Publication Information

{'id': 'https://openalex.org/W2518202212', 'doi': 'https://doi.org/10.1016/j.arr.2016.08.006', 'title': 'Inflammation and frailty in the elderly: A systematic review and meta-analysis', 'display_name': 'Inflammation and frailty in the elderly: A systematic review and meta-analysis', 'publication_year': 2016, 'publication_date': '2016-09-09', 'ids': {'openalex': 'https://openalex.org/W2518202212', 'doi': 'https://doi.org/10.1016/j.arr.2016.08.006', 'mag': '2518202212', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27592340'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.arr.2016.08.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S117312820', 'display_name': 'Ageing Research Reviews', 'issn_l': '1568-1637', 'issn': ['1568-1637', '1872-9649'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.arr.2016.08.006', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068471813', 'display_name': 'Pınar Soysal', 'orcid': 'https://orcid.org/0000-0002-6042-1718'}, 'institutions': [{'id': 'https://openalex.org/I193615760', 'display_name': 'Dokuz Eylül University', 'ror': 'https://ror.org/00dbd8b73', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I193615760']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Pinar Soysal', 'raw_affiliation_strings': ['Center for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey'], 'affiliations': [{'raw_affiliation_string': 'Center for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey', 'institution_ids': ['https://openalex.org/I193615760']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005008571', 'display_name': 'Brendon Stubbs', 'orcid': 'https://orcid.org/0000-0001-7387-3791'}, 'institutions': [{'id': 'https://openalex.org/I51216347', 'display_name': 'Anglia Ruskin University', 'ror': 'https://ror.org/0009t4v78', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I51216347']}, {'id': 'https://openalex.org/I200323923', 'display_name': 'South London and Maudsley NHS Foundation Trust', 'ror': 'https://ror.org/015803449', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I200323923']}, {'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Brendon Stubbs', 'raw_affiliation_strings': ['Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK', 'Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom', 'United Kingdom and Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London Box SE5 8AF, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK', 'institution_ids': ['https://openalex.org/I51216347']}, {'raw_affiliation_string': 'Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom', 'institution_ids': ['https://openalex.org/I200323923']}, {'raw_affiliation_string': 'United Kingdom and Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London Box SE5 8AF, United Kingdom', 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035780777', 'display_name': 'Paola Lucato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Lucato', 'raw_affiliation_strings': ['Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057229016', 'display_name': 'Claudio Luchini', 'orcid': 'https://orcid.org/0000-0003-4901-4908'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Claudio Luchini', 'raw_affiliation_strings': ['Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083734796', 'display_name': 'Marco Solmi', 'orcid': 'https://orcid.org/0000-0003-4877-7233'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Solmi', 'raw_affiliation_strings': ['Department of Neurosciences, University of Padova, Padova, Italy', 'Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy', 'Local Health Unit 17, Mental Health Department, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosciences, University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Local Health Unit 17, Mental Health Department, Padova, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054775813', 'display_name': 'Roberto Peluso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberto Peluso', 'raw_affiliation_strings': ['Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035706665', 'display_name': 'Giuseppe Sergi', 'orcid': 'https://orcid.org/0000-0001-9757-856X'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Sergi', 'raw_affiliation_strings': ['Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019380921', 'display_name': 'Ahmet Turan Işık', 'orcid': 'https://orcid.org/0000-0001-5867-6503'}, 'institutions': [{'id': 'https://openalex.org/I193615760', 'display_name': 'Dokuz Eylül University', 'ror': 'https://ror.org/00dbd8b73', 'country_code': 'TR', 'type': 'education', 'lineage': ['https://openalex.org/I193615760']}], 'countries': ['TR'], 'is_corresponding': False, 'raw_author_name': 'Ahmet Turan Isik', 'raw_affiliation_strings': ['Center for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey'], 'affiliations': [{'raw_affiliation_string': 'Center for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey', 'institution_ids': ['https://openalex.org/I193615760']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040984253', 'display_name': 'Enzo Manzato', 'orcid': 'https://orcid.org/0000-0002-1261-6270'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Enzo Manzato', 'raw_affiliation_strings': ['Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081622372', 'display_name': 'Stefania Maggi', 'orcid': 'https://orcid.org/0000-0002-0453-8663'}, 'institutions': [{'id': 'https://openalex.org/I4210113153', 'display_name': 'Neuroscience Institute', 'ror': 'https://ror.org/0240rwx68', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113153', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefania Maggi', 'raw_affiliation_strings': ['Aging Branch, Institute of Neuroscience, National Research Council-CNR, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Aging Branch, Institute of Neuroscience, National Research Council-CNR, Padova, Italy', 'institution_ids': ['https://openalex.org/I4210113153', 'https://openalex.org/I4210155236']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016660184', 'display_name': 'Marcello Maggio', 'orcid': 'https://orcid.org/0000-0002-1727-6797'}, 'institutions': [{'id': 'https://openalex.org/I124601658', 'display_name': 'University of Parma', 'ror': 'https://ror.org/02k7wn190', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I124601658']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marcello Maggio', 'raw_affiliation_strings': ['Geriatric Clinic and Laboratory of Movement Analysis, Geriatric and Rehabilitation Department, University Hospital of Parma, Via Gramsci 14, I-431126 Parma, Italy'], 'affiliations': [{'raw_affiliation_string': 'Geriatric Clinic and Laboratory of Movement Analysis, Geriatric and Rehabilitation Department, University Hospital of Parma, Via Gramsci 14, I-431126 Parma, Italy', 'institution_ids': ['https://openalex.org/I124601658']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076005488', 'display_name': 'Matthew Prina', 'orcid': 'https://orcid.org/0000-0001-6698-3263'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'A. Matthew Prina', 'raw_affiliation_strings': ['King’s College London, Centre for Global Mental Health, Health Service and Population Department, Institute of Psychiatry, Pscyhology and Neuroscience, De Crespigny Park, SE5 8AF London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'King’s College London, Centre for Global Mental Health, Health Service and Population Department, Institute of Psychiatry, Pscyhology and Neuroscience, De Crespigny Park, SE5 8AF London, United Kingdom', 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068364602', 'display_name': 'Theodore D. Cosco', 'orcid': 'https://orcid.org/0000-0002-9977-8888'}, 'institutions': [{'id': 'https://openalex.org/I4210139815', 'display_name': 'MRC Unit for Lifelong Health and Ageing', 'ror': 'https://ror.org/03kpvby98', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210139815', 'https://openalex.org/I45129253', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Theodore D. Cosco', 'raw_affiliation_strings': ['MRC Unit for Lifelong Health & Ageing, University College London, 33 Bedford Place, London WC1B 5JU, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'MRC Unit for Lifelong Health & Ageing, University College London, 33 Bedford Place, London WC1B 5JU, United Kingdom', 'institution_ids': ['https://openalex.org/I4210139815', 'https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018462205', 'display_name': 'Yu‐Tzu Wu', 'orcid': 'https://orcid.org/0000-0002-0874-4448'}, 'institutions': [{'id': 'https://openalex.org/I23923803', 'display_name': 'University of Exeter', 'ror': 'https://ror.org/03yghzc09', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I23923803']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Yu-Tzu Wu', 'raw_affiliation_strings': ['REACH: The Centre for Research in Aging and Cognitive Health, College of Life and Environmental Sciences—Psychology, University of Exeter, Exeter EX4 4QG, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'REACH: The Centre for Research in Aging and Cognitive Health, College of Life and Environmental Sciences—Psychology, University of Exeter, Exeter EX4 4QG, United Kingdom', 'institution_ids': ['https://openalex.org/I23923803']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033950708', 'display_name': 'Nicola Veronese', 'orcid': 'https://orcid.org/0000-0002-9328-289X'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Nicola Veronese', 'raw_affiliation_strings': ['Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy', 'Nicola Veronese, Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy'], 'affiliations': [{'raw_affiliation_string': 'Nicola Veronese, Geriatrics Section, Department of Medicine (DIMED), University of Padova, Padova, Italy', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 11, 'corresponding_author_ids': ['https://openalex.org/A5033950708'], 'corresponding_institution_ids': ['https://openalex.org/I138689650'], 'apc_list': {'value': 4820, 'currency': 'USD', 'value_usd': 4820, 'provenance': 'doaj'}, 'apc_paid': {'value': 4820, 'currency': 'USD', 'value_usd': 4820, 'provenance': 'doaj'}, 'fwci': 7.336, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 783, 'citation_normalized_percentile': {'value': 0.992647, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '31', 'issue': None, 'first_page': '1', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11011', 'display_name': 'Frailty in Older Adults', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11011', 'display_name': 'Frailty in Older Adults', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10397', 'display_name': 'Nutrition and Health in Aging', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10804', 'display_name': 'Health Systems, Economic Evaluations, Quality of Life', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/2002', 'display_name': 'Economics and Econometrics'}, 'field': {'id': 'https://openalex.org/fields/20', 'display_name': 'Economics, Econometrics and Finance'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/white-blood-cell', 'display_name': 'White blood cell', 'score': 0.46617436}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.789057}, {'id': 'https://openalex.org/C95190672', 'wikidata': 'https://www.wikidata.org/wiki/Q815382', 'display_name': 'Meta-analysis', 'level': 2, 'score': 0.75166416}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.6346307}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6041259}, {'id': 'https://openalex.org/C2781195455', 'wikidata': 'https://www.wikidata.org/wiki/Q422766', 'display_name': 'C-reactive protein', 'level': 3, 'score': 0.602097}, {'id': 'https://openalex.org/C2779036427', 'wikidata': 'https://www.wikidata.org/wiki/Q381899', 'display_name': 'Fibrinogen', 'level': 2, 'score': 0.54725635}, {'id': 'https://openalex.org/C2778488018', 'wikidata': 'https://www.wikidata.org/wiki/Q42395', 'display_name': 'White blood cell', 'level': 2, 'score': 0.46617436}, {'id': 'https://openalex.org/C74909509', 'wikidata': 'https://www.wikidata.org/wiki/Q10387', 'display_name': 'Gerontology', 'level': 1, 'score': 0.45395085}, {'id': 'https://openalex.org/C189708586', 'wikidata': 'https://www.wikidata.org/wiki/Q1504425', 'display_name': 'Systematic review', 'level': 3, 'score': 0.42330486}, {'id': 'https://openalex.org/C2779473830', 'wikidata': 'https://www.wikidata.org/wiki/Q1540899', 'display_name': 'MEDLINE', 'level': 2, 'score': 0.33278945}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3249427}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D016330', 'descriptor_name': 'Frail Elderly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 11, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.arr.2016.08.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S117312820', 'display_name': 'Ageing Research Reviews', 'issn_l': '1568-1637', 'issn': ['1568-1637', '1872-9649'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1514775/', 'pdf_url': 'https://discovery.ucl.ac.uk/1514775/1/1-s2.0-S1568163716301106-main.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1514775/1/1-s2.0-S1568163716301106-main.pdf', 'pdf_url': 'https://discovery.ucl.ac.uk/id/eprint/1514775/1/1-s2.0-S1568163716301106-main.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://eprint.ncl.ac.uk/fulltext.aspx?url=266586/24BC6658-F69B-4F2C-91DF-1B329C581981.pdf&pub_id=266586', 'pdf_url': 'https://eprint.ncl.ac.uk/fulltext.aspx?url=266586/24BC6658-F69B-4F2C-91DF-1B329C581981.pdf&pub_id=266586', 'source': {'id': 'https://openalex.org/S4306402485', 'display_name': 'Newcastle University ePrints (Newcastle Univesity)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I84884186', 'host_organization_name': 'Newcastle University', 'host_organization_lineage': ['https://openalex.org/I84884186'], 'host_organization_lineage_names': ['Newcastle University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Inflammation_and_frailty_in_the_elderly_A_systematic_review_and_meta-analysis/23775624', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Inflammation_and_frailty_in_the_elderly_A_systematic_review_and_meta-analysis/23775624/1/files/41711487.pdf', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://ora.ox.ac.uk/objects/uuid:37e96e50-4318-47e6-b419-d21a8734d530', 'pdf_url': 'https://ora.ox.ac.uk/objects/uuid:37e96e50-4318-47e6-b419-d21a8734d530/files/me1583a70984063f3b092b999310614dc', 'source': {'id': 'https://openalex.org/S4306402636', 'display_name': 'Oxford University Research Archive (ORA) (University of Oxford)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I40120149', 'host_organization_name': 'University of Oxford', 'host_organization_lineage': ['https://openalex.org/I40120149'], 'host_organization_lineage_names': ['University of Oxford'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10447/463258', 'pdf_url': 'https://iris.unipa.it/bitstream/10447/463258/2/1-s2.0-S1568163716301106-main.pdf', 'source': {'id': 'https://openalex.org/S4306401065', 'display_name': 'Nova Science Publishers (Nova Science Publishers, Inc.)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://kclpure.kcl.ac.uk/portal/en/publications/c30f59be-6d25-4fd6-b33e-296e1f0a9609', 'pdf_url': 'https://kclpure.kcl.ac.uk/portal/files/56971750/1_s2.0_S1568163716301106_main.pdf', 'source': {'id': 'https://openalex.org/S4306400216', 'display_name': "Research Portal (King's College London)", 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I183935753', 'host_organization_name': "King's College London", 'host_organization_lineage': ['https://openalex.org/I183935753'], 'host_organization_lineage_names': ["King's College London"], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11577/3208490', 'pdf_url': 'https://www.research.unipd.it/bitstream/11577/3208490/2/Inflammation%20and%20frailty%202016.pdf', 'source': {'id': 'https://openalex.org/S4306402547', 'display_name': 'Padua Research Archive (University of Padova)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I138689650', 'host_organization_name': 'University of Padua', 'host_organization_lineage': ['https://openalex.org/I138689650'], 'host_organization_lineage_names': ['University of Padua'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://kclpure.kcl.ac.uk/ws/files/56971750/1_s2.0_S1568163716301106_main.pdf', 'pdf_url': 'https://kclpure.kcl.ac.uk/ws/files/56971750/1_s2.0_S1568163716301106_main.pdf', 'source': {'id': 'https://openalex.org/S4306400216', 'display_name': "Research Portal (King's College London)", 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I183935753', 'host_organization_name': "King's College London", 'host_organization_lineage': ['https://openalex.org/I183935753'], 'host_organization_lineage_names': ["King's College London"], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27592340', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.arr.2016.08.006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S117312820', 'display_name': 'Ageing Research Reviews', 'issn_l': '1568-1637', 'issn': ['1568-1637', '1872-9649'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.59}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1125533528', 'https://openalex.org/W1480076783', 'https://openalex.org/W1493610819', 'https://openalex.org/W1494322293', 'https://openalex.org/W1544712355', 'https://openalex.org/W1581404153', 'https://openalex.org/W1924777139', 'https://openalex.org/W1963828374', 'https://openalex.org/W1964435302', 'https://openalex.org/W1967567549', 'https://openalex.org/W1975944924', 'https://openalex.org/W1988354245', 'https://openalex.org/W1992692008', 'https://openalex.org/W2006546769', 'https://openalex.org/W2011667605', 'https://openalex.org/W2016068403', 'https://openalex.org/W2029690418', 'https://openalex.org/W2030557276', 'https://openalex.org/W2037100900', 'https://openalex.org/W2040542758', 'https://openalex.org/W2048270339', 'https://openalex.org/W2049787291', 'https://openalex.org/W2052596282', 'https://openalex.org/W2053714713', 'https://openalex.org/W2055887038', 'https://openalex.org/W2067600180', 'https://openalex.org/W2074843822', 'https://openalex.org/W2079923924', 'https://openalex.org/W2084593052', 'https://openalex.org/W2086946216', 'https://openalex.org/W2088724702', 'https://openalex.org/W2090523257', 'https://openalex.org/W2104859015', 'https://openalex.org/W2107328434', 'https://openalex.org/W2109982307', 'https://openalex.org/W2125850078', 'https://openalex.org/W2126930838', 'https://openalex.org/W2127412235', 'https://openalex.org/W2131140036', 'https://openalex.org/W2140509802', 'https://openalex.org/W2142514031', 'https://openalex.org/W2144040170', 'https://openalex.org/W2144775127', 'https://openalex.org/W2155577996', 'https://openalex.org/W2157823046', 'https://openalex.org/W2159750202', 'https://openalex.org/W2164059021', 'https://openalex.org/W2165602127', 'https://openalex.org/W2166127731', 'https://openalex.org/W2171349433', 'https://openalex.org/W2190975361', 'https://openalex.org/W2210962886', 'https://openalex.org/W2226987069', 'https://openalex.org/W2233881453', 'https://openalex.org/W2280708766', 'https://openalex.org/W2307532565', 'https://openalex.org/W2485736273', 'https://openalex.org/W2599076725', 'https://openalex.org/W2612891587', 'https://openalex.org/W3022903699', 'https://openalex.org/W4292229870', 'https://openalex.org/W49712109', 'https://openalex.org/W78649709'], 'related_works': ['https://openalex.org/W4294636802', 'https://openalex.org/W3198212963', 'https://openalex.org/W3030423913', 'https://openalex.org/W2897413314', 'https://openalex.org/W2414951211', 'https://openalex.org/W2399334738', 'https://openalex.org/W2389304242', 'https://openalex.org/W2385444830', 'https://openalex.org/W2091458228', 'https://openalex.org/W1984921258'], 'abstract_inverted_index': {'The': [0], 'pathogenesis': [1], 'of': [2, 7, 33, 124, 153], 'frailty': [3, 22, 41, 89, 205], 'and': [4, 21, 27, 40, 71, 76, 111, 137, 165, 176, 191, 206, 214, 218], 'the': [5, 14, 17], 'role': [6], 'inflammation': [8, 20], 'is': [9], 'poorly': [10], 'understood.': [11], 'We': [12], 'examined': [13], 'evidence': [15], 'considering': [16], 'relationship': [18], 'between': [19], 'through': [23], 'a': [24], 'systematic': [25, 30], 'review': [26], 'meta-analysis.': [28], 'A': [29], 'literature': [31], 'search': [32], 'papers': [34], 'providing': [35], 'data': [36], 'on': [37], 'inflammatory': [38, 212], 'biomarkers': [39], 'was': [42], 'carried': [43], 'out': [44], 'in': [45, 215], 'major': [46], 'electronic': [47], 'databases': [48], 'from': [49], 'inception': [50], 'until': [51], 'May': [52], '2016.': [53], 'From': [54], '1856': [55], 'initial': [56], 'hits,': [57], '35': [58], 'studies': [59, 62, 83, 95, 222], '(32': [60], 'cross-sectional': [61], 'n': [63, 67, 72, 84], '=': [64, 68, 73, 85, 107, 115, 130, 133, 140, 143, 162, 187, 194], '3232': [65], 'frail,': [66], '11,483': [69], 'pre-frail': [70, 78, 113], '8522': [74], 'robust,': [75], '563': [77], '+': [79], 'robust;': [80], '3': [81], 'longitudinal': [82, 181, 221], '3402': [86], 'participants': [87, 119], 'without': [88], 'at': [90], 'baseline)': [91], 'were': [92, 147, 159, 167, 198], 'meta-analyzed.': [93], 'Cross-sectional': [94], 'reported': [96], 'that': [97], 'compared': [98, 155], 'to': [99, 156], '6757': [100], 'robust': [101, 160], 'participants,': [102], 'both': [103], '1698': [104], 'frail': [105], '(SMD': [106, 114], '1.00,': [108], '95%CI:': [109, 117, 135, 145, 189, 196], '0.40–1.61)': [110], '8568': [112], '0.33,': [116], '0.04–0.62)': [118], 'had': [120], 'significantly': [121, 169], 'higher': [122, 150, 183, 211], 'levels': [123, 152], 'C-reactive': [125], 'protein': [126], '(CRP).': [127], 'Frailty': [128, 164], '(n': [129, 139, 161], '1057;': [131], 'SMD': [132, 142], '1.12,': [134], '0.27–2.13)': [136], 'pre-frailty': [138, 166, 207], '4467;': [141], '0.56,': [144], '0.00–1.11)': [146], 'associated': [148, 170, 200, 209], 'with': [149, 171, 201, 210], 'serum': [151, 184], 'interleukin-6': [154], 'people': [157], 'who': [158], '2392).': [163], 'also': [168], 'elevated': [172], 'white': [173], 'blood': [174], 'cell': [175], 'fibrinogen': [177], 'levels.': [178], 'In': [179, 203], 'three': [180], 'studies,': [182], 'CRP': [185, 217], '(OR': [186, 193], '1.06,': [188], '0.78–1.44,)': [190], 'IL-6': [192], '1.19,': [195], '0.87–1.62)': [197], 'not': [199], 'frailty.': [202], 'conclusion,': [204], 'are': [208, 223], 'parameters': [213], 'particular': [216], 'IL-6.': [219], 'Further': [220], 'needed.': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2518202212', 'counts_by_year': [{'year': 2024, 'cited_by_count': 113}, {'year': 2023, 'cited_by_count': 105}, {'year': 2022, 'cited_by_count': 133}, {'year': 2021, 'cited_by_count': 125}, {'year': 2020, 'cited_by_count': 113}, {'year': 2019, 'cited_by_count': 73}, {'year': 2018, 'cited_by_count': 65}, {'year': 2017, 'cited_by_count': 43}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-12-10T13:30:16.746979', 'created_date': '2016-09-16'}