Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation

Name: Work Video:
Duration: 3 min 30 s
Aoli Wang; Xiao-E Yan; Hong Wu; Wenchao Wang; Hu Chen; Chen Cheng; Zheng Zhao; Peng Zhao; Xixiang Li; Li Wang; Beilei Wang; Zi Ye; Jinhua Wang; Chu Wang; Wei Zhang; Nathanael S. Gray; Ellen Weisberg; Liang Chen; Jing Liu; Cai‐Hong Yun; Qingsong Liu
{'id': 'https://openalex.org/W2514059094', 'doi': 'https://doi.org/10.18632/oncotarget.11951', 'title': 'Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation', 'display_name': 'Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation', 'publication_year': 2016, 'publication_date': '2016-09-10', 'ids': {'openalex': 'https://openalex.org/W2514059094', 'doi': 'https://doi.org/10.18632/oncotarget.11951', 'mag': '2514059094', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27626175', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5342513'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11951', 'pdf_url': 'https://www.oncotarget.com/article/11951/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/11951/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029503387', 'display_name': 'Aoli Wang', 'orcid': 'https://orcid.org/0000-0002-2329-2865'}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Aoli Wang', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020872603', 'display_name': 'Xiao-E Yan', 'orcid': 'https://orcid.org/0000-0003-2701-6769'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-E Yan', 'raw_affiliation_strings': ['Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002206693', 'display_name': 'Hong Wu', 'orcid': 'https://orcid.org/0000-0002-9424-6022'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Wu', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I4210102600']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115594424', 'display_name': 'Wenchao Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I2802624667', 'display_name': 'Hefei Institutes of Physical Science', 'ror': 'https://ror.org/046n57345', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenchao Wang', 'raw_affiliation_strings': ['Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057426807', 'display_name': 'Hu Chen', 'orcid': 'https://orcid.org/0000-0001-8136-7442'}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chen Hu', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100637279', 'display_name': 'Chen Cheng', 'orcid': 'https://orcid.org/0000-0003-0423-4659'}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cheng Chen', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000273221', 'display_name': 'Zheng Zhao', 'orcid': 'https://orcid.org/0000-0003-1453-3230'}, 'institutions': [{'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I2802624667', 'display_name': 'Hefei Institutes of Physical Science', 'ror': 'https://ror.org/046n57345', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Zhao', 'raw_affiliation_strings': ['Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I2802624667', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057131883', 'display_name': 'Peng Zhao', 'orcid': 'https://orcid.org/0000-0002-9296-5293'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Zhao', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China', 'institution_ids': ['https://openalex.org/I20231570']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104316958', 'display_name': 'Xixiang Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xixiang Li', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100336119', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0002-8686-6627'}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Wang', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000728648', 'display_name': 'Beilei Wang', 'orcid': 'https://orcid.org/0000-0001-5404-260X'}, 'institutions': [{'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Beilei Wang', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341724', 'display_name': 'Zi Ye', 'orcid': 'https://orcid.org/0000-0003-1846-2572'}, 'institutions': [{'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}, {'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210160507', 'display_name': 'Center for Life Sciences', 'ror': 'https://ror.org/05kje8j93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4210160507', 'https://openalex.org/I99065089']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zi Ye', 'raw_affiliation_strings': ['High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'institution_ids': ['https://openalex.org/I4210116048', 'https://openalex.org/I20231570', 'https://openalex.org/I4210160507']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I4210102600']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}, {'raw_affiliation_string': 'Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'institution_ids': ['https://openalex.org/I4210160507', 'https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100339649', 'display_name': 'Jinhua Wang', 'orcid': 'https://orcid.org/0000-0002-1214-4103'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jinhua Wang', 'raw_affiliation_strings': ['Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA', 'Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100694433', 'display_name': 'Chu Wang', 'orcid': 'https://orcid.org/0000-0002-6925-1268'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210160507', 'display_name': 'Center for Life Sciences', 'ror': 'https://ror.org/05kje8j93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570', 'https://openalex.org/I4210160507', 'https://openalex.org/I99065089']}, {'id': 'https://openalex.org/I4210116048', 'display_name': 'Beijing National Laboratory for Molecular Sciences', 'ror': 'https://ror.org/02601yx74', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210116048']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chu Wang', 'raw_affiliation_strings': ['Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210160507']}, {'raw_affiliation_string': 'Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, P. R. China', 'institution_ids': ['https://openalex.org/I4210116048', 'https://openalex.org/I20231570', 'https://openalex.org/I4210160507']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115592026', 'display_name': 'Wei Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210086405', 'display_name': 'National Institute of Biological Sciences, Beijing', 'ror': 'https://ror.org/00wksha49', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Zhang', 'raw_affiliation_strings': ['Collaborative Innovation Center of Cancer Medicine, National Institute of Biological Sciences, Beijing 102206, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Collaborative Innovation Center of Cancer Medicine, National Institute of Biological Sciences, Beijing 102206, P. R. China', 'institution_ids': ['https://openalex.org/I4210086405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022352605', 'display_name': 'Nathanael S. Gray', 'orcid': 'https://orcid.org/0000-0001-5354-7403'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nathanael S. Gray', 'raw_affiliation_strings': ['Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA', 'Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055853326', 'display_name': 'Ellen Weisberg', 'orcid': 'https://orcid.org/0000-0002-5679-9531'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ellen L. Weisberg', 'raw_affiliation_strings': ['Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100334557', 'display_name': 'Liang Chen', 'orcid': 'https://orcid.org/0000-0001-7300-6604'}, 'institutions': [{'id': 'https://openalex.org/I4210086405', 'display_name': 'National Institute of Biological Sciences, Beijing', 'ror': 'https://ror.org/00wksha49', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210086405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liang Chen', 'raw_affiliation_strings': ['Collaborative Innovation Center of Cancer Medicine, National Institute of Biological Sciences, Beijing 102206, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Collaborative Innovation Center of Cancer Medicine, National Institute of Biological Sciences, Beijing 102206, P. R. China', 'institution_ids': ['https://openalex.org/I4210086405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112723885', 'display_name': 'Jing Liu', 'orcid': 'https://orcid.org/0000-0001-9513-3591'}, 'institutions': [{'id': 'https://openalex.org/I2802624667', 'display_name': 'Hefei Institutes of Physical Science', 'ror': 'https://ror.org/046n57345', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Jing Liu', 'raw_affiliation_strings': ['Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I2802624667', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006840181', 'display_name': 'Cai‐Hong Yun', 'orcid': 'https://orcid.org/0000-0002-5880-8307'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cai-Hong Yun', 'raw_affiliation_strings': ['Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112066295', 'display_name': 'Qingsong Liu', 'orcid': 'https://orcid.org/0000-0002-7829-2547'}, 'institutions': [{'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I4210102600', 'display_name': 'High Magnetic Field Laboratory', 'ror': 'https://ror.org/01gh88804', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667', 'https://openalex.org/I4210102600']}, {'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I2802624667', 'display_name': 'Hefei Institutes of Physical Science', 'ror': 'https://ror.org/046n57345', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingsong Liu', 'raw_affiliation_strings': ['Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Hefei Science Center, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I19820366', 'https://openalex.org/I2802624667']}, {'raw_affiliation_string': 'High Magnetic Field Laboratory, Chinese Academy of Sciences, Anhui, Hefei 230031, P. R. China', 'institution_ids': ['https://openalex.org/I4210102600', 'https://openalex.org/I19820366']}, {'raw_affiliation_string': 'University of Science and Technology of China, Anhui, Hefei 230036, P. R. China', 'institution_ids': ['https://openalex.org/I126520041']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 10, 'corresponding_author_ids': ['https://openalex.org/A5112723885'], 'corresponding_institution_ids': ['https://openalex.org/I2802624667', 'https://openalex.org/I19820366', 'https://openalex.org/I4210102600'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.264, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.89845, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '7', 'issue': '43', 'first_page': '69760', 'last_page': '69769'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/christian-ministry', 'display_name': 'Christian ministry', 'score': 0.46548122}], 'concepts': [{'id': 'https://openalex.org/C2778304055', 'wikidata': 'https://www.wikidata.org/wiki/Q657474', 'display_name': 'Beijing', 'level': 3, 'score': 0.7791228}, {'id': 'https://openalex.org/C191935318', 'wikidata': 'https://www.wikidata.org/wiki/Q148', 'display_name': 'China', 'level': 2, 'score': 0.68401426}, {'id': 'https://openalex.org/C2984488660', 'wikidata': 'https://www.wikidata.org/wiki/Q530471', 'display_name': 'Chinese academy of sciences', 'level': 3, 'score': 0.5678491}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.5344827}, {'id': 'https://openalex.org/C521751864', 'wikidata': 'https://www.wikidata.org/wiki/Q1729207', 'display_name': 'Christian ministry', 'level': 2, 'score': 0.46548122}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3779399}, {'id': 'https://openalex.org/C17744445', 'wikidata': 'https://www.wikidata.org/wiki/Q36442', 'display_name': 'Political science', 'level': 0, 'score': 0.27599767}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.20536548}, {'id': 'https://openalex.org/C27206212', 'wikidata': 'https://www.wikidata.org/wiki/Q34178', 'display_name': 'Theology', 'level': 1, 'score': 0.15116587}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.102122575}, {'id': 'https://openalex.org/C199539241', 'wikidata': 'https://www.wikidata.org/wiki/Q7748', 'display_name': 'Law', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11951', 'pdf_url': 'https://www.oncotarget.com/article/11951/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5342513', 'pdf_url': 'https://europepmc.org/articles/pmc5342513?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342513', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072107', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/32072107/1/5342513.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.11951', 'pdf_url': 'https://www.oncotarget.com/article/11951/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.71, 'display_name': 'Industry, innovation and infrastructure', 'id': 'https://metadata.un.org/sdg/9'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1988750150', 'https://openalex.org/W1993345471', 'https://openalex.org/W1995017064', 'https://openalex.org/W2018466312', 'https://openalex.org/W2019216438', 'https://openalex.org/W2030263904', 'https://openalex.org/W2039432759', 'https://openalex.org/W2055068449', 'https://openalex.org/W2071189101', 'https://openalex.org/W2071549499', 'https://openalex.org/W2088540000', 'https://openalex.org/W2093859044', 'https://openalex.org/W2100794900', 'https://openalex.org/W2103503400', 'https://openalex.org/W2110474703', 'https://openalex.org/W2114367386', 'https://openalex.org/W2114622716', 'https://openalex.org/W2114869204', 'https://openalex.org/W2124026197', 'https://openalex.org/W2128307445', 'https://openalex.org/W2133963438', 'https://openalex.org/W2146418087', 'https://openalex.org/W2149270596', 'https://openalex.org/W2154066874', 'https://openalex.org/W2159013299', 'https://openalex.org/W2163341755', 'https://openalex.org/W2163690533', 'https://openalex.org/W2180229411'], 'related_works': ['https://openalex.org/W4285546032', 'https://openalex.org/W3208995543', 'https://openalex.org/W3197037034', 'https://openalex.org/W2946847040', 'https://openalex.org/W2382418233', 'https://openalex.org/W2362050182', 'https://openalex.org/W2278001431', 'https://openalex.org/W2121575220', 'https://openalex.org/W2071070538', 'https://openalex.org/W2015747722'], 'abstract_inverted_index': {'//': [0], 'Aoli': [1], 'Wang': [2, 19, 48, 53, 62, 67], '1,': [3, 14, 20, 26, 31, 36, 49, 54, 91, 100], '2,': [4, 15, 101], '*': [5, 10, 16, 22, 288], ',': [6, 11, 17, 23, 28, 33, 38, 42, 46, 51, 56, 60, 65, 69, 73, 79, 84, 88, 93, 97], 'Xiao-E': [7], 'Yan': [8], '3,': [9], 'Hong': [12], 'Wu': [13], 'Wenchao': [18], '4,': [21], 'Chen': [24, 30, 86], 'Hu': [25], '2': [27, 32, 50, 55, 118], 'Cheng': [29], 'Zheng': [34], 'Zhao': [35, 40], '4': [37, 92, 102, 169], 'Peng': [39], '3': [41, 96, 132], 'Xixiang': [43], 'Li': [44, 47], '1': [45, 103], 'Beilei': [52], 'Zi': [57], 'Ye': [58], '5': [59, 68, 183], 'Jinhua': [61], '6,': [63, 77], '9': [64, 78, 273], 'Chu': [66], 'Wei': [70], 'Zhang': [71], '7': [72, 87, 240], 'Nathanael': [74], 'S.': [75], 'Gray': [76], 'Ellen': [80], 'L.': [81], 'Weisberg': [82], '8': [83, 257], 'Liang': [85], 'Jing': [89, 298], 'Liu': [90, 99], 'Cai-Hong': [94, 302], 'Yun': [95], 'Qingsong': [98, 306], 'High': [104], 'Magnetic': [105], 'Field': [106], 'Laboratory,': [107], 'Chinese': [108, 173], 'Academy': [109, 174], 'of': [110, 120, 124, 134, 138, 143, 155, 175, 197, 203, 205, 208, 227, 244, 249, 259, 275, 387, 451, 471, 480], 'Sciences,': [111, 158, 176, 194, 217, 251], 'Anhui,': [112, 126, 177], 'Hefei': [113, 127, 170, 178], '230031,': [114, 179], 'P.': [115, 129, 166, 180, 222, 254], 'R.': [116, 130, 167, 181, 223, 255], 'China': [117, 131, 168, 182, 224, 256], 'University': [119, 160], 'Science': [121, 162, 171], 'and': [122, 147, 151, 185, 200, 210, 278, 344, 360, 474], 'Technology': [123], 'China,': [125], '230036,': [128], 'Institute': [133, 248], 'Systems': [135, 145], 'Biomedicine,': [136], 'Department': [137, 226, 258, 274], 'Biophysics,': [139], 'Beijing': [140, 164, 189, 220, 252], 'Key': [141, 195], 'Laboratory': [142, 191, 196], 'Tumor': [144], 'Biology': [146], 'Center': [148, 214, 243], 'for': [149, 192, 215, 339, 366, 415, 477, 486, 507], 'Molecular': [150, 193, 201, 211, 279], 'Translational': [152], 'Medicine,': [153, 246], 'School': [154], 'Basic': [156], 'Medical': [157, 234, 260, 267, 282], 'Peking': [159, 218], 'Health': [161], 'Center,': [163, 172, 188], '100191,': [165], 'Synthetic': [184], 'Functional': [186], 'Biomolecules': [187], 'National': [190, 247], 'Bioorganic': [198], 'Chemistry': [199, 209, 277], 'Engineering': [202], 'Ministry': [204], 'Education,': [206], 'College': [207], 'Engineering,': [212], 'Peking-Tsinghua': [213], 'Life': [216], 'University,': [219], '100871,': [221], '6': [225], 'Cancer': [228, 231, 245, 264, 371], 'Biology,': [229], 'Dana-Farber': [230], 'Institute,': [232, 265], 'Harvard': [233, 266, 281], 'School,': [235, 268, 283], 'Boston,': [236, 269, 284], 'MA': [237, 270, 285], '02115,': [238, 271, 286], 'USA': [239, 272, 287], 'Collaborative': [241], 'Innovation': [242], 'Biological': [250, 276], '102206,': [253], 'Oncology,': [261], 'Dana': [262], 'Farber': [263], 'Pharmacology,': [280], 'These': [289, 491], 'authors': [290], 'contributed': [291], 'equally': [292], 'to': [293, 353, 397, 430, 511], 'this': [294], 'work': [295], 'Correspondence': [296], 'to:': [297], 'Liu,': [299, 307], 'email:': [300, 304, 308], '[email protected]': [301], 'Yun,': [303], '[email protected]': [305], '[email protected]': [309], 'Keywords:': [310], 'Ibrutinib,': [311, 331], 'EGFR': [312, 357, 374, 390, 400, 424, 452, 488, 521], 'kinase,': [313], 'DFG-in/c-Helix-out,': [314], 'inactive': [315, 462], 'conformation,': [316, 464], 'NSCLC': [317], 'Received:': [318], 'June': [319], '08,': [320], '2016': [321, 325, 329], 'Accepted:': [322], 'September': [323, 327], '05,': [324], 'Published:': [326], '10,': [328], 'ABSTRACT': [330], 'a': [332, 409, 459], 'clinically': [333], 'approved': [334], 'irreversible': [335, 384, 399, 433, 483, 499], 'BTK': [336], 'kinase': [337, 359, 392, 426], 'inhibitor': [338, 434, 485], 'Mantle': [340], 'Cell': [341, 369], 'Lymphoma': [342], '(MCL)': [343], 'Chronic': [345], 'Lymphocytic': [346], 'Leukemia': [347], '(CLL)': [348], 'etc,': [349], 'has': [350], 'been': [351], 'reported': [352], 'be': [354, 505], 'potent': [355], 'against': [356, 520], 'mutant': [358, 489], 'currently': [361], 'being': [362], 'evaluated': [363], 'in': [364, 422, 454, 509, 516], 'clinic': [365, 518], 'Non': [367], 'Small': [368], 'Lung': [370], '(NSCLC).': [372], 'Through': [373], 'wt/mutant': [375, 391], 'engineered': [376], 'isogenic': [377], 'BaF3': [378], 'cell': [379], 'lines': [380], 'we': [381], 'confirmed': [382], 'the': [383, 405, 423, 468, 487, 497, 513, 517], 'binding': [385, 414, 419, 443, 463, 473, 484], 'mode': [386], 'Ibrutinib': [388, 439, 457, 508], 'with': [389, 456], 'via': [393], 'Cys797.': [394], 'However,': [395], 'comparing': [396, 429], 'typical': [398], 'inhibitor,': [401, 500], 'such': [402], 'as': [403], 'WZ4002,': [404], 'washing-out': [406], 'experiments': [407], 'revealed': [408, 427], 'much': [410], 'less': [411, 441, 469], 'efficient': [412, 432, 442, 482], 'covalent': [413, 472], 'Ibrutinib.': [416], 'The': [417], 'biochemical': [418], 'affinity': [420], 'examination': [421], 'L858R/T790M': [425], 'that,': [428, 495], 'more': [431], 'WZ4002': [435], '(Kd:': [436, 444], '0.074': [437], 'μM),': [438], 'exhibited': [440, 458], '0.18': [445], 'μM).': [446], 'An': [447], 'X-ray': [448], 'crystal': [449], 'structure': [450], '(T790M)': [453], 'complex': [455], 'unique': [460], 'DFG-in/c-Helix-out': [461], 'which': [465], 'partially': [466], 'explained': [467], 'efficiency': [470], 'provided': [475], 'insight': [476], 'further': [478], 'development': [479], 'highly': [481], 'kinase.': [490], 'results': [492], 'also': [493], 'imply': [494], 'unlike': [496], 'canonical': [498], 'sustained': [501], 'effective': [502], 'concentration': [503], 'might': [504], 'required': [506], 'order': [510], 'achieve': [512], 'maximal': [514], 'efficacy': [515], 'application': [519], 'driven': [522], 'NSCLC.': [523]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2514059094', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}], 'updated_date': '2024-12-24T12:04:06.328862', 'created_date': '2016-09-16'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
