HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

Name: Work Video:
Duration: 3 min 30 s
Jon M. Steichen; Daniel W. Kulp; Talar Tokatlian; Amelia Escolano; Pia Dosenovic; Robyn L. Stanfield; Laura E. McCoy; Gabriel Ozorowski; Xiaozhen Hu; Oleksandr Kalyuzhniy; Bryan Briney; Torben Schiffner; Fernando Garcés; Natalia T. Freund; Alexander D. Gitlin; Sergey Menis; Erik Georgeson; Michael Kubitz; Yumiko Adachi; Meaghan Jones; Andrew A. Mutafyan; Dong Soo Yun; Christian T. Mayer; Andrew B. Ward; Dennis R. Burton; Ian A. Wilson; Darrell J. Irvine; M C Nussenzweig; William R. Schief
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'immunogens': [43], 'to': [44, 54, 113, 141], 'prime': [45, 120], 'responses.': [47], 'We': [48], 'employed': [49], 'mammalian': [50], 'cell': [51], 'surface': [52], 'display': [53], 'design': [55, 126, 135], 'stabilized': [56], 'trimers': [58, 69], 'with': [59, 130], 'germline-reverted': [62], 'PGT121-class': [65], 'bnAbs.': [67], 'The': [68, 133], 'maintained': [70], 'native-like': [71], 'antigenicity': [72], 'structure,': [74], 'activated': [75], 'PGT121': [76, 91], 'inferred-germline': [77, 92], 'B': [78], 'cells': [79], 'ex': [80], 'vivo': [81], 'when': [82], 'multimerized': [83], 'on': [84, 145], 'liposomes,': [85], 'primed': [87], 'PGT121-like': [88], 'responses': [89], 'in': [90, 116], 'knockin': [93], 'mice.': [94], 'Design': [95], 'intermediates': [96, 127], 'have': [97], 'levels': [98], 'epitope': [100], 'modification': [101], 'between': [102], 'wild-type': [103], 'germline-targeting': [105, 119], 'trimers;': [106], 'their': [107], 'mutation': [108], 'gradient': [109], 'suggests': [110], 'sequential': [111], 'immunization': [112], 'induce': [114], 'bnAbs,': [115], 'which': [117], 'is': [121], 'followed': [122], 'by': [123], 'progressively': [124], 'less-mutated': [125], 'and,': [128], 'lastly,': [129], 'native': [131], 'trimers.': [132], 'strategies': [136], 'described': [137], 'could': [138], 'be': [139], 'utilized': [140], 'target': [142], 'other': [143, 148], 'epitopes': [144], 'or': [147], 'pathogens.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2520562417', 'counts_by_year': [{'year': 2024, 'cited_by_count': 34}, {'year': 2023, 'cited_by_count': 34}, {'year': 2022, 'cited_by_count': 48}, {'year': 2021, 'cited_by_count': 47}, {'year': 2020, 'cited_by_count': 54}, {'year': 2019, 'cited_by_count': 42}, {'year': 2018, 'cited_by_count': 51}, {'year': 2017, 'cited_by_count': 48}, {'year': 2016, 'cited_by_count': 7}], 'updated_date': '2024-12-24T16:52:12.628271', 'created_date': '2016-09-23'}
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