Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2515965377', 'doi': 'https://doi.org/10.1038/srep32518', 'title': 'Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity', 'display_name': 'Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity', 'publication_year': 2016, 'publication_date': '2016-09-02', 'ids': {'openalex': 'https://openalex.org/W2515965377', 'doi': 'https://doi.org/10.1038/srep32518', 'mag': '2515965377', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27585557', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5009432'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep32518', 'pdf_url': 'https://www.nature.com/articles/srep32518.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/srep32518.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068452513', 'display_name': 'Qingyu Huang', 'orcid': 'https://orcid.org/0000-0002-5076-2084'}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qingyu Huang', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101027960', 'display_name': 'Lianzhong Luo', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lianzhong Luo', 'raw_affiliation_strings': ['Department of Pharmacy, Xiamen Medical College, Xiamen, 361008, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacy, Xiamen Medical College, Xiamen, 361008, PR China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029852165', 'display_name': 'Ambreen Alamdar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ambreen Alamdar', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100436769', 'display_name': 'Jie Zhang', 'orcid': 'https://orcid.org/0000-0002-5902-3317'}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jie Zhang', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051587426', 'display_name': 'Liangpo Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liangpo Liu', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091852209', 'display_name': 'Meiping Tian', 'orcid': 'https://orcid.org/0000-0001-9354-803X'}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meiping Tian', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004209116', 'display_name': 'Syed Ali Musstjab Akber Shah Eqani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Syed Ali Musstjab Akber Shah Eqani', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085323287', 'display_name': 'Heqing Shen', 'orcid': 'https://orcid.org/0000-0002-6544-4919'}, 'institutions': [{'id': 'https://openalex.org/I4210119653', 'display_name': 'Institute of Urban Environment', 'ror': 'https://ror.org/025gq5q04', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210119653']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Heqing Shen', 'raw_affiliation_strings': ['Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, PR China', 'institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5068452513'], 'corresponding_institution_ids': ['https://openalex.org/I4210119653', 'https://openalex.org/I19820366'], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 2.579, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.843517, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10790', 'display_name': 'Metal-Induced Oxidative Stress and Health Effects', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10790', 'display_name': 'Metal-Induced Oxidative Stress and Health Effects', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10710', 'display_name': 'Arsenic Contamination in Natural Waters', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11107', 'display_name': 'Role of Selenium in Human Health and Disease', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/reproductive-toxicity', 'display_name': 'Reproductive toxicity', 'score': 0.6964394}, {'id': 'https://openalex.org/keywords/arsenic-toxicity', 'display_name': 'Arsenic toxicity', 'score': 0.5864458}, {'id': 'https://openalex.org/keywords/metal-toxicity', 'display_name': 'Metal Toxicity', 'score': 0.537784}, {'id': 'https://openalex.org/keywords/arsenic', 'display_name': 'Arsenic', 'score': 0.503688}], 'concepts': [{'id': 'https://openalex.org/C21565614', 'wikidata': 'https://www.wikidata.org/wiki/Q12149006', 'display_name': 'Metabolomics', 'level': 2, 'score': 0.7934468}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.70665425}, {'id': 'https://openalex.org/C99432707', 'wikidata': 'https://www.wikidata.org/wiki/Q3427345', 'display_name': 'Reproductive toxicity', 'level': 3, 'score': 0.6964394}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.65344226}, {'id': 'https://openalex.org/C172507514', 'wikidata': 'https://www.wikidata.org/wiki/Q730249', 'display_name': 'Arsenic toxicity', 'level': 3, 'score': 0.5864458}, {'id': 'https://openalex.org/C502230775', 'wikidata': 'https://www.wikidata.org/wiki/Q871', 'display_name': 'Arsenic', 'level': 2, 'score': 0.5656256}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.55046886}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4114307}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40918553}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3982965}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37938827}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3466143}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.254206}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2293649}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1711522}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08082107}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001151', 'descriptor_name': 'Arsenic', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D055432', 'descriptor_name': 'Metabolomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012098', 'descriptor_name': 'Reproduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001151', 'descriptor_name': 'Arsenic', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001151', 'descriptor_name': 'Arsenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016002', 'descriptor_name': 'Discriminant Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053263', 'descriptor_name': 'Gene Regulatory Networks', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053263', 'descriptor_name': 'Gene Regulatory Networks', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006728', 'descriptor_name': 'Hormones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006728', 'descriptor_name': 'Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016018', 'descriptor_name': 'Least-Squares Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008403', 'descriptor_name': 'Mass Screening', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055442', 'descriptor_name': 'Metabolome', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055442', 'descriptor_name': 'Metabolome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012098', 'descriptor_name': 'Reproduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012984', 'descriptor_name': 'Software', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013081', 'descriptor_name': 'Sperm Motility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013081', 'descriptor_name': 'Sperm Motility', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep32518', 'pdf_url': 'https://www.nature.com/articles/srep32518.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5009432', 'pdf_url': 'https://europepmc.org/articles/pmc5009432?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009432', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27585557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep32518', 'pdf_url': 'https://www.nature.com/articles/srep32518.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1815255263', 'https://openalex.org/W1817538280', 'https://openalex.org/W1829387340', 'https://openalex.org/W1842187318', 'https://openalex.org/W1900670142', 'https://openalex.org/W1917786288', 'https://openalex.org/W1923366896', 'https://openalex.org/W1970827077', 'https://openalex.org/W1979014983', 'https://openalex.org/W1984580491', 'https://openalex.org/W2003371280', 'https://openalex.org/W2003388209', 'https://openalex.org/W2004167073', 'https://openalex.org/W2007571492', 'https://openalex.org/W2009764108', 'https://openalex.org/W2010615531', 'https://openalex.org/W2011473978', 'https://openalex.org/W2014326045', 'https://openalex.org/W2015997966', 'https://openalex.org/W2018374650', 'https://openalex.org/W2030268850', 'https://openalex.org/W2030806474', 'https://openalex.org/W2032984035', 'https://openalex.org/W2047921800', 'https://openalex.org/W2048525855', 'https://openalex.org/W2052563395', 'https://openalex.org/W2057607323', 'https://openalex.org/W2058071169', 'https://openalex.org/W2059898775', 'https://openalex.org/W2068052728', 'https://openalex.org/W2069644908', 'https://openalex.org/W2070164699', 'https://openalex.org/W2073677169', 'https://openalex.org/W2081087203', 'https://openalex.org/W2081796845', 'https://openalex.org/W2086827567', 'https://openalex.org/W2088327571', 'https://openalex.org/W2090547086', 'https://openalex.org/W2095156079', 'https://openalex.org/W2096730361', 'https://openalex.org/W2097100969', 'https://openalex.org/W2101516681', 'https://openalex.org/W2103243951', 'https://openalex.org/W2105171996', 'https://openalex.org/W2107340600', 'https://openalex.org/W2108106126', 'https://openalex.org/W2113507546', 'https://openalex.org/W2114649240', 'https://openalex.org/W2115040692', 'https://openalex.org/W2118306896', 'https://openalex.org/W2121836743', 'https://openalex.org/W2123132519', 'https://openalex.org/W2141587967', 'https://openalex.org/W2144292929', 'https://openalex.org/W2149498732', 'https://openalex.org/W2150492618', 'https://openalex.org/W2163028973', 'https://openalex.org/W2165365177', 'https://openalex.org/W2167089701', 'https://openalex.org/W2170776626', 'https://openalex.org/W2211564907', 'https://openalex.org/W2267755288', 'https://openalex.org/W2293134363', 'https://openalex.org/W2315335639', 'https://openalex.org/W2324601245', 'https://openalex.org/W2335077276', 'https://openalex.org/W2409271770', 'https://openalex.org/W4285719527', 'https://openalex.org/W813084057', 'https://openalex.org/W904747487'], 'related_works': ['https://openalex.org/W4300195897', 'https://openalex.org/W3165419425', 'https://openalex.org/W2988004870', 'https://openalex.org/W2296797808', 'https://openalex.org/W2246275983', 'https://openalex.org/W2182330899', 'https://openalex.org/W2161386800', 'https://openalex.org/W2127967852', 'https://openalex.org/W1985684970', 'https://openalex.org/W1978112282'], 'abstract_inverted_index': {'Abstract': [0], 'Arsenic': [1], 'is': [2, 29, 140], 'a': [3, 14, 21], 'widespread': [4], 'metalloid': [5], 'in': [6, 52, 79], 'environment,': [7], 'whose': [8], 'exposure': [9, 44, 73, 194], 'has': [10], 'been': [11], 'associated': [12], 'with': [13], 'broad': [15], 'spectrum': [16], 'of': [17, 24, 71, 84, 153, 176, 192], 'toxic': [18], 'effects.': [19], 'However,': [20], 'global': [22, 69], 'view': [23], 'arsenic-induced': [25, 181], 'male': [26, 120, 155, 182], 'reproductive': [27, 121, 183], 'toxicity': [28], 'still': [30], 'lack,': [31], 'and': [32, 48, 59, 77, 89, 92, 97, 113, 124, 130, 136, 148, 158, 185], 'the': [33, 62, 68, 75, 165, 177], 'underlying': [34], 'mechanisms': [35, 178], 'remain': [36], 'largely': [37], 'unclear.': [38], 'Our': [39], 'results': [40], 'revealed': [41], 'that': [42, 143], 'arsenic': [43, 72, 107, 144, 193], 'decreased': [45], 'testosterone': [46], 'level': [47], 'reduced': [49], 'sperm': [50, 128], 'quality': [51], 'rats.': [53], 'By': [54], 'conducting': [55], 'an': [56], 'integrated': [57], 'proteomics': [58], 'metabolomics': [60], 'analysis,': [61], 'present': [63], 'study': [64], 'aims': [65], 'to': [66, 102, 119], 'investigate': [67], 'influence': [70], 'on': [74], 'proteome': [76], 'metabolome': [78], 'rat': [80], 'testis.': [81], 'The': [82], 'abundance': [83], '70': [85], 'proteins': [86, 112, 157], '(36': [87], 'up-regulated': [88], '34': [90], 'down-regulated)': [91], '13': [93], 'metabolites': [94, 115], '(8': [95], 'increased': [96], '5': [98], 'decreased)': [99], 'were': [100, 116], 'found': [101], 'be': [103, 162, 196], 'significantly': [104], 'altered': [105], 'by': [106, 164], 'treatment.': [108], 'Among': [109], 'these,': [110], '19': [111], '2': [114], 'specifically': [117], 'related': [118], 'system': [122], 'development': [123], 'function,': [125], 'including': [126], 'spermatogenesis,': [127], 'function': [129], 'fertilization,': [131], 'fertility,': [132], 'internal': [133], 'genitalia': [134], 'development,': [135], 'mating': [137], 'behavior.': [138], 'It': [139], 'further': [141], 'proposed': [142], 'mainly': [145], 'impaired': [146], 'spermatogenesis': [147], 'fertilization': [149], 'via': [150], 'aberrant': [151], 'modulation': [152], 'these': [154, 170], 'reproduction-related': [156], 'metabolites,': [159], 'which': [160], 'may': [161], 'mediated': [163], 'ERK/AKT/NF-κB-dependent': [166], 'signaling': [167], 'pathway.': [168], 'Overall,': [169], 'findings': [171], 'will': [172], 'aid': [173], 'our': [174], 'understanding': [175], 'responsible': [179], 'for': [180], 'toxicity,': [184], 'from': [186], 'such': [187], 'studies': [188], 'useful': [189], 'biomarkers': [190], 'indicative': [191], 'could': [195], 'discovered.': [197]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2515965377', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-09-13T12:49:49.395714', 'created_date': '2016-09-16'}