Publication Information

{'id': 'https://openalex.org/W2508191807', 'doi': 'https://doi.org/10.1016/j.stemcr.2016.07.014', 'title': 'A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers', 'display_name': 'A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers', 'publication_year': 2016, 'publication_date': '2016-08-22', 'ids': {'openalex': 'https://openalex.org/W2508191807', 'doi': 'https://doi.org/10.1016/j.stemcr.2016.07.014', 'mag': '2508191807', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27546532', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5034562'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2016.07.014', 'pdf_url': 'https://www.cell.com/article/S2213671116301382/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.cell.com/article/S2213671116301382/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036136107', 'display_name': 'Satoshi Okawa', 'orcid': 'https://orcid.org/0000-0003-3916-3109'}, 'institutions': [{'id': 'https://openalex.org/I186903577', 'display_name': 'University of Luxembourg', 'ror': 'https://ror.org/036x5ad56', 'country_code': 'LU', 'type': 'education', 'lineage': ['https://openalex.org/I186903577']}], 'countries': ['LU'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Okawa', 'raw_affiliation_strings': ['Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg'], 'affiliations': [{'raw_affiliation_string': 'Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg', 'institution_ids': ['https://openalex.org/I186903577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035743947', 'display_name': 'Sarah Nicklas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186903577', 'display_name': 'University of Luxembourg', 'ror': 'https://ror.org/036x5ad56', 'country_code': 'LU', 'type': 'education', 'lineage': ['https://openalex.org/I186903577']}], 'countries': ['LU'], 'is_corresponding': False, 'raw_author_name': 'Sarah Nicklas', 'raw_affiliation_strings': ['Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg'], 'affiliations': [{'raw_affiliation_string': 'Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg', 'institution_ids': ['https://openalex.org/I186903577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038407812', 'display_name': 'Sascha Zickenrott', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I186903577', 'display_name': 'University of Luxembourg', 'ror': 'https://ror.org/036x5ad56', 'country_code': 'LU', 'type': 'education', 'lineage': ['https://openalex.org/I186903577']}], 'countries': ['LU'], 'is_corresponding': False, 'raw_author_name': 'Sascha Zickenrott', 'raw_affiliation_strings': ['Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg'], 'affiliations': [{'raw_affiliation_string': 'Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg', 'institution_ids': ['https://openalex.org/I186903577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061805930', 'display_name': 'Jens C. Schwamborn', 'orcid': 'https://orcid.org/0000-0003-4496-0559'}, 'institutions': [{'id': 'https://openalex.org/I186903577', 'display_name': 'University of Luxembourg', 'ror': 'https://ror.org/036x5ad56', 'country_code': 'LU', 'type': 'education', 'lineage': ['https://openalex.org/I186903577']}], 'countries': ['LU'], 'is_corresponding': False, 'raw_author_name': 'Jens\xa0C. Schwamborn', 'raw_affiliation_strings': ['Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg'], 'affiliations': [{'raw_affiliation_string': 'Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg', 'institution_ids': ['https://openalex.org/I186903577']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075664103', 'display_name': 'Antonio del Sol', 'orcid': 'https://orcid.org/0000-0002-9926-617X'}, 'institutions': [{'id': 'https://openalex.org/I186903577', 'display_name': 'University of Luxembourg', 'ror': 'https://ror.org/036x5ad56', 'country_code': 'LU', 'type': 'education', 'lineage': ['https://openalex.org/I186903577']}], 'countries': ['LU'], 'is_corresponding': True, 'raw_author_name': 'Antonio del\xa0Sol', 'raw_affiliation_strings': ['Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg'], 'affiliations': [{'raw_affiliation_string': 'Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg', 'institution_ids': ['https://openalex.org/I186903577']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5075664103'], 'corresponding_institution_ids': ['https://openalex.org/I186903577'], 'apc_list': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'apc_paid': {'value': 3500, 'currency': 'USD', 'value_usd': 3500, 'provenance': 'doaj'}, 'fwci': 2.138, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 49, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '7', 'issue': '3', 'first_page': '307', 'last_page': '315'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cell-fate-determination', 'display_name': 'Cell fate determination', 'score': 0.8065165}, {'id': 'https://openalex.org/keywords/gene-regulatory-network', 'display_name': 'Gene regulatory network', 'score': 0.6212878}, {'id': 'https://openalex.org/keywords/cell-type', 'display_name': 'Cell type', 'score': 0.45656618}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8453977}, {'id': 'https://openalex.org/C163952510', 'wikidata': 'https://www.wikidata.org/wiki/Q5058196', 'display_name': 'Cell fate determination', 'level': 4, 'score': 0.8065165}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.6827729}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.6809691}, {'id': 'https://openalex.org/C67339327', 'wikidata': 'https://www.wikidata.org/wiki/Q1502576', 'display_name': 'Gene regulatory network', 'level': 4, 'score': 0.6212878}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.55359954}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.5187831}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5088837}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.46211413}, {'id': 'https://openalex.org/C189014844', 'wikidata': 'https://www.wikidata.org/wiki/Q189118', 'display_name': 'Cell type', 'level': 3, 'score': 0.45656618}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.34408265}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30261344}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.26067132}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.1702117}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053263', 'descriptor_name': 'Gene Regulatory Networks', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2016.07.014', 'pdf_url': 'https://www.cell.com/article/S2213671116301382/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b93eb6f3d8564d0e93a91a22d5bcc5a3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5034562', 'pdf_url': 'https://europepmc.org/articles/pmc5034562?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27546532', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.stemcr.2016.07.014', 'pdf_url': 'https://www.cell.com/article/S2213671116301382/pdf', 'source': {'id': 'https://openalex.org/S2764425922', 'display_name': 'Stem Cell Reports', 'issn_l': '2213-6711', 'issn': ['2213-6711'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1547855212', 'https://openalex.org/W1608762409', 'https://openalex.org/W1958673105', 'https://openalex.org/W1963879539', 'https://openalex.org/W1990786962', 'https://openalex.org/W1994596418', 'https://openalex.org/W1997708534', 'https://openalex.org/W1997812904', 'https://openalex.org/W2018235103', 'https://openalex.org/W2025046506', 'https://openalex.org/W2026663073', 'https://openalex.org/W2028223005', 'https://openalex.org/W2029991507', 'https://openalex.org/W2030047266', 'https://openalex.org/W2032619610', 'https://openalex.org/W2035036685', 'https://openalex.org/W2053367939', 'https://openalex.org/W2055568103', 'https://openalex.org/W2059270106', 'https://openalex.org/W2059485110', 'https://openalex.org/W2061837158', 'https://openalex.org/W2067423804', 'https://openalex.org/W2073303427', 'https://openalex.org/W2075529268', 'https://openalex.org/W2078324969', 'https://openalex.org/W2082931608', 'https://openalex.org/W2104708641', 'https://openalex.org/W2111676921', 'https://openalex.org/W2118430622', 'https://openalex.org/W2135801344', 'https://openalex.org/W2141392414', 'https://openalex.org/W2159559130', 'https://openalex.org/W2166676212', 'https://openalex.org/W2224277895', 'https://openalex.org/W2228779922', 'https://openalex.org/W2287379375', 'https://openalex.org/W2794178849', 'https://openalex.org/W2962678531', 'https://openalex.org/W3099614534'], 'related_works': ['https://openalex.org/W4393191903', 'https://openalex.org/W4390011121', 'https://openalex.org/W4387096200', 'https://openalex.org/W4387096194', 'https://openalex.org/W4366722611', 'https://openalex.org/W4281759407', 'https://openalex.org/W2508191807', 'https://openalex.org/W1995507342', 'https://openalex.org/W1985607197', 'https://openalex.org/W1522194210'], 'abstract_inverted_index': {'Identification': [0], 'of': [1, 38, 58, 96, 104, 124], 'cell-fate': [2, 18, 44, 78, 92, 99], 'determinants': [3, 19, 45, 79, 100], 'for': [4], 'directing': [5], 'stem': [6, 39, 111, 125, 136], 'cell': [7, 40, 126, 137], 'differentiation': [8, 41, 127, 133], 'remains': [9], 'a': [10, 36, 56, 71], 'challenge.': [11], 'Moreover,': [12], 'little': [13], 'is': [14], 'known': [15, 61], 'about': [16], 'how': [17], 'are': [20], 'regulated': [21], 'in': [22, 26, 42, 55, 108, 135], 'functionally': [23], 'important': [24], 'subnetworks': [25], 'large': [27], 'gene-regulatory': [28], 'networks': [29], '(i.e.,': [30], 'GRN': [31, 59, 82], 'motifs).': [32], 'Here': [33], 'we': [34, 69], 'propose': [35], 'model': [37, 123], 'which': [43], 'work': [46], 'synergistically': [47], 'to': [48, 88], 'determine': [49], 'different': [50], 'cellular': [51], 'identities,': [52], 'and': [53, 80, 94, 106, 115, 128, 139], 'reside': [54], 'class': [57], 'motifs': [60], 'as': [62], 'feedback': [63], 'loops.': [64], 'Based': [65], 'on': [66], 'this': [67], 'model,': [68], 'develop': [70], 'computational': [72, 129], 'method': [73, 85, 130], 'that': [74, 102], 'can': [75, 131], 'systematically': [76], 'predict': [77], 'their': [81], 'motifs.': [83], 'The': [84], 'was': [86], 'able': [87], 'recapitulate': [89], 'experimentally': [90], 'validated': [91], 'determinants,': [93], 'validation': [95], 'two': [97], 'predicted': [98], 'confirmed': [101], 'overexpression': [103], 'ESR1': [105], 'RUNX2': [107], 'mouse': [109], 'neural': [110], 'cells': [112], 'induces': [113], 'neuronal': [114], 'astrocyte': [116], 'differentiation,': [117], 'respectively.': [118], 'Thus,': [119], 'the': [120], 'presented': [121], 'GRN-based': [122], 'guide': [132], 'experiments': [134], 'research': [138], 'regenerative': [140], 'medicine.': [141]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2508191807', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2024-12-21T19:35:25.668679', 'created_date': '2016-09-16'}