Publication Information

{'id': 'https://openalex.org/W2512063176', 'doi': 'https://doi.org/10.1158/1538-8514.pi3k14-b24', 'title': 'Abstract B24: Natural withanolides: A new group of anticancer drugs that selectively target the PI3K-mTOR pathway as novel potent therapeutics against colon cancers in vitro and in vivo', 'display_name': 'Abstract B24: Natural withanolides: A new group of anticancer drugs that selectively target the PI3K-mTOR pathway as novel potent therapeutics against colon cancers in vitro and in vivo', 'publication_year': 2015, 'publication_date': '2015-07-01', 'ids': {'openalex': 'https://openalex.org/W2512063176', 'doi': 'https://doi.org/10.1158/1538-8514.pi3k14-b24', 'mag': '2512063176'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-8514.pi3k14-b24', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075065118', 'display_name': 'Chitra Subramanian', 'orcid': 'https://orcid.org/0000-0003-1871-2834'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chitra Subramanian', 'raw_affiliation_strings': ['1University of Michigan, Ann Arbor, MI,'], 'affiliations': [{'raw_affiliation_string': '1University of Michigan, Ann Arbor, MI,', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060274085', 'display_name': 'Peter White', 'orcid': 'https://orcid.org/0000-0003-2933-8323'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter White', 'raw_affiliation_strings': ['1University of Michigan, Ann Arbor, MI,'], 'affiliations': [{'raw_affiliation_string': '1University of Michigan, Ann Arbor, MI,', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075999686', 'display_name': 'Alicia A. Gingrich', 'orcid': 'https://orcid.org/0000-0002-7239-0154'}, 'institutions': [{'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alicia Gingrich', 'raw_affiliation_strings': ['2University of Kansas Medical Center, Kansas City, KS,'], 'affiliations': [{'raw_affiliation_string': '2University of Kansas Medical Center, Kansas City, KS,', 'institution_ids': ['https://openalex.org/I4210128618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111986568', 'display_name': 'Barbara N. Timmermann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146416000', 'display_name': 'University of Kansas', 'ror': 'https://ror.org/001tmjg57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I146416000']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara N. Timmermann', 'raw_affiliation_strings': ['3University of Kansas, Lawrence, KS.'], 'affiliations': [{'raw_affiliation_string': '3University of Kansas, Lawrence, KS.', 'institution_ids': ['https://openalex.org/I146416000']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057675169', 'display_name': 'Mark S. Cohen', 'orcid': 'https://orcid.org/0000-0002-2517-0757'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Steven Cohen', 'raw_affiliation_strings': ['1University of Michigan, Ann Arbor, MI,'], 'affiliations': [{'raw_affiliation_string': '1University of Michigan, Ann Arbor, MI,', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.61, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.744908, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '14', 'issue': '7_Supplement', 'first_page': 'B24', 'last_page': 'B24'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12298', 'display_name': 'Phytochemicals and Medicinal Plants', 'score': 0.8967, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12298', 'display_name': 'Phytochemicals and Medicinal Plants', 'score': 0.8967, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.80954605}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6176903}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6085995}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5242032}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.49669725}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4748495}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.4515679}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3916386}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.36960793}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3600844}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14385846}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.104519844}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-8514.pi3k14-b24', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597', 'https://openalex.org/W2019551003'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Current': [2], 'targeted': [3, 83, 348], 'inhibitors': [4, 38, 84, 351], 'for': [5, 32, 104, 124, 146, 156, 171, 184, 228], 'colon': [6, 90, 134, 188, 211, 316, 327, 388, 494, 567], 'cancer': [7, 65, 135, 189, 317, 389], 'can': [8], 'reduce': [9], 'tumor': [10, 128, 422], 'burdens': [11], 'or': [12, 235, 432], 'stabilize': [13], 'disease,': [14], 'but': [15], 'are': [16, 39, 482], 'limited': [17], 'by': [18, 142, 148, 153, 167, 288, 426, 436, 476], 'their': [19, 528], 'toxicity': [20, 231, 518], 'and': [21, 35, 60, 66, 116, 151, 160, 173, 197, 218, 226, 239, 284, 292, 308, 336, 354, 375, 462, 496, 502, 516, 571], 'lack': [22], 'of': [23, 76, 85, 119, 230, 244, 304, 323, 415, 424, 486, 553, 577], 'durable': [24], 'efficacy.': [25], 'Efforts': [26], 'continue': [27], 'to': [28, 52, 266, 326, 369, 372, 411, 466, 473, 506, 526], 'identify': [29], 'novel': [30, 102, 484, 563], 'agents': [31], 'this': [33, 73, 86, 105, 285, 532], 'disease': [34, 371], 'newer': [36], 'multi-kinase': [37], 'currently': [40], 'being': [41, 508], 'evaluated': [42, 509], 'in': [43, 58, 61, 63, 89, 92, 97, 213, 260, 268, 310, 314, 340, 413, 493, 500, 503, 510, 519, 531, 569, 572, 586], 'clinical': [44, 511, 529], 'trials.': [45], 'Novel': [46], 'natural': [47], 'withanolides': [48, 273, 330, 481], 'have': [49], 'been': [50], 'shown': [51], 'selectively': [53, 82, 301, 490, 557], 'inhibit': [54, 359], 'the': [55, 214, 245, 252, 261, 315, 329, 360, 373, 395, 400, 467, 559, 578, 583], 'PI3K-Akt-mTOR': [56], 'pathway': [57, 87, 561], 'vitro': [59, 93, 501, 570], 'vivo': [62, 98, 504], 'adrenal': [64], 'medullary': [67], 'thyroid': [68], 'cancers.': [69], 'We': [70], 'hypothesize': [71], 'that': [72, 489, 556], 'new': [74, 551], 'class': [75, 485], 'drug': [77], 'compounds': [78, 522], 'will': [79], 'be': [80], 'potent,': [81], 'network': [88], 'cancers': [91, 495, 568], 'as': [94, 96, 99, 181, 183, 256, 258, 562], 'well': [95, 182], 'a': [100, 311, 341, 376, 407, 421, 483], 'promising': [101], 'therapeutics': [103, 565], 'disease.': [106, 533], 'Methods:': [107], 'In': [108, 200, 363], 'vitro:': [109], 'Withaferin': [110], 'A': [111, 114, 550], '(WA),': [112], 'withalongolide': [113], '(WGA)': [115], 'acetylated': [117, 253], 'derivatives': [118, 254], 'each': [120], 'were': [121, 205, 224, 255], 'first': [122], 'tested': [123], 'anticancer': [125, 554], 'effect': [126], 'on': [127, 131, 187, 281, 295], 'cell': [129, 263], 'viability': [130], '5': [132, 262], 'different': [133], 'lines': [136, 264, 318], '(SW48,': [137], 'SW480,': [138], 'HT-29,': [139], 'SW-620,': [140], 'HCT-116)': [141], 'MTS': [143], 'assay,': [144], 'then': [145], 'apoptosis': [147, 276], 'flow': [149, 282], 'cytometry': [150, 283], 'confirmed': [152, 166, 287], 'western': [154, 168], 'analysis': [155, 170], 'caspase': [157, 289], '3': [158, 290], 'activation': [159, 291], 'PARP': [161, 293], 'cleavage.': [162], 'PI3K-mTOR': [163, 361, 492, 560, 584], 'inhibition': [164], 'was': [165, 286, 457], 'blot': [169], 'total': [172], 'phosphorylated': [174], 'levels': [175, 243, 339], 'of:': [176], 'mTOR,': [177, 305], 'Akt,': [178, 306], '4EBP1,': [179, 307], 'p70-S6K;': [180], 'specific': [185], 'effects': [186], 'regulatory': [190], 'pathways': [191], 'including:': [192], 'GSK3β,': [193, 332], 'β-catenin,': [194, 333], 'Notch1': [195, 334], 'cleavage,': [196, 335], 'cyclin': [198, 337], 'D1.': [199], 'vivo:': [201], 'Athymic': [202], 'nude': [203], 'mice': [204, 416, 441], 'injected': [206], 'with': [207, 398, 420, 459, 471, 513], '10^7': [208], 'HT-29': [209, 387], 'human': [210], 'cancer-cells': [212], 'left': [215], 'posterior': [216], 'flank': [217], 'treated': [219], 'x': [220], '21days': [221], 'once': [222], 'tumors': [223], '>100mm3(N=10/drug)': [225], 'followed': [227], 'endpoints': [229], '(decreased': [232], 'body': [233, 236], 'weight': [234, 453, 475], 'score),tumor': [237], 'growth>1500mm3': [238], 'survival.': [240], 'Results:': [241], 'IC50': [242], 'parent': [246], 'compound': [247], 'WA': [248, 401], 'averaged': [249], '640nM': [250], 'whereas': [251], 'low': [257], '30-100nM': [259], 'compared': [265, 465, 505], '4500nM': [267], 'normal': [269], 'fibroblast': [270], 'cells.': [271], 'The': [272], 'potently': [274, 346], 'induced': [275], '(starting': [277], 'at': [278, 320, 391, 404], '250-500nM': [279], 'drug)': [280], 'cleavage': [294], 'Western': [296], 'analysis.': [297], 'These': [298, 521], 'drugs': [299, 488, 555], 'also': [300, 442], 'inhibited': [302, 386], 'phosphorylation': [303], 'p70S6K': [309], 'dose-dependent': [312, 342], 'manner': [313, 343], 'starting': [319], 'only': [321, 399], '500nM': [322], 'drug.': [324], 'Specific': [325], 'cancers,': [328], 'modulated': [331], 'D1': [338], 'all': [344, 365, 449], 'more': [345], 'than': [347], 'tyrosine': [349], 'kinase': [350], 'like': [352], 'ventadenib': [353], 'cabozantenib': [355, 433], 'which': [356], 'did': [357], 'not': [358], 'pathway.': [362], 'vivo,': [364], 'control': [366], 'animals': [367], 'progressed': [368], 'metastatic': [370], 'liver': [374], 'terminal': [377], 'study': [378], 'endpoint': [379], 'within': [380], '6': [381], 'weeks.': [382], 'All': [383], 'treatment': [384, 396, 402, 412, 456, 469], 'arms': [385], 'growth': [390], 'varying': [392], 'rates': [393], 'during': [394, 455], 'period': [397], 'arm': [403], '8mg/kg/day': [405], 'demonstrating': [406], 'complete': [408], 'pathologic': [409], 'response': [410], '80%': [414], '(p<0.001': [417, 429], 'vs': [418], 'controls': [419], 'increase': [423, 435], '363±31%': [425], 'day': [427, 437], '21);': [428], 'vs.': [430, 448], 'vandetanib': [431, 460], '31-282%': [434], '21': [438], 'respectively).': [439], 'WA-treated': [440], 'had': [443], '100%': [444], 'survival': [445], 'after': [446], '8wks': [447], 'other': [450], 'arms(0-71%survival;p<0.01).': [451], 'Body': [452], 'loss': [454], 'worst': [458], '(18.5±1.3%)': [461], 'cabozantinib': [463], '(6.85±1.8%)': [464], 'withanolide': [468], 'arms(p<0.01)': [470], 'return': [472], 'baseline': [474], 'week': [477], '5.': [478], 'Conclusions:': [479], 'Natural': [480, 548], 'chemotherapy': [487], 'target': [491, 558], 'demonstrate': [497], 'potent': [498, 564], 'efficacy': [499], 'TKIs': [507], 'trials': [512], 'improved': [514], 'tolerability': [515], 'less': [517], 'vivo.': [520, 573], 'warrant': [523], 'further': [524], 'evaluation': [525], 'determine': [527], 'potential': [530], 'Citation': [534], 'Format:': [535], 'Chitra': [536], 'Subramanian,': [537], 'Peter': [538], 'White,': [539], 'Alicia': [540], 'Gingrich,': [541], 'Barbara': [542], 'N.': [543], 'Timmermann,': [544], 'Mark': [545], 'Steven': [546], 'Cohen.': [547], 'withanolides:': [549], 'group': [552], 'against': [566], '[abstract].': [574], 'In:': [575], 'Proceedings': [576], 'AACR': [579], 'Special': [580], 'Conference:': [581], 'Targeting': [582], 'Network': [585], 'Cancer;': [587], 'Sep': [588], '14-17,': [589], '2014;': [590], 'Philadelphia,': [591], 'PA.': [592], 'Philadelphia': [593], '(PA):': [594], 'AACR;': [595], 'Mol': [596], 'Cancer': [597], 'Ther': [598], '2015;14(7': [599], 'Suppl):Abstract': [600], 'nr': [601], 'B24.': [602]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2512063176', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:38:09.034171', 'created_date': '2016-09-16'}