Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2517769616', 'doi': 'https://doi.org/10.1073/pnas.1521741113', 'title': 'Midgut microbiota and host immunocompetence underlie<i>Bacillus thuringiensis</i>killing mechanism', 'display_name': 'Midgut microbiota and host immunocompetence underlie<i>Bacillus thuringiensis</i>killing mechanism', 'publication_year': 2016, 'publication_date': '2016-08-09', 'ids': {'openalex': 'https://openalex.org/W2517769616', 'doi': 'https://doi.org/10.1073/pnas.1521741113', 'mag': '2517769616', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27506800', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5003288'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1521741113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1073/pnas.1521741113', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008287607', 'display_name': 'Silvia Caccia', 'orcid': 'https://orcid.org/0000-0003-1954-7180'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Caccia', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009725341', 'display_name': 'Ilaria Di Lelio', 'orcid': 'https://orcid.org/0000-0001-8933-0919'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ilaria Di Lelio', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052071877', 'display_name': 'Antonietta La Storia', 'orcid': 'https://orcid.org/0000-0002-8318-9376'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonietta La Storia', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103533086', 'display_name': 'Adriana Marinelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Adriana Marinelli', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014349489', 'display_name': 'Paola Varricchio', 'orcid': 'https://orcid.org/0000-0003-4611-3695'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Varricchio', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017210388', 'display_name': 'Eleonora Franzetti', 'orcid': 'https://orcid.org/0000-0003-2255-7785'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Eleonora Franzetti', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074715165', 'display_name': 'Núria Banyuls', 'orcid': 'https://orcid.org/0000-0002-5941-6786'}, 'institutions': [{'id': 'https://openalex.org/I16097986', 'display_name': 'Universitat de València', 'ror': 'https://ror.org/043nxc105', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I16097986']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Núria Banyuls', 'raw_affiliation_strings': ['Interdisciplinary Research Structure for Biotechnology and Biomedicine, University of Valencia, 46100 Burjassot, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Interdisciplinary Research Structure for Biotechnology and Biomedicine, University of Valencia, 46100 Burjassot, Spain;', 'institution_ids': ['https://openalex.org/I16097986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016723531', 'display_name': 'Gianluca Tettamanti', 'orcid': 'https://orcid.org/0000-0002-0665-828X'}, 'institutions': [{'id': 'https://openalex.org/I115752224', 'display_name': 'University of Insubria', 'ror': 'https://ror.org/00s409261', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I115752224']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianluca Tettamanti', 'raw_affiliation_strings': ['Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy;', 'institution_ids': ['https://openalex.org/I115752224']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030240387', 'display_name': 'Morena Casartelli', 'orcid': 'https://orcid.org/0000-0002-1413-7660'}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Morena Casartelli', 'raw_affiliation_strings': ['Department of Biosciences, University of Milano, 20133 Milan, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences, University of Milano, 20133 Milan, Italy;', 'institution_ids': ['https://openalex.org/I189158943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071840525', 'display_name': 'B. Giordana', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Giordana', 'raw_affiliation_strings': ['Department of Biosciences, University of Milano, 20133 Milan, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences, University of Milano, 20133 Milan, Italy;', 'institution_ids': ['https://openalex.org/I189158943']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011707883', 'display_name': 'Juan Ferré', 'orcid': 'https://orcid.org/0000-0001-5535-0612'}, 'institutions': [{'id': 'https://openalex.org/I16097986', 'display_name': 'Universitat de València', 'ror': 'https://ror.org/043nxc105', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I16097986']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Juan Ferré', 'raw_affiliation_strings': ['Interdisciplinary Research Structure for Biotechnology and Biomedicine, University of Valencia, 46100 Burjassot, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Interdisciplinary Research Structure for Biotechnology and Biomedicine, University of Valencia, 46100 Burjassot, Spain;', 'institution_ids': ['https://openalex.org/I16097986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050568447', 'display_name': 'Silvia Gigliotti', 'orcid': 'https://orcid.org/0000-0002-1772-3825'}, 'institutions': [{'id': 'https://openalex.org/I4210155236', 'display_name': 'National Research Council', 'ror': 'https://ror.org/04zaypm56', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I4210108634', 'display_name': 'Institute of Biosciences and Bioresources', 'ror': 'https://ror.org/01gtsa866', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210108634', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Gigliotti', 'raw_affiliation_strings': ['Institute of Biosciences and Bioresources, National Research Council of Italy, 80131 Naples, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biosciences and Bioresources, National Research Council of Italy, 80131 Naples, Italy', 'institution_ids': ['https://openalex.org/I4210155236', 'https://openalex.org/I4210108634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026270573', 'display_name': 'Danilo Ercolini', 'orcid': 'https://orcid.org/0000-0003-3061-9560'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Danilo Ercolini', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009984296', 'display_name': 'Francesco Pennacchio', 'orcid': 'https://orcid.org/0000-0002-8794-9328'}, 'institutions': [{'id': 'https://openalex.org/I4210117450', 'display_name': 'Federico II University Hospital', 'ror': 'https://ror.org/02jr6tp70', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210117450', 'https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Pennacchio', 'raw_affiliation_strings': ['Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Agricultural Sciences, University of Napoli Federico II, 80055 Portici, Italy;', 'institution_ids': ['https://openalex.org/I4210117450']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.226, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 156, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '113', 'issue': '34', 'first_page': '9486', 'last_page': '9491'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12134', 'display_name': 'Insect symbiosis and bacterial influences', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11436', 'display_name': 'Entomopathogenic Microorganisms in Pest Control', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bacillus-thuringiensis', 'display_name': 'Bacillus thuringiensis', 'score': 0.7262275}, {'id': 'https://openalex.org/keywords/immunocompetence', 'display_name': 'Immunocompetence', 'score': 0.6263284}], 'concepts': [{'id': 'https://openalex.org/C150149183', 'wikidata': 'https://www.wikidata.org/wiki/Q1940081', 'display_name': 'Midgut', 'level': 3, 'score': 0.9250925}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.82786345}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.735724}, {'id': 'https://openalex.org/C2779035793', 'wikidata': 'https://www.wikidata.org/wiki/Q310467', 'display_name': 'Bacillus thuringiensis', 'level': 3, 'score': 0.7262275}, {'id': 'https://openalex.org/C126831891', 'wikidata': 'https://www.wikidata.org/wiki/Q221673', 'display_name': 'Host (biology)', 'level': 2, 'score': 0.6736187}, {'id': 'https://openalex.org/C2777422395', 'wikidata': 'https://www.wikidata.org/wiki/Q3149136', 'display_name': 'Immunocompetence', 'level': 3, 'score': 0.6263284}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.5745337}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.48807275}, {'id': 'https://openalex.org/C104727253', 'wikidata': 'https://www.wikidata.org/wiki/Q116890', 'display_name': 'Biological pest control', 'level': 2, 'score': 0.48638156}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.4819886}, {'id': 'https://openalex.org/C2777612826', 'wikidata': 'https://www.wikidata.org/wiki/Q1390', 'display_name': 'Insect', 'level': 2, 'score': 0.47573757}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.26122326}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.11808705}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.096785545}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.094653755}], 'mesh': [{'descriptor_ui': 'D001413', 'descriptor_name': 'Bacillus thuringiensis', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004731', 'descriptor_name': 'Endotoxins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006460', 'descriptor_name': 'Hemolysin Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D064307', 'descriptor_name': 'Microbiota', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D010572', 'descriptor_name': 'Pest Control, Biological', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001413', 'descriptor_name': 'Bacillus thuringiensis', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D001413', 'descriptor_name': 'Bacillus thuringiensis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000083722', 'descriptor_name': 'Bacillus thuringiensis Toxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003013', 'descriptor_name': 'Clostridium', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': False}, {'descriptor_ui': 'D003013', 'descriptor_name': 'Clostridium', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D003013', 'descriptor_name': 'Clostridium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018556', 'descriptor_name': 'Crops, Agricultural', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': False}, {'descriptor_ui': 'D018556', 'descriptor_name': 'Crops, Agricultural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004731', 'descriptor_name': 'Endotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006434', 'descriptor_name': 'Hemocytes', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D006434', 'descriptor_name': 'Hemocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006434', 'descriptor_name': 'Hemocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006460', 'descriptor_name': 'Hemolysin Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007165', 'descriptor_name': 'Immunosuppression Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007422', 'descriptor_name': 'Intestines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064307', 'descriptor_name': 'Microbiota', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010572', 'descriptor_name': 'Pest Control, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012705', 'descriptor_name': 'Serratia', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': False}, {'descriptor_ui': 'D012705', 'descriptor_name': 'Serratia', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D012705', 'descriptor_name': 'Serratia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1521741113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5003288', 'pdf_url': 'https://europepmc.org/articles/pmc5003288?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003288', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27506800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1521741113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321873', 'funder_display_name': 'Ministero dell’Istruzione, dell’Università e della Ricerca', 'award_id': 'CTN01_00230_248064'}], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W167200717', 'https://openalex.org/W177969938', 'https://openalex.org/W1955615093', 'https://openalex.org/W1964504260', 'https://openalex.org/W1971157069', 'https://openalex.org/W1973120292', 'https://openalex.org/W1978549125', 'https://openalex.org/W1981107494', 'https://openalex.org/W1982048816', 'https://openalex.org/W1989772592', 'https://openalex.org/W1992280767', 'https://openalex.org/W1994009849', 'https://openalex.org/W1996718064', 'https://openalex.org/W1997579211', 'https://openalex.org/W2000858689', 'https://openalex.org/W2003587139', 'https://openalex.org/W2003734402', 'https://openalex.org/W2023542511', 'https://openalex.org/W2025514046', 'https://openalex.org/W2028370541', 'https://openalex.org/W2029051866', 'https://openalex.org/W2030388248', 'https://openalex.org/W2031306566', 'https://openalex.org/W2036293996', 'https://openalex.org/W2038366236', 'https://openalex.org/W2038960430', 'https://openalex.org/W2040497281', 'https://openalex.org/W2061476970', 'https://openalex.org/W2063227014', 'https://openalex.org/W2069894146', 'https://openalex.org/W2074942268', 'https://openalex.org/W2082270598', 'https://openalex.org/W2085841524', 'https://openalex.org/W2088638245', 'https://openalex.org/W2096424344', 'https://openalex.org/W2096847727', 'https://openalex.org/W2098634155', 'https://openalex.org/W2099172121', 'https://openalex.org/W2102549002', 'https://openalex.org/W2103683312', 'https://openalex.org/W2104032830', 'https://openalex.org/W2115629461', 'https://openalex.org/W2122707110', 'https://openalex.org/W2123149873', 'https://openalex.org/W2123273830', 'https://openalex.org/W2124668729', 'https://openalex.org/W2141699327', 'https://openalex.org/W2153718995', 'https://openalex.org/W2164955809', 'https://openalex.org/W2166505257', 'https://openalex.org/W2201909989', 'https://openalex.org/W2267285071', 'https://openalex.org/W2463253142', 'https://openalex.org/W342335416'], 'related_works': ['https://openalex.org/W3205982544', 'https://openalex.org/W3046600945', 'https://openalex.org/W2963816263', 'https://openalex.org/W2943027999', 'https://openalex.org/W2339728795', 'https://openalex.org/W2084462471', 'https://openalex.org/W2062087578', 'https://openalex.org/W1998396422', 'https://openalex.org/W1988870418', 'https://openalex.org/W1582369042'], 'abstract_inverted_index': {'Significance': [0], 'Bacillus': [1], 'thuringiensis': [2], 'and': [3, 55, 92], 'its': [4, 20, 56], 'toxins': [5], 'are': [6], 'widely': [7], 'used': [8], 'for': [9, 96], 'insect': [10, 18, 99], 'control.': [11], 'Notwithstanding': [12], 'the': [13, 33, 37, 51, 64, 76, 83, 94, 111], 'remarkable': [14], 'importance': [15], 'of': [16, 60, 82, 113], 'this': [17], 'pathogen,': [19], 'killing': [21], 'mechanism': [22], 'has': [23], 'yet': [24], 'to': [25, 90, 109], 'be': [26], 'fully': [27], 'elucidated.': [28], 'Here': [29], 'we': [30], 'show': [31], 'that': [32], 'microbiota': [34, 78], 'resident': [35, 88], 'in': [36], 'host': [38, 52, 104], 'midgut': [39, 61, 77], 'triggers': [40], 'a': [41, 107], 'lethal': [42], 'septicemia.': [43], 'The': [44, 71], 'infection': [45], 'process': [46], 'is': [47], 'enhanced': [48], 'by': [49], 'reducing': [50], 'immune': [53], 'response': [54], 'control': [57], 'on': [58, 103], 'replication': [59], 'bacteria': [62], 'invading': [63], 'body': [65], 'cavity': [66], 'through': [67], 'toxin-induced': [68], 'epithelial': [69], 'lesions.': [70], 'experimental': [72], 'approach': [73], 'used,': [74], 'leaving': [75], 'unaltered,': [79], 'allows': [80], 'identification': [81], 'bacterial': [84], 'species': [85], 'switching': [86], 'from': [87], 'symbionts': [89], 'pathogens': [91], 'sets': [93], 'stage': [95], 'developing': [97], 'new': [98], 'biocontrol': [100], 'technologies': [101], 'based': [102], 'immunosuppression': [105], 'as': [106], 'strategy': [108], 'enhance': [110], 'impact': [112], 'natural': [114], 'antagonists.': [115]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2517769616', 'counts_by_year': [{'year': 2024, 'cited_by_count': 21}, {'year': 2023, 'cited_by_count': 29}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2025-01-09T16:10:55.606353', 'created_date': '2016-09-16'}