Abstract: Sjogren’s syndrome (SS) is a chronic autoimmune disease, primarily affecting middle-aged women. The major SS characteristic is the accumulation of periepithelial lymphocytic cell infiltrates in the exocrine glands, mainly labial and lachrymal glands, resulting in oral and ocular dryness. SS epithelial cell also plays a central role in disease pathogenesis serving as an antigen-presenting cell, recruiting B and T lymphocytes through lympho-attractant chemokines, and ensuring B-cell lymphocyte survival and proliferation through BAFF production. This chapter will focus on the interaction among genetic, epigenetic, and environmental contributors underling the pathogenesis of this complex disease
Publication Year: 2016
Publication Date: 2016-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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