793], 'weight:': [2794], '0.2': [2795], 'peptides,': [2798], '1.0': [2799], 'others).': [2801], 'source': [2804, 2890], 'settings': [2805, 2832, 4085], 'follows:': [2808], '4900–5500': [2809], 'V,': [2810], '175': [2811], '°C,': [2812], '(CUR)': [2815], '30psi,': [2816], 'nebulizer': [2817], '(GS1)': [2819], '20–40psi,': [2820], 'GS2': [2821], '30psi': [2822], 'CAD': [2824], 'high.': [2826], 'Transitions': [2827, 4219], 'individual': [2830], 'MS': [2831, 4023], 'I': [2837], 'S3.': [2841, 4039], 'Two': [2842], 'three': [2844], 'transitions': [2845, 3202], 'per': [2846], 'correct': [2852], 'transition': [2853], 'verified': [2859], 'all': [2861, 3201, 3239, 4012], 'Skyline': [2864], 'software': [2865, 3223], '3.1': [2866], '(16.MacLean': [2867], 'Tomazela': [2869], 'D.M.': [2870], 'Shulman': [2871], 'Chambers': [2873], 'Finney': [2875], 'G.L.': [2876], 'Frewen': [2877], 'Kern': [2879], 'Tabb': [2881], 'D.L.': [2882], 'Liebler': [2883], 'D.C.': [2884], 'MacCoss': [2885], 'Skyline:': [2887], 'open': [2889], 'document': [2891], 'editor': [2892], 'creating': [2894], 'targeted': [2897], 'experiments.Bioinformatics.': [2899], '2010;': [2900, 3367], '966-968Crossref': [2902], '(2964)': [2905], 'Scholar).Table': [2907], 'IMS': [2908], 'parameters': [2909, 3903, 3928, 4024], 'chromatographic': [2911], 'characteristics.': [2912], 'CE:': [2913], 'energy,': [2915], 'RT:': [2916], 'retention': [2917], 'time,': [2918], 'z:': [2919], 'charge': [2920, 4009], 'statePeptide': [2921], '(position)ProteinPrecursor': [2923], '(labeled': [2925], 'peptide)zProduct': [2926], 'ionCE': [2927], '(V)FractionRT': [2928], '(min)MDVFMK': [2929], '(1–6)αSyn385.7': [2930], '(389.2)2+y5,': [2931], 'y319,': [2932], '2345.1(1–6)βSynAc-MDVFMK': [2933], '(1–6)αSyn812.4': [2934], '(820.4)1+b3,': [2935], 'y349,': [2936], '4729.2(1–6)βSynEGVVAAAEK': [2937], '(13–21)αSyn437.2': [2938], '(442.2)2+y5,': [2939], 'y6,': [2940, 2993], 'y318,': [2941], '20,': [2942], '1823.5(13–21)βSynQGVAEAAGK': [2943], '(24–32)αSyn415.7': [2944], '(421.2)2+y6,': [2945], 'y421,': [2946], '2122.1EGVLYVGSK': [2947], '(35–43)αSyn476.3': [2948], '(481.3)2+y5,': [2949], 'y320,': [2950], '2134.4(35–43)βSynEGVVHGVATVAEK': [2951], '(46–58)αSyn648.4': [2952], '(656.3)2+y8,': [2953], 'y935,': [2954], '3443.4EGVVHGVAT(Phospho)VAEK': [2955], '(46–58)αSyn688.3': [2956], '(692.3)2+b5,': [2957], 'y8,': [2958, 2965], 'y437,': [2959], '35,': [2960, 2970], '3936.1EGVVHGVAT(O-GlcNAc)VAEK': [2961], '(46–58)αSyn749.9': [2962], '(753.9)2+b5,': [2963], 'b7,': [2964], '204.1': [2966, 2994], '(oxonium': [2967, 2995], 'ion)38,': [2968], '46,': [2969, 2997], '3833.1EQVTNVGGAVVTGVTAVAQK': [2971], '(61–80)αSyn964.5': [2972], '(976.5)2+y10,': [2973], 'y9,': [2974, 3014], 'y1144,': [2975], '44,': [2976], '4427.9TVEGAGSIAAATGFVK': [2977], '(81–96)αSyn739.9': [2978], '(748.4)2+y8,': [2979], 'y11,': [2980], 'y734,': [2981], '34,': [2982, 2988], '3436.7TVEGAGS(Phospho)IAAATGFVK': [2983], '(81–96)αSyn779.9': [2984], '(785.9)2+Y8,': [2985], 'y7,': [2986, 2992, 3008], 'y142+34,': [2987], '2917.8TVEGAGS(O-GlcNAc)IAAATGFVK': [2989], '(81–96)αSyn841.4': [2990], '(847.4)2+y8,': [2991], 'ion)43,': [2996], '49,': [2998], '2736.3EGYQDYEPEA': [2999], '(103–112)αSyn1121200.5': [3000], '(1206.5)1+b7,': [3001], 'b6,': [3002], 'y752,': [3003], '52,': [3004], '5915.3EGVLYVVAEK': [3005], '(35–44)αSyn126553.8': [3006], '(557.8)2+y6,': [3007], 'y423,': [3009], '25,': [3010], '2836.0EGVVQGVASVAEK': [3011], '(46–58)βSyn636.8': [3012], '(640.9)2+y8,': [3013], 'y1030,': [3015], '28,': [3016], '2827.0EQASHLGGAVFSGAGNIAAATGLVK': [3017], '(61–85)βSyn776.1': [3018], '(778.8)3+Y8,': [3019], 'b172+31,': [3020], '2748.1ENVVQSVTSVAEK': [3021], '(46–58)γSyn695.4': [3022], '(699.4)2+y8,': [3023], 'y1034,': [3024], '3427.2TVEEAENIAVTSGVVR': [3025], '(81–96)γSyn837.4': [3026], '(842.4)2+y8,': [3027], 'y746,': [3028], '3736.0VNVDEVGGEALGR': [3029], '(19–31)Hbb657.8': [3030], '(662.8)2+y7,': [3031], 'y830,': [3032], '3126.9': [3033], 'Open': [3034], 'table': [3035], 'tab': [3039], 'sequence,': [3043], 'standards,': [3045], 'blank': [3050], '(aCSF+HSA)': [3052], 'IS': [3056, 3257, 3283], 'duplicate': [3060, 3106], '(one': [3061], 'beginning': [3064], 'one': [3066], 'end': [3069], 'sequence).': [3072], 'order': [3074], '(single': [3078], 'measurement)': [3079], 'defined': [3081, 3120], 'systematic': [3083], 'randomization.': [3084], 'Intra-assay': [3085], 'precision': [3086, 3102], '(%CV)': [3087], 'four': [3093, 3110], 'CSF-QC': [3094, 3107], 'run': [3099], 'inter-assay': [3101], 'independent': [3111], 'runs.': [3112], '(LLOQ)': [3118], 'lowest': [3123], 'CV': [3127], 'deviation': [3129], '≤20%': [3131], '(LOD)': [3137], 'signal-to-noise': [3140], '3.': [3143], 'Stability': [3144], 'tested': [3150, 4065, 4123], 'incubation': [3152], 'bench-top': [3156], 'conditions': [3157, 4063], '(RT),': [3158], 'different': [3163, 4066], 'freeze-thaw': [3164], 'cycles': [3165], '(thawing': [3166], 'least': [3169, 3175], '2': [3170, 3894], 'h,': [3171], 'freezing': [3172], 'h).': [3177], 'Dilution': [3178], 'stability': [3179], 'dilution': [3183], 'up': [3188], 'fourfold.': [3190], 'IS-normalized': [3192], 'peak': [3193, 3258], 'area': [3194, 3259], '(synucleins)': [3199], 'summed': [3208], 'up.': [3209], 'Peptide': [3210], 'calculated': [3213, 3233, 3269], 'curve': [3218], '(weighting': [3219], '1/x2)': [3220], 'Analyst': [3222], '1.6.2': [3224], '(AB': [3225], 'Sciex).': [3226], 'Total': [3227], 'mean': [3236], 'Fig.': [3243, 4040], 'Concentration': [3245], 'Hbb': [3248, 3282], '(hemoglobin': [3249], 'subunit)': [3251], 'one-point': [3261], 'total': [3264], '(Hb)': [3266], 'assuming': [3270], '1:1': [3272], 'Hb': [3276], 'alpha': [3277], 'subunit.': [3280], 'added': [3285], 'final': [3290], 'ng/ml': [3294, 3308], 'accuracy': [3297], 'cut-off.': [3300], '>200': [3307], 'ruled': [3310], 'out': [3311, 3444], 'recommended': [3318], '(17.Hong': [3319], 'Shi': [3321], 'Chung': [3323], 'K.A.': [3324, 3763], 'Quinn': [3325, 3536, 3710], 'J.F.': [3326], 'Peskind': [3327], 'E.R.': [3328], 'Galasko': [3329, 3601], 'Jankovic': [3331, 3708], 'Zabetian': [3333], 'C.P.': [3334], 'Leverenz': [3335], 'J.B.': [3336, 3650], 'Baird': [3337], 'Montine': [3339], 'T.J.': [3340], 'Hancock': [3341], 'A.M.': [3342], 'Hwang': [3343], 'Pan': [3345], 'Bradner': [3347], 'Kang': [3349], 'U.J.': [3350], 'Jensen': [3351], 'P.H.': [3352], 'Zhang': [3353], 'DJ-1': [3355], 'disease.Brain.': [3366], '133:': [3368], '713-726Crossref': [3369], '(503)': [3372], '(Covance': [3382], '#SIG-38974)': [3383], 'measurements': [3384, 3404], '1:20': [3387], '1:200,': [3389], 'respectively,': [3390], 'commercial': [3400], '(Fujirebio).': [3402], 'performed': [3406, 3944, 3964], 'according': [3407, 3456, 3496, 3821, 3896], "manufacturer's": [3410], 'instructions.': [3411], 'Patients': [3412], 'enrolled': [3414], 'Ulm': [3417, 3869, 3879], 'University': [3418, 3880], 'Hospital,': [3419, 3881], 'Department': [3420, 3882], 'Neurology.': [3422, 3884], 'Characteristics': [3423], 'depicted': [3427], 'S4.': [3431], 'Control': [3432], 'had': [3434], 'no': [3435], 'collected': [3441, 3873], 'rule': [3443], 'acute': [3445], 'chronic': [3447], 'inflammation': [3448], 'brain.': [3451], 'diagnosed': [3455, 3820], 'accepted': [3458], 'criteria': [3459, 3546, 3684, 3718, 3816, 3826, 3833], '(18.Hughes': [3460], 'A.J.': [3461, 3467], 'Daniel': [3462], 'S.E.': [3463, 3767], 'Kilford': [3464], 'Lees': [3466, 3524, 3629], 'Accuracy': [3468], 'idiopathic': [3473], 'disease:': [3475], 'clinico-pathological': [3477], 'cases.J.': [3481], 'Neurol.': [3482, 3932], 'Neurosurg.': [3483], 'Psychiatry.': [3484], '1992;': [3485], '55:': [3486], '181-184Crossref': [3487], '(8449)': [3490], 'Scholar),': [3492], '(19.Emre': [3498], 'Aarsland': [3500, 3584], 'Brown': [3502], 'Burn': [3504, 3592], 'D.J.': [3505, 3593], 'Duyckaerts': [3506], 'Mizuno': [3508, 3639], 'Broe': [3510], 'G.A.': [3511], 'Cummings': [3512, 3576], 'Dickson': [3514, 3566, 3756], 'D.W.': [3515, 3567, 3757], 'Gauthier': [3516, 3603], 'Goldman': [3518], 'Goetz': [3520, 3605, 3698], 'Korczyn': [3522, 3623], 'Levy': [3526], 'Litvan': [3528, 3631, 3744], 'Olanow': [3532], 'W.': [3533, 3535], 'Poewe': [3534], 'Sampaio': [3538], 'Tolosa': [3540, 3712, 3774], 'Dubois': [3542, 3599, 3694], 'Clinical': [3544, 3716], 'disease.Mov.': [3552], '22': [3555], '(quiz': [3556], '1837):': [3557], '1689-1707Crossref': [3558], '(2062)': [3561], 'Scholar,': [3563, 3741], '20.McKeith': [3564], 'Lowe': [3568], 'Emre': [3570], "O'Brien": [3572], 'J.T.': [3573], 'Feldman': [3574], 'Duda': [3578], 'Lippa': [3580], 'E.K.': [3583], 'Arai': [3586], 'Ballard': [3588], 'C.G.': [3589, 3606, 3699], 'Boeve': [3590], 'Costa': [3594], 'Del': [3596], 'Ser': [3597], 'T.': [3598, 3616], 'Gomez-Tortosa': [3607], 'Hansen': [3611], 'L.A.': [3612], 'Iwatsubo': [3615], 'Kalaria': [3617], 'R.N.': [3618], 'Kaufer': [3619], 'Kenny': [3621], 'R.A.': [3622], 'Kosaka': [3625], 'V.M.Y.': [3628], 'Londos': [3633], 'Lopez': [3635], 'O.L.': [3636], 'Minoshima': [3637], 'Molina': [3641], 'Mukaetova-Ladinska': [3643], 'Pasquier': [3645], 'R.H.': [3648], 'Schulz': [3649], 'Yamada': [3653], 'Diagnosis': [3655, 3677], 'management': [3657], 'bodies:': [3662], 'third': [3663], 'report': [3664, 3728], 'DLB': [3667], 'Consortium.Neurology.': [3668], '2005;': [3669], '65:': [3670], '1863-1872Crossref': [3671], '(4132)': [3674], 'PSP': [3679], 'CBS': [3681], 'followed': [3682], '(21.Litvan': [3686], 'Agid': [3688], 'Calne': [3690], 'Campbell': [3692], 'Duvoisin': [3696], 'R.C.': [3697], 'Golbe': [3700], 'L.I.': [3701], 'Grafman': [3702], 'Growdon': [3704], 'Hallett': [3706, 3760], 'N.P.': [3711], 'Zee': [3714], 'D.S.': [3715], 'research': [3717], '(Steele-Richardson-Olszewski': [3726], 'syndrome):': [3727], 'NINDS-SPSP': [3731], 'international': [3732], 'workshop.Neurology.': [3733], '1996;': [3734], '1-9Crossref': [3736], '(2099)': [3739], '22.Armstrong': [3742], 'Lang': [3746], 'A.E.': [3747], 'Bak': [3748], 'T.H.': [3749], 'Bhatia': [3750], 'K.P.': [3751], 'Borroni': [3752], 'Boxer': [3754], 'A.L.': [3755], 'Grossman': [3758], 'Josephs': [3762], 'Kertesz': [3764], 'Miller': [3768], 'B.L.': [3769], 'Reich': [3770], 'S.G.': [3771], 'Riley': [3772], 'D.E.': [3773], 'Tröster': [3776], 'A.I.': [3777], 'Vidailhet': [3778], 'Weiner': [3780], 'W.J.': [3781], 'Criteria': [3782], 'degeneration.Neurology.': [3788], '80:': [3790], '496-503Crossref': [3791], '(1000)': [3794], 'fulfilled': [3799], 'NINCDS-ADRDA': [3801], '(National': [3802], 'Association)': [3815], 'WHO': [3824], 'consensus': [3825], '(23..World': [3827], 'Health': [3828], 'Organization': [3829], '(1998)': [3830], 'Consensus': [3831], 'sporadic': [3835], 'CJD.Google': [3836], 'relatives': [3842], 'gave': [3843], 'written': [3844], 'informed': [3845], 'consent': [3846], 'participate': [3848], 'collection': [3854], 'approved': [3863], 'Ethics': [3866], 'Committee': [3867], 'University.': [3870], 'lumbar': [3875], 'puncture': [3876], 'within': [3893], 'h': [3895], 'local': [3898], 'SOPs': [3899], '(24.Jesse': [3906], 'Brettschneider': [3908], 'Süssmuth': [3910], 'S.D.': [3911], 'Landwehrmeyer': [3912], 'B.G.': [3913], 'Tumani': [3919], 'Summary': [3923], 'routine': [3927], 'diseases.J.': [3931], '2011;': [3933], '258:': [3934], '1034-1041Crossref': [3935], '(61)': [3938], 'Statistical': [3941], 'GraphPad': [3946], 'Prism': [3947], '5.0.': [3948], 'groups': [3950], 'Kruskal-Wallis': [3954], 'test': [3955], 'Dunn′s': [3957], 'post': [3958], 'hoc': [3959], 'test.': [3960], 'Correlation': [3961], 'Spearman′s': [3966], 'rank': [3967], 'coefficient.': [3969], 'theoretical': [3971], 'except': [3976], 'C-terminal': [3978], 'section)': [3982], 'selected': [3984, 4015, 4046, 4165, 4225], 'cover': [3989], 'largest': [3991], 'part': [3992], '(about': [3994], '70%)': [3995], 'Proteotypic': [4000], 'optimal': [4008], 'state': [4010], 'selectivity.': [4022], 'optimized': [4026, 4087], 'direct': [4028], 'infusion': [4029], 'gives': [4042], 'overview': [4044], 'variants.': [4059], 'optimize': [4061], 'temperatures,': [4068], 'flow': [4069], 'rates': [4070], 'compositions': [4072], 'phases': [4076], 'ACN,': [4078], 'MeOH,': [4079], 'TFA.': [4083], 'fraction': [4091], 'given': [4094], 'S2.': [4098], 'dynamic': [4101], 'significantly': [4108], 'abundance': [4114], 'LC-MS/MS': [4120], 'approaches': [4125], 'modify': [4127], 'protocol': [4130], 'favor': [4132], 'synucleins.': [4134, 4194], 'do': [4138], 'contain': [4140], 'Cys-residues': [4141], 'reduction': [4144, 4152], 'alkylation': [4146, 4154], 'step': [4147], 'necessary.': [4150], 'Omitting': [4151], 'markedly': [4161], 'decreased': [4162], 'intensity': [4163, 4215], '(10–1000x,': [4168], 'label-free': [4169], 'estimation).': [4170], 'Using': [4171], 'temperature': [4174], 'instead': [4178, 4185], '37': [4180], 'trypsin/LysC': [4184], 'trypsin': [4187], 'alone': [4188], 'improved': [4190], 'Heating': [4195], 'amount': [4200], '(5–10%)': [4203], 'before': [4206], 'detection/quantification': [4223], 'examined': [4232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2521150622', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 31}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2025-01-12T17:32:40.349439', 'created_date': '2016-09-30'}