Title: 325. The prognostic value of serum levels of CCL2 and CCL5 in colorectal cancer
Abstract: Chemokines are the chemotactic cytokines. They play an important role in induction and maintenance of immune reactions by regulation of migration of immunocompetent cells, angiogenesis and migration of stem cells. They have also been shown to regulate other processes such as cancer progression and cancer cell migration. The aim of the study was to determine the prognostic role of serum levels of CCL2 (chemokine (C-C motif) ligand 2) and CCL5 (chemokine (C–C motif) ligand 5) in case of patients with colorectal cancer. The study involved 45 patients with colorectal cancer. The serum concentration of CCL2 and CCL5 was measured before the surgery. Calculated optimal cut ff points based on ROC curve were 103.6 pg/ml for CCL2 and 11933.2 pg/ml for CCL5. An analysis of survival and multivariate analysis of prognostic factors were performed.
Publication Year: 2016
Publication Date: 2016-08-25
Language: en
Type: article
Indexed In: ['crossref']
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