Title: Regulation of Neutrophil Functions by Long Chain Fatty Acids
Abstract: The Neutrophils, pp. 169-228 (2005) No AccessRegulation of Neutrophil Functions by Long Chain Fatty AcidsAntonio Ferrante, Charles S. Hii and Maurizio CostabileAntonio FerranteCorrespondence to: Antonio Ferrante. Department of Immunopathology, The Women's and Children's Hospital, University of Adelaide, 72, King William Road, North Adelaide, SA 5006, Australia; phone: 61 8 81617216; fax: 61 8 81616046, Charles S. Hii and Maurizio Costabilehttps://doi.org/10.1142/9781860946059_0006Cited by:4 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Abstract: Long chain fatty acids such as arachidonic acid regulate key neutrophil functional responses, either directly as free fatty acids or through the generation of biologically active metabolites such as leukotrienes. The metabolites of arachidonic can either promote or suppress neutrophil responses. Alteration in specific structural elements on long chain fatty acids modifies their biological properties, giving rise to a network of lipid mediators which regulate the inflammatory reaction. These fatty acids activate several intracellular signaling molecules, including protein kinase c, mitogen activated protein kinases, phospholipase A2 and phosphatidyinositol 3 kinase which are relevant to the stimulation of the cellular inflammatory response. Keywords: long chain fatty acidsneutrophilsinflammation intracellular signalingarachidonic acidleukotrienes FiguresReferencesRelatedDetailsCited By 4n -3 Fatty acid supplementation and regular moderate exercise: differential effects of a combined intervention on neutrophil functionAlison M. Hill, Caroline Worthley, Karen J. Murphy, Jonathan D. Buckley and Antonio Ferrante et al.1 August 2007 | British Journal of Nutrition, Vol. 98, No. 2Mechanisms by which fatty acids regulate leucocyte functionThais Martins de Lima, Renata Gorjão, Elaine Hatanaka, Maria Fernanda Cury-Boaventura and Erica Paula Portioli Silva et al.13 June 2007 | Clinical Science, Vol. 113, No. 2Novel action ofn-3 polyunsaturated fatty acids: Inhibition of arachidonic acid–induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteasesNahid Moghaddami, James Irvine, Xiuhui Gao, Phulwinder K. Grover and Maurizio Costabile et al.1 January 2007 | Arthritis & Rheumatism, Vol. 56, No. 3A Novel β-Oxa Polyunsaturated Fatty Acid Downregulates the Activation of the IκB Kinase/Nuclear Factor κB Pathway, Inhibits Expression of Endothelial Cell Adhesion Molecules, and Depresses InflammationAntonio Ferrante, Brenton S. Robinson, Harmeet Singh, Hubertus P.A. Jersmann and Judith V. Ferrante et al.7 Jul 2006 | Circulation Research, Vol. 99, No. 1 The NeutrophilsMetrics History Keywordslong chain fatty acidsneutrophilsinflammation intracellular signalingarachidonic acidleukotrienesPDF download
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 10
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